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    1

    1
    NIH - Funded Training in Cell Signaling & Lung Pathobiology
    		 

    Haynes, Johnson Jr., M.D
    Professor
    Phone: (251) 460-7334
    jhaynes@usouthal.edu
      

    Activation of the vascular endothelium is characteristics of the inflammatory process. Solovey et al demonstrated that in sickle cells anemia, patients have increased circulating endothelial cells that are predominately microvascular in origin (CD36 positive) and most of the EC’s expressed four markers of EC-activation: ICAM-, VCAM-, E-selectin and P-selectin. This data support that vascular endothelium is activated in SCA. Adherence of sickle erythrocytes to microvascular endothelium is posited to initiated vaso-occlusion crisis and the acute chest syndrome. This altered adherence of the sickle erythrocytes to ECs is at least in part related to the EC activation/inflammation characterized by the up-regulation of VCAM-1 and CD36-thrombus protein interactions, and vWf and lipid procoagulants resulting from EC regulated secretion or exocytosis. These processes provide a means by which endothelial cells rapidly and selectively alter the microenvironment of individual vascular beds and modulate the interrelated processes of coagulation, fibrinolysis, inflammation and vaso-occlusion.
     

    EDUCATION

    HIGH SCHOOL EDUCATION:

    Darden High School and Opelika High, Opelika, Alabama (May, 1971)

    UNDERGRADUATE SCHOOL:

    Tuskegee Institute, Tuskegee, Alabama (May 11, 1975)
    Bachelors of Science in Biology (with High Honors)


    OFESSIONAL EDUCATION:

    University of South Alabama Medical School
    Mobile, Alabama (June 8, 1980)
     

    INTERNSHIP:

    (7/1/80-6/30/81) 

    University of South Alabama Medical Center

    Mobile, Alabama, Internal Medicine
     

    RESIDENCY:

    (7/1/81-6/30/83) 

    University of South Alabama Medical Center

    Mobile, Alabama, Internal Medicine

    (7/1/83-6/30/84)

    University of South Alabama Medical Center

    Mobile, Alabama, Chief Medical Resident
     

    FELLOWSHIP:

    (7/1/84-6/30/86)

    University of South Alabama Medical Center

    Mobile, Alabama, Fellowship in Pulmonary 
    Medicine

    (7/1/86-6/30/88) 

    University of Colorado Health Sciences Center,

    Denver, Colorado, Cardiovascular Pulmonary Research
     

    HONORARY AWARDS:

    National Research Service Award (1986 – 1988)
    American Lung Association Fellowship Recipient (1983 – 1986)
    Alpha Kappa Mu Honor Society (1974)
    Who's Who in American Colleges and Universities (1975)
    Victor Benator Award for Teaching Excellence (1983)
    Alpha Omega Alpha Honor Medical Society (1991)
    Who’s Who in American Thoracic Society (1999)
    America’s Top Doctors (2001) (2002)
     

    FRATERNITY:

    Alpha Phi Alpha
     

    PROFESSIONAL QUALIFICATIONS

    MALPRACTICE INSURANCE:

    USA Liability Trust Fund
     

    MEDICAL SPECIALTY BOARDS:

    (9/14/83)

    American Board of Internal Medicine, #090224

    (11/11/86)

    American Board of Internal Medicine, Pulmonary

    Diseases, #90224


    PROFESSIONAL LICENSES:

    (1981)

    Alabama State Licensing Board of the Healing 

    Arts, #9948

     

    PROFESSIONAL CERTIFICATES:

    (1978-1980)

    National Board of Medical Examiners,

    Parts I-III
     

    PROFESSIONAL SOCIETY MEMBERSHIPS:

    Fellow, American College of Physicians, #043866 (1/91); Membership ID#1215
    Member, The American Physiological Society, #138485
    Fellow, American College of Chest Physicians, #22418
    Southern Society for Clinical Investigation, AFCR
    American Thoracic Society, #00012733
     

    TEACHING COURSES:

    MED472 - Senior Student Pulmonary Elective
    CRC342 - Intermittent Cardiopulmonary Care Practical
    CRC345 - Intensive Cardiopulmonary Care Practical 
    MED402 - Medicine Wards
    FMP311 - Family Practice
    PHY451 – Physiology Research
    MSII – Medicine Subspecialty II
      

    ACADEMIC AND PROFESSIONAL APPOINTMENTS

    PRESENT APPOINTMENT:

    (6/88-5/92)

    Assistant Professor, Department of  Medicine,

    University of South Alabama
    College of Medicine

      

    (6/88-5/93)

    Assistant Professor, Department of  Physiology, 

    USA COM
      

    (7/89- )

    Associate Scientist, USA Comprehensive 

    Sickle Cell Center
      

    PRESENT APPOINTMENT:

    (5/92-5/95)

    Associate Professor, Department of Medicine, 

    University of South Alabama
    College of Medicine
      

    (5/93- )

    Associate Professor, Department of Physiology, 

    University of South 
    Alabama College of Medicine
     

    (5/93- )

    Associate Director of Adult Clinical Programs, 

    University of South Alabama,
    Comprehensive Sickle Cell Center
     

    (5/95- ) 

    Professor of Medicine, Department of Medicine, 

    University of South Alabama College of Medicine
     

    (3/99- )

    Adjunct Professor of Medicine, Department of 

    Physician Assistant Studies, University of South Alabama College of Medicine
     

    (2/01- ) 

    Committee on Honorary Doctorate Degrees, 

    University of South Alabama College of Medicine
     

    (8/01- )

    Director, USA Comprehensive Sickle Cell Center, 

    University of South Alabama College of Medicine
      

    HOSPITAL STAFF APPOINTMENTS:

    University of South Alabama Medical Center
    USA Knollwood Park Hospital
    USA Doctors Hospital of Mobile
    Providence Hospital
     

    ADVISORY COMMITTEE APPOINTMENTS:

    Institutional Animal Care and Use Committee (1989-1992) (2001-2003)
    Research Advisory Committee (1989- )
    Research and Career Development Committee (1989- )

    Admission Committee (1990-1993)

    a) Admissions Policy & Procedure Subcommittee,
    Chairman (1992-1993)

    b) Early Acceptance Subcommittee (1991-1992)

    c) Alternate Subcommittee (1993)

    Search Committee for Director of Minority Student Affairs (1991)
    Minority Affairs Advisory Committee: Chairman (1991-present)
    Promotions and Tenure Advisory Committee (4/92-7/93), (1999-2001)
    Basic Science Department Subcommittee (LCME site visit for accreditation) (1994)
    BEAR Committee (1994-1997) (1999-2002 )
    Promotion and Tenure Committee (1995- ) (Departmental)
    Resident Evaluations/Selection Committee (Chairman 1997)
    Resident Recruitment/Selection Committee (Chairman 1998- )
    Institutional Review Board (2000-2003)
    Summer Student Research Committee Meeting (2001-2003)
    Cancer Institute: Basic/Translational Research Task Force (2001-2002)
    Recruitment/Selection Committee (Chairman – 2001-2002)
    Search Committee/Physiology Chair (2001)
    Student Promotions and Evaluation Committee (2001-2004)
    Committee on Honorary Doctorate Degrees (2000-2001)
    Committee for MD with Research Honors Program (2003-2005)
     

    LOCAL APPOINTMENTS/COMMITTEES:

    Leadership Mobile Class of 1995
    Leadership Mobile Membership Committee (1997)
    Board of Directors, Sickle Cell Disease Association of America, Mobile Chapter (1993-present)
    Chairman, Board of Directors, SCDAA, Mobile Chapter (1996-97)
    BAY Health Plan Special Needs Population Health Care Delivery Subcommittee (1996-97) BAY Health Plan Special Needs Advisory Committee
    American Red Cross (1997-2000)
    Big Brothers/Big Sisters of Metropolitan Mobile (1995-1998)
    United Way, Board of Directors (1999-2000)
    One Hundred Black Men of America, Mobile Chapter (2002 - )
     

    REGIONAL COMMITTEES:

    American College of Physicians
    Council of the Alabama Chapter (1992-1996)
    Alabama Sickle Cell Association Oversight Regulatory Commission 
                    (August, 2001 - )
    Vice-President, Alabama Sickle Cell Association Oversight Regulatory Commission
                    (January, 2002 - )
     

    NATIONAL COMMITTEES AND OFFICES:

    American College of Physicians

    (1989-1992)

    Member, Underrepresented Groups 

    Subcommittee

    NIH Planning Committee: Workshop of "Pathogenesis of Lung Disease 

    (1991-1992)

    in Sickle Hemoglobinopathies", NIH NHLBI 

    Division

    American College of 

     – American Society of Internal Medicine

    Physicians

    (1992 - 1994)

    Membership Enhancement Committee

    (1996 - 2000)

    “Internist of Today” Steering Committee 

    (2000 - 2002)

    Marketing and Communications Committee

    American Thoracic Society

    (1993 - 1995) 

    Nominating Committee

    (1994 - 1998)

    Planning Committee (Chairman 1997-98)

    (1998 - 2000)

    Subcommittee for Program Review

    (1999 - 2000)

    ATS Bylaws Committee

    (2002 - 2003)

    Program Review Subcommittee

    (2003-2004)

    Program Review Subcommittee

    Department of Veterans Affairs

        (1994-1995)

    Merit Review Committee for Respiration

    National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI) 

    (7/2003-3/2008) 

    Comprehensive Sickle Cell Center Program (CSCC) 

    Data and Safety Monitoring Board (DSMB) for the Clinical Trials Consortium 

    (7/2003-6/2007)

    Sickle Cell Disease Advisory Committee 

     
    RESEARCH GRANTS

    AS PRINCIPAL INVESTIGATOR:

    (1988-1989)

    Minority Investigator Research Supplement

    (MIRS) to Grant P60 HL38039
    ($30,000.00)
      

    (1988-2000)

    The Florence Foundation Research Career Development 

    Grant Award
    ($450,000.00)
     

    (1989)

    Intramural Research Grant

    ($4,839.00)
      

    (1989-1994) 

    Mechanisms of Sickle Cell Induced Lung Injury (NIH)

    ($299,985.00)
     

    (1990-1992)

    American Heart Association, Alabama Affiliate

    ($50,000.00)
      

    (1991-1992)

    Neutrophil and Oxygen Radicals, Sickle Cell Grant

    Project #5
    ($64,334.00)
      

    (1993-2003) 

    Acute Lung Injury in Sickle Cell Disease Project #4 in  

    Sickle Cell Center Program Grant NIH (P60 HL38639)
    ($656,043.00)
      

    (1993-2003)

    Education Component in Sickle Cell Program Project 

    Grant (P60 HL38639) Project #6
    ($1,640,099.00)
      

    (2003-2004)

    Comprehensive Sickle Cell Center Program NIH, 

    Administrative Core
    ($250,000)

    (2003)

    Purdue Pharma Unrestricted Educational Grant

    ($2,000)

     
    PUBLICATIONS

    Articles:
    1. Haynes J, Allison R. Pulmonary Edema: A complication of the management of sickle cell pain crises. Am J Med 80:833-840, 1986. 2. Voelkel NF, Chang SW, McDonnell TJ,
    1. Westcott JY, Haynes J. Role of membrane lipids in the control of normal vascular tone. Am Rev Respir Dis 136:214-217, 1987.
    1. Voelkel NF, McDonnell T, Chang S, He L, Westcott J, Haynes J, and Sakai A. Mechanisms of hypoxic vasoconstriction. First Matsumoto High Altitude Medicine Symposium, 1987.
    1. Haynes J, Bass J, Maisel D. Thoracic empyema necessitates with recovery of Mycobacterium avium-intracellulare. Alabama J Med Sci 24:138-139, 1987.
    1. Haynes J, Chang SW, Morris KG, Voelkel NF. Platelet activating factor antagonists increase vascular reactivity in perfused rat lungs. J Appl Physiol 65(5):1921-1928, 1988.
    1. Haynes J. Hypersensitivity pneumonitis. The Airway 1989; Jan-Feb, p.7.
    1. Walker BR, Haynes J, Wang LH, Voelkel NF. Vasopressin-induced pulmonary vasodilation in rats. Am J Physiol 257(Heart Circ Physiol 26):H415-H422, 1989.
    1. American College of Physicians. Parenteral leave for residents. (Position Paper) Ann Intern Med 111(12):1035-1038, 1989.
    1. Haynes J, Seibert A, Bass J, and Taylor A. U74500A inhibition of oxidant lung injury. Am J Physiol 259(Heart Circ Physiol 28):H144-H148, 1990.
    1. Haynes J, Seibert A, Shah A, and Taylor A. Normal vs sickle red blood cells:hemodynamic and permeability characteristics in reperfusion lung injury. JAAMP 1(3):62-66, 1990.
    1. Seibert A, Haynes J, Middleton R, and Bass J. Tuberculous pleural effusion:20 year experience. Chest 99:883-886, 1991.
    1. Kirkpatrick MB, Haynes J, and Bass J. Results of bronchoscopically-obtained lower airway cultures from adult sickle cell disease patients with acute chest syndrome. Am J Med 90:206-210, 1991.
    1. Seibert A, Taylor AE, Bass J, and Haynes J. Hemoglobin potentiates oxidant injury in isolated rat lungs. Am J Physiol 260(Heart Circ Physiol 29):H1980-H1984, 1991.
    1. Haynes J, Kithas P, Taylor AE, and Strada SJ. Selective inhibition of cGMP-inhibitable cAMP phosphodiesterase decrease pulmonary vasoreactivity. Am J Physiol 261(Heart Circ Physiol 30):H487-H492, 1991.
    1. American College of Physicians. Promotion and tenure of women and minorities on medical school faculties. (Position Paper) Ann Intern Med 114(1):63-68, 1991.
    1. Haynes J, Robinson J, Saunders L, Taylor AE, and Strada SJ. The role of cAMP-dependent protein kinase in cAMP-mediated vasodilation. Am J Physiol 262(Heart Circ Physiol 31):H511-H516, 1992.
    1. Seibert AF, Taylor A, Thompson WJ, Wilborn WH, Barnard J, and Haynes J. Reversal of increased microvascular permeability associated with ischemia-reperfusion: role of cAMP. J Appl Physiol 72(1):389-395, 1992.
    1. Adkins WK, Barnard JW, May S, Seibert AF, Haynes J, and Taylor AE. Compounds which increase cyclic-AMP prevent ischemia-reperfusion pulmonary capillary injury. J Appl Physiol 72(2):492-497, 1992.
    1. Haynes, Jr. J, Taylor AE, Dixon D, and Voelkel N. Microvascular hemodynamics in the sickle red blood cell perfused isolated rat lung. Am J Physiol 264(Heart Circ Physiol 33):H484-H489, 1993.
    1. Haynes J and Bass J. Sickle cell lung disease. Pulmonary Critical Care Update, Lesson 20, Volume 8, 1993.
    1. Haynes J and Kirkpatrick M. The acute chest syndrome of sickle cell disease. Am J Med Sci 305(5):326-330, 1993.
    1. Seibert AF, Haynes J, and Taylor A. Ischemia-reperfusion injury in the isolated rat lung: role of flow and endogenous leukocytes. Am Rev Respir Dis 147:270-275, 1993.
    1. NHLBI Workshop. Pathogenesis of lung disease in sickle hemoglobinopathies. Am Rev Respir Dis 148:249-256, 1993.
    1. Castro OL, Chicoye LS, Greenberg J, Haynes J, and Peterson KR. Brighter horizons for sickle cell disease. Patient Care 28(8):26-44, 1994.
    1. Kirkpatrick MB and Haynes J. Sickle cell disease and the pulmonary circulation. Seminars in Respir Crit Care Med 15(6):473-481, 1994.
    1. Haynes J, Obiako B, Thompson J, and Downey J. Adenosine-induced vasodilation: receptor characterization in pulmonary circulation. Am J Physiol 268 (Heart Circ Physiol 37):H1862-H1868, 1995.
    1. Haynes J, DW Killilea, PD Peterson and WJ Thompson. Erythro-9-(2-hydroxy-3- nonyl) adenine (EHNA) inhibits cGMP-stimulated phosphodiesterase (PDE2) to reverse hypoxic pulmonary vasoconstriction in the perfused rat lung. JPET 276:752-757, 1996.
    1. Haynes J, Obiako B, Babal P and Stevens T. 5’-(N-ethylcarboxamido)-adenosine desensitizes the A2 adenosine receptor in lung circulation. Am J Physiol 276 (Heart Circ. Physiol. 45):H1877-H1883, 1999.
    1. Culberson DE, Manci EA, Shah AK, Haynes J, Ballas SK, Pegelow C, and Vichinsky E. Nesidioblastosis in sickle cell disease. Pediatric Pathol and Molecular Medicine 20(2):155-165, 2001.
    1. Pack-Mabien A, Labbe E, Herbert D and Haynes J Jr. Nurses’ attitudes and practices in sickle cell pain management. Applied Nursing Research 14(4):187-192, 2001. 
    1. Haynes J, Obiako B. Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. (Am J Physiol (Heart Circ Physio.) 282:H122-H130, 2002. 
    1. Haynes J, Baliga BS, Dixon B, Obiako B, and Pace B. Zileuton and hydroxyurea: effects on activated polymorphonuclear cell mediated sickle erythrocyte retention in lung and hemoglobin F induction in erythroid progenitors. (In preparation)
    1. Labbe E, Herbert D and Haynes J Jr. Physicians’ attitude and practices in sickle cell disease pain management. Ann Intern Med (Submitted 5-1-03). 
    1. Morales R and Haynes J Jr. Sickle cell lung disease. Pulm Crit Care Update Online. Lesson 12, Vol.17. 2003. (In press).
    1. Morales RE, Babal PL, Stevens T, Obiako B and Haynes, J. A2 adenosine receptor (A2AR) distribution in rat lung. Am J Respir Cell Molecular Biol (Submitted 6-26-03).
    1. Wu S, Haynes J, Taylor JT, Obiako BO, Stubbs JR, Li M and Stevens T. Caν3.1 (α1G) T-type Ca2+ channels mediate vaso-occlusion of sickled erythrocytes in the lung microcirculation. Cir Res (Accepted 7-15-03).
    1. Manci EA, Culberson DE, Yang Y-M, Gardner TM, Powell R, Haynes J, Shah AK, Mankad VN and Investigators of the Cooperative Study of Sickle Cell Disease. Causes of death in sickle cell disease: an autopsy study. Br J Hematology (Accepted July, 2003) 

    BOOK CHAPTERS

    1. Haynes J. Acute localized pulmonary infiltrate. In: Schwarz MI (ed): Pulmonary Grand Rounds. B.C. Decker, Inc., 1990.

    2. Taylor AE, Barnard JW, Seibert AF, and Haynes J. Models of tissue injury in critical care research. In: Critical Care State of the Art: Society of Critical Care Medicine 13:129-131, 1992.

    3. Taylor AE, Seibert A, Haynes J, Bernard J, and Wilson P. Increased lymph flow associated with damaged capillary endothelium. In: Progress in Lymphology - XIII. Proceedings of the XIII International Congress of Lymphology. Edited by RV Cluzan, AP Pecking and FM Lokiec. Exerta Medica, 1992.

    4. Haynes J, Manci E, Voelkel N. The lung in sickle cell disease. In: The Sickle Hemoglobinopathies: Science and Medicine. Edited by SH Embury, RP Hebbel, N Mohandas and M Steinberg. Raven Press, 1994.

    5. Haynes J and Obiako B. Phospholipid products from activated polymorphonuclear cells: Potential role in sickle red blood cell microvascular occlusion. In: Interactions of Blood and the Pulmonary Circulation. Edited by EK Weir, HL Reeve and JT Reeves. Armonk, NY: Futura Publishing Company, Inc., 2002. P123-131.

    PUBLICATIONS

    Abstracts:

    1. Haynes J, Allison R, Hernandez EM, Taylor AE. Effects of acid injury on the filtration (kf) in isolated dog lungs. Federation Proceedings 1986; 45(3):A751.

    2. Haynes J, Chang SW, Voelkel NF. Platelet activating factor decreases vascular reactivity in rat lungs. Federation Proceedings 1987; 46(3):A4637.

    3.  Haynes J, Voelkel NF, Chang SW. Oxygen radical scavengers inhibit hypoxic pulmonary vasoconstriction (HPV) in perfused rat lungs. Am Rev Respir Dis 1987; 135 (Suppl:A127).

    4. Haynes J, Peterson V, Voelkel NF. Sickle cell effects in the pulmonary circulation: The rat lung perfusion model. Am Rev Respir Dis 1988; 137(4) (Suppl:A399).

    5. Haynes J, Chang SW, Voelkel NF. Chronic administration of a platelet activating factor antagonist does not produce pulmonary hypertension in the rat. FASEB J 1988; 2(4):A2482.

    6. Haynes J, Dixon D, Taylor AE, Voelkel NF. Sickle erythrocytes:A lack of protection in reperfusion lung injury. FASEB J 1989; 3(3):A1997.

    7. Haynes J, Seibert A, Mankad V, Shah A, and Taylor A. Normal vs sickle red blood cells: Hemodynamic and permeability characteristics in reperfusion lung injury. Blood 1989; 74(7) Suppl 1:A1127.

    8. Haynes J, Kithas PA, Bass JB, and Strada SJ. The role of cyclic nucleotides in hypoxic pulmonary vasoconstriction. FASEB J 1990; 4:A812.

    9. Seibert A, Taylor A, Bass J, and Haynes J. Role of hemoglobin in ischemic reperfusion and t-butylhydroperoxide lung injury: A biologic Fenton reagent? Am Rev Respir Dis 1990; 141(4) (Suppl:A162).

    10. Seibert A, Haynes J, Middleton R, and Bass J. Tuberculous pleural effusion:20 year experience. Am Rev Respir Dis 1990; 141(4) (Suppl:A443).

    11. Haynes J, Robinson J, Saunders L, and Taylor AE. The role of cAMP dependent protein kinase in cAMP mediated vasodilation. FASEB J 1991; 5(6):A1723.

    12. Seibert AF, Taylor AE, and Haynes J. Role of cAMP in lung injury due to ischemia-reperfusion. FASEB J 1991; 5(6):A1723.

    13. Allison R, Prasad V, Engerson T, Adkins K, Barnard J, Haynes J, and Taylor A. Dibutyrl cyclic AMP (dBcAMP) inhibits ischemia-reperfusion lung injury independent of xanthine oxidase. FASEB J 1991; 5(5):A1429.

    14. Kirkpatrick MB, Haynes J, and Bass JB. Bronchoscopic cultures from adult sickle cell patients with the acute chest syndrome. Clinical Research 1990; 38(4):984A.

    15. Seibert A, Haynes J, Prasad R, and Taylor A. Endogenous leukocytes contribute to microvascular injury due to ischemia-reperfusion. Am Rev Respir Dis 1992; 145(4) (Suppl:A844).

    16. Haynes J, Obiako B, and Thompson J. Adenosine-induced vasodilation: Receptor characterization during hypoxic pulmonary vasoconstriction. FASEB J 1993; 7(4):A3769.

    17. Allison RC, Haynes J, Prasad R, and Taylor AE. Protection from ischemia-reperfusion injury by endotoxin and monophosphoryl lipid A in rat lungs. FASEB J 1993; 7(4):A3303.

    18. Thompson WJ, Taylor AE, Haynes J, Strada SJ. Cyclic AMP production and reversal of ischemia-reperfusion injury by rolipram in rat lung. The Pharmacologist 1993; 35:170.

    19. Haynes J and Obiako B. Normal red blood cell (NRBC) vs sickle red blood cell (SRBC) retention in the isolated-perfused rat lung under constant flow conditions. The 19th Annual Meeting, The National Sickle Cell Disease Program, 1994.

    20. Manci EA, Culberson DE, and Haynes J. A clinical pathologic study of sickle cell lung disease in 324 autopsies. The 19th Annual Meeting, The National Sickle Cell Disease Program, 1994.

    21. Haynes J and Obiako B. A2 adenosine receptor (A2AR) desensitization in the pulmonary circulation. FASEB J 1994; 8(4):A698.

    22. Haynes J and Obiako B. Adenosine-induced vasodilation: Role of the A 2a receptor during hypoxic vasoconstriction. Drug Development Research 5th International Adenosine Symposium 1994; 31(4):A1157.

    23. Sinay LJ, Obiako B, Peterson P and Haynes J. Comparison of high osmolar (HOCM) and low osmolar (LOCM) contrast media effects on pulmonary microvascular hemodynamics in the isolated rat lung perfused with sickle red blood cells (SRBC). Respir Care Med 151(4):A520, 1995.

    24. Haynes J, Peterson P, Killilea D, and Thompson WJ. Erythro-2-(2-hydroxy-3 nonyl) adenine (EHNA) attenuates the hypoxic pressor response (HPR) via and adenosine receptor independent, A-kinase dependent mechanism. FASEB J 1995; 9(3):A276.

    25. Haynes J and Obiako B. Plasma factors enhance sickle red blood cell (SRBC) retention in the isolated rat lung independent of complement. The 20th Annual Meeting, The National Sickle Cell Disease Program, 1995.

    26. Manci EA, Haynes J and Culberson DE. Histochemical findings in chronic sickle cell lung disease. The 20th Annual Meeting, The National Sickle Cell Disease Program, 1995.

    27. Haynes J and Obiako B. PMA-activated polymorphonuclear cells enhance sickle red blood cell (SRBC) retention in the isolated rat lung. 21st Annual Meeting, The National Sickle Cell Disease Program, 1996.

    28. Hale S, Durggin S, and Haynes J. Outpatient management of pain episodes in adults with sickle cell disease: potential impact of opioid analgesics prescribing patterns. 21st Annual Meeting, The National Sickle Cell Disease Program, 1996.

    29. Cepada M, Yang Y-M, Allen F, and Haynes J. Recreational drug use among adults with sickle cell disease. 21st Annual Meeting, The National Sickle Cell Disease Program, 1996.

    30. Haynes J and Obiako B. A soluble product of the stimulated neutrophil enhance sickle red blood cell retention in the isolated rat lung. 22th National Sickle Cell Program Meeting, 1997.

    31. Haynes J, Herbert D, and Labbe E. Physician attitudes and practices in sickle cell pain management. 22th National Sickle Cell Program Meeting, 1997.

    32. Haynes J and Obiako B. Platelet activating factor with leukotriene B4 enhance sickle red blood cell (SRBC) retention in the lung circulation. 23th National Sickle Cell Program Meeting, 1999. 

    33. Pack-Mabien A, Labbe E, Herbert D, and Haynes J. Nurse attitudes and practices in sickle cell pain management. 23th National Sickle Cell Program Meeting, 1999, pp.251.

    34. Haynes J, Obiako B, Babal P, and Stevens T. 5’-(N-ethylcarboxamido)-adenosine desensitizes the A2b adenosine receptor in lung circulation. Am J Respir Crit Care Med, 1999; 159(3):A574.

    35. Haynes J, Obiako B. WEB 2170 and zileuton inhibit enhanced sickle red blood cell (SRBC) retention mediated by the activated polymorphonuclear cell (A-PMN) in the lung circulation. 24th National Sickle Cell Program Meeting, April 11, 2000 Philadelphia PA.

    36. Dixon B, Pace B, Obiako B, Haynes J. Zileuton: A potential new treatment approach for acute chest syndrome (ACS). Blood 2000; 96(11):A29.

    37. Haynes J and Obiako B. WEB 2170: A potential new treatment approach for acute chest syndrome (ACS). Am J Respir Crit Care Med, 2001; 163(5):A124.

    38. Haynes J, Baliga BS, Dixon B, Obiako B and Pace B. Zileuton: An inhibitor of activated polymorphonuclear cell mediated sickle erythrocyte retention in lung and promotor of hemoglobin f induction in vitro. 25th National Sickle Cell Program Meeting, (Abstract #91) December 15, 2000 New York NY.

    39. Morales RE, Babal P, Khimenko PL, Stevens T, Obiako B and Haynes J. A2 adenosine receptor (A2AR) distribution in the rat pulmonary circulation. Am J Respir and Crit Care Med, 2002; 165(8):A336.

    40. S.W. Wu, J. Haynes, B. Obiako, L. Ming, T. Stevens. T-type Ca2 channel activation contributes to vaso-occlusion of sickled erythrocytes in inflamed lung. FASEB J, 2002; 16:A407.

    41. B.S. Baliga, B. Obiako and J. Haynes. Reversal of zileuton inhibition of BFU-E colonies and fetal hemoglobin expression by L-Arginine. 26th National Sickle Cell Program Meeting, Washington, DC, September, 2002.

    42. J. Haynes, J. Cummings, A. Pack-Mabien and J. Boullier. Voiding dysfunction in women with sickle cell anemia. 26th National Sickle Cell Program Meeting, Washington, DC, September, 2002.

    43. J. Haynes, R. Hester and B. Obiako. Hydroxyurea decreases sickle erythrocyte retention/adherence in the pulmonary circulation. 26th National Sickle Cell Program Meeting, Washington, DC, September, 2002.

    INVITED PRESENTATIONS

    A. Community Based Presentations

    (1988)

    AIDS Update, Revelation Baptist Church, Mobile, 
    Alabama 

    (1988)

    AIDS Update, Stone Street Baptist Church, Mobile, 
    Alabama 

    (1988)

    Medicine as a Career, Nazaree Baptist Church, Mobile, 
    Alabama

    (1989)

    Third Annual Brown Bag Lunch Fest, University of South 

    Alabama, Mobile, Alabama

    (1989)

    Unity: The Joy of Brotherhood, Bethesda Men's Day 
    Program

    (1991)

    Divinity, Dignity and Dominion, St. Luke AME Church 
    Men's Day Program

    (1992)

    Medicine as a Career, Phillips Preparatory School Career

     Day (May 15, 1992)

    (1992)

    Medicine as a Career, Church Career Day (May 23, 1992)

    (1992)

    Lung Disease Research, Dauphin Way Methodist Church, 

    Mobile, Alabama

    (1994)

    Shadows of Yesterday, Reflection of Tomorrow. Black 

    History Week Celebration, SNMA, USA COM (February 19, 1994)

    (1995)

    United Negro College Fund Participant

    (2002)

    Focusing On Our Youth For A Better Tomorrow, Todd 

    Town  Community Development Center, Jackson, Alabama (March 2, 2002)

    (2002)

    Youth Day Program Speaker, Bethesda Baptist Church, 

    Opelika, Alabama (June 23, 2002)
     

    B. Clinical/Scientific Presentations

    (1988)

    Asthma. Bay Area Medical Association, Mobile, 
    Alabama 

    (1989) 

    Chronic Obstructive Pulmonary Disease. Baton Rouge 

    Medical Society, Baton Rouge, Louisiana

    (1990) 

    The Role of Cyclic Nucleotides in Hypoxic Pulmonary 

    Vasoconstriction. FASEB Meeting, Washington, D.C.

    (1991)

    Mechanism of cAMP-mediated Vasodilation. FASEB 

    Meeting, Atlanta, Georgia

    (1991)

    Acute Pulmonary Complications of Sickle Cell Disease. 

    ALA/ATS International Conference, Anaheim, California

    (1991) 

    Potential Mechanisms of Acute Lung Injury in Sickle Cell 

    Disease. Sickle Cell Advisory Committee, NIH, NHLBI (October 4, 1991)

    (1992)

    Pathogenesis of Lung Disease in Sickle 

    Hemoglobinopathies. NIH, NHLBI (April 2, 1992)

    (1992)

    Forum in Biomedical Sciences: Requirements for 

    Matriculation into Medical School (May 14, 1992)

    (1992)

    Adenosine and Pulmonary Vascular Reactivity. 

    Department of Physiology Seminar (October 22, 1992)

    (1993)

    Adenosine-induced Vasodilation: Characterization During 

    Hypoxic Pulmonary Vasoconstriction. FASEB Meeting, New Orleans, Louisiana

    (1993)

    Keeping a Proper Perspective. AED at USA (April 22, 
    1993)

    (1993)

    Pulmonary Complications of Sickle Cell Disease: The 

    Acute Chest Syndrome. ALA/ATS Conference, San Francisco, California

    (1993)

    Sickle Cell Lung Disease. Meet the Professor Seminar, 

    ALA/ATS Conference, San Francisco, California

    (1993)

    HIV Pulmonary Complications and Treatment. Alabama 

    State Medical Association Annual Symposium, Mobile, Alabama

    (1993)

    Sickle Cell Lung Disease. BEAR Program, University of 

    South Alabama, Mobile, Alabama 

    (1993)

    Sickle Cell Disease: Pathophysiology and Medical 

    Manifestations. Sickle Cell Disease Educator Certification Program, Mobile, Alabama (October 18, 1993)

    (1993)

    Adenosine and Pulmonary Vasoreactivity: An Update. 

    Department of Physiology Seminar, USA COM (October 21, 1993)

    (1994) 

    Sickle Cell Lung Disease: Diagnosis and Treatment. 

    Thomas Hospital, Fairhope, Alabama (January 11, 1994)

    (1994)

    Pulmonary Complications of Sickle Cell Disease. 

    Surgery Grand Rounds, USAMC, Mobile, Alabama (January 21, 1994)

    (1994)

    Pulmonary Vaso-occlusion by Sickle Cells. Biophysical 

    Society, Red Cell Club, New Orleans, Louisiana (March 7, 1994)

    (1994)

    Care of Sickle Cell Patients, Clinical Pharmacology and 

    Therapeutics. (4th Year Medical Students) USA COM (March 10, 1994)

    (1994)

    Normal Red Blood Cell (NRBC) vs Sickle Red Blood Cell 

    (SRBC) Retention in the Isolated-Perfused Rat Lung Under Constant Flow Conditions. The 19th Annual Meeting, The National Sickle Cell Disease Program

    (1994)

    Sickle Cell Disease. Searcy-Poundstone, Daphne, 

    Alabama (June 8, 1994)

    (1994)

    Sickle Cell Disease. Searcy Hospital, Mt. Vernon, 

    Alabama (June 15, 1994)

    (1994)

    Sickle Cell Disease: An Overview. USA COM, 

    BEAR/HCOP Program, Mobile, Alabama 

    (1994)

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease. Sickle Cell Association Educator Certification Program, Mobile, Alabama (July 13, 1994)

    (1994)

    Management Techniques for the Pregnant Patient with Sickle 

    Cell Conditions. 2nd Annual Sickle Cell Anemia Seminar for Health Care Providers, Huntsville, Alabama (August 4, 1994)

    (1994)

    Sickle Cell Disease: Medical Management. Enterprise, 

    Alabama (August 17, 1994)

    (1994)

    Sickle Cell Disease: Medical Management. Eutaw, 

    Alabama (August 17, 1994)

    (1994)

    Sickle Cell Lung Disease: Diagnostic Utility of the Chest 

    Roentgenogram, V/Q Scan and Angiogram. Radiology Grand Rounds, USAMC (November 3, 1994)

    (1994)

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease. Educator Certification Program, Mobile, AL (November 28, 1994)

    (1995)

    Clinical Overview of Sickle Cell Disease and Related 

    Hemoglobinopathies. Sickle Cell Basics for Health Care Professionals Conference, Livingston, AL (March 10, 1995)

    (1995)

    Pulmonary Complications in Sickle Cell Disease: The 

    Acute Chest Syndrome. Wayne State University, Detroit, MI (March 13, 1995)

    (1995)

    Comparison of high osmolar (HOCM) and low osmolar 

    (LOCM) contrast media effects on pulmonary microvascular hemodynamics in the isolated rat lung perfused with sickle red blood cells (SRBC). ATS Conference, Seattle, Washington.

    (1995)

    Erythro-2-(2-hydroxy-3 nonyl) adenine (EHNA) attenuates 

    the hypoxic pressor response (HPR) via and adenosine receptor independent, A-kinase dependent mechanism. FASEB Meeting.

    (1995) 

    Plasma factors enhance sickle red blood cell (SRBC) 

    retention in the isolated rat lung independent of complement. National Sickle Cell Meeting.

    (1995)

    Histochemical findings in chronic sickle cell lung 

    disease. National Sickle Cell Meeting.

    (1995)

    Pathophysiology and Clinical Manifestations of Sickle 

    Cell Disease. Sickle Cell Disease Association of America, Alabama Chapter, Inc., Statewide Conference, Mobile, AL (June 10, 1995)

    (1995) 

    Sickle Cell Disease: Update. USAMC, Grand Rounds, 

    Mobile, AL (July 20, 1995)
    (1995) Sickle Cell Disease. CME Education Program, 

    Southeast Alabama Medical Center, Dothan, AL (August 31, 1995)

    (1996) 

    Potential Mechanisms of Acute Lung Injury in Sickle Cell 

    Disease. 21st Annual Sickle Cell Program Meeting, Mobile, AL (March 9, 1996)

    (1996) 

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease, Educator Certification Program, Mobile, AL (April 8, 1996) 

    (1996)

    Sickle Cell Lung Disease: Basic Principles and Clinical  

    Practice, ATS/ALA International Conference, New Orleans, LA (May 15, 1996)

    (1996)

    Mental Disorders in Children, Adolescents and Adults 

    with Sickle Cell Disease, Dept. of Psychiatry, USAMC (June 5, 1996)

    (1996)

    Emergency Room Care for Sickle Cell Related Pain, 

    North Alabama Sickle Cell Foundation, Huntsville Hospital East, Huntsville, AL (Sept. 20, 1996)

    (1996)

    Lung Problems in Sickle Cell Disease, Sickle Cell 

    Association of America, 24th Annual Convention, Little Disease Rock, AR (Oct. 4, 1996)

    (1996) 

    Standards of Care for Individuals with Sickle Cell disease, 

    Alabama Primary Health Care Association, Orange Beach, AL (October 10, 1996)

    (1996)

    Rib Infarcts and Acute Chest Syndrome in Sickle Cell 

    Disease, Dept. of Medicine Grand Rounds, USAMC (November 14, 1996)

    (1996)

    Sickle Cell Disease: Acute Chest Syndrome, Morehouse 

    Medical School, Atlanta, GA (November 20, 1996)

    (1997)

    Clinical Management of Sickle Cell Lung: The Role of the 

    Pulmonologist, Meet the Professor, American College of Chest Physicians Meeting, New Orleans, LA (October 29, 1997)

    (1997) 

    Sickle Lung Disease: The Radiologic Interface, USAMC, 

    Radiology Grand Rounds, Mobile, AL (October 23, 1997)

    (1998)

    Management of Pain in Sickle Cell Patient, Family 

    Medicine Residency Conference, USAMC (April 7, 1998)

    (1998) 

    Animal Models of Sickle Cell Anemia and Sickle Cell 

    Lung Disease, ATS/ALA International Conference, Chicago, IL (April 28, 1998)

    (1998)

    Update on Sickle Cell Disease, ACP Annual Scientific 

    Meeting, AL Chapter, Orange Beach, AL (June 11-12, 1998)

    (1998)

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease, Educator Certification Program, Mobile, AL (July 20, 1998) 

    (1998)

    Acute Chest Syndrome, Alabama State Medical 

    Association Conference, Mobile, AL (September 25-27, 1998)

    (1998)

    Later Manifestations of Sickle Cell Disease: Lung  

    Disorders, 26th Annual Sickle Cell Disease Association of America Convention, Buffalo, N.Y. (October 9, 1998)

    (1998)

    Acute Chest Syndrome and It’s Sequalae. Meharry 

    Medical School, Robert Brown Lecture, Nashville, TN (November 4, 1998)

    (1998)

    Pulmonary Complications of Sickle Cell Disease. Baptist 

    Health Care Systems, Birmingham, AL (November 17, 1998)

    (1998)

    Liberation from Mechanical Ventilation. Baptist Health 

    Care Systems, Birmingham, AL (November 17, 1998)

    (1999)

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease, Educator Certification Program, Mobile, AL (January 25, 1999)

    1999

    Animal Modeling of Acute Lung Injury in Sickle Cell 

    Disease, 26th National Sickle Cell Program Meeting, 1999 San Francisco, CA. (1999) 5

    1999

    5?-(N-ethylcarboxamido)-adenosine Desensitizes the 

    A2b Adenosine Receptor in Lung Circulation. ATS/ALA International Conference. San Diego, CA (April 27, 1999)

    (1999) 

    Review of Sickle Cell Disease and Trait. Counselor 

    Educator Certification Program, Mobile, AL (May 18, 1999)

    (1999)

    Sickle Cell Disease in Pregnancy. 10th Annual 

    Continuing Education Conference in OB/GYN & Neonatology, Mobile, AL (May 21, 1999).

    (1999)

    To Treat Pain with Understanding, Alabama State 

    Medical Association Conference, Mobile, AL (June 25, 1999)

    (1999)

    Sickle Cell Pearls. Department of Family Medicine USA; 

    Mobile, AL (August 4, 1999)

    (1999)

    Potential Role of Neutrophils in Pulmonary Microvascular 

    Occlusion. Department of Physiology Seminar USA; Mobile, AL (October 28, 1999)

    (1999)

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease, Counselor, Education Certification Program; Mobile, AL (November 15, 1999)

    (1999)

    Acute Chest Syndrome: Practical Aspects of the 

    Management of Sickle Cell Disease. CSCC at the LAC/USC Medical Center; San Pedro, CA (September 25-26, 1999) 

    (2000)

    Pain Management in Adults. Practical Issues in Sickle 

    Cell Disease: Clinical and Psychosocial. Montgomery, AL (February 15, 2000)

    (2000)

    Acute Chest Syndrome. Practical Issues in Sickle Cell 

    Disease: Clinical and Psychosocial. Montgomery, AL (February 15, 2000)

    (2000)

    Pain Management in Adults. Practical Issues in Sickle 

    Cell Disease: Clinical and Psychosocial. Huntsville, AL (February 16, 2000)

    (2000) 

    Acute Chest Syndrome. Practical Issues in Sickle Cell 

    Disease: Clinical and Psychosocial. Huntsville, AL (February 16, 2000)

    (2000)

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease. Counselor, Education Certification Program, Mobile, AL (March 27, 2000)

    (2000)

    Overview: Pulmonary Complications of Sickle Cell 

    Disease 24th Annual Meeting of the National Sickle Cell Disease Programs. Philadelphia, PA (April 11, 2000)

    (2000)

    WEB 2170 and Zileuton Inhibit Enhanced Sickle Red 

    Blood Cell Retention Mediated by the Activated Polymorphonuclear Cell in the Lung Circulation. 24th Annual Meeting of the National Sickle Cell Disease Programs. Philadelphia, PA (April 11, 2000)

    (2000)

    Acute Chest Syndrome: Diagnosis and Management. 

    USA 2000 Annual Medical Alumni Association Weekend. Gulf Shores, AL (June 9, 2000)

    (2000)

    Phospholipid products from activated polymorphonuclear 

    cells increase sickle red blood cell retention in the pulmonary circulation. Interaction Of Blood And Pulmonary Circulation Scientific Conference/AHA. Sedalia, CO (September 7, 2000)

    (2000)

    Pathophysiology and Medical Manifestations of Sickle 

    Cell Disease Counselor, Education Certification Program. Mobile, AL (November 6, 2000)

    (2000)

    Pathophysiology and Manifestations of Sickle Cell 

    Disease. Counselor, Education Certification Program. Mobile, AL (January 22, 2001)

    (2001) 

    Practical Issues of Pain Management in Sickle Cell 

    Disease. Columbus/Ft. Benning Medical Society. Columbus, GA (January 19, 2001)

    (2001)

    Zileuton: An Inhibitor of Activated Polymorphonuclear 

    Cell-Mediated Sickle Erythrocyte Retention in Lung and Promoter of Hemoglobin F Induction In Vitro. 25th Annual National Sickle Cel l Disease Program Meeting. New York, NY (April 17, 2001)

    (2001)

    Sickle Lung Disease: Diagnosis and Treatment. Meet the 

    Professor’ Seminar. 97th International Conference, American Thoracic Society. San Francisco, CA (May 20, 2001)

    (2001)

    Pain Management of Sickle Cell Disease. Mobile 

    Infirmary CME Program. Grove Hill, AL (June 5, 2001)

    (2001)

    Pain Management of Sickle Cell Disease. USA Nursing 

    Staff Development. Mobile, AL (June 6, 2001)

    (2001)

    Pathophysiology and Management of Sickle Cell 

    Disease. Sickle Cell Association of Hillsborough County. Tampa, FL (June 15, 2001)

    (2001)

    Management of Sickle Cell Pain. Mobile Infirmary 

    Hospital Physicians. Mobile, AL (August 23, 2001)

    (2001)

    Sickle Cell Disease as an Inflammatory Disorder: Basic 

    Science Evidence. American College of Chest Physicians Meeting. Philadelphia, PA (November 7, 2001)

    (2002)

    Sickle Cell Disease as an Inflammatory Disorder: Basic 

    Science Evidence. USA Grand Rounds. Mobile, AL (February 28, 2002)

    (2002)

    Acute Chest Syndrome. University of Mississippi, 

    Pulmonary/Critical Care Division Noon Conference. Jackson, MS (April 5, 2002)

    (2002)

    Pathophysiology and Manifestations of Sickle Cell 

    Disease. Counselor Education Certification Program. Mobile, AL (June 17, 2002)

    (2002)

    Practical Issue in Sickle Cell Disease: Understanding the 

    Dynamics of Today’s Changing Health Care Trends. Tuskegee University (July 24, 2002)

    (2002)

    Legal Implications Regarding the Use and Dispensing of 

    Opioids for Pain Management in Patients with Sickle Cell Disease. Tuskegee University (July 24, 2002)

    (2002)

    Update on Clinical Implications of Sickle Cell Trait. 

    Tuskegee University (July 24, 2002)

    (2002)

    Pain Management. University of South Alabama Staff 

    Development. Mobile, AL (September 30, 2002)

    (2002)

    Legal Implications In Opioid Dispensing for Pain 

    Management. USA Medicine M & M Conference. Mobile, AL (October 9, 2002)

    (2003)

    Pathophysiology and Manifestations of Sickle Cell Disease. 

    Counselor Education Certification Program. Mobile, AL (January 13, 2003)

    (2003)

    Sickle Cell Disease: Acute Pulmonary Complications. USA 

    Comprehensive Sickle Cell Center Conference for Medical Professionals. Mobile, AL (February 15, 2003)

    (2003)

    Hospital Acquired Pneumonia. Mobile Infirmary Medical 

    Center. Mobile, AL (May 13, 2003)

    (2003)

    Orthopedic Issues in Sickle Cell Disease. USA Orthopedic 

    Surgery Grand Rounds. Mobile, AL (June 20, 2003) 

     

    C. National Sessions/Chairperson Presentations

    (1990)

    Prostaglandin and Thrombocytopenia. World 

    Congress on Lung Disease, Boston, Massachusetts.

    (1993)

    Moderator of the 2nd African-American 

    Physician Luncheon, American College of Physicians Annual Session, Washington, D.C.

    (1993)

    Pulmonary Complication of Sickle Cell Disease. 

    Chairperson, 18th Annual Meeting of the National Sickle Cell Disease Program, Philadelphia, PA.

    (1996)

    Plenary Session II, Co-Chair. 21st Annual 

    Sickle Cell Program Meeting. Mobile, AL.

    (2000)

    Phospholipid products from activated 

    polymorphonuclear cells increase sickle red blood cell retention in the pulmonary circulation. Interaction Of Blood And Pulmonary Circulation Scientific Conference/AHA. Sedalia CO (September 7, 2000)
      

    Sponsor for Summer Research Project:

    Student:

    Juliet A. Robinson, 1990

    Ron Kelley, 1991

    Cindy Cook, 1993

    Recruiting Trips:

    a) Tuskegee University, Alabama State University, Alabama
    A&M University, Talledega College, Oakwood College 1991-1993
    b) NIH site visitor for the Minority Biomedical Research Support Grant. Tennessee State University, Nashville, Tennessee 9/16-9/18, 1992