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    NIH - Funded Training in Cell Signaling & Lung Pathobiology
    		 

    William Thomas Gerthoffer, Ph.D.
    Professor
    Phone: (251) 460-6402
    Fax: (251) 460-6850
    wgerthoffer@usouthal.edu

       
    EDUCATION
     
    1970‑1974 B.S., Biology, Waynesburg College
      Waynesburg, Pennsylvania
    1974‑1978 Ph.D., Pharmacology, West Virginia University,
      Morgantown, West Virginia
       
    POSTGRADUATE TRAINING
     
    1980‑1982 Research Associate, Department of Physiology
      University of Virginia
    1978‑1980 Postdoctoral Fellow, Section of Cardiovascular Sciences, Department of Medicine
     

    Baylor College of Medicine, Houston, TX
       
    FACULTY APPOINTMENTS
     
    1982‑1987 Assistant Professor, Department of Pharmacology University of Nevada School of Medicine
      Reno, NV
    1987-1995 Associate Professor, Department of Pharmacology
    University of Nevada School of Medicine
      Reno, NV
    1993     Sabbatical Leave, Laboratory of Molecular Cardiology National Institutes of Health
      Bethesda, MD
    1995-2007 

    Professor, Department of Pharmacology
    University of Nevada School of Medicine
      Reno, NV
    2006    Visiting Scientist, Molecular and Integrative Physiology Program, Harvard School of Public Health
      Boston, MA
    2007-present  Professor and Chair, Department of Biochemistry and Molecular Biology, University of South Alabama
      Mobile, AL
       
    ADMINSTRATIVE APPOINTMENTS
     
    1990‑1996   Director, Cellular and Molecular Pharmacology and Physiology Graduate Program, University of Nevada, Reno
    1995-1996 Vice Chairman, Department of Pharmacology, University of Nevada School of Medicine
    1996-2001   Interim Chairman of Pharmacology, University of Nevada School of Medicine
    2007-present  Chairman, Department of Biochemistry and Molecular Biology, University of South Alabama
     

       
    AWARDS AND HONORS
     
    1979‑1981 National Research Service Award Postdoctoral Fellowship
    1985‑1987 Pharmaceutical Manufacturers Assn. Foundation Faculty Development Award
    2004-2007 Foundation Professor, University of Nevada, Reno
       
    MEMBERSHIP IN PROFESSIONAL AND HONORARY SOCIETIES
      American Association for the Advancement of Science, member
    American Society for Pharmacology and Therapeutics, member
    American Society for Cell Biology, member
    American Thoracic Society, member
     

     
    UNIVERSITY SERVICE
      Department Committees
     
    1983‑1986   Course coordinator for General Pharmacology.
    1984‑1987   System operator for department multiuser microcomputer.
    1984-1986 Organizer of Departmental Research Discussion Group.
       
     

    College of Medicine Committees
     
    1988‑1990  Admissions Committee, University of Nevada School of Medicine
    1989‑1990 Admissions Committee, Cell and Molecular Biology Graduate Program
    1991-1994 Minority Recruitment Advisory Committee
    1994   Chair, Basic Sciences Subcommittee, LCME Self Study Task Force  
    1994-1996 Medical School Council, Pharmacology Dept. Representative
    1995-1996 Research Committee
    1996-  Performance Compensation Plan Board
    2001 Graduate Education, LCME  accreditation self study committee, Chair
    Task Force on Graduate Education, Univ. Nevada, Reno, Chair,
    LCME Accreditation Task Force, Univ. Nevada School of Medicine
    Search committee for Chair of Dept. Biochemistry
    2002  Promotions and Tenure Committee, School of Medicine, Chair
    Outstanding Teacher Committee, School of Medicine
    2003     Promotions and Tenure Committee, School of Medicine
    Course Coordinators Committee, School of Medicine
    Faculty search committees: Dept. Physiology and Dept. Biochemistry
    2004 Course Coordinators Committee, School of Medicine
    Faculty search committee: Dept. Biochemistry
    2005 Course Coordinators Committee, School of Medicine
    Course Coordinator, Medical Pharmacology
    Reviewer, Surgery rotation course
    Executive Committee, Cell and Molecular Pharmacology and Physiology graduate program
    2006-2007  Chair of Course Coordinators Committee, School of Medicine
    Student Development Committee, School of Medicine
    Executive Committee, Cell and Molecular Pharmacology and Physiology graduate program
       
      University Committees
     
    1984‑1987   Medical School representative to the University Faculty Senate
    1985‑1987  University representative at the Nevada Leadership Forum
    1990-1997 Biological Sciences Advisory Council (Graduate School)
    1997        Univ. Nevada Reaccreditation Self Study Steering Committee
    Research and Scholarship subcommittee, CoChair
    Editorial subcommittee
    1999    Excellence in Teaching Advisory Board, University of Nevada, Reno
    2000   University of Nevada School of Pharmacy Planning Committee
    School of Pharmacy, Articulation Subcommittee, Co-Chair
    2005 Administrative Officer on behalf of the UNR Provost’s office
    Selection Committee for UNR Foundation Professor candidates
    2007   Institutional Animal Care and Use, Univ. South Alabama
       
    EXTRAMURAL SUPPORT
     

    Research Grants:

     
    1979‑1981 National Research Service Award Postdoctoral Fellowship
    1982‑1983 University of Nevada School of Medicine Research Committee Grant, $2,500
    1983‑1984 University of Nevada Research Advisory Board
    Junior Faculty Award, $11,000
    American Heart Association ‑ Nevada Affiliate
    Grant‑in‑Aid, $9,960
    Pharmaceutical Manufacturers Association Foundation
    Research Starter Grant, $7,750
    United Way of Northern Nevada, gift $400
    1984‑1987

    American Heart Association Grant‑in‑Aid (AHA National)
    Cellular mechanisms of arterial muscle relaxation. $90,000

    1985‑1987  Pharmaceutical Manufacturers Association Foundation,
    Faculty Development Award, $50,000
    1985‑1986 American Lung Association Research Grant
    Myosin dephosphorylation and airway muscle relaxation. $17,500
    1985‑1989   National Heart, Lung and Blood Institute
    Regulation of contraction and relaxation of airway muscle. $195,494
    1986‑1987 Bentley Scholar in Hypertension Research
    Calcium activity in hypertensive tissue. Co‑investigator, $30,000 
    1988‑1989 Research Advisory Board, University of Nevada‑Reno
    Immunoaffinity chromatography assay for muscle protein phosphorylation.  $3,900
    1989-1991  

    Pharmaceutical Manufacturers Association Foundation
    Predoctoral Fellowship
    Regulation of smooth muscle contraction by caldesmon phosphorylation
    Awardee - J. Pohl; Sponsor - W.T. Gerthoffer
    Annual Stipend:  $10,000
    1990 Max Baer Heart Fund, Fraternal Order of Eagles Molecular control of vascular smooth muscle contraction, $5,000
    1990 Alliance Pharmaceutical Corp.
    Effect of artificial blood emulsion on airway smooth muscle tone $5,250
    1989‑1994    National Institutes of Health, NIDDK
    Mechanisms of Colonic Motility ‑ Program Project P.I.: K.M. Sanders
    Subproject: Regulation of phasic and tonic contractions in colonic muscles.
    P.I. of Subproject  (24% effort)
    Direct Costs (1993‑1994): $50,000   
    1989‑1994   National Institutes of Health
    The Role of Adenyl purines in myometrial function
    P.I.: I.L.O. Buxton
    Coinvestigator: W.T. Gerthoffer (8% effort)
    1991-1994   National Institutes of Health, NHLBI
    Role of ATP in bladder neuroeffector function
    P.I.: David P. Westfall
    Coinvestigator: W.T. Gerthoffer (18% effort)
    Direct Costs (1993-1994): $138,476
    1992-1995  National Institutes of Health, NCI
    Kaposi's Sarcoma: Cell cycle studies of vascular cells
    P.I.: Stephen C. St. Jeor, Ph.D.
    Coinvestigator: W.T. Gerthoffer (10% effort)
    Direct Costs (1992-1993): $166,092
    1991-1996  National Institutes of Health, NHLBI
    Postjunctional mechanisms of airway hyperreactivity.
    P.I.: W.T. Gerthoffer (45% effort)
    Direct Costs (1995): $121,776
    1992-1996 National Institutes of Health, National Nursing Research Institute
    Mechanisms of hypoxic constriction of pulmonary artery,
    Predoctoral Fellowship NR06831
    Awardee - J. McHugh\
    Sponsor - W.T. Gerthoffer
    Annual Stipend:  $12,800
    1997-1998 Amer. Heart Association/Nevada Affiliate
    Activation of MAP kinases in pulmonary artery
    P.I.: I.A. Yamboliev
    Coinvestigator: W.T. Gerthoffer  (10% effort)
    Direct Costs (1997‑1998): $25,000
    1994‑1999 National Institutes of Health, NIDDK
    Mechanisms of Colonic Motility ‑ Program Project
    P.I.: K.M. Sanders, Ph.D.
    Subproject: Regulation of the contractile element of colonic smooth muscle.
    P.I. of Subproject: WT. Gerthoffer  (24% effort)
    Direct Costs (1998‑1999): $82,740   
    1998-2001 National Institutes of Health, NHLBI
    National Research Service Award Postdoctoral Fellowship
    Role of IL-1b in MAP kinase mediated airway responses
    Awardee - C. A. Singer
    Sponsor - W.T. Gerthoffer
    Annual Stipend:  $25,000
    1997-2002 National Institutes of Health, NHLBI
    Role of ATP in vascular neuroeffector processes
    P.I.: D.P. Westfall
    Coinvestigator: W.T. Gerthoffer  (10% effort)
    Direct Costs (1997‑1998): $164,321
    2001-2003 GlaxoSmithKline  (P.I. – W.T. Gerthoffer)
    Role of MK2 and MK3 in cytokine gene expression in airway smooth muscle. Direct costs: $60,000
    2001-2004  National Institutes of Health, NHLBI
    MIRS supplement to Mechanisms of airway hyperreactivity
    Awardee - C. A. Singer; Sponsor - W.T. Gerthoffer
    Direct Costs (2001)  $75,400
    1999-2004  National Institutes of Health, NIDDK
    Mechanisms of Colonic Motility ‑ Program Project
    P.I.: K.M. Sanders, Ph.D.
    Subproject 5: Signal transduction in colonic smooth muscle.
    P.I. of Subproject 5: W.T. Gerthoffer (30% effort)
    Direct Costs: $108,919    
    2002-2006 National Institutes of Health, NHLBI
    Maturation of cerebrovascular contractile mechanisms
    P.I.: W. Pearce, Co-investigator, W.T. Gerthoffer (10% effort)
    Direct Costs (2002): $1500, 000
    2003-2008 National Institutes of Health, NCRR
    Smooth muscle plasticity: a COBRE
    P.I.: K.M. Sanders
    Molecular expression and transgenics, Core B
    Director, W.T. Gerthoffer (20% effort)                     
    Direct Costs, Core B (2005): $177, 495     
    2005-2007 National Institutes of Health, NCRR
    Chloride channel function and role in cardiovascular disease, COBRE P.I.: J. Hume
    Mentor for project P.I. Ilia Yamboliev, W.T. Gerthoffer (10% effort)
    2005-2006 National Institutes of Health, NCRR
    Nevada IDeA Network of Biomedical Research Excellence
    P.I.: L. Weber
    Mentor for project P.I. , W.T. Gerthoffer (5% effort)
    2005-2009   National Institutes of Health, NHLBI
    Small heat shock proteins in smooth muscle plasticity
    P.I.:  W.T. Gerthoffer, - 40% effort
    Direct Costs:   $225,000
       
    PROFESSIONAL SERVICE
      Leadership and Committee Positions:
     
    1991-1993  Peer Review Site Visit Team - American Heart Association, National Center
    1988-1993  American Heart Association/Nevada Affiliate:
    President of the Northern Division, 1988‑1990
    Chairman of the Research Committee, 1987‑1990
    Chairman of the Program Committee, 1991-1992
    President of Nevada Affiliate, 1992-1993
    2005    Short Course-Continuing Education Committee, ASPET
    2005-2007 Lung Cellular, Molecular and Immunobiology, Special Emphasis Panel, Chair
     
     
    Aditorial Boards:
    1991-present  Editorial Board, American Journal of Physiology (Cell)
    2002-2009  Associate Editor, American Journal of Physiology (Cell) (2002 - 2008)
       
      Peer Review:
    Journals and Textbooks:
    1985- present:  Manuscript reviewer for:
     

    American Journal of Physiology (Cell)
    American Journal of Physiology (Gastrointestinal)
    American Journal of Physiology (Heart and Circulatory)
    American Journal of Physiology (Lung Cell and Molecular)
    Canadian Journal of Pharmacology & Physiology
    Journal of Applied Physiology
    Journal of Biological Chemistry
    Journal of Cellular Physiology
    Journal of Muscle Research & Cell Motility
    Journal of Pharmacology and Experimental Therapeutics
    Journal of Physiology
    Journal of Vascular Research
    Life Sciences
    Proceedings of the National Academy of Sciences
     
    1990-1993   Reviewer for Pharmacology in Nursing, C.V. Mosby Co. (1990-1993)
    1993 Abstract referee for Amer. Pediatric Soc. and Soc. for Pediatric Research (1993)
     

                 
     

    Study Sections :
     
    1985 American Heart Association, Nevada Affiliate peer review committee
    1986-1993   Mountain West Peer Review Group of the American Heart Association
    1989  National Science Foundation, ad hoc
    1989 American Lung Association, Chicago Division (1989)
    1994-1997  American Heart Association Affiliate Study Group B
    1998-1999 American Heart Association, Western States Affiliate
    2006-2007  Arizona Biomedical Research Commission
    1988-2007  NIH Study Sections:
      Program project site visit and peer review teams (1988, 1992, 1996, 1997).
    RFA - Interstitial Cystitis (1995)
    SCOR - Cellular and Molecular  Mechanisms  of Asthma (1996)
    Urology Special Emphasis Panel (1998, 1999)
    Experimental Cardiovascular Sciences Special Emphasis Panel (1998)
    Cardiovascular A Special Emphasis Panel (1998)
    Respiratory and Applied Physiology Special Emphasis Panel (1999)
    Experimental Cardiovascular Sciences, Ad Hoc (1999)
    SCOR - Molecular  Mechanisms  of Asthma (2001)
    Cardiovascular Sciences Special Emphasis Panel (2001)
    Experimental Cardiovascular Sciences, Regular member (2000-2003)
    Vascular Cell and Molecular Biology, Regular member (2003-2004)
    Surgery, Anesthesiology and Trauma Study Section (SAT), Ad Hoc (2006)
    Lung Cellular, Molecular and Immunobiology, Special Emphasis Panel, Chair (2005,2006)
                            Lung Cellular, Molecular and Immunobiology, ad hoc (2003, 2007)
       
      Invited Lectures/Workshops/Presentations:
     
    1979 History of denervation supersensitivity in smooth muscle.         Department of Physiology, Baylor College of Medicine
    1981 The role of the Na+, K+ pump in supersensitivity of the vas deferens.
    Department of Physiology, University of Virginia
    1982 The role of the Na+, K+ pump in regulating smooth muscle reactivity.
    Department of Physiology,  Uniformed Services University of Health Sciences, Bethesda, MD.
    1983 Calcium and contractile system regulation in smooth muscle. FASEB symposium on "Control of gastrointestinal smooth muscle contraction", St. Louis, MO. 
    1983 Calcium and myosin phosphorylation in contractile system regulation in smooth muscle.  Department of Molecular Biology,  Smith, Kline and French Laboratories, Philadelphia, PA
    1984 The role of Ca2+ and  myosin phosphorylation in regulation of smooth muscle contraction.  Department of Human Physiology, Univ. California School of Medicine, Davis, CA
    1985 Ca2+ and myosin phosphorylation in control of airway smooth muscle tone.  Department of Pharmacology, Smith, Kline and French, Swedeland, PA. 
    1986  Agonist and calcium dependence of myosin phosphorylation and contraction of airway smooth muscle.  European Molecular Biology Organization workshop on Smooth Muscle Contractility, Maria Alm, Austria.
    1987 Calcium and myosin phosphorylation in regulation of airway smooth muscle contraction.  Boccus Research Institute, Graduate Hospital, Philadelphia, PA.
    1989 Regulation of tonic and phasic contraction of colonic smooth muscle. Inflammatory Bowel Disease Center, Harbor‑UCLA Hospital, Torrance, CA.
    1993 Calcium regulation of the contractile system of airway smooth muscle.  Pulmonary Pharmacology Symposium, Western Pharmacology Society.
    1993    Caldesmon and calponin phosphorylation in intact smooth muscles.  International Symposium on Smooth Muscle Contraction, Minaki, Ontario
    1994 Contractile protein phosphorylation in regulation of smooth muscle contraction. University of Calgary
    1995 Actin binding proteins in airway smooth muscle.  Cytoskeletal mechanisms of regulation of airway smooth muscle, Amer. Lung Association/Amer. Thoracic Society, International Conference, Seattle
    Regulation of contractile proteins.  Asthma '95, Chigago, IL
    Myosin phosphorylation, caldesmon and calponin in regulation of smooth muscle contraction. Distinguished Alumni Seminar, West Virginia University.
    Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction.  Boston Biomedical Research Institute.
    Small heat shock protein (HSP27) in smooth muscle.  University of  Calgary
    1996  MAP Kinases in signal transduction in smooth muscles. Dept. Urology, University of Pennsylvania School of Medicine.       
    MAP Kinases in signal transduction in smooth muscles.
    Dept. Physiology and Biophysics, Indiana University School of Medicine.
    1997 Effects of inflammation on airway smooth muscle mechanics, American Lung Association/American Thoracic Society, San Francisco, CA
    1998 p38 MAP kinase and HSP27 in smooth muscle function.
    Respiratory Biology Section, Harvard School of Public Health, Boston, MA
    p38 MAP kinase and HSP27 in smooth muscle function.
    Boston Biomedical Research Institute, Boston, MA
    p38 MAP kinase and HSP27 in smooth muscle function.
    Medical College of Georgia, Augusta, GA
    1999 Muscarinic signal transduction in colonic smooth muscle
    Visiting Scholar, Loma Linda University School of Medicine
    p38 MAP kinase and HSP27 mediate smooth muscle cell motility
    Visiting Scholar, Loma Linda University School of Medicine
    p38 MAP kinase and HSP27 mediate smooth muscle cell motility
    Loyola University School of Medicine, Chicago, IL
    Functions of p38 MAPkinase in smooth muscle
    West Virginia University School of Medicine,  Morgantown, WV
    Functions of p38 MAPkinase in airway smooth muscle
    Symposium speaker, American Thoracic Society Annual Meeting, San Diego, CA
    Functions of p38 MAPkinase in airway smooth muscle
    Johns Hopkins University School of Medicine, Baltimore, MD
    Functions of p38 MAPkinase in airway smooth muscle
    Ross University Medical School, Dominica
    2000 Functions of p38 MAP kinases in airway smooth muscle: Cell motility and cytokine gene expression. Northwestern University
    p38 MAP kinase and HSP27 mediate smooth muscle cell motility
    Symposium co-organizer and speaker, American Thoracic Society 2000, Toronto
    Functions of p38 MAP kinases in smooth muscle
    Symposium co-chair and speaker, FASEB Summer Conference on Smooth Muscle, Snowmass, Colorado
    Functions of p38 MAP kinases in smooth muscle
    Department of Biology, Marquette University, Milwaukee, WI
    P38 MAP kinases signaling in airway smooth muscle           
    Respiratory Pharmacology, SmithKline Beecham, King of Prussia, PA
    2001 Functions of MAP kinases in smooth muscles
    Cell and Molecular Biology Program, University of Nevada, Reno
    Functions of MAP kinases in smooth muscles
    Department of Pharmacology, Temple University
    Functions of MAP kinases in smooth muscles
    Vascular Biology and Hypertension Symposium,  Univ. Alabama Birmingham
    Functions of MAP kinases in smooth muscles
    University of Tennessee, Memphis, Department of Physiology
    Regulation of cytokine gene expression by MAP kinases in airway smooth muscle
    Genetics Institute, Wyeth Corp. Andover, MA
    2002 MAP kinases in airway smooth muscle: Cell motility and cytokine gene expression
    American Thoracic Society Symposium on Airway Smooth Muscle Plasticity
    Regulation of the contractile system in smooth muscle
    10th Vascular Neuroeffector Mechanisms,  Smooth Muscle Contractility, symposium chair
    MAP kinases in airway smooth muscle: Cell motility and cytokine gene expression
    Boston Biomedical Research Institute
    MAP kinases in airway smooth muscle
    Harvard School of Public Health, Physiology Section
    MAP kinases in airway smooth muscle
    Southeastern Pharmacology Society, symposium on Signal Transduction
    MAP kinases in airway smooth muscle
    University of Manitoba, Visiting Professor, Department of Physiology
    2003

    Multiple functions of p38 MAP kinases in smooth muscles: Contraction, migration and gene expression
    Medical College of Wisconsin, Department of Physiology
    Multiple functions of p38 MAP kinases in smooth muscles: Contraction, migration and gene expression
    University of Pennsylvania, Department of Urology
    Mechanisms of airway smooth muscle cell migration
    American Thoracic Society, Symposium on “Cell and Molecular Biology of Smooth Muscle”
    Functions of HSP27 in smooth muscles: Contraction, cell migration and gene expression
    FASEB Summer Conference, Smooth Muscle
    2004

    Functions of HSP27 in smooth muscles: Contraction, cell migration and gene expression
    University of Chicago, Dept. Medicine, Respiratory and Critical Care
    Actin cytoskeleton remodeling in smooth muscle
    Experimental Biology 2004, Washington DC, Symposium on “Calcium mobilization to calcium sensitization”
    Small heat shock proteins in smooth muscle
    University of Virginia, Symposium in honor of Richard A. Murphy
    Asthma and airway smooth muscle         
    Honors Program, University of Nevada, Reno
    2005

    Small heat shock proteins in smooth muscle
    Cardiovascular Research Center, Temple University School of Medicine
    Small heat shock proteins in smooth muscle
    James Hogg ICAPTURE Center, University of British Columbia, Vancouver, BC
    Small heat shock proteins in smooth muscle
    Meakins-Christie Labs, McGill University, Montreal, Quebec
    Small heat shock proteins in airway smooth muscle
    Northeast Smooth Muscle Society, keynote speaker, Sherbrooke, Quebec
    2006

    Mechanisms of calcium sensitization in airway smooth muscle contraction
    NHLBI workshop on “Airway smooth muscle in bronchomotor tone, inflammation and remodeling, invited speaker
    Regulation of cytokine gene expression by MAP kinases in airway smooth muscle
    Department Surgery, University of Missouri, Kansas City Medical School
    Small heat shock proteins in airway smooth muscle
    Department of Anesthesiology, Columbia University
    Small heat shock proteins in airway smooth muscle
    Boston Biomedical Research Institute
    Structure, regulation and function of small heat shock proteins in smooth muscle. 
    International Symposium: “Recent research advances in asthma pathogenesis”, invited speaker
    Mechanism of smooth muscle relaxation by HSP20
    Dept. Environmental Sciences, Harvard School of Public Health
    2007

    Mechanism of smooth muscle relaxation by HSP20
    Dept. Physiology and Biophysics, Univ. Alabama, Birmingham    Functions of p38 MAPkinases in smooth muscles: Contraction, cell migration and cytokine expression
    epartment of Biochemistry and Molecular Biology, University of South Alabama           

       

    CONTRIBUTIONS TO EDUCATION

     

    Undergraduate Education:
     
    1983-1986 General Pharmacology (nursing undergraduates) ‑ Served as the course coordinator and presented lectures on cardiovascular pharmacology, nonsteroidal antiinflammatory drugs, antimicrobial and cancer chemotherapy. 
    1985-1998  Selected Topics in Pharmacology (undergraduate and graduate) ‑ biochemistry of smooth muscle contraction and excitation‑contraction coupling.   
    1999-2001 Introduction to Human Pharmacology -  Survey of clinically useful drugs intended for undergraduate students with upper division standing. Lectures were presented on antibiotics, antiviral drugs and anticancer drugs.
       
      Graduate Education:
     
    1990-2005 Molecular Pharmacology ‑ Presented lectures to graduate students on autonomic pharmacology and the role of covalent modification of protein in drug‑receptor signal transduction.  Topics included protein phosphorylation in signal transduction.
    1989-1998 Neuroeffector Pharmacology ‑ Served as the course coordinator and presented lectures to graduate students on cellular physiology and pharmacology of smooth muscles and current topics in neurobiology.
    1985-2007 Molecular Cell Biology - Lectures were presented to graduate students on muscle contraction, nonmuscle cell motility, cytoskeleton and the extracellular matrix.
    1995, 1998   Communications in Pharmacology and Physiology – Graduate course on lecture techniques, preparation of seminars and professional presentations, preparation of manuscripts, grant applications and peer review process, scientific ethics.
       
      Medical Student Education:
     
    1974‑1978 Graduate assistant in the Medical Pharmacology course at West Virginia University. The main duties were assisting with in vivo autonomic and cardiovascular pharmacology laboratories.
    1982‑2007  Medical Pharmacology ‑ Primary assignment is lectures on antimicrobial drugs and cancer chemotherapy.  Also presented lectures on nonsteroidal anti-inflammatory drugs, antihypertensive drugs and a brief overview of toxicology.  Assistant course coordinator (1997-2001).  Course Coordinator (2002-2007).
    1996-2004  Medical Cell Biology (1996, 1997, 2004) - Lectures were presented to medical students on nonmuscle cell motility, cytoskeleton and extracellular matrix proteins.
    1998-2007 Problems in Clinical Pharmacology and Therapeutics (1998 - 2002) - Fourth year elective rotation for medical students.  Reviewed current topics in therapeutics of interest to the student.
       
     

    Students/Faculty/Fellows Mentored:
      Undergraduates:
     
    1994 Steven Dang, Biochemistry (Senior thesis)
    1996  Kenneth Burnett, Biochemistry (Senior thesis)
    1997 Mai Ngo, Biochemistry (Senior thesis)
    1998 Kevin Wiesmann, Biology (Honors)
    Sa Vang (American Heart Assn. Student Research Program)
    Shaner Bongalon, Biology (Howard Hughes Summer Research Fellowship)
    Amy K. Cook, Biochemistry (Senior Thesis)
    1999 Michael Carty (Biomedical Sciences, Queens University, Belfast)
    Matthew Free, Biochemistry (Senior Thesis)
    Jennifer Holder, Biochemistry (Senior Thesis)
    2000 Beata Lontay, University of Debrecen, Hungary
    Esther Jimenez-Ridal, University of the Basque Country, Bilboa, Spain
    Suzie Paik, Biology (Honors)
    2001 Alan McCaffrey, Biochemistry (Senior Thesis)
    2002 Jessica Schulz, Biochemistry (Senior Thesis)
    2003 Tristan Stiles, Biochemistry (Senior Thesis)
    2004 Benjamin Jaquish, Biochemistry (Senior Thesis)
    2005 Mindy Chan, Biochemistry (Honors Thesis)
    Nael Aboul-Hosn, Biochemistry (Senior Thesis)
       
      Ph.D. Students:
     
    1994 Jennifer Pohl, Ph.D., M.D., Staff Physician, Department of. Radiology, University of New Mexico School of Medicine
    1996   Jeannette McHugh, MSN, Ph.D., Postdoctoral fellow/Instructor, University of California, San Francisco
    1997  Janice K. Larsen, Ph.D., Postdoctoral fellow, University of Illinois, Department of Physiology and Biophysics
    1999 Jason C. Hedges, Ph.D., Cell and Molecular Biology, University of Nevada, Reno            
    2002 Melissa A. Dechert, Ph.D.  Cell and Molecular Biology
    Instructor, Truckee Meadows Community College
    2003 Kimberly Baker Deadmond, B.S., Ph.D., Cell and Molecular Biology
    Postdoctoral Fellow, University of Texas, Tyler TX
    Liza Retchnik, B.S., M.S., Cell and Molecular Biology
    Scientist, Charles Rivers Laboratories, Reno, NV
    Lisa Hanson, Graduate student (II), Cell and Molecular Biology          
    2006

    Sonemany Salinthone, Ph.D., Cell and Molecular Biology
    Postdoctoral Fellow, Portland VA Medical Center, Portland, OR
    2009(expected) Andrew Kuhn, MS, Cell and Molecular Biology
       
      Postdoctoral trainees:
     
    1993-1994  Takashi Miyauchi, M.D., Ph.D., Clinical Fellow, Department of Internal Medicine, University of Tsukuba, Japan.
    1993-1996 Ilia A. Yamboliev, Ph.D., Research Associate Professor, University of Nevada School of Medicine
    1998-2001 Cherie A. Singer, Ph.D., Research Assistant Professor, Univ. Nevada School of Medicine
       
      Visiting Scientists:
     
    1993  Koichi Sato, Assistant Professor, Dept. Veterinary Pharmacology, University of Tokyo
    2002 William Pearce, Professor of Physiology, Center of Perinatal Biology, Loma Linda University, Loma Linda, CA
    2007 Geoffrey Maksym, Associate Professor School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia
       

    OTHER CONTRIBUTIONS TO SERVICE
     

    Community Service:
    Laboratory sponsor, High School Apprentice and Gifted and Talented Programs of the Washoe County School District (1985-1987)
    Chairman, Board of Trustees, St. Paul's United Methodist Church, Reno (1989-1991)
    Asst. Cubmaster, Cub Scout Pack 180, Reno (1993-1994)
    Cubmaster, Cub Scout Pack 180, Reno (1992, 1995-1998)
    Guest speaker, Washoe County School District Gifted and Talented Program, Reno, NV, (1999, 2000, 2001)
    Presentation to students of Education Collaborative of Washoe County (2005)
    Volunteer, Food Bank of Northern Nevada (2005, 2006)
       

    BIBLIOGRAPHY

     

    Journal Publications/Original Papers:

     

          1. Gerthoffer WT, Fedan JS, Westfall DP, Goto K and Fleming WW. Involvement of the sodium-potassium pump in the mechanism of postjunctional supersensitivity of the vas deferens of the guinea pig. J Pharmacol Exp Ther 210: 27-36, 1979.
          2.   Allen JC, Smith DJ and Gerthoffer WT. Ca++ accumulation and latent Na+, K+-ATPase activity of heterogeneous membrane fractions of vascular smooth muscle. Life Sci 28: 945-950, 1981.
          3.   Gerthoffer WT and Allen JC. Characteristics of binding of [3H]ouabain to smooth muscle sodium-potassium adenosine triphosphatase and quantitation of sodium-potassium pump sites. J Pharmacol Exp Ther 217: 692-696, 1981.
          4.   Gerthoffer WT and Murphy RA. Myosin phosphorylation and regulation of cross-bridge cycle in tracheal smooth muscle. Am J Physiol 244: C182-C187, 1983.
          5.   Gerthoffer WT and Murphy RA. Ca2+, myosin phosphorylation, and relaxation of arterial smooth muscle. Am J Physiol 245: C271-C277, 1983.
          6.   Gerthoffer WT, Trevethick MA and Murphy RA. Myosin phosphorylation and cyclic adenosine 3',5'-monophosphate in relaxation of arterial smooth muscle by vasodilators. Circ Res 54: 83-89, 1984.
          7.   Ramos K, Gerthoffer WT and Westfall DP. Atypical calcium sensitivity of chemically skinned smooth muscle of the guinea-pig vas deferens. Proc West Pharmacol Soc 27: 387-389, 1984.
          8.   Ramos K, Gerthoffer WT and Westfall DP. Denervation-induced supersensitivity to calcium of chemically skinned smooth muscle of the guinea-pig vas deferens. J Pharmacol Exp Ther 236: 80-84, 1986.
          9.   Gerthoffer WT. Calcium dependence of myosin phosphorylation and airway smooth muscle contraction and relaxation. Am J Physiol 250: C597-C604, 1986.
        10.   Gerthoffer WT. Dissociation of myosin phosphorylation and active tension during muscarinic stimulation of tracheal smooth muscle. J Pharmacol Exp Ther 240: 8-15, 1987.
        11.   Gerthoffer WT, Shafer PG and Taylor S. Selectivity of phenytoin and dihydropyridine calcium channel blockers for relaxation of the basilar artery. J Cardiovasc Pharmacol 10: 9-15, 1987.
        12.   Khoyi MA, Westfall DP and Gerthoffer WT. Effects of potassium and norepinephrine on calcium influx in guinea-pig vas deferens. Eur J Pharmacol 140: 55-62, 1987.
        13.   Gerthoffer WT, Murphey KA and Khoyi MA. Inhibition of tracheal smooth muscle contraction and myosin phosphorylation by ryanodine. J Pharmacol Exp Ther 246: 585-590, 1988.
        14.   Carey HV, Cooke HJ, Gerthoffer WT and Welling LW. Intestinal transport in megacolonic mice. Alterations in sugar absorption. Dig Dis Sci 34: 185-192, 1989.
        15.   Kamm KE, Gerthoffer WT, Murphy RA and Bohr DF. Mechanical properties of carotid arteries from DOCA hypertensive swine. Hypertension 13: 102-109, 1989.
        16.   Gerthoffer WT, Murphey KA and Gunst SJ. Aequorin luminescence, myosin phosphorylation, and active stress in tracheal smooth muscle. Am J Physiol 257: C1062-C1068, 1989.
        17.   Merkel L, Gerthoffer WT and Torphy TJ. Dissociation between myosin phosphorylation and shortening velocity in canine trachea. Am J Physiol 258: C524-C532, 1990.
        18.   Ozaki H, Gerthoffer WT, Publicover NG and Sanders KM. Time-dependent decrease in Ca(2+)-sensitivity in "phasic smooth muscle". Adv Exp Med Biol 304: 481-489, 1991.
        19.   Ozaki H, Gerthoffer WT, Publicover NG, Fusetani N and Sanders KM. Time-dependent changes in Ca2+ sensitivity during phasic contraction of canine antral smooth muscle. J Physiol 440: 207-224, 1991.
        20.   Gerthoffer WT, Murphey KA, Mangini J, Boman S and Lattanzio FA, Jr. Myosin phosphorylation and calcium in tonic and phasic contractions of colonic smooth muscle. Am J Physiol 260: G958-G964, 1991.
        21.   Xie YN, Gerthoffer WT, Reddy SN, Cominelli F, Eysselein VE and Snape WJ, Jr. An abnormal rate of actin myosin cross-bridge cycling in colonic smooth muscle associated with experimental colitis. Am J Physiol 262: G921-G926, 1992.
        22.   Gunst SJ, Gerthoffer WT and al-Hassani MH. Ca2+ sensitivity of contractile activation during muscarinic stimulation of tracheal muscle. Am J Physiol 263: C1258-C1265, 1992.
        23.   Ozaki H, Gerthoffer WT, Hori M, Karaki H, Sanders KM and Publicover NG. Ca2+ regulation of the contractile apparatus in canine gastric smooth muscle. J Physiol 460: 33-50, 1993.
        24.   Smith TK, Ward SM, Zhang L, Buxton IL, Gerthoffer WT, Sanders KM and Keef KD. Beta-adrenergic inhibition of electrical and mechanical activity in canine colon: role of cAMP. Am J Physiol 264: G708-G717, 1993.
        25.   Torihashi S, Kobayashi S, Gerthoffer WT and Sanders KM. Interstitial cells in deep muscular plexus of canine small intestine may be specialized smooth muscle cells. Am J Physiol 265: G638-G645, 1993.
        26.   Khoyi MA, Dalziel HH, Zhang L, Bjur RA, Gerthoffer WT, Buxton IL and Westfall DP. [Ca2+]i-sensitive, IP3-independent Ca2+ influx in smooth muscle of rat vas deferens revealed by procaine. Br J Pharmacol 110: 1353-1358, 1993.
        27.   Torihashi S, Gerthoffer WT, Kobayashi S and Sanders KM. Identification and classification of interstitial cells in the canine proximal colon by ultrastructure and immunocytochemistry. Histochemistry 101: 169-183, 1994.
        28.   Gerthoffer WT and Pohl J. Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction. Can J Physiol Pharmacol 72: 1410-1414, 1994.
        29.   Sato K, Sanders KM, Gerthoffer WT and Publicover NG. Sources of calcium utilized in cholinergic responses in canine colonic smooth muscle. Am J Physiol 267: C1666-C1673, 1994.
        30.   Sato K, Leposavic R, Publicover NG, Sanders KM and Gerthoffer WT. Sensitization of the contractile system of canine colonic smooth muscle by agonists and phorbol ester. J Physiol 481 ( Pt 3): 677-688, 1994.
        31.   Larsen JK, Gerthoffer WT, Hickey E and Weber LA. Cloning and sequencing of a cDNA encoding the canine HSP27 protein. Gene 161: 305-306, 1995.
        32.   Burke EP, Gerthoffer WT, Sanders KM and Publicover NG. Wortmannin inhibits contraction without altering electrical activity in canine gastric smooth muscle. Am J Physiol 270: C1405-C1412, 1996.
        33.   Gerthoffer WT. Agonist synergism in airway smooth muscle contraction. J Pharmacol Exp Ther 278: 800-807, 1996.
        34.   Gerthoffer WT, Yamboliev IA, Shearer M, Pohl J, Haynes R, Dang S, Sato K and Sellers JR. Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle. J Physiol 495 ( Pt 3): 597-609, 1996.
        35.   Pohl J, Winder SJ, Allen BG, Walsh MP, Sellers JR and Gerthoffer WT. Phosphorylation of calponin in airway smooth muscle. Am J Physiol 272: L115-L123, 1997.
        36.   Gerthoffer WT, Yamboliev IA, Pohl J, Haynes R, Dang S and McHugh J. Activation of MAP kinases in airway smooth muscle. Am J Physiol 272: L244-L252, 1997.
        37.   Horner MJ, Ward SM, Gerthoffer WT, Sanders KM and Horowitz B. Maintenance of morphology and function of canine proximal colon smooth muscle in organ culture. Am J Physiol 272: G669-G680, 1997.
        38.   Mutafova-Yambolieva VN, Yamboliev IA, Gerthoffer WT and Westfall DP. Effects of natriuretic peptides and endothelins on the nerve-evoked release of adenine nucleotides and nucleosides in guinea-pig vas deferens. Can J Physiol Pharmacol 75: 1083-1087, 1997.
        39.   Larsen JK, Yamboliev IA, Weber LA and Gerthoffer WT. Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle. Am J Physiol 273: L930-L940, 1997.
        40.   Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP and Gerthoffer WT. p38 mitogen-activated protein kinase expression and activation in smooth muscle. Am J Physiol  275: C527-C534, 1998.
        41.   Yamboliev IA, Hruby A and Gerthoffer WT. Endothelin-1 activates MAP kinases and c-Jun in pulmonary artery smooth muscle. Pulm Pharmacol Ther 11: 205-208, 1998.
        42.   Hedges JC, Dechert MA, Yamboliev IA, Martin JL, Hickey E, Weber LA and Gerthoffer WT. A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 274: 24211-24219, 1999.
        43.   Cook AK, Carty M, Singer CA, Yamboliev IA and Gerthoffer WT. Coupling of M(2) muscarinic receptors to ERK MAP kinases and caldesmon phosphorylation in colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 278: G429-G437, 2000.
        44.   Yamboliev IA, Hedges JC, Mutnick JL, Adam LP and Gerthoffer WT. Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway. Am J Physiol Heart Circ Physiol 278: H1899-H1907, 2000.
        45.   Hedges JC, Singer CA and Gerthoffer WT. Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes. Am J Respir Cell Mol Biol 23: 86-94, 2000.
        46.   Yamboliev IA, Wiesmann KM, Singer CA, Hedges JC and Gerthoffer WT. Phosphatidylinositol 3-kinases regulate ERK and p38 MAP kinases in canine colonic smooth muscle. Am J Physiol Cell Physiol 279: C352-C360, 2000.
        47.   Hedges JC, Oxhorn BC, Carty M, Adam LP, Yamboliev IA and Gerthoffer WT. Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol Cell Physiol 278: C718-C726, 2000.
        48.   Yamboliev IA and Gerthoffer WT . Modulatory role of ERK MAPK-caldesmon pathway in PDGF-stimulated migration of cultured pulmonary artery SMCs. Am J Physiol Cell Physiol 280: C1680-C1688, 2001.
        49.   Dechert MA, Holder JM and Gerthoffer WT. p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 Mapk. Am J Physiol Cell Physiol 281: C123-C132, 2001.
        50.   Yamboliev IA, Chen J and Gerthoffer WT. PI 3-kinases and Src kinases regulate spreading and migration of cultured VSMCs. Am J Physiol Cell Physiol 281: C709-C718, 2001.
        51.   Gerthoffer WT and Gunst SJ. Invited review: focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle. J Appl Physiol 91: 963-972, 2001.
        52.   Garcia JG, Liu F, Verin AD, Birukova A, Dechert MA, Gerthoffer WT, Bamberg JR and English D. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest 108: 689-701, 2001.
        53.   Nauli SM, Ally A, Zhang L, Gerthoffer WT and Pearce WJ. Maturation attenuates the effects of cGMP on contraction, [Ca2+]i and Ca2+ sensitivity in ovine basilar arteries. Gen Pharmacol 35: 107-118, 2000.
        54.   Singer CA, Vang S and Gerthoffer WT. Coupling of M(2) muscarinic receptors to Src activation in cultured canine colonic smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 282: G61-G68, 2002.
        55.   Wang XY, Ward SM, Gerthoffer WT and Sanders KM. PKC-epsilon translocation in enteric neurons and interstitial cells of Cajal in response to muscarinic stimulation. Am J Physiol Gastrointest Liver Physiol 285: G593-G601, 2003.
        56.   Pearce WJ, Williams JM, Chang MM and Gerthoffer WT. ERK inhibition attenuates 5-HT-induced contractions in fetal and adult ovine carotid arteries. Arch Physiol Biochem 111: 36-44, 2003.
        57.   Singer CA, Baker KJ, McCaffrey A, AuCoin DP, Dechert MA and Gerthoffer WT. p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes. Am J Physiol Lung Cell Mol Physiol 285: L1087-L1098, 2003.
        58.   An SS, Fabry B, Mellema M, Bursac P, Gerthoffer WT, Kayyali US, Gaestel M, Shore SA and Fredberg JJ. Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cell. J Appl Physiol 96: 1701-1713, 2004.
        59.   Weber DS, Taniyama Y, Rocic P, Seshiah PN, Dechert MA, Gerthoffer WT and Griendling KK. Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration. Circ Res 94: 1219-1226, 2004.
        60.   Salinthone S, Singer CA and Gerthoffer WT. Inflammatory gene expression by human colonic smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 287: G627-G637, 2004.
        61.   Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Stelmack GL, Halayko AJ, Solway J and Mitchell RW. Latrunculin B increases force fluctuation-induced relengthening of ACh-contracted, isotonically shortened canine tracheal smooth muscle. J Appl Physiol 98: 489-497, 2005.
        62.   Borbiev T, Birukova A, Liu F, Nurmukhambetova S, Gerthoffer WT, Garcia JG and Verin AD. p38 MAP kinase-dependent regulation of endothelial cell permeability. Am J Physiol Lung Cell Mol Physiol 287: L911-L918, 2004.
        63.   Bai TR, Bates JH, Brusasco V, Camoretti-Mercado B, Chitano P, Deng LH, Dowell M, Fabry B, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gunst SJ, Hai CM, Halayko AJ, Hirst SJ, James AL, Janssen LJ, Jones KA, King GG, Lakser OJ, Lambert RK, Lauzon AM, Lutchen KR, Maksym GN, Meiss RA, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Pare PD, Schellenberg RR, Seow CY, Sieck GC, Smith PG, Smolensky AV, Solway J, Stephens NL, Stewart AG, Tang DD and Wang L. On the terminology for describing the length-force relationship and its changes in airway smooth muscle. J Appl Physiol 97: 2029-2034, 2004.
        64.   Islamovic E, Gerthoffer WT and Mestril R. Hsp20 is essential for the viability of neonatal rat cardiomyocytes. Am J Physiol Heart Circ Physiol 2005.
        65.   Gerthoffer WT. Signal-transduction pathways that regulate visceral smooth muscle function. III. Coupling of muscarinic receptors to signaling kinases and effector proteins in gastrointestinal smooth muscles. Am J Physiol Gastrointest Liver Physiol 288: G849-G853, 2005.
        66.   Woolfolk EA, Eguchi S, Ohtsu H, Nakashima H, Ueno H, Gerthoffer WT and Motley ED. Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells. Am J Physiol Cell Physiol  289: C1286-C1294, 2005.
        67.   Nauli SM, Williams JM, Gerthoffer WT and Pearce WJ. Chronic hypoxia modulates relations among calcium, myosin light chain phosphorylation, and force differently in fetal and adult ovine basilar arteries. J Appl Physiol 99: 120-127, 2005.
        68.   Cao H, Dronadula N, Rizvi F, Li Q, Srivastava K, Gerthoffer WT and Rao GN. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Circ Res 98: 913-922, 2006.
        69.   Gosens R, Stelmack GL, Dueck G, McNeill KD, Yamasaki A, Gerthoffer WT, Unruh H, Gounni AS, Zaagsma J and Halayko AJ. Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 291: L523-L534, 2006.
        70.   Tran T, McNeill KD, Gerthoffer WT, Unruh H and Halayko AJ. Endogenous laminin is required for human airway smooth muscle cell maturation. Respir Res 7: 117, 2006.
        71.   Ohama T, Hori M, Momotani E, Elorza M, Gerthoffer WT and Ozaki H. IL-1beta inhibits intestinal smooth muscle proliferation in an organ culture system: involvement of COX-2 and iNOS induction in muscularis resident macrophages. Am J Physiol Gastrointest Liver Physiol 292: G1315-G1322, 2007.
        72.   Gosens R, Dueck G, Gerthoffer WT, Unruh H, Zaagsma J, Meurs H and Halayko AJ. p42/p44 MAP kinase activation is localized to caveolae-free membrane domains in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 292: L1163-L1172, 2007.
        73.   Islamovic E, Duncan A, Bers DM, Gerthoffer WT and Mestril R. Importance of small heat shock protein 20 (hsp20) C-terminal extension in cardioprotection. J Mol Cell Cardiol 42: 862-869, 2007.
        74.   Al-Madhoun AS, Chen YX, Haidari L, Rayner K, Gerthoffer W, McBride H and O'Brien ER. The interaction and cellular localization of HSP27 and ERbeta are modulated by 17beta-estradiol and HSP27 phosphorylation. Mol Cell Endocrinol 270: 33-42, 2007.
        75.   An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Pare PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T and Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 29: 834-860, 2007.
        76.   Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP and Fredberg JJ. Universal physical responses to stretch in the living cell. Nature 447: 592-595, 2007.
    77.    Salinthone, S., L. Hansen, A.J. Halayko and W.T. Gerthoffer. Modulation of Airway Smooth Muscle Myocyte Proliferation and Survival by Hsp27. Am. J. Physiology, Lung Cell and Molec., in press.
       78.    Sandoval, R.J., E.R. Inheti, J.M. Williams, W.T. Gerthoffer and W.J. Pearce.  Myogenic contractility is more dependent on myofilament calcium sensitization in fetal that adult ovine cerebral arteries, in preparation.
       
     

    Invited Reviews and Chapters:

     
    1. Murphy, R.A., Aksoy M.O., Dillon, P.F., Gerthoffer, W.T., and Kamm, K.E.  The role of myosin light chain phosphorylation in regulation of the cross‑bridge cycle. Fed. Proc., 42: 45‑50, 1983.
    2. Murphy, R.A., Aksoy, M.O., Cohen, D.M., Fatigati, V., and Gerthoffer, W.T. The contractile apparatus and functional diversity in vertebrate smooth muscle.  In Vascular Neuroeffector Mechanisms, ed. by J.A. Bevan et al., Raven Press, N.Y.75‑84, 1983.
    3. Murphy, R.A., Aksoy, M.O., Dillon, P.F., Gerthoffer, W.T., Kamm, K.E., and Weisbrodt, N.W.  Myosin light chain phosphorylation modulates crossbridge kinetics in mammalian smooth muscles.  In The Mechanics of Smooth Muscle, ed. by N.L. Stephens, Marcel Dekker, pp. 391‑403, 1984.
    4. Murphy, R.A. and Gerthoffer, W.T.  Cell calcium and contractile system regulation in arterial smooth muscle.  In Calcium Antagonists and Cardiovascular Disease, ed. by L.H. Opie, Raven Press, N.Y pp. 37‑45, 1984. 
    5. Murphy, R.A., Gerthoffer, W.T., Trevethick, M.A., and Singer, H.A. Ca2+‑dependent regulatory mechanisms in smooth muscle.  In Mechanisms of Vasodilation, ed. by P.M. Vanhoutte et al., S. Karger, Basel, pp. 99‑107, 1984.
    6. Westfall, D.P., Ramos, K. and Gerthoffer, W.T.  Mechanisms of altered effector responsiveness.  In Vascular Neuroeffector Mechanisms, ed. by J.A. Bevan et al., Elsevier Science Pub., Amsterdam, pp. 187‑191, 1985.
    7. Torphy, T.J., and W.T. Gerthoffer.  Biochemical regulation of airway smooth muscle tone.  In Current Topics in Pulmonary Pharmacology and Toxicology, ed. by M.A. Hollinger, Praeger Publishing Co., Vol. 1, 23‑56, 1987.
    8. Xie, Y.N., Gerthoffer, W.T., Reddy, S.N., Eysselein, V.E., Cominelli, F, and Snape, W. J. Effect of mucosal inflammation on colonic smooth muscle contraction.  In Effects of Immune Cells and Inflammation of Smooth Muscle Enteric Nerves, ed. by W.J. Snape, Jr. and S. Collins, CRC Press, pp. 65‑81, 1990.
    9. Gerthoffer, W.T. Regulation of the contractile element of airway smooth muscle.  Am. J. Physiol (Lung Cell. and Molec.), 261: L15‑L28, 1991.
    10. Gerthoffer, W.T. Current concepts of force maintenance in airways smooth muscle. In: Airways Smooth  Muscle: A Reference Source.  Vol. II Biochemical Control of Airways  Smooth Muscle Tone, ed. by M.A. Giembycz and D. Raeburn, Birkhauser Verlag, pp. 117-136, 1994.
    11. Westfall, D.P. and W.T. Gerthoffer. Vasodilators. In Human Pharmacology - Molecular to Clinical, 2 nd Edition, ed. by T.M. Brody, pp. 239-248, 1997.
    12. Gerthoffer, W.T. and Larsen, J.K.  Regulation of smooth muscle contraction. In: A Functional view of Smooth Muscle, ed. By E.E. Bittar, L. Barr and G.J. Christ, JAI Press, Stamford, CN, pp. 49-79, 2000.
    13. Gerthoffer, W.T. and Singer, C.A.  Secretory functions of smooth muscle cells mediated by cytokines and growth factors. Molecular Interventions, 2: 447-456, 2002.
    14. Singer, C.A., Salinthone, S., Baker, K.J. and Gerthoffer, W.T.  Synthesis of immune modulators by smooth muscles. BioEssays, 26: 646-655, 2004.
    15. Gerthoffer, W.T. Mechanisms of vascular smooth muscle cell migration. Circ. Res., 100: 607-621, 2007.
    16. Gerthoffer, W.T. Migration of airway smooth muscle cells. Proc. Amer. Thoracic. Soc., in press. Panettieri, R. A., Lakser, O. J., Gerthoffer, W. T., Hickey, E., Woodruff, P. G., Hall, I. P., and Banks-Schlegel, S. Airway Smooth Muscle in Bronchial Tone, Inflammation and Remodeling: Basic Knowledge to Clinical Relevance. Am.J.Respir.Critical Care Med. X(in press), 1-x., 2007.
       
      Abstracts:
     
    1. Gerthoffer, W.T. and Westfall, D.P.  Characterization of the beta‑adrenoceptors of the guinea‑pig vas deferens.  Pharmacologist. 18: 141, 1976.
    2. Gerthoffer, W.T., Fedan, J.S., Westfall, D.P., Fleming, W.W., and Stitzel, R.E.  Effect of denervation on the (Na+,K+) activated, Mg++‑dependent ATPase activity in guinea‑pig vas deferens. Fed. Proc. 36: 1021, 1976.
    3. Gerthoffer, W.T., Fedan, J.S., Westfall, D.P., and Fleming, W.W.  Effect of chronic reserpine treatment on the (Na+,K+) ATPase activity in guinea‑pig vas deferens. Pharmacologist 19: 141, 1977.
    4. Gerthoffer,W.T., Fedan, J.S., Westfall, D.P. and Fleming, W.W.  Characterization of subcellular fractions of the guinea‑pig vas deferens: Effect of denervation on marker enzymes.  Fed. Proc. 37: 784, 1978.
    5. Gerthoffer, W.T., Fedan, J.S., Westfall, D.P., and Fleming, W.W.  Kinetic characteristics of Na+, K+ ATPase of supersensitive guinea‑pig vas deferens. Pharmacologist 20: 208, 1978.
    6. Gerthoffer, W.T. and Allen, J.C. Binding of 3H‑ouabain to crude microsomes from the smooth muscle of the vas deferens of the guinea pig.  Fed. Proc. 38: 372, 1979.
      Gerthoffer, W.T. and Allen, J.C.  Estimation of the number of 3H‑ouabain (3H‑O) binding sites in the smooth muscle of the vas deferens.  Pharmacologist 21: 145, 1979.
    7. Gerthoffer, W.T. and Allen, J.C.  Comparison of the number of Na+,K+‑pump sites in cardiac and smooth muscle. Physiologist  23: 95, 1980.
    8. Gerthoffer, W.T. and Murphy, R.A. Myosin phosphorylation and contraction of airway smooth muscle.  Physiologist 24: 118, 1981.
      Gerthoffer, W.T., Murphy, R.A. and Mras, S. Myosin phosphorylation and relaxation rates of smooth muscle from swine carotid artery. Fed. Proc. 41:978, 1982.
    9. Gerthoffer, W.T. and Murphy, R.A.  Vasodilator mechanisms: Ca++, cyclic AMP and myosin phosphorylation.  Fed. Proc. 42: 572, 1983.        
    10. Kamm, K.E., Singer, H.A., Gerthoffer, W.T. and Murphy, R.A.  Activation rates in arterial smooth muscle.  Fed. Proc. 42: 1262, 1983.
    11. Gerthoffer, W.T., Franzl, R.E. and Cooke, H.J. Intestinal mucosal ATPase activities of the piebald mouse model for Hirschprung's disease. Fed. Proc. 43: 1080, 1984.
    12. Gerthoffer, W.T. Dose‑dependence of isotonic shortening velocity and isometric stress in canine tracheal smooth muscle.  Proc. W. Pharm. Soc., 27: 137‑139, 1984.
    13. Ramos, K., Gerthoffer, W.T. and Westfall, D.P.  Atypical calcium‑sensitivity of chemically skinned smooth muscle of the guinea‑pig vas deferens. Proc. W. Pharm. Soc., 27: 387‑389, 1984.
    14. Gerthoffer, W.T.  Dose‑dependence of shortening velocity and isometric stress in tracheal smooth muscle.  Proc. 9th Int. Congress Pharmacol., 524, 1984.
    15. Gerthoffer, W.T.  Calcium‑dependence of myosin dephosphorylation during relaxation of tracheal smooth muscle.  Biophys. J .  47: 298a, 1985.
    16. Gerthoffer, W.T.  Myosin phosphorylation in airway smooth muscle in low extracellular calcium. Biophys. J., 49: 72a, 1986.
    17. Gerthoffer, W.T. Agonist and calcium‑dependence of myosin phosphorylation and contraction of airway smooth muscle. J. Muscle Res. Cell Motil., 1986.
    18. Gerthoffer, W.T., K. Murphey and M. McGinnis. Calcium‑dependence of shortening velocity in canine tracheal smooth muscle. Biophys. J. 51: 335a, 1987.
    19. Gerthoffer, W.T., and M. McGinnis.  Calcium‑dependence of shortening velocity in canine basilar artery. Fed. Proc. 46: 652, 1987.
    20. Gerthoffer, W.T., M.A. Khoyi and K.A. Murphey. Ryanodine disrupts excitation‑contraction coupling in tracheal smooth muscle. Biophys. J. 53:523a, 1988.
    21. Gerthoffer, W.T. and K.A. Murphey. Time‑dependent changes in myosin phosphorylation and shortening velocity during contraction of canine colonic smooth muscle.  Amer. Motil. Soc., 1988.
    22. Gerthoffer, W.T., Stropp, J.Q., and Gunst, S.J. Correlation of aequorin luminescence, myosin phosphorylation and contraction of canine tracheal smooth muscle. Fed. Proc. 47: 1988.
    23. Al‑Hassani, M.H., W.T. Gerthoffer and S.J. Gunst.  Receptor occupancy affects changes in intracellular free Ca2+ ([Ca2+]) and myosin phosphorylation caused by muscarinic activation of canine tracheal smooth muscle.  Biophys J. 55: 470a, 1989.
    24. Khoyi, M.A., W.T. Gerthoffer and D.P. Westfall. Modulation of Ca2+ translocation by procaine in the rat vas deferens: Evidence for calcium‑dependent inactivation of calcium influx. The Pharmacologist, 1989.
    25. Gerthoffer, W.T., K.A. Murphey, J. Mangini and F. Lattanzio.  Regulation of the contractile system in colonic smooth muscle. Physiologist 32:147a, 1989.
    26. Pike, M.M., T.P. Ringkob, Y.O. Koh, and W.T. Gerthoffer.  Effect of early postmortem pH on beef tenderness.  J. Anim. Sci.  67 (Suppl. 22): 21a, 1989.     
    27. Gerthoffer, W.T. and J. Mangini.  Differential effect of W7 on Ca‑induced contraction and myosin phosphorylation in tracheal smooth muscle.  Biophys. J.  57: 159a, 1990.
    28. Xie, Y.N., S.N. Reddy, W. Gerthoffer, W.J. Snape, Jr.  Effect of mucosal inflammation on colonic smooth muscle contraction.  American Gastroenterological Association, 1990.
    29. Ozaki, H., W.T. Gerthoffer, N.G. Publicover, and K.M. Sanders.  Time‑dependent decrease in Ca2+‑sensitivity in "phasic smooth muscle". In: Regulation of Smooth Muscle, ed. by R.S. Moreland, 1991.         
    30. Gerthoffer, W.T., T.J. Torphy and K.A. Murphey.  Correlation of shortening velocity with myosin phosphorylation and cAMP‑dependent protein kinase activity (A‑kinase) in canine tracheal smooth muscle. In: Regulation of Smooth Muscle, ed. by R.S. Moreland, 1991.
    31. Xie, Y.N., W.T. Gerthoffer, J.J. Chen, L. Chang, V.E. Eysselein, X.H. Hou and W.J. Snape, Jr. Phosphatidylinositol metabolism and myosin light chain phosphorylation in colitic colon smooth muscle.  Amer. Gastroenterological Assoc., 1991.
    32. Pohl, J., M.P. Walsh, and W.T.Gerthoffer. Calponin and caldesmon phosphorylation in canine tracheal smooth muscle. Biophys. J. 59: 58a, 1991.
    33. Gerthoffer, W.T., K.A. Murphey and J. Mangini.  Differences in the calcium-dependence of myosin light chain phos­pho­ryla­tion and force in canine smooth muscles.  Biophys. J.  61: 16a, 1992.
    34. Gerthoffer,W.T., Hamelin,M., and Buxton,L.Z.  Mechanism of contractile system sensitization of circular smooth muscle of canine colon. American Motilitly Society, 1992.
    35. Zhang,L., W.T. Gerthoffer, and Buxton,I.L.O.  The action of 5-hydroxytyptamine on canine colonic motility. American Motility Society, 1992.
    36. Zhang,L. W.T. Gerthoffer, and I.L.O. Buxton.  Inhibition of canine colonic motility by 5-hydroxytryptamine.  2nd International Symposium on Serotonin, 1992.
    37. Xie, Y.N., W.T. Gerthoffer, H. Ennes and W.J. Snape Jr.  Effect of mucosal inflammation on the major contractile proteins in colonic smooth muscle.  Amer. Gastroenterology Soc. 1992.
    38. Gerthoffer, W.T., J. Pohl, M. Montella and J. McHugh. hosphorylation of a 25 kDa protein associated with smooth muscle actin, ropomyosin and calponin.  Biophys. J.  64: A29, 1993.
    39. McHugh, J., M. Hamelin, K. Korver, and W.T. Gerthoffer.Thin filament associated 25 kDa protein (p25) induced by heat stress in tracheal smooth muscle.  Proc. W. Pharm. Soc., 1993.
    40. Warth, J. and W.T. Gerthoffer.  Purification of a 25 kda thin filament associated protein from canine colon smooth muscle.  Proc. W. Pharm. Soc., 1993.
    41. Torihashi, S., W.T. Gerthoffer and K.M. Sanders.  Ultrastructure and immunocytochemistry of interstitial cells of the deep muscular plexus in the canine small intestine.  Proc. 51st Annual Meeting of the Microscopy Society of America, ed.  by G.W. Bailey and C.L. Rieder, San Francisco Press, San Francisco CA, pp. 24-25, 1993.
    42. Pohl, J., and W.T. Gerthoffer.  Calponin phosphorylation stoichiometry in intact smooth muscle. Biophys. J. 60: A198, 1994
    43. Sato, K., R. Leposavic, N.G. Publicover, W.T. Gerthoffer and K.M. Sanders.  Effects of neurokinin A and vasopressin on cytosolic Ca2+ concentration and contraction in colonic smooth muscle. Biophys. J. 60: A97, 1994.
    44. Gerthoffer, W.T. and J.R. Sellers.  Effects of phosphorylation of calponin and caldesmon on actin sliding velocity.  Biophys. J. 60: A198, 1994.
    45. Gerthoffer, W.T., I. Yamboliev, R. Haynes and J. Pohl. Activation of MAP kinases by muscarinic agonists in mammalian smooth muscle.  J. Cell Biol. 5: 399a, 1994.
    46. Yamboliev, I., Pliml, J. and W.T. Gerthoffer.  Mitogen activated protein kinases in mammalian smooth muscle.  Biophys. J. 68: 339A, 1995.
    47. Larsen, J., I. Yamboliev and W.T. Gerthoffer. Phosphorylation of the 27kDa heat shock protein (HSP27) in smooth muscle. Biophys. J. 70: A434, 1996.
    48. Yamboliev, I.Y., J. Larsen, K. Burnett and W.T. Gerthoffer.  Activation of MAPKAP Kinase-2 in smooth muscle by a muscarinic agonist. J. Cell Biol. 7:539a, 1996.
    49. Gerthoffer, W.T., J. Larsen, J. Hedges, A. Cook and L. Weber.  Adenovirus mediated expression of mutant human hsp27 in cultured canine smooth muscle cells. Biophys. J.  72:  A178, 1997. 
    50. Hedges, J.C., Yamboliev, I.A., Horowitz, B., Adam, L.P. and Gerthoffer, W.T. p38 MAP kinase expression and activation in smooth muscle.  FASEB J.  12: A449, 1998.
    51. Gerthoffer, W.T., K. Wiesmann, J.C. Hedges and I.A. Yamboliev. PI3-kinase couples muscarinic receptors to ERK and p38 map kinases in canine colonic smooth muscle. FASEB J.  12: A149, 1998.
    52. Hedges, J.C., M. Dechert, S. Bongalon, I. A. lamboliev, and W.T. Gerthoffer.  p38 MAP kinase activation by growth factors and proinflammatory cytokines mediates cell migration in airway smooth muscle. J. Cell Biol., 9: 288a, 1998.
    53. Gerthoffer, W.T., C.A. Singer and S. Vang. Coupling of muscarinic receptors and Src-family tyrosine kinases in mammalian smooth muscle J. Cell Biol., 9: 359a, 1998.
    54. Hedges, J.C., Yamboliev, I.A., Horowitz, B., Adam, L.P. and Gerthoffer, W.T. p38 MAP kinase expression and activation in smooth muscle.  J. Muscle Res. And Cell Motility. 20, pp581-601, 1999.
    55. Gerthoffer, W.T., J.C. Hedges and C.A. Singer.  P38 and ERK MAP kinases regulate cytokine gene expression in human airway myocytes. Am. J. Respir. Cell and Molec. Biol., 2000.
    56. Dechert, M.A., J.M. Holder and W.T. Gerthoffer.  PAK1 participates in tracheal smooth muscle cell migration by signaling to p38 MAPK.  Molec. Biol. Cell, 11, Supplement, 180a, 2000.
    57. Singer, C.A., K.J. Baker and W.T. Gerthoffer.  A role for HSP27 in mechanotransduction of airway smooth muscle gene expression.  Molec. Biol. Cell, 11, Supplement, 434a, 2000.
    58. Singer,  C.A., J.C. Hedges and W.T. Gerthoffer.  MAPK regulation of cytokine gene expression in airway myocytes.  FASEB Summer Conference on Smooth Muscle, 2000.
    59. Yamboliev, I.A. and W.T. Gerthoffer. ERK MAP kinase, caldesmon phosphorylation and migration of vascular smooth muscle cells.  FASEB Summer Conference on Smooth Muscle, 2000.
    60. Dechert, M.A., J.M. Holder and W.T. Gerthoffer.  PAK1 regulates smooth muscle cell migration by signaling to the p38 MAPK pathway. FASEB Summer Conference on Smooth Muscle, 2000.
    61. Gerthoffer, W.T., J.C. Hedges and V. Flannigan. Protein transduction of airway smooth muscle with TAT-RHO A chimeric protein sensitizes contraction. Am. J. Resp. Cell and Molec. Biol., vol. p. 2002.
    62. Islamovic, E. W.T. Gerthoffer, R. Mestril1. Effects of small heat shock protein 20 (Hsp20) withdrawal on neonatal rat cardiomyocytes under both normal and stressed conditions. FASEB J., 2002.
    63. Salinthone, S., C.A. Singer, C.A., Gerthoffer.  Inflammatory gene expression in human colonic smooth muscle cells. Molec. Biol. Cell, 13, 241a, 2002.
    64. Rechetnik, L., C. A. Singer, and W. T. Gerthoffer. Expression of Tristetraprolin in Human Smooth Muscle Cells. Molec. Biol. Cell, 13, 241a, 2002.
    65. Baker, K.J. and W. T. Gerthoffer.  HSP27 mediates cytokine stimulated gene expression in human bronchial smooth muscle cells. Molec. Biol. Cell, 13, 243a, 2002.
    66. Dechert, M.A., and W. T. Gerthoffer.  TNFα-mediated NF-κB activation and gene expression does not involve p21-activated kinase 1. Molec. Biol. Cell, 13, 242a, 2002.
    67. Singer, C.A., and W. T. Gerthoffer.  Cytokine stimulated expression of the T-box transcription factorT-bet in human bronchial smooth muscle cells.  Molec. Biol. Cell, 13, 243a, 2002.
    68. Baker, K.J., C. A. Singer and W. T. Gerthoffer.  HSP27 Mediated Gene Expression in Human Bronchial Smooth Muscle Cells: Potential Mechanisms. Molec. Biol. Cell 14, 494a, 2003.
    69. Gerthoffer, W.T. and E. Rechetnik. Cytokines Induce Expression of Tristetraprolin in Human Bronchial Smooth Muscle Cells.   Am. J. Resp. Cell and Molec. Biol., 2003.
    70. Hanson, L.J., C. A. Singer and W. T. Gerthoffer.  Characterization of Adenoviral-Mediated Overexpression of MAPKAP kinases MK2 and MK3 in Human Airway Myocytes.  Molec. Biol. Cell 14, 494a, 2003.
    71. Salinthone, S. and W.T. Gerthoffer. Apoptotic Response of Human Bronchial Smooth Muscle Cells to Hydrogen Peroxide and Sodium Nitroprusside. Molec. Biol. Cell 14, 159a, 2003.
    72. Singer, C.A. and W. T. Gerthoffer. Downstream Effectors of Src Signaling Pathways Involved in Cytokine-Stimulated Gene Expression in Human Airway Myocytes. Molec. Biol. Cell 14, 496a, 2003.
    73. Dowell, M., O.J. Lasker, N. Dulin, M. Hershenson, W.T. Gerthoffer, J. Solway and R.W. Mitchell. Both ERK1/2 and p38 MAPK regulate the plasticity/elasticity balance of Ach-contraced canine tracheal smooth muscle (TSM). Am. J. Resp. Crit. Care Med. 169(7), A28, 2004.
    74. Gerthoffer, W.T., G.S. Pari, and R.B. Wysolmerski. Immortalized human airway smooth muscle cells with a contractile phenotype. Am. J. Resp. Crit. Care Med. 169(7), A188, 2004.
    75. Mitchell, R.W., M. Dowell, O. Lakser, N. Dulin, W. Gerthoffer, and J. Solway. Very different force (F) oscillation-induced lengthening of Ach- vs KCl-contracted canine tracheal smooth muscle (TSM). Am. J. Resp. Crit. Care Med. 169(7), A447, 2004.
    76. Lakser, O., M. Dowell, W. Gerthoffer, J. Solway and R.W. Mitchell. Jasplakinolide (Jasp) blunts latrunculin B (Lat B)-inducd increase in mechanical plasticity of Ach-contracted canine tracheal smooth muscle (CTSM) strips. Am. J. Resp. Crit. Care Med. 169(7), A447, 2004.
    77. Singer, C.A., L.J. Hanson, M. Grous, M. Salmon, W.T. Gerthoffer. Role of MK2 and MK3 in cytokine gene expression and secretion in airway smooth muscle. Proc. American Thoracic Soc. 2: A78, 2005.
    78. Yamasaki, A., G. Dueck, K. McNeill, G.L. Stelmack, S.Y. Ji, H. Unruh, W.T. Gerthoffer, and A.J. Halayko. TGFbeta induces a contractile phenotype in immortalized human bronchial smooth muscle cells. Proc. American Thoracic Soc. 2: A251, 2005.
    79. Salinthone, S., and W.T. Gerthoffer. The effect of HSP27 overexpression on human airway smooth muscle cell survival. Proc. American Thoracic Soc. 2: A236, 2005.
    80. Gerthoffer, W.T., M.Ba, C. Brophy. HSP20 phosphorylation and airway smooth muscle relaxation.  Proc. American Thoracic Soc. 3: A27, 2006.
    81. Tran, T., E. Rector, K. McNeill, W.T. Gerthoffer, H. Unruh, and A.J. Halayko. Laminin is required for human airway smooth muscle phenotype maturation. Proc. American Thoracic Soc. 3: A261, 2006.
    82. McNeill, K., T. Tran, a. Reinisch, R. Gosens, E.J. Frohwerk, W.T. Gerthoffer, H. Unruh, and A.J. Halayko. Caveolae modulate TGFb1 signaling in human airway smooth muscle cells. Proc. American Thoracic Soc. 3: A261, 2006.
    83. Gosens, R., G.L. Stelmack, G. Dueck, K.D. McNeill, A. Yamasaki, W.T. Gerthoffer, H. Unruh, J. Zaagsma, and A.J. Halayko. Caveolin-1 modulates cell signaling that controls airway smooth muscle cell proliferation and quiescence. Proc. American Thoracic Soc. 3: A281, 2006.
    84. S. Salinthone, and W.T. Gerthoffer. The effect of 14-3-3 theta overexpression on human airway smooth muscle function. Proc. American Thoracic Soc. 3: A708, 2006.
    85. Islamovic, E., A. Duncun, D.M. Bers, W.T. Gerthoffer and R. Mestril. Importance of small heat shock protein 20 (HSP20) C-terminal extension in cardioprotection and calcium handling of rat cardiomyocytes.  Circulation, abstract, 2006.
    86. Nguyen, T.B., M. Tarrant, M.R. Wasserman, W.T. Gerthoffer, J.J. Fredberg. Transforming growth factor - b enhances ASM Stiffening. Proc. Amer. Thoracic Soc., 2007.
    87. Gerthoffer, W.T. Contraction of immortalized human airway smooth muscle cells in 3d collagen rings. Biomedical Engineering Soc. Annual Meeting, 2007.
       
      Last Update: Dec. 18, 2007