EDUCATION

POSTGRADUATE TRAINING

PROFESSIONAL EXPERIENCE

MAJOR RESEARCH INTERESTS

Microparticle generation and signaling in pulmonary vasculature

Pulmonary microparticle signaling to systemic vascular beds

Hypoxia regulated RhoA/Rho kinase signaling in the pulmonary microvasculature

PROFESSIONAL AND HONORARY SOCIETIES

Sigma Xi

Order of Omega

Omicron Delta Kappa

Beta Beta Beta (President, 1995-96)

Alpha Epsilon Delta (National Delegate and Vice President 1994; President 1995)

Orientation Leader/Freshman mentor

Basic Medical Sciences Student Organization (Vice President, 1997-98; Secretary-Treasurer 1999)

American Association for the Advancement of Science

The American Physiological Society

American Association for Cancer Research

American Thoracic Society

AWARDS/HONORS

2008, Who’s Who in America

2001, Graduate Student travel award, Department of Pharmacology, University of South Alabama

2000, The Proctor and Gamble Professional Opportunity Award for Meritorious Research, awarded by The American Physiological Society

2000, Graduate Student travel award, Department of Pharmacology, University of South Alabama

1999, Graduate Student travel award, Department of Pharmacology, University of South Alabama

1996, Graduated with Honors, Delta State University

1996, American Association of University Women Award

1996, Who’s Who Among American College Students

CONTRIBUTIONS TO EDUCATION

Instructor, Medical Pharmacology, Biomedical Enrichment and Recruitment (BEAR) program.  University of South Alabama.  2004.

Co-course director and Instructor, Medical Cell Biology, Biomedical Enrichment and Recruitment (BEAR) program.  University of South Alabama.  2004.

Course director and Instructor, Medical Cell Biology, Biomedical Enrichment and Recruitment (BEAR) program.  University of South Alabama.  2005.

Clinical Correlation Studies, Medical Pharmacology.  Department of Pharmacology, University of South Alabama.  2005-2008.

Graduate student Lung Biology (IDL 630).  “Lung Cell Turnover”.  2007-present

Graduate student Lung Pathobiology (IDL 631) “Microparticles in Lung Pathobiology”  2008-present

PHM221/PHA540 Medical Pharmacology, “Anti-neoplastics and Immunotherapy” Spring 2009. 

MENTORSHIP

Dr. Justin Campbell, COM 2006, Summer Medical Research Student, 2004. 

Dr. Grantham M. Shell, COM 2007, Summer Medical Research Student, 2005.

Jyoti Rai, B.S. University of South Alabama, 2007, Undergraduate Honors Research.

Salina Gairhe, Ph.D. Candidate, University of South Alabama, 2007 to present, serving as Committee Member.

John Bozek, Summer Undergraduate Research Program, 2008.

Jean-Pierre Arditi, Undergraduate Research Scholarship Recipient, 2009.

Carlton Andrew Smith, COM 2012, Summer Medical Research Student, 2009.

April Burton, University Committee on Undergraduate Research, 2009.

Vrajesh Derodra, Master’s Student,  Environmental Toxicology Program, Mentor and Committee Chair, 2009-.

RESEARCH GRANTS

American Heart Association, Desert Mountain Affiliate.  Postdoctoral Fellowship. AHA Reference # 0320020Z.  2002-2005

American Heart Association, Greater Southeast Affiliate, Beginning Grant-in-Aid.  AHA Reference # 0765413B.  2007-2009

Parker Families Foundation, Parker B. Francis Fellowship, 2008-2011

PUBLICATIONS

1. Moore, T., Norwood, N.,  Creighton, J.,  Babal, P.,Brough, G., Shasby, D., and Stevens, T. Receptor-Dependent Activation of Store-Operated Calcium Entry Increases Endothelial Cell Permeability. Am J Physiol Lung Cell Mol Physiol 279: L691-L698, 2000.
2. Norwood, N., Moore, T., Dean, D., Bhattacharjee, R.,  Li, M., and Stevens, T. Store-Operated Calcium Entry and Endothelial Cell Permeability.  Am J Physiol Lung Cell Mol Physiol 279: L815-L824, 2000.
3. McMurtry, I., Bauer, N., Fagan, K., Nagaoka, T., Gebb, S.,  and Oka, M.  Hypoxia and Rho/Rho-kinase signaling.  Lung development versus hypoxic pulmonary hypertension.  Adv Exp Med Biol 543: 127-37, 2003.
4. Nagaoka, T.,  Morio, Y.,  Casanova, N.,  Bauer, N.,  Gebb, S.,  McMurtry, I.,  and Oka, M. Rho/Rho kinase Signaling Mediates Increased Basal Pulmonary Vascular Tone in Chronically Hypoxic Rats.  Am J Physiol Lung Cell Mol Physiol 287(4): L665-72, 2004.
5. Fagan, K., Oka, M., Bauer, N., Gebb, S., Ivy, D., Morris, K.,  and McMurtry, I.  Attenuation of Acute Hypoxic Pulmonary Vasoconstriction and Hypoxic Pulmonary Hypertension in Mice by Inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287(4): L656-64, 2004.
6. Sisbarro, L.,  Ihida-Stansbury, K.,  Stevens, T.,  Bauer, N., McMurtry, I.,  and Jones, P.  The Extracellular Matrix Microenvironment Specifies Pulmonary Endothelial Cell Identity:  Roles of Tenascin-C and RhoA.  Chest 128 (6 Suppl): 564S, 2005. 
7. Garat, C., Fankell, D.,  Erickson, P.,  Reusch, J.,  Bauer, N., McMurtry,I.,  and Klemm, D.  Platelet Derived Growth Factor BB Induces Nuclar Export and Proteasomal  Degradation of CREB via Phosphatidylinositol 3-kinase/Akt Signaling in Pulmonary Artery Smooth Muscle Cells.  Mol Cell Biol 26(13): 4934-4948, 2006. 
8. Bauer, N., Moore, T., and McMurtry, I.  Rodent models of PAH:  Are we there yet?  Am J Physiol Lung Cell Mol Physiol 293(3): L580-582, 2007.
9. Bauer, N.,  Chen, Y., Samant, R., Shevde-Samant, L.,  Fodstad, O.   Rac1-dependent NFκB Activity Regulates proliferation of Aggressive Metastatic Melanoma.  Exp Cell Res313 (18): 3832-3839, 2007.
10. King, J., Syklawer,E., Chen, H.,  Resmondo, J., McDonald, F.,  Stevens, T., Shevde, L.,  Ofori-Acquah, S.,  Moore, T.,  and Bauer, N.  Lung endothelial cells express ALCAM on released exosomes/microparticles.  Microsc Microanal 14(Suppl 2), 2008.
11. King, J., Agarwal, S., Syklawer,E.,  Prasain, N.,  Chen, H.,  Resmondo, J.,  McDonald, F.,  Bauer, N., Alvarez, D., Wu, S.,  Stevens, T.,  Shevde, L.,  Moore, T., and Townsley, M.  Quantum dots-Utilization in TEM.  Microsc Microanal 14(Suppl 2), 2008.
12. Bauer, N., Rai, J., Chen, H., Harris, L., Shevde, L., Moore, T., and King, J.  Microparticles/Exosomes: Isolation and TEM Analysis.  Microscopy Today 17(2):42-45, 2009.
13. Rai,J., McMurtry,I., King, J., and Bauer, N.  Hypoxia-induced pulmonary microvascular endothelial microparticles regulate pulmonary vascular barrier function.  In preparation.

ABSTRACTS

1. Moore, T., Norwood, N., Brough, G., and Stevens, T. F-actin Gates Thapsigargin-Sensitive Store Operated Calcium Channels in Pulmonary Endothelial Cells. FASEB J, 12: A777, 1998.
2. Moore, T., Norwood, N., Brough, G., Creighton, J., Lee, L., Babal, P.  and Stevens, T. Calcium Influx Is Sufficient But Not Required For Thrombin-Induced Endothelial Cell Shape Change. FASEB J., 13: A501, 1999.
3. Norwood, N., Dean, D., Moore, T., Creighton, J., Babal, P., and Stevens, T. Inhibition of Myosin Light Kinase Stimulates Calcium Release in Pulmonary Artery Endothelial Cells.  FASEB J., 13: A502, 1999.
4. Norwood, N., Moore, T., Creighton, J., Babal, P., Bhattacharjee, R., and Stevens, T.  Myosin Light Chain Kinase Regulates Activation of Store-Operated Calcium Entry in Pulmonary Artery Endothelial Cells. FASEB J., 13: A502, 1999.
5. Norwood, N., Cioffi, D., Moore, T., and Stevens, T. Distinct Regulation of Endothelial Cell Permeability by Proteolytic and Direct Activation of the Thrombin Receptor.    FASEB J., 14: A694, 2000.
6. Norwood, N., Moore, T.,  and Stevens, T. Use of Myosin Light Chain Kinase Inhibitor, ML-9, Reveals a Mechanism for Increased Pulmonary Artery Endothelial Permeability.   FASEB J., 14:  A693, 2000   
7. El-Menshawi, M., Moore, T., Norwood, N.,  and Stevens,T. Transcytosis Through Lung Endothelium.  Implications for Inflammation.  FASEB J.,14:  A129, 2000
8. Norwood, N., Wu, S., Dudek, S., Garcia, J. and Stevens, T.  Endothelial Cell Myosin Light Chain Kinase-1 and Activation of Store Operated Calcium Entry.  FASEB J., 15, A492,  2001.
9. Norwood, N., Cioffi, D., Wu, S., Dudek, S., Garcia, J., and Stevens, T.  Calcium Store Depletion Promotes Tyrosine Phosphorylation of Myosin Light Chain Kinase.  FASEB J., 2002.
10. Gebb, S., Bauer, N.,Oka, M., Morio, Y., Fagan, K.,  and McMurtry, I.  Rho/Rho Kinase Signaling Mediates Increased Vascular Tone in Hypoxic Pulmonary Hpertension.  Grover Conference on Proinflammatory Signaling Mechanisms in the Pulmonary Circulation.  American Heart Association, 2002.
11. Bauer, N., Stevens, T., Gebb, S., and McMurtry, I.  Hypoxia Stimulates Rho A/Rho Kinase Signaling and Stress Fiber Formation in Pulmonary Microvascular, but not Macrovascular Endothelial Cells.  FASEB J, 2003.
12. Bauer, N., Chen, Y., Samant, R., Shevde-Samant, L., Fodstad, O.  Rac1-dependent NFκB Activity Regulates proliferation of Aggressive Metastatic Melanoma.  AACR 2006
13. King, J., Agarwal, S., Syklawer, E.,  Prasain, N., Chen, H.,  Resmondo, J.,  McDonald, F.,  Bauer, N., Alvarez, D.,  Wu, S., Stevens, T.,  Shevde, L., Moore, T.,  and Townsley, M.  Quantum dots-TEM Applications.  Proceedings of the Southeastern Microscopy Society 28:14, 2008.
14. Bauer, N., Moore, T.,  Kapadia, P.,  Townsley, M.,  and McMurtry, I. Hypoxia-induced pulmonary endothelial microparticle (EMP) generation regulates pulmonary microvascular endothelial cell (PMVEC) permeability.  FASEB J 2008
15. Rai, J., Moore, T., Kapadia, P.,  King, J., Townsley, M., and Bauer, N.  Hypoxia-stimulated microparticles induce permeability in pulmonary microvascular endothelium.  University of South Alabama, College of Medicine Research Forum, November 21, 2008
16. Gairhe, S.,  Bauer, N., Gerthoffer, W.,  McMurtry. I.,   Effects of Co-culture with pulmonary arterial endothelial cells on phenotype of pulmonary arterial smooth muscle cells.  University of South Alabama, College of Medicine Research Forum, November 21, 2008.
17. Rai, J., King, J., Moore, T.,  Bauer, N.  Soluble CD40 ligand stimulates functional microparticle release from pulmonary microvascular endothelium.  FASEB J 2009.
18. Gairhe, S., Bauer, N., Gerthoffer, W., McMurtry, I.  Effect of co-culture with pulmonary arterial endothelial cells on phenotype of pulmonary arterial smooth muscle cells.  FASEB J 2009.
19. Bauer, N., Baker, J.,  Rai, J.,  and Moore, T.  Soluble CD40L Directly Regulates PMVEC Barrier Function.  American Thoracic Society 2009.

BOOKS, CHAPTERS, AND REVIEWS

1. Bauer, N. and Stevens, T.  Putative Role for a Molecular Motor in Store Operated Calcium Entry.  Invited Review.  Cell Biochem Biophys37 (1): 53-70, 2002.
2. McMurtry, I., Bauer, N., Nagaoka, T., Gebb S., Oka, M.  Hypoxia and Rho/Rho-kinase Signaling: Lung development versus hypoxic pulmonary hypertension.  In: Hypoxia: Through the Lifecycle, edited by Roach RC, Wagner PD, and Hackett P.  New York: Kluwer Academic/Plenum, 2003. 
3. McMurtry, I., Bauer, N., Gebb, S., Fagan, K., Nagaoka, T., Oka, M. , Robertson, T.  Rho/Rho-kinase signaling in hypoxic pulmonary hypertension. In, Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms, edited by Jason X-J Yuan.  New York: Kluwer Academic/Plenum, 2004, 419-436.