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Donna L. Cioffi, Ph.D


donna

Donna L. Cioffi, Ph.D
Assistant Professor
Phone: (251) 460-6995
Fax: (251) 460-6798
dlc302@jaguar1.usouthal.edu

EDUCATIONAL HISTORY

Institution / Location Degree Year Conferred Field of Study
University of Connecticut
 B.S. 1982 Chemistry
Storrs, CT (Magna Cum Laude)
       
Yale University M.S. 1985 Organic Chemistry
New Haven, CT
       
University of South Alabama Ph.D. 2006 Pharmacology
Mobile, AL

HONORS AND AWARDS
Young Investigator Award, American Physiological Society, Respiration Section, 2003
Outstanding Senior Award, American Chemical Society, 1982
University Scholar, University of Connecticut, 1980
Honors Scholar, University of Connecticut, 1980

ACADEMIC EXPERIENCE
1980 – 1982 Research Assistant, Department of Chemistry, University of Connecticut
Teaching Assistant, Department of Chemistry, University of Connecticut
1982 – 1983 Teaching Assistant, Department of Chemistry, Pennsylvania State University
1983 – 1985 Research Assistant, Department of Chemistry, Yale University
Teaching Assistant, Department of Chemistry, Yale University
1998 – 1999 Instructor, Department of Chemistry, University of South Alabama

INDUSTRIAL EXPERIENCE
1985 – 1990 Pfizer, Inc., Hospital Products Group, Groton, CT
Assistant/Associate Scientist
  • Research and Development of Medical Devices
  • Quality Assurance/Quality Control
1990 – 1996 Crystal Springs Laboratory, Inc., Groton, CT
Co-founder/Owner
  • Federal and State Licensed Facility (USEPA# 06340; CTDPHAS# 0070)
  • Environmental Testing
  • Specialty Chemical Testin
1996 – 1998 Pfizer, Inc., Medical Technology Group, Groton, CT
Associate Scientist
  • Research and Development of Medical Devices and Pharmaceuticals
  • Analytical Method Development

PROFESSIONAL ORGANIZATIONS
American Physiological Society
American Chemical Society

FUNDING
American Heart Association Predoctoral Fellowship; “Regulation of Endothelial Barrier Integrity by Protein 4.1 Dependent Store Operated Calcium Entry”; 7/1/2002 – 6/30/2004; $36,000.

PUBLICATIONS
  1. Cioffi, D.L., Wu, S., Alexeyev, M., Goodman, S.R., Zhu, M.X., Stevens, T., Activation of the Endothelial Store-Operated ISOC Ca2+ Channel Requires Interaction of Protein 4.1 with TRPC4. Circ. Res., 97 (11), 1164-1172, 2005.
  2. Wu, S., Cioffi, E.A., Alvarez, D., Sayner, S., Chen, H., Cioffi, D.L., King, J., Creighton, J.R., Townsley, M., Goodman, S.R., Stevens, T., Essential Role of a Ca2+ Selective, Store Operated Current (ISOC) in Endothelial Cell Gap Formation. Circ. Res., 96 (8), 856-63, 2005.
  3. Cioffi, D.L., Wu, S., Stevens, T., Transient Receptor Potential Cation Channels and Store-Operated Ca2+ Channels. In “Ion Channels in the Pulmonary Vasculature”; Lung Biology in Health and Ca2+, Volume 197, pages 125-146; Yuan, J.X.J, ed.; Taylor & Francis Group, Florida; 2005.
  4. Wu, S., Cioffi, D.L., Stevens, T., Receptor-operated Ca2+ Channels. In “Ion Channels in the Pulmonary Vasculature”; Lung Biology in Health and Disease, Volume 197, pages 99-124; Yuan, J.X.J, ed.; Taylor & Francis Group, Florida; 2005.
  5. Cioffi, D.L., Wu, S., Stevens, T., On the Endothelial Cell ISOC. Cell Calcium, 33, 323-336, 2003.
  6. Cioffi, D.L., Moore, T.M., Creighton, J.R., Cooper, D.M.F., Stevens, T., Dominant Regulation of Endothelial Cell Adhesion by the Calcium-Inhibited Type 6 Adenylyl Cyclase. J. Cell Biol., 157 (7), 1267-1278, 2002.
  7. Brough, G.H., Wu, S., Cioffi, D., Moore, T.M., Li, M., Dean, N., Stevens, T. Contribution of Endogenously Expressed Trp1 to a Ca2+-Selective, Store-Operated Ca2+ Entry Pathway. FASEB J., 15, 1727-1738, 2001.
  8. McBride, J.M., Bertman, S.B., Cioffi, D.L., Segmuller, B.E., Weber, B.A. Interpreting Substituent Effects on the Crystal Packing of Long-Chain Diacyl Peroxides. The Crystal Structures of Di(11-bromoundecanoyl)Peroxide and Di(undecanoyl) Peroxide. Mol. Cryst. Liq. Cryst., 161, 1, 1988.
  9. Bailey, W.F., and Zartun, D.L. (Cioffi), Facile SN' Reaction of Alkyl-lithiums with 2-Vinyl-1,3- dioxane. J. Chem. Soc., Chem. Comm., 34, 1984.

ABSTRACTS
  1. Cioffi, D.L., Cioffi, E.A., Stevens, T., Regulation of Endothelial ISOC Function by Calcium Phosphate Complexation. FASEB J., 20:A748, 2006.
  2. Barry, C.J., Cioffi, D.L., Wu, S., Zhu, Stevens, T., Disruption of the Proline Rich Region / Protein 4.1 Binding Domain on the EndothelialISOC Channel Inhibits Intercellular Gap Formation. FASEB J., 20:A748, 2006.
  3. Cioffi, D.L., Alexeyev, M., Wu, S., Zhu, M.X., Goodman, S.R., Stevens, T., The EndothelialISOC Channel is Gated by Interaction of Protein 4.1 with TRPC4. Gordon Research Conference on Calcium Signaling, Oxford University, Oxford, UK, 2005.
  4. Cioffi, D.L., Alexeyev, M., Wu, S., Zhu, M.X., Goodman, S.R., Stevens, T., The EndothelialISOC Channel is Gated by Interaction of Protein 4.1 with TRPC4. FASEB J., 19:A1276, 2005.
  5. Cioffi, D.L., Alexeyev, M., Wu, S., Zhu, M.X., Goodman, S.R., Stevens, T., Protein 4.1 Gates the TRPC4-Dependent EndothelialISOC Channel. Grover Conference on the Pulmonary Circulation, Sedalia, CO, 2004.
  6. Cioffi, D.L., Alexeyev, M., Wu, S., Zhu, M.X., Goodman, S.R., Stevens, T., Activation of EndothelialISOC Requires Interaction between TRPC4 and Protein 4.1. The Third Gulf Coast Physiological Society Meeting, Mobile, AL, 2004.
  7. Barry, C.J., Cioffi, D.L., Alexeyev, M., Stevens, T., Contribution of TRPC4-DependentISOC to Endothelial Cell Gap Formation. The Third Gulf Coast Physiological Society Meeting, Mobile, AL, 2004.
  8. Cioffi, D.L., Zhu, M.X., Goodman, S.R., Stevens, T., Protein 4.1 Provides the Functional Scaffold Linking TRPC4 Calcium Channels to the Spectrin-Actin Membrane Skeleton. Gordon Research Conference on Calcium Signaling, Mount Holyoke College, MA, 2003.
  9. Cioffi, D.L., Zhu, M.X., Goodman, S.R., Stevens, T., Protein 4.1 Provides the Functional Scaffold Linking Trp4 Calcium Channels to the Membrane Skeleton. FASEB J., 17:A413, 2003.
  10. King, J., Wu, S., Cioffi, D., Sayner, S., Stevens, T., Inhibition of Type 4 Phosphodiesterase Induces Abluminal Translocation of Endoplasmic Reticulum Tubules in Lung Microvascular Endothelial Cells. FASEB J., 17:A413, 2003.
  11. Cioffi D.L., Zhu, M., Goodman, S.R., Stevens, T., Protein 4.1 Provides the Functional Scaffold Linking Trp4 Calcium Channels to the Spectrin Membrane Skeleton. Grover Conference on the Pulmonary Circulation, Sedalia, CO, 2002.
  12. Cioffi, D.L., Zhu. M., Goodman, S., Stevens, T., Association of TRP-1 and –4 Store Operated Ca2+ Entry Channels with Protein 4.1 in Endothelium. FASEB J., 16:A406, 2002.
  13. Norwood, N., Cioffi, D., Wu, S., Dudek, S., Garcia, J.G.N., Stevens, T., Ca2+ Store Depletion Promotes Tyrosine Phosphorylation of Myosin Light Chain Kinase. FASEB J., 16:A406, 2002.
  14. Cioffi, E.A., Cioffi, D.L., Stevens, T., cAMP Resolution in Endothelia Using 31P Nuclear Magnetic Resonance Spectroscopy. FASEB J., 16:A406, 2002.
  15. Cioffi, D., Creighton, J., Canales, K., Cooper, D.M.F., Stevens, T., Expression of Calcium-Stimulated Adenylyl Cyclase Prevents Thrombin-Induced Gap Formation in Microvascular Endothelium. FASEB J., 15:A161, 2001.
  16. Cioffi, D., Zhu, M., Goodman, S.R., Stevens, T., Association of Trp-1 and –4 Store Operated Ca2+Entry Channels with the Spectrin Membrane Skeleton in Endothelium. FASEB J., 15:A161, 2001.
  17. Norwood, N., Cioffi, D., Moore, T., Stevens, T., Distinct Regulation of Endothelial Permeability by Proteolytic and Direct Activation of the Thrombin Receptor. FASEB J., 14:A693, 2000.

PRESENTATIONS

  1. Cambridge University, Cambridge, UK, 2005. “The ISOC Signaling Complex, What We Know So Far”.
  2. Massachusetts General Hospital, Boston, MA, 2005. “Acute Respiratory Distress Syndrome, the Calcium Connection”.
  3. Cell Signaling Seminar Series, Departments of Pharmacology and Physiology, University of South Alabama, Mobile, AL, 2004. “Protein 4.1 Stars in the Opening of the Endothelial ISOC Calcium Channel”.
  4. Experimental Biology, International Convention, San Diego, CA, 2003. “Protein 4.1 Provides the Functional Scaffold Linking Trp4 Calcium Channels to the Membrane Skeleton”.
  5. Experimental Biology, International Convention, New Orleans, LA, 2002. “Ca2+ Store Depletion Promotes Tyrosine Phosphorylation of Myosin Light Chain Kinase”.
  6. Experimental Biology, International Convention, Orlando, FL, 2001. “Expression of Calcium-Stimulated Adenylyl Cyclase Prevents Thrombin-Induced Gap Formation in Microvascular Endothelium”.
  7. Pfizer, Inc., Consumer Health Products, Trenton, NJ, 1998. “NMR Spectroscopy in Research & Development”.
  8. Howmedica, Inc., Rutherford, NJ, 1997. “Applications of NMR Spectroscopy to Medical Device Development”.
  9. Department of Chemistry, University of Connecticut, Storrs, CT, 1991. “Careers in Chemistry
  10. Department of Chemistry, University of Massachusetts, Amherst, MA, 1982. “Vinylogous Acyl Anion Equivalents”.

TEACHING
  1. Introduction to Research Methods, IDL 577, Department of Interdepartmental Studies, University of South Alabama, November 2005. Cell Proliferation
  2. Introduction to Research Methods, IDL 577, Department of Interdepartmental Studies, University of South Alabama, November 2004. Cell Proliferation
  3. Invited Lecture, Biochemistry, BLY 441/541, Department of Chemistry, University of South Alabama, March 2004. Ion Channels as Current and Future Therapeutics.
  4. Introduction to Research Methods, IDL 577, Department of Interdepartmental Studies, University of South Alabama, November 2003. Cell Proliferation.
  5. Invited Lecture, Special Topics, CH490, Department of Chemistry, University of South Alabama, May 2003. Ion Channels as Current and Future Therapeutics.
  6. Biomedical Enrichment and Recruitment Program, Department of Pharmacology, University of South Alabama, July 2002. Pharmacokinetics.

UNIVERSITY SERVICE
  1. Expanding Your Horizons Workshop, Women in Science, University of South Alabama, 2004.
  2. Expanding Your Horizons Workshop, Women in Science, University of South Alabama, 2003.
  3. Science Olympiad, University of South Alabama, 2003.
  4. Expanding Your Horizons Workshop, Women in Science, University of South Alabama, 2002.
  5. Science Olympiad, University of South Alabama, 2002.
  6. Graduate Admissions Committee, College of Medicine, University of South Alabama, 2002-2003.
  7. Graduate Council Student Representative, University of South Alabama, 2001 – 2002.
  8. Biomedical Science Student Organization; Student Representative for Department of Pharmacology, University of South Alabama, 1999 – 2000.
Last Update: May 03, 2006
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