| PHARMACOLOGY
(PHA) |
| |
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| PHA 540 |
Medical
Pharmacology |
7 cr |
|
| This
course is designed to provide the student with
a basic understanding of the actions of drugs
and their clinical uses. Basic principles, including
dose-response relationships and receptor theory,
are emphasized. Current concepts of drug effects,
mechanisms, and sites of action are explored in
detail with respect to major classes of drugs.
Important considerations are also given to drug
interactions and the toxicology of therapeutic
agents, chemicals in the environment, and other
biologically active substances. |
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| PHA 546
|
Literature Reports
|
1 cr |
|
| Students
and faculty participate in a supervised reading
of the current literature and meet periodically
(usually once a week) to interact in a discussion
of the selected article or topic. The goal of
this course is to maintain the faculty's and students'
level of information at a "state of the art"
in both methods and theory in the discipline and
to develop critical skills in reviewing the literature. |
| |
| PHA 547
|
Directed
Studies |
1-6 cr |
|
| Students
participate in research under the direction of
a graduate faculty member. The student may pursue
independent research or participate in a literature
project. |
| |
| PHA 548
|
Physiological
Pharmacology |
6 cr |
|
| This
course covers both cellular and organ system physiology.
It is designed to prepare graduate students for
Medical Pharmacology (PHA 540), for research in
pharmacology, and includes reading and discussion
of articles from the literature. |
| |
| PHA 590
|
Special
Topics |
1-3 cr |
|
| Each
course provides in-depth tutorial exposure to
specific areas in the discipline. Student and/or
faculty presentations followed by group discussions
(usually in the Socratic mode), examine the subject
matter in an area of current interest either to
one student or to a group of students. Credits
and titles are arranged with an individual faculty
member. |
| |
| PHA 640 |
Molecular
and Cellular Pharmacology |
3 cr |
|
| In
this course, the central themes of signal transduction
from cellular receptor to amplified response,
structure-activity relationships, and drug design
are studied comprehensively. Specific topics include
receptor-ligand interactions, receptor structure
and coupling mechanisms, the biochemical and molecular
aspects of G-proteins, protein phosphorylation
mechanisms, molecular modeling and protein crystallography.
Prerequisites: Biochemistry. |
| |
| PHA 643 |
Molecular
and Cellular Toxicology |
3 cr |
|
| This
course is concerned with the mechanisms by which
toxic substances exert their effects at the molecular
and cellular level. Detailed analysis of the processes
by which toxic materials are metabolized to toxic
intermediates is addressed. The mode of action
of how toxic compounds interact with structural
proteins and other macromolecules, enzymes and
receptors, and the genome is included. Examples
of toxicity of the heart, liver, lung, pancreas,
and brain, including teratogenic, mutagenic, and
carcinogenic effects are discussed at the mechanistic
level. Prerequisites: Biochemistry. |
| |
| PHA 646 |
Research
Seminar |
1 cr |
|
| Students
and faculty present a research topic for discussion
before members of the department. The presentations
are usually scheduled on a rotational basis. The
student may present research data for critique
by the faculty.
|
| |
| PHA 799 |
Research/Dissertation |
1-6 cr |
|
| Independent
research by the student under the sponsorship
of the graduate faculty in individual departments
in the Basic Medical Sciences. Prerequisite: Approved
formal research proposal. |
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