EDUCATION

University of Arkansas College of Medicine, Little Rock, AR, B. S., Medical Technology (with Honors), 1970
 

University of Arkansas School of Medicine, Ph.D., Biochemistry, 1975
 

RESEARCH AND PROFESSIONAL EXPERIENCE

USPH-NIHD Pre-doctoral Trainee, Department of Biochemistry, University of Arkansas College of Medicine, 1970-1973
 

Graduate Teaching Assistant, University of Arkansas College of Medicine, 1973-1974
 

Postdoctoral Research fellow USPH-NIHD (F22-HD00502), Division of Growth and Development, University of South Alabama, 1974-1976
 

Assistant Professor, Biochemistry and Pediatrics, College of Medicine , University of South Alabama, 1976-1981
 

Visiting Scientist, University of Utrecht , The Netherlands , 1980-1981
 

Assistant Professor, Biochemistry, College of Medicine , University of South Alabama, 1981-1982
 

Associate Professor, Biochemistry, College of Medicine , University of South Alabama, 1982-1989
 

Professor, Biochemistry & Molecular Biology, College of Medicine , University of South Alabama , 1989 to present
 

HONORS

Overton Scholarship Award, University of Arkansas, 1968
 

B. S. with Honors, University of Arkansas , 1970
 

NIH Pre-doctoral Traineeship, 1970-1973
 

NIH Post-doctoral Fellowship, 1974-1976
 

USPHS-NIHD Research Career Development Award, 1976-1983
 

Editorial Board of American Journal of Physiology: Lung Cellular and Molecular Physiology, 1988-1993
 

NIH Pathology A Study Section, 1981-1985
  

NIH Special Study Section on Cell to Cell Interaction in the Developing Lung, 1981
   

NIH Special Study Section on Oncogenes and Growth in Fetal Lung, 1989
 

NIH Study Section, Lung Biology and Pathology, 1991-1995
  

Editorial Board of American Journal of Physiology: Lung Cellular and Molecular Physiology, 1997-1999
  

PAST GRANT SUPPORT

1. American Heart Association, Southeastern Affiliate, 1999-2002
   TITLE: Alveolar epithelial cell ectopeptidases: A possible role in regulating the cytokine cascade. Principal Investigator: Jane Funkhouser, $70,000 (direct costs)

2. American Heart Association, Alabama Affiliate. 1995-1997
   TITLE: Cytokine networks in lung inflammation: Investigation of epithelial cell ectopeptidases as cytokine regulators. PI: Jane Funkhouser, $60,000 (direct costs)

3. NIH HL42330 1989-1995
   TITLE: Lung epithelial development: A molecular approach. PI: Jane Funkhouser, $560,788 (direct costs)

4. NIH HL38750 1988-1992
   TITLE: Surfactant recycling by type II epithelial cells. PI: Jane Funkhouser, $314,232 (direct costs)

5. NIH HL41283, 1988-1991
   TITLE: Lung fibroblasts assessed by monoclonal antibodies, PI:  R.D.A. Peterson, Co-investigator, Jane Funkhouser, $331,836

6. NIH HL23492 1978-1986
   TITLE: Phospholipid exchange proteins in lung. PI: Jane Funkhouser, $384,111 (direct costs)

7. NIH KO4-HD00210 1978-1983
   TITLE: Fetal lung development and differentiation in Organ Culture.   PI: Jane Funkhouser, $166,993

8. NIH HD10314 1976-1983
   TITLE: Lung development and differentiation in organ culture. PI: Jane Funkhouser, $493,583

9. NICHD. Post-doctoral Fellowship Stipend and Institutional Allowance, HD00520.

ORIGINAL PUBLICATIONS

1. Funkhouser JD, Abraham A, Smith VA, Smith WG, 1974. Kinetic and molecular properties of lysine sensitive aspartokinase. J Biol Chem 249:5478-5484.

2. Funkhouser JD, Smith WG, 1974. Monovalent cation effects on lysine-sensitive aspartokinase catalytic activity and allosteric regulation. J Biol Chem 249:7580-7582.

3. Funkhouser JD, Hughes ES, Peterson RDA, 1976. An organ culture system for study of fetal lung development. Biochim Biophys Res Comm 70:634-637.

4. Funkhouser JD, Hughes ER, 1977. Glucocorticoids and fetal lung development. J Steroid Biochem 8:519-524.

5. Funkhouser JD, Peavy KJ, Mockridge PB, Hughes ER, 1978.  Distribution of dexamethasone between mother and fetus following maternal administration. Pediat Res 12: 1053-1057.

6. Funkhouser JD, Hughes ER, 1978. Differentiation of the pulmonary surfactant system: disaturated phosphatidylcholine accumulation in fetal rat lung in vivo and in vitro. Biochim Biophys Acta 530: 9-16.

7. Funkhouser JD, Hughes ER, 1980. Fetal lung disaturated phosphatidylcholine: ostensible increase following exposure to dexamethasone. Biochim Biophys Acta 619: 506-514.

8. Funkhouser JD, Batenburg JJ, van Golde LMG, 1981. Acylation of 1-palmitoyl lysophosphatidylglycerol in alveolar type II cells from rat lung. Biochim Biophys Acta 666:1-6.

9. Shaw J-F, Funkhouser JD, Smith VA, Smith WG, 1983.  Additional effects of monovalent cations on the lysine-sensitive aspartokinase of E. coli B. J Inorganic Biochem 18: 49-58.

10. Batenburg JJ, Funkhouser JD, Klazinga W, van Golde LMG, 1983. On the suitability of organotypic cultures of fetal rat lung type II cells for biochemical studies concerning development. Biochim Biophys Acta 750: 60-67.

11. Funkhouser JD, Hughes ER, 1983. The lung lamellar body as a functioning membrane in protein-catalyzed phosphatidylcholine transfer. Arch Biochem Biophys 221: 449-506.

12. Read RJ, Funkhouser JD, 1983. Properties of a non-specific phospholipid transfer protein purified from rat lung. Biochim Biophys Acta 752: 118-136.

13. Read RJ, Funkhouser JD, 1984.  Acyl-chain specificity and membrane fluidity, factors that influence the activity of a purified phospholipids-transfer protein from lung. Biochim Biophys Acta 794: 9-17.

14. Funkhouser JD, Read RJ, 1985.  Phospholipid transfer proteins from lung:  properties and possible physiological functions. Chem Phys Lipids 38: 17-27.

15. Funkhouser JD, Cheshire LB, Berrara BT, Peterson RDA, 1987.  Monoclonal antibody identification of a type II alveolar epithelial cell antigen and expression of the antigen during lung development. Dev Biol 119: 190-198.

16. Funkhouser JD, Cheshire LB, Read RJ, Hester RJ, Peterson RDA, 1987. Cytometry 8:321-326.

17. Funkhouser JD, 1987. Amino-terminal sequence of a phospholipids transfer protein from rat lung. Biochim Biophys Res Comm 145: 1311-1314.

18. Peterson RDA, Funkhouser JD, 1989. Speculations on ataxia-telangiectasia:  defective regulation of the immunoglobin gene superfamily. Immunol Today 10: 313-314.

19. Funkhouser JD, Peterson RDA, 1989. Immunotargeting: a contemporary approach to the study of lung development. Am J Physiol 257: L311-317.

20. Peterson RDA, Funkhouser JD, 1990. Ataxia-telangiectasia: an important clue. N Engl J Med 322: 124-5.

21. Funkhouser JD, Tangada SD, Jones M, O SJ, Peterson RDA, 1991. P146 type II alveolar epithelial cell antigen is identical to aminopeptidase N. Am J Physiol 260: L274-279.

22. Funkhouser JD, Tangada SD, Peterson RDA, 1991.  Ectopeptidases of alveolar epithelium: candidates for roles in alveolar regulatory mechanisms. Am J Physiol 1991; 260: L381-385.

23. Peterson RD , Funkhouser JD, Tuck-Muller CM, Gatti RA, 1992.  Cancer susceptibility in ataxia-telangiectasia. Leukemia 6 Suppl 1: 8-13.

24. Peterson RDA, Funkhouser JD, Turrens M, Jones M, Hester R, 1992. Utilization of the monoclonal antibody strategy to study fibroblast heterogeneity. In: Pulmonary Fibroblast Heterogenetiy. RP Phipps, ed., CRC Press, Boca Raton , FL , pp.105-118.

25. Jiang, X, Tangada S, Peterson RDA, Funkhouser JD, 1992.  Expression of aminopeptidase N in fetal rat lung during development.  Am J Physiol 263: L460-465.

26. Tangada S, Peterson RDA, Funkhouser JD, 1995. Regulation of expression of aminopeptidase N in fetal rat lung by dexamehasone and epidermal growth factor. Biochim Biophys Acta 1268: 191-199.

27. Ibrahim AMA, Funkhouser JD, 1997. Phosphatidylinositol transfer protein in lung: cellular and subcellular localization. J Histochem Cytochem 45: 551-558.

28. Gillis LD, Pendley DS, Funkhouser JD, 1998. The major APN transcript of the alveolar type II epithelial cell originates from a unique upstream promoter region. Biochim Biophys Acta 1399: 126-140.

29. Heidecker JH, Nair UK , Funkhouser JD, 2002. An HNF-3 binding element in the APN promoter is required for high-level expression.  In: Cell-Surface Aminopeptidases: Basic and Clinical Aspects, S Mizutani and AJ Turner, eds., Elsevier, Amsterdam , pp. 345-349.