University of Wyoming - B.S. Zoology, 1965

University of Nebraska - M.S. Physiology, 1968

Colorado State University - Ph.D. Physiology, 1973

Postdoctoral Fellow in Cardiopulmonary Research, University of Colorado School of Medicine, Cardiovascular Pulmonary Research Laboratory, 1973-1976

Sabbatical, Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, 1995

Graduate Teaching Assistant, Department of Zoology and Physiology
University of Nebraska, 1966-1968
Graduate Research Assistant, Department of Physiology and Biophysics
Colorado State University, 1968-1971
Research Associate, Department of Pathology
Colorado State University, 1971-1973
Postdoctoral Research Fellow
Cardiovascular Pulmonary Research Laboratory
University of Colorado School of Medicine 1973-1976
Instructor, Department of Medicine
University of Colorado School of Medicine 1976-1979
Assistant Professor, Department of Medicine
University of Colorado School of Medicine 1979-1983
Associate Professor, Department of Medicine
University of Colorado School of Medicine 1983-1993
Professor, Department of Medicine
University of Colorado School of Medicine 1993-2006
Faculty Affiliate, Department of Physiology and Biophysics
Colorado State University, 1982-2004
Professor, Department of Pharmacology                                             University of South Alabama School of Medicine 2006-present

NHLI, National Research Service Award, 1975-1977
NHLI, Research Career Development Award, 1982-1987
Chairman, Pulmonary Circulation Scientific Session, FASEB, 1985, 1986, 1990, 1998
President, Pulmonary Circulation Section, ATS, 1988-1989
Member, Executive Committee, 1989-1990; Nominating Committee, 1990-1992, Cardiopulmonary Council, AHA
Member-at Large, Executive Committee, Council on Cardiopulmonary and Critical Care, AHA, 1996-2000
Chairman, Cardiopulmonary Scientific Session, AHA, 1991, 1998
Associate Editor, Am J Physiol: Lung Cell Mol Physiol, 1994-2005
Member, APS Respiration Section Steering Committee, 1994-1999
Chairman, APS Respiration Section Program Committee, 1996-1999
AHA Dickinson W. Richards Memorial Lecturer, 2002
Robert F. Grover Prize, Pulmonary Circulation Assembly, ATS, 2005
Pulmonary Circulation Assembly Planning Committee, ATS, 2006-2007

American Physiological Society
American Thoracic Society
American Heart Association

Department of Medicine Research Electives Committee, 1982
Department of Medicine Future Research Directions Committee
Co-Chairman, 1985
Academic Affair's Committee on PRAs, 1986
Updating Department of Medicine Research Directory
Chairman, 1985-1986, 1990-1991
Animal Care and Use Committee, 1984-1991
Animal Resource Center Oversight Committee, 1991-2001, Chairman, 1994-1995
Department of Medicine Role of Ph.D.s - Co-Chairman, 1990-1996
ICR Variance Committee, 1999-2001
Dean’s Search Committee for Chair of Anesthesiology, 1999
School of Medicine Research Track Committee, 2001
SOM Research Professor Series Committee, 2002-2005
IACUC Co-Chair, 2002-2006
Search Committee for Director of Lab Animal Resources, 2005
Search Committee for Lab Animal Resources clinical veterinarian, 2005-2006
External Review Committee of Trauma Research Center, 2005
Department of Medicine Small Grant Award Committee, 2004-2006

REVIEW WORK

American Journal of Physiology: Lung Cellular and Molecular Physiology - Associate Editor, 1994-2005
American Journal Physiology: Heart and Circulatory Physiology - Editorial board, 1989-2005
Journal Applied Physiology - Editorial board, 1982-1989, 1993-1999
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory Cell and Molecular Biology
Biochemical Pharmacology
Cardiovascular Research
Circulation Research
Circulation
Clinical Science
Journal of Cardiovascular Pharmacology
Journal of Clinical Investigation
Journal of Pharmacology and Experimental Therapeutics
Pediatric Pulmonology
Pulmonary Pharmacology

NIH-HL Lung Biology and Pathology Study Section: member, 1990-1994
NIH Reviewers Reserve, 1994-1998
NIH-HL Research Review Committee A: ad hoc
Veteran's Administration Merit Review Board: ad hoc
American Heart Association Research Administration
American Lung Association: ad hoc
Medical Research Council of Canada: ad hoc
California Tobacco-Related Disease Research Program
NASA Life Sciences Cardiopulmonary Physiology Peer Review Panel, 1994-2000
NIH-HL Lung Biology and Pathology Study Section: ad hoc, 2000
NIH-HL Lung Injury Repair and Remodeling Study Section: ad hoc, 2004
AHA CMREF, 2005

1975	$3,559, Colorado Heart Association
1975 - 1977	$29,400, NIH National Research Service Award #HL05036
1976 - 1977	$2,168, Colorado Heart Association
1976 - 1979	$97,778, NIH HL20429
1979	$610, National Research Council
1979 - 1985	$512,496, NIH PPG HL14985
1982 - 1987	$219,201, NIH RCDA HL00955
1982 - 1984	$38,500, Cystic Fibrosis Foundation
1984	$28,741, Pfizer Central Research
1985 - 1988	$263,197, NIH HL35621
1988 - 1991	$315,363, NIH PPG HL14985
1989 - 1992	$100,000, Pfizer Postdoctoral Fellowship (sponsor)
1989 - 1992	$96,000, Parker B. Francis Foundation Fellowship (sponsor)
1993 - 1998	$726,000, NIH PPG HL14985 - Project 1
1994	$20,000 Parke-Davis Pharmaceutical Research
1995	$20,000 Parke-Davis Pharmaceutical Research
1995 - 1998	$110,000, Parker B. Francis Foundation Fellowship (sponsor)
1996	$25,000, Foundation for Anesthesia Education and Research
	(sponsor)
1998 - 2003	$4,248,500, NIH PPG HL14985
2002 - 2007	$1,675,326, NIH T32 HL07171
2003 – 2008	$5,955,038  NIH PPG HL14985

Pulmonary Vasoregulation
Hypoxic Pulmonary Vasoconstriction
Pulmonary Hypertension
Endothelial Control of Vascular Tone
Pulmonary Vascular RhoA/Rho Kinase Signaling

1. McMurtry IF. Erythropoieses in the white rat. M.S. Thesis, University of Nebraska, 1968.
2. Will DH, Frith CH, McMurtry IF, MacCarter, DJ. Effects of hypertension and hypoxemia on arterial metabolism and structure. In: Comparative Pathophysiology of Circulatory Disturbances. ed., CM Bloor, New York, Plenum, 1972, p185-302.
3. McMurtry IF, Frith CH, Will DH. Cardiopulmonary responses of male and female swine to simulted high altitude. J Appl Physiol 35:459-462, 1973.
4. McMurtry IF. Hypoxia and arterial metabolism in swine. Ph.D. Thesis, Colorado State University, 1973.
5. Frith DH, McMurtry IF, Alexander AF, Will DH. Influence of hypertension and hypoxemia on arterial biochemistry and morphology in swine. Athersclerosis 20: 189-206, 1974.
6. Tucker A, McMurtry IF, Reeves JT, Alexander AF, Will DH, Grover RF. Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude. Amer J Physiol 228:762-767, 1975.
7. Grover RF, Will DH, Reeves JT, Weir EK, McMurtry IF, Alexander AF. Genetic transmission of susceptibility to hypoxic pulmonary hypertension. Prog Resp Res 9:112-117, 1975.
8. Weir EK, McMurtry IF, Grover RF. Experimental models of complete heart block. Basic Res Cardiol 70:446-455, 1975.
9. McMurtry IF, Reeves JT, Will DH, Grover RF. Hemodynamic and ventilatory effects of skin-cooling in cattle. Experientia 31:1303-1304, 1975.
10. McMurtry IF, Davidson AB, Reeves JT, Grover RF. Inhibition of hypoxic pulmonary vascoconstriction by calcium antagonists in isolated rat lungs. Circ Res 38:99-104, 1976.
11. Tucker A, McMurtry IF, Reeves JT, Grover RF. Attenuation of hypoxic pulmonary vasoconstriction by verapamil in intact dogs. Proc Soc Exp Biol Med 151:611-626, 1976.
12. McMurtry IF, Weir EK, Reeves JT, Will DH, Grover RF. Prostaglandin synthesis does not mediate the pulmonary vasodilatory effect of acetylcholine in hypoxic cattle. Prostaglandins 11: 63-69, 1976.
13. Weir EK, McMurtry IF, Tucker A, Reeves JT, Grover RF. Prostaglandin synthetase inhibitors do not decrease hypoxic pulmonary vasoconstriction. J Appl Physiol 41:714-718, 1976.
14. McMurtry, IF, Tucker A, Reeves JT, Grover RF. Hyperreactivity of normotensive and hypertensive pulmonary vasculature in spontaneously hypertensive rats. In: Spontaneous Hypertension: Its Pathogenesis and Complications. Proc 2nd Int Symp on the Spontaneously Hypertensive Rat. April 1976, DHEW Publication NO. 77:1179.
15. Tucker A, McMurtry IF, Alexander AF, Reeves JT, Grover RF. Lung mast cell density and distribution in chronically hypoxic animals. J Appl Physiol 42:174-178, 1977.
16. McMurtry IF, Hookway BW, Roos SD. Red blood cells play a crucial role in maintaining vascular reactivity to hypoxia in isolated rat lungs. Chest 71s: 255s-256s, 1977.
17. McMurtry IF, Dickey DW, Souhrada JF, Reeves JT, Grover RF. Vascular effects of compound 48/80 in isolated lungs and pulmonary arteries. Artery 3:1-12, 1977.
18. McMurtry IF, Reeves JT, Will DH, Grover RF. Reduction of bovine pulmonary hypertension by normoxia, verapamil and hexoprenaline. Experientia 33:1192-1194, 1977.
19. McMurtry IF, Hookway BW, Roos SD. Red blood cells but not platelets prolong vascular reactivity of isolated rat lungs. Am J Physiol 234:H186-H191, 1978.
20. Davidson A, McMurtry IF, Reeves JT. Pulmonary vascular effects of verapamil. Am Heart J 95:810-811, 1978.
21. McMurtry IF, Petrun MD, Reeves JT. Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia. Am J Physiol 235:H104-H109, 1978.
22. Will DH, McMurtry IF, Reeves JT, Grover RF. Cold-induced pulmonary hypertension in cattle. J Appl Physiol 45: 469-473, 1978.
23. Moore LG, McMurtry IF, Reeves JT. Effects of sex hormones on cardiovascular and hematologic responses to chronic hypoxia in rats. Proc Soc Exp Biol Med 158:658-662, 1978.
24. Grover RF, Hyers TM, McMurtry IF, Reeves JT. High altitude pulmonary edema. In: Pulmonary Edema, ed., A.P. Fishman and E.M. Renkin, Bethesda, American Physiological Society, 1979, p229-240.
25. McMurtry IF, Petrun MD, Tucker A, Reeves JT. Pulmonary vascular reactivity in the spontaneously hypertensive rat. Blood Vessels 16:61-70, 1979.
26. Weir EK, Will DH, Alexander AF, McMurtry IF, Looga R, Reeves JT, Grover RF. Vascular hypertrophy in cattle susceptible to hypoxic pulmonary hypertension. J Appl Physiol 46:517-521, 1979.
27. Reeves JT, Wagner WW, McMurtry IF, Grover RF. Physiological effects of high altitude on the pulmonary circulation. Int Rev Physiol III 20:289-310, 1979.
28. Voelkel NF, Gerber JG, McMurtry IF, Reeves JT, Nies AS. Release of dilator prostaglandins from lung tissue during angiotensin II-induced vasoconstriction. Adv Prostaglandin Thromboxane Res 7:957-960, 1979.
29. Voelkel NF, McMurtry IF, Reeves JT. Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude. J Appl Physiol 48: 473-478, 1980.
30. McMurtry IF, Morris, Petrun MD. Blunted hypoxic vasoconstriction in lungs from short-term high-altitude rats. Am J Physiol 238:H849-H857, 1980.
31. Voelkel NF, Morris KG, McMurtry IF, Reeves JT. Calcium augments hypoxic vasoconstriction in lungs from high-altitude rats. J Appl Physiol 49:450-455, 1980.
32. Gerber JG, Voelkel NF, Nies AS, McMurtry IF, Reeves JT. Moderation of hypoxic vasoconstriction by infused arachidonic acid: role of PGI2. J Appl Physiol 49:107-112, 1980.
33. Rounds SIS, Moore LG, Voelkel NF, McMurtry IF, Reeves JT. Cardiac output is decreased and hypoxic vasoconstriction is intact in chronically hypoxic sheep. Proc Soc Exp Biol Med 165:1-5, 1980.
34. Voelkel NF, McMurtry IF, Reeves JT. Hypoxia impairs vasodilation in the lung. J Clin Invest 67:238-246, 1981.
35. Rounds S, McMurtry IF. Inhibitors of oxidative ATP production cause transient vasoconstriction and block subsequent pressor responses in rat lungs. Circ Res 48:393-400, 1981.
36. Voelkel NF, Gerber JG, McMurtry IF, Nies AS, Reeves JT. Release of vasodilatory prostaglandin, PGI2, from isolated rat lung during vasoconstriction. Circ Res 48:207-213, 1981.
37. Voelkel NF, Hegstrand L, Reeves JT, McMurtry IF, Molinoff PB. Effects of hypoxia on density of beta-adrenergic receptors. J Appl Physiol 50:363-366, 1981.
38. Rounds SS, McMurtry IF, Reeves JT. Glucose metabolism accelerates the decline of hypoxic vasoconstriction in rat lungs. Resp Physiol 44:239-249, 1981.
39. Newman JH, McMurtry IF, Reeves JT. Blunted pulmonary pressor responses to hypoxia in blood-perfused, ventilated lung isolated from oxygen toxic rats: possible role of prostaglandins. Prostaglandins 22:11-20, 1981.
40. Walker BR, Voelkel NF, McMurtry IF, Adams M. Evidence for the diminished sensitivity of the hamster pulmonary vasculature to hypoxia. J Appl Physiol 52:1571-1574, 1982.
41. McMurtry IF, Stanbrook HS, Rounds S. The mechanism of hypoxic pulmonary vasoconstriction - a working hypothesis. In: Oxygen Transport to Human Tissues, ed., JA Loeppky and ML Riedesel, New York, Elsevier, 1982, p77-89.
42. McMurtry IF, Rounds S, Stanbrook HS. Studies of the mechanism of hypoxic pulmonary vasoconstriction. Adv Shock Res 8:21-33, 1982.
43. Shasby DM, VanBenthuysen KM, Tate RM, Shasby SS, McMurtry IF, Repine JE. Granulocytes mediate acute edematous lung injury in rabbits and isolated rabbit lungs perfused with phorbol myristate acetate: role of oxygen radicals. Am Rev Resp Dis 125:443-447, 1982.
44. Tate RM, Shasby DM, VanBenthuysen KM, McMurtry IF, Repine JE. Oxygen radical-induced pulmonary edema, a mechanism for the production of noncardiogenic pulmonary edema by neutrophils. Chest 81s: 575-595, 1982.
45. VanBenthuysen KM, Shasby DM, Tate RM, Repine JE, McMurtry IF. Inhibitors of arachidonic acid metabolism prevent neutrophil-dependent acute lung injury in isolated, perfused rabbit lungs. Chest 81s: 60s-61s, 1982.
46. Sugita T, Hyers TM, Dauber IM, Wagner WW, McMurtry IF, Reeves JT. Lung vessel leak precedes right ventricular hypertrophy in monocrotaline treated rats. J Appl Physiol 54:371-374, 1983.
47. Tate RM, VanBenthuysen KM, Shasby DM, McMurtry IF, Repine JE. Oxygen radical mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs. Am Rev Resp Dis 126:802-806, 1982.
48. Heffner JE, Shoemaker SA, Canham EM, Patel M, McMurtry IF, Morris HG, Repine JE. Acetyl glyceryl ether phosphorylcholine-stimulated human platelets cause pulmonary hypertension and edema in isolated rabbit lungs. J Clin Invest 71:351-357, 1983.
49. Canham EM, Shoemaker SA, Tate RM, Harado RN, McMurtry IF, Repine JE. Mepacrine but not methylprednisolone decreases acute edematous lung injury after injection of phorbol myristate acetate in rabbits. Am Rev Resp Dis 127: 594-598, 1983.
50. Stanbrook HS, McMurtry IF. Inhibition of glycolysis potentiates hypoxic vasoconstriction in rat lungs. J Appl Physiol 55:1467-1473, 1983.
51. Grover RF, Wagner WW Jr, McMurtry IF, Reeves JT. Pulmonary circulation. In: Handbook of Physiology, Sec 2, The Cardiovascular System, Vol III, Peripheral Circulation and Organ Blood Flow, Part 1, ed., JT Shepherd, FM Abboud, SR Geiger. Bethesda, Am Physiological Soc 1983.
52. McMurtry IF. Angiotensin is not required for hypoxic constriction in salt solution-perfused rat lungs. J Appl Physiol 56:375-380, 1984.
53. Shoemaker SA, Heffner JE, Canham EM, Tate RM, Morris HG, McMurtry IF, Repine JE. Staphylococcus aureus and human platelets cause pulmonary hypertension and thromboxane generation in isolated saline-perfused rabbit lungs. Am Rev Resp Dis 129: 92-95, 1984.
54. Burghuber O, Mathias MM, McMurtry IF, Reeves JT, Voelkel NF. Lung edema due to hydrogen peroxide is independent of cyclooxygenase products. J Appl Physiol 56: 900-905, 1984.
55. Stanbrook HS, Morris KG, McMurtry IF. Prevention and reversal of hypoxic pulmonary hypertension by calcium antagonists. Am Rev Resp Dis 130:81-85, 1984.
56. Redding GJ, McMurtry IF, Reeves JT. Effects of meclofenamate on pulmonary vascular resistance correlated with postnatal age in young piglets. Pediatr Res 18:579-583, 1984.
57. Herget J, McMurtry IF. Effects of ouabain, low K+, and aldosterone on hypoxic pressor reactivity of rat lungs. Am J Physiol 248:H55-H60, 1985.
58. McMurtry IF. BAY K 8644 potentiates and A23187 inhibit hypoxic vasoconstriction in rat lungs. Am J Physiol 249:H741-H746, 1985.
59. Weir EK, McMurtry IF, Reeves JT. The pulmonary circulation conferences. Chest 885:199s-200s, 1985.
60. Reeves JT, Grover RF, McMurtry IF, Weir EK. Pulmonary vascular reactivity. Bull Eur Physiopathol Respir 21:583-590, 1985.
61. Herget J, McMurtry IF. Possible mechanisms of hypoxic pulmonary vasoconstriction. Progr Resp Res 20:5-10, 1985.
62. McMurtry IF. Humoral control. In: Abnormal Pulmonary Circulation, ed., EH Bergofsky. New York, Churchill Livingstone, 1986, p83-126.
63. Gillespie MN, Owasoyo JO, McMurtry IF, O'Brien RF. Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture. J Pharmacol Exp Ther 236:339-343, 1986.
64. Feddersen CO, McMurtry IF, Henson P, Voelkel NF. Acetylcholine-induced pulmonary vasodilation in lung vascular injury. Am Rev Respir Dis 133:197-204, 1986.
65. Feddersen CO, Mathias MM, McMurtry IF, Voelkel NF. Acetylcholine induces vasodilation and prostaglandin synthesis in rat lungs. Prostaglandins 31:973-987, 1986.
66. McMurtry IF, Morris KG. Platelet-activating factor causes pulmonary vasodilation in the rat. Am Rev Respir Dis 134:757-762, 1986.
67. Harrsion GL, McMurtry IF, Moore LG. Meclofenamate potentiates vasoreactivity to alpha-adrenergic stimulation in chronically hypoxic guinea pigs. Am J Physiol 251:H496-H501, 1986.
68. Jackson JH, White CW, McMurtry IF, Berger EM, Repine JE. Dimethylthiourea decreases acute lung edema in phorbol myristate acetate-treated rabbits. J Appl Physiol 61:353-360, 1986.
69. Voelkel NF, Chang SW, Worthen SG, McMurtry IF, Henson PM. PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. Prostaglandins 32:359- 372, 1986.
70. VanBenthuysen KM, McMurtry IF, Horowitz LD. Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylocholine and auguments contractile reactivity in vitro. J Clin Invest 79:265-274, 1987.
71. O'Brien RF, Robbins RJ, McMurtry IF. Endothelial cells in culture produce a vasoconstrictor substance. J Cellular Physiol 132: 263-270, 1987.
72. McMurtry IF, Raffestin B. Potential mechanisms of hypoxic pulmonary vasoconstriction. In: The Pulmonary Circulation in Health and Disease, ed. JA Will and EK Weir. Academic Press, 1987, p455-468.
73. Herget J, McMurtry IF. Dexamethasone potentiates hypoxic vasoconstriction in salt solution-perfused rat lungs. Am J Physiol 253: H574-H581, 1987.
74. Raffestin B, McMurtry IF. Intracellular alkalosis potentiates hypoxic vasoconstriction in salt solution-perfused rat lungs. J Appl Physiol 63: 2524-2531, 1987.
75. White CW, Ghezzi P, Dinarello CA, Caldwell SA, McMurtry IF, Repine JE. Recombinant tumor necrosis factor/cachectin and interleukin 1 pretreatment decreases lung oxidized glutathione accumulation, lung injury, and mortality in rats exposed to hyperoxia. J Clin Invest 79:1868-1873, 1987.
76. Reeves, JT, McMurtry IF, Voelkel NF. Possible role for membrane lipids in the function of the normal and abnormal pulmonary circulation. Am Rev Respir Dis 136:196-199, 1987.
77. Reeves JT, McMurtry IF. Mediators of hypoxic pulmonary vasoconstriction. In: Hypoxia and Cold, ed., J Sutton, C Houston, and G Coates. New York: Praeger, 1987, p197-206.
78. Meyrick B, McMurtry IF. Endothelial control of the pulmonary circulation: permeability, tone, and structure-part 1. Am Rev Respir Dis 136:1025-1026, 1987.
79. Herget J, Frydrychova M, Kawikova I, McMurtry IF. Thyroxine treatment increases the hypoxic pulmonary vasoconstriction in isolated lungs from thyrodectomized rats. Bull Eur Physiopathol Respir 23:217-221, 1987.
80. McMurtry IF, Rodman DM, Yamaguchi T, O'Brien RF. Pulmonary vascular reactivity. Chest 98:88s-93s, 1988.
81. Rodman DM, Yamaguchi T, O'Brien RF, McMurtry IF. Methylene blue enhances hypoxic contraction in isolated rat pulmonary arteries. Chest 98:93s-94s, 1988.
82. White CW, Jackson JH, McMurtry IF, Repine JE. Hypoxia increases glutathione redox cycle and protects rat lungs against oxidants. J Appl Physiol 65:2607-2616, 1988.
83. Archer SL, McMurtry IF, Weir EK. Mechanisms of acute hypoxic and hyperoxic changes in pulmonary vascular reactivity. In: Pulmonary Vascular Physiology and Pathophysiology, ed. JT Reeves and EK Weir. New York, Marcel Dekker, 1988, 241-290.
84. Yamaguchi T, Rodman D, O'Brien R, McMurtry I. Modulation of pulmonary artery contraction by endothelium-derived relaxing factor. Eur J Pharmacol 161:259-262, 1989.
85. Rodman DM, Yamaguchi T, O'Brien RF, McMurtry IF. Hypoxic contraction of isolated rat pulmonary artery. J Pharmacol Exp Ther, 248:952-959, 1989.
86. Yamaguchi T, O'Brien RF, Hanson W, Wagner WW Jr, McMurtry IF. Prostacyclin contributes to inhibition of hypoxic pulmonary vasoconstriction by alkalosis. Prostaglandins 38:53-63, 1989.
87. Rodman DM, McMurtry IF, Peach JL, O'Brien RF. Comparative pharmacology of rat and porcine endothelin in isolated rat arteries. Eur J Pharmacol 165:297-300, 1989.
88. Lesnefsky EJ, Fennessey PM, VanBenthuysen KM, McMurtry IF, Travis VL, Horwitz LD. Superoxide dismutase decreases early reperfusion release of conjugated dienes following regional canine ischemia. Basic Res Cardiol 84:191-196, 1989.
89. Lesnefsky EJ, VanBenthuysen KM, McMurtry IF, Shikes RH, Johnston RB Jr, Horwitz LD. Lidocaine reduces canine infarct size and decreases release of a lipid peroxidation product. J Cardiovasc Pharmacol 13:895-901, 1989.
90. Portz SJ, Lesnefsky EJ, VanBenthuysen KM, Repine JE, Parker NB, McMurtry IF, Horwtiz LD. Dimethylthiourea, but not dimethylsulfoxide, reduces canine myocardial infarct size. Free Radical Biol Med 7:53-58, 1989.
91. Orton EC, Raffestin B, McMurtry IF. Protein Kinase C is a determinant of rat pulmonary vascular reactivity. Am Rev Respir Dis 141:654-658, 1990.
92. Rodman DM, Yamaguchi T, Haunuma K, O'Brien RF, McMurtry IF. Effects of hypoxia on endothelium-dependent relaxation of rat pulmonary artery. Am J Physiol: Lung Cell Molec Physiol 258:L207-L214, 1990.
93. Ashmore RC, O'Brien RD, Stelzner TJ, Dauber IM, Horwitz LD, McMurtry IF, VanBenthuysen KM. Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. Biochem Biophys Res Commun 166:909-915, 1990.
94. Westcott JY, Henson J, McMurtry IF, O'Brien RF. Uptake and metabolism of endothelin in the isolated perfused rat lung. Exp Lung Res 16:521-532, 1990.
95. Hasunuma K, Rodman DM, O'Brien RF, McMurtry IF. Endothelin-1 causes pulmonary vasodilation in the rat. Am J Physiol: Heart Circ Physiol 259:H48-H54,1990.
96. Dauber IM, VanBenthuysen KM, McMurtry IF, Wheeler GS, Lesnefsky EJ, Horwitz LD, Weil JV. Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion. Circ Res 66:986-998, 1990.
97. Horwitz LD, VanBenthuysen KM, Sheridan FM, Lesnefsky EJ, Dauber IM, McMurtry IF. Coronary endothelial dysfunction from ischemia and reperfusion; effect of reactive oxygen metabolite scavengers. Free Rad Biol Med 8:381-386, 1990.
98. Dempsey EC, Stenmark KR, McMurtry IF, O'Brien RF, Voelkel NF, Badesch DB. Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways. J Cellular Physiol 144:159-165, 1990.
99. Abman SH, Chatfield BA, Hall SL, McMurtry IF. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol: Heart Circ Physiol 259:H1921-H1927, 1990.
100. Rodman DM, Hasunuma K, Peach JL, McMurtry IF. Inhibitor of ATP-sensitive K+ channel alters neither hypoxic contraction nor relaxation of rat aorta. Blood Vessels, 27:365-368, 1990.
101. Abman SH, Chatfield BA, Hall SL, McMurtry IF. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol: Heart Circ Physiol 259:H1921-1927, 1990.
102. Lippton HL, Cohen GA, McMurtry IF, Hyman AL. Pulmonary vasodilation to endothelin isopeptides in vivo is mediated by potassium channel activation. J Appl Physiol 70:947-952, 1991.
103. Hasunuma K, Yamaguchi T, Rodman DM, O'Brien RF, McMurtry IF. Effects of inhibitors of EDRF and EDHF on the vasoreactivity of perfused rat lungs. Am J Physiol: Lung Cellular Molec Physiol. 260:L97-L104, 1991.
104. Hasunuma K, Rodman DM, McMurtry IF. Effects of K+-channel blockers on vascular tone in the perfused rat lung. Am Rev Respir Dis, 144:884-887, 1991.
105. Rodman DM, Mallet J, McMurtry IF. Effects of inhibitors of energy metabolism on endothelium-dependent relaxation of rat pulmonary artery and aorta. Am J Resp Cell Molec Biol. 4:237-242, 1991.
106. Dempsey EC, McMurtry IF, O'Brien RF. Protein kinase C activation allows bovine pulmonary artery smooth muscle cells to proliferate in response to hypoxia. Am J Physiol: Lung Cellular Molec Physiol 260:L136-L145, 1991.
107. Abman SH, Chatfield BA, Rodman DM, Hall SL, McMurtry IF. Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro. Am J Physiol: Lung Cellular Molec Physiol 260:L280-L285, 1991.
108. Sheridan FM, Horwitz LD, McMurtry IF. Effects of phorbol esters on canine coronary artery constriction and dilation in vitro. Am J Physiol: Heart Circ Physiol 261:H236-H242, 1991.
109. Ashmore RC, Rodman DM, Sato K, Webb SA, O'Brien RF, McMurtry IF, Stelzner TJ. Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension. Am J Physiol: Heart Circ Physiol 260:H1929-H1934, 1991.
110. Chatfield BA, McMurtry IF, Hall SL, Abman SH. Hemodynamic effects of endothelin-1 on ovine fetal pulmonary circulation. Am J Physiol: Regulat Integr Comp Physiol 261:R182-R187, 1991.
111. Lippton HL, Cohen GA, Knight M, McMurtry IF, Gillot D, Arena F, Summer W, Hyman AL. Evidence for distinct endothelin receptors in the pulmonary vascular bed in vivo. J Cardiovasc Pharmacol, 17(Suppl 70:s370-s373, 1991.
112. Sheridan FM, Dauber IM, McMurtry IF, Lesnefsky EJ, Horwitz LD. Role of leukocytes in coronary vascular endothelial injury due to ischemia and reperfusion. Circ Res 69:1566-1574, 1991.
113. Sato K, Webb S, Tucker A, Rabinovitch M, O'Brien RF, McMurtry IF, Stelzner TJ. Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am Rev Resp Dis, 145: 793-797, 1992.
114. Stelzner TJ, O'Brien RF, Yanagisawa M, Sanurai T, Sato K, Webb S, Zamora M, McMurtry IF, Fisher JH. Increased lung endothelin-1 production in rats with idiopathic pulmonary hypertension. Am J Physiol: Lung Cellular Molec Physiol 262: L614-L620, 1992.
115. McMurtry IF, Oka M, Hasunuma K, Yamaguchi T, Morris K, Rodman D. Role of EDRF in control of normoxic and hypoxic pulmonary vascular tone. In: High Altitude Medicine, ed G Ueda, JT Reeves, and M Sekiguchi. Matsumoto, Shinshu University Press, 1992, 131-138.
116. Rodman DM, Stelzner TJ, Zamora MR, Bonvallet ST, Oka M, Sato K, O'Brien RF, McMurtry IF. Endothelin-1 increases pulmonary microvascular pressure and causes pulmonary edema in salt solution - but not blood-perfused rat lungs. J Cardiovasc Pharmacol 20:658-663, 1992.
117. Cornfield DN, Chatfield BA, McQueston JA, McMurtry IF , Abman SH. Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am J Physiol: Heart Circ Physiol 262:H1474-H1481, 1992.
118. Cornfield DN, McQueston JA, McMurtry IF, Rodman DM, Abman SH. Role ATP-sensitive potassium channels in ovine fetal pulmonary vascular tone. Am J Physiol: Heart Circ Physiol 263:H1363-H1368, 1992.
119. Lanese DM, Yuan BH, McMurtry IF, Conger JD. Comparative sensitivities of isolated rat renal arterioles to endothelin. Am J Physiol: Renal Fluid Electrolyte Physiol 263:F894-F899, 1992.
120. McQueston JA, Cornfield DN, McMurtry IF, Abman SH. Effects of oxygen and exogenous L-arginine on EDRF activity in fetal pulmonary circulation. Am J Physiol: Heart Circ Physiol 264:H865-H871, 1993.
121. Oka M, Hasunuma K, Webb SA, Stelzner TJ, Rodman DM, McMurtry IF. Endothelium-derived relaxing factor suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am J Physiol: Lung Cellular Molec Physiol 264:L587-L597,1993.
122. Oka M, Morris KG, McMurtry IF. NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension. J Appl Physiol 75:1075-1080, 1993.
123. Bonvallet ST, Oka M, Yano M, Zamora MR, McMurtry IF, Stelzner TJ. BQ123, an ETA receptor antagonist, attenuates endothelin-1-induced vasoconstriction in rat pulmonary circulation. J Cardiovasc Pharmacol 22:39-43, 1993.
124. Stevens T, Morris K, McMurtry IF, Zamora M, Tucker A. Pulmonary and systemic vascular responsiveness to TNF-a in conscious rats. J Appl Physiol 74:1905-1910, 1993.
125. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Acute hypoxia increases cytosolic calcium in fetal pulmonary artery smooth muscle cells. Am J Physiol: Lung Cellular Molec Physiol 265:L53-L56, 1993.
126. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells. Am J Physiol: Lung Cellular Molec Physiol 266:L469-L475, 1994.
127. Stevens T, Cornfield DN, McMurtry IF, Rodman DM. Acute reductions in PO2 depolarize pulmonary artery endothelial cells and decrease [Ca2+]i. Am J Physiol: Heart Circ Physiol 266:H1416-H1421, 1994.
128. McQueston JA, Kinsella JP, Ivy DD, McMurtry IF, Abman SH. Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation. Am J Physiol: Heart Circ Physiol 268: H288-H294, 1995.
129. Stevens T, Nakahashi Y, Cornfield D, McMurtry IF, Cooper DMF, Rodman DM. Calcium-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Proc Natl Acad Sci 92: 2696-2700, 1995.
130. Atanasova I, Burke TJ, McMurtry IF, Schrier RW. Nitric oxide synthase inhibition and acute renal ischemia: effect on systemic hemodynamics and mortality. Renal Failure 17: 1-15, 1995.
131. Niederberger M, Gines P, Tsai P, Martin P-Y, Morris K, Weigert A, McMurtry IF, Schrier RW. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 21: 1625-1631, 1995.
132. Weigert AL, Higa EMS, Niederberger M, McMurtry IF, Raynolds M, Schrier RW. Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats. J Am Soc Nephrol 5: 2067-2072, 1995.
133. Gillespie MN, Lipke DW, McMurtry IF. Regulation of pulmonary vasomotor tone in hypertensive pulmonary vascular remodelling. In: Pulmonary Vascular Remodelling, ed., JE Bishop, JT Reeves, and GJ Laurent, London, Portland, 1995, p117-147.
134. Weigert AL, Martin PY, Niederberger M, Higa EMS, McMurtry IF, Gines P, Schrier RW. Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats. Hepatology 22: 1856-1862, 1995.
135. Niederberger M, Martin PY, Gines P, Morris K, Tsai P, Xu DL, McMurtry IF, Schrier RW. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 109: 1624-1630, 1995.
136. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Thapsigargin stimulates increased NO activity in hypoxic hypertensive rat lungs and pulmonary arteries. J Appl Physiol 80: 1336-1344, 1996.
137. Cohen AH, Hanson K, Morris K, Fouty B, McMurtry IF, Clarke W, Rodman DM. Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats. J Clin Invest 97: 172-179, 1996.
138. Niederberger M, Gines P, Martin PY, Tsai P, Morris K, McMurtry I, Schrier RW. Comparison of vascular nitric oxide production and systemic hemodynamics in cirrhosis versus prehepatic portal hypertension in rats. Hepatology 24: 947-951, 1996.
139. Stevens T, Fouty B, Hepler L, Richardson D, Brough G, McMurtry IF, Rodman DM. Cytosolic Ca++ and adenylyl cyclase responses in phenotypically distinct pulmonary endothelial cells. Am J Physiol: Lung Cellular Molec Physiol 16: L51-L59, 1997.
140. Muramatsu M, Oka M, Rodman DM, McMurtry IF. Endothelin-1 mediates nitro-L-arginine vasoconstriction of hypertensive rat lungs. Am J Physiol: Lung Cellular Molec Physiol 16: L807-L812, 1997.
141. Muramatsu M, Tyler RC, Gutkowska J, Klinger JR, Hill NS, Rodman DM, McMurtry IF. Atrial natriuretic peptide accounts for increased cGMP in hypoxia-induced hypertensive rat lungs. Am J Physiol: Lung Cellular Molec Physiol, 16: L1126-1132, 1997.
142. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Possible role of T-type Ca++ channels in L-NNA vasoconstriction of hypertensive rat lungs. Am J Physiol: Heart Circ Physiol 41: H2616-H2621, 1997.
143. Chetham PM, Sefton WD, Bridges JP, Stevens T, McMurtry IF. Inhaled nitric oxide pretreatment but not post-treatment attenuates ischemia-reperfusion-induced pulmonary microvascular leak. Anesthesiology 86: 895-902, 1997.
144. Presson RG, Todoran TM, De Witt BJ, McMurtry IF, Wagner WW. Capillary recruitment and transit time in the rat lung. J Appl Physiol 83: 543-549, 1997.
145. Tyler RC, Bullock C, Lapuz C, Gorman C, Hepler LK, Tudor RM, McMurtry IF, Rodman DM. Polycationic lipid-mediated gene transfer to the abnormal pulmonary circulation. Chest 111: 122S-123S, 1997.
146. Fouty B, Muramatsu M, Komalavilas P, Cohen A, McMurtry IF, Lincoln TM, Rodman DM. Protein kinase G is not essential to NO/cGMP modulation of basal tone in the hypertensive pulmonary circulation. Am J Physiol: Heart Circ Physiol 43: H672-H678, 1998.
147. Le Cras TD, Tyler RC, Horan MP, Morris KG, Tuder RM, McMurtry IF, Johns RA, Abman SH. Effects of chronic hypoxia and altered hemodynamics on endothelial nitric oxide synthase expression in the adult rat lung. J Clin Invest 101: 795-801, 1998.
148. Fagan K, Hepler LK, McMurtry IF, Rodman DM. Effect of nitric oxide on transgene expression in vascular smooth muscle. Chest 114: 100S-101S, 1998.
149. Tyler RC, Muramatsu M, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF. Variable expression of endothelial NOS in three forms of rat pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 20: L297-L303, 1999.
150. Sato K, Rodman DM, McMurtry IF. Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs. Am J Physiol Lung Cell Mol Physiol 20: L511-L581, 1999.
151. Fagan KA, Tyler RC, Sato K, Fouty BW, Morris KG, Huang PL, McMurtry IF, Rodman DM. Relative contributions of endothelial, inducible, and neuronal nitric oxide synthase to tone in the murine pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 21: L472-L478, 1999.
152. Fagan KA, Fouty BW, Tyler RC, Morris KG, Hepler LK, Sato K, Le Cras TD, Abman SH, Weinberger HD, Huang PL, McMurtry IF, Rodman DM. The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia. J Clin Invest 103: 291-299, 1999.
153. Li KX, Fouty BW, McMurtry IF, Rodman DM. Enhanced ETA-receptor-mediated inhibition of KV channels in hypoxic hypertensive rat pulmonary artery myocytes. Am J Physiol Heart Circ Physiol 46: H363-H370, 1999.
154. Sato K, Morio Y, Morris KG, Rodman DM, McMurtry IF. Mechanism of hypoxic pulmonary vasoconstriction involves ETA receptor-mediated inhibition of KATP channel. Am J Physiol Lung Cell Mol Physiol, 278: L434-L442, 2000.
155. Le Cras TD, Markham NE, Morris KG, Ahrens CR, McMurtry IF, Abman SH. Neonatal dexamethasone treatment increases the risk for pulmonary hypertension in adult rats. Am J Physiol Lung Cell Mol Physiol 278: L822-L829, 2000.
156. Carter E, Sato K, Morio Y, McMurtry IF. Inhibition of KCa channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis. Am J Physiol Lung Cell Mol Physiol 279: L903-L910, 2000.
157. McMurtry IF, Rodman DM. Possible reconciliation: a role for endothelin-1 and KATP channels in the mechanism of hypoxic pulmonary vasoconstriction. Cardiopulmonary Crit Care Council Newsletter, 11-14, Fall 2000.
158. Fagan KA, McMurtry I, Rodman DM. Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice. Physiol Res 49: 539-548, 2000.
159. Ivy DD, McMurtry IF, Yanagisawa M, Gariepy CE, Le Cras TD, Gebb SA, Morris KG, Abman SH. Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol 280: L1040-L1048, 2001.
160. Fagan KA, McMurtry IF, Rodman DM. Role of endothelin-1 in lung disease (invited review). Respir Res 2: 90-101, 2001.
161. Le Cras TD, McMurtry IF. Nitric oxide production in the hypoxic lung (invited review). Am J Physiol Lung Cell Mol Physiol 280: L575-L582, 2001.
162. Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y. Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol 127: 53-60, 2001.
163. Fagan KA, Morrissey B, Fouty BW, Sato K, Harral JW, Morris KG, Hoedt-Miller M, Vidmar S, McMurtry IF, Rodman DM. Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension. Respir Res 2: 306-313, 2001.
164. Ivy DD, Yanagisawa M, Gariepy CE, Gebb SA, Colvin KL, McMurtry IF. Exaggerated hypoxic pulmonary hypertension in endothelin B receptor deficient rats. Am J Physiol Lung Cell Mol Physiol 282: L703-L712, 2002.
165. Morio Y, McMurtry IF. Ca2+ release from ryanodine-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J Appl Physiol 92: 527-534, 2002.
166. McMurtry IF. Introduction: pre- and postnatal lung development, maturation, and plasticity (editorial). Am J Physiol Lung Cell Mol Physiol 282: L341-L344, 2002.
167. Carter EP, Hartsfield CL, Miyazono M, Jakkula M, Morris KG, McMurtry IF. Regulation of heme oxygenase-1 by nitric oxide during hepatopulmonary syndrome. Am J Physiol Lung Cell Mol Physiol 283: L346-L353, 2002.
168. Littler CM, Morris KG, Fagan KA, McMurtry IF, Messing RO, Dempsey EC. Protein kinase C epsilon null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol 284: H1321-H1331, 2003.
169. Morio Y, Cater EP, Oka M, McMurtry IF. EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs. Am J Physiol Heart Circ Physiol 284: H1762-H1770, 2003.
170. McMurtry IF, Bauer NR, Fagan KA, Nagaoka T, Gebb SA, Oka M. Hypoxia and Rho/Rho-kinase signaling: lung development versus hypoxic pulmonary hypertension (book chapter). Adv Exper Med Biol 543: 127-137, 2003.
171. McMurtry IF. Rho family GTPases (editorial). Am J Physiol Lung Cell Mol Physiol 287: L623, 2004.
172. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, McMurtry IF. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287: L656-L664, 2004.
173. Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M. Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287: L665-L672, 2004.
174. Robertson TP, McMurtry IF. Critical role of Ca2+-sensitization in acute hypoxic pulmonary vasoconstriction (chapter 7, p 103). In, Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms, Jason X-J Yuan, Kluwer Academic, 2004.
175. McMurtry IF, Bauer NR, Gebb SA, Fagan KA, Nagaoka T, Oka M, Robertson TP. Rho/Rho-kinase signaling in hypoxic pulmonary hypertension (chapter 24, p 419). In, Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms, Jason X-J Yuan, Kluwer Academic, 2004.
176. Tang JR, Markham NE, Lin YJ, McMurtry IF, Maxey A, Kinsella JP, Abman SH. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol 287: L344-L351, 2004.
177. Hartsfield CL, McMurtry IF, Ivy DD, Morris KG, Vidmar S, Rodman DM, Fagan KA. Cardio protective and vasomotor effects of HO activity during acute and chronic hypoxia. Am J Physiol Heart Circ Physiol 287: H2009-H2015, 2004.
178. Imamura M, Luo B, Limbird J, Vitello A, Oka M, Ivy DD, McMurtry IF, Garat CV, Fallon MB, Carter EP. Hypoxic pulmonary hypertension is prevented in rats with common bile duct ligation. J Applied Physiol 98: 739-747, 2005.
179. Nagaoka T, Fagan KA, Gebb AS, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171: 494-499, 2005.
180. Fagan KA, McMurtry IF. Pulmonary vascular pharmacology (chapter 10, p 280). In, Murray and Nadel’s Textbook of Respiratory Medicine, fourth edition, RJ Mason, JF Murray, VC Broaddus, JA Nadel, WB Saunders, 2005.
181. Ivy DD, McMurtry IF, Colvin K, Lee DS, Gebb S, Jones PL. Development of occlusive neointimal lesions in endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension. Circulation 111: 2988-2996, 2005.
182. Ling X, Cota-Gomez A, Flores NC, Hernandez-Saavedra D, McCord JM, Marecki JC, Haskins K, McDuffie M, Powers K, Kench J, Oka M, McMurtry IF, Flores SC. Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice. Free Rad Biol Med 39: 1089-1098, 2005.
183. Stenmark KR, McMurtry IF. Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension; a time for reappraisal? (editorial) Circ Res, 97: 95-98, 2005.
184. Gupte SA, Okada T, McMurtry IF, Oka M. Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction. Pulm Pharmacol Ther 19: 303-309, 2006.
185. McMurtry IF, Gebb SA, Jones PL. Pulmonary vascular remodeling (p 591). In, Encyclopedia of Respiratory Medicine, GJ Laurent and SD Shapiro, Elsevier, 2006.
186. Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M. Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. J Appl Physiol 100: 996-1002, 2006.
187. Garat CV, Fankell D, Erickson PF, Reusch JE-B, Bauer NN, McMurtry IF, Klemm DJ. Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells. Mol Cell Biol 26: 4934-4948, 2006.
188. Oka M, Karoor V, Homma N, Nagaoka T, Sakao E, Golembeski SM, Limbird J, Imamura M, Gebb SA, Fagan KA, McMurtry IF. Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension. Cardiovasc Res, in press, 2007.
189. McLoughlin P, McMurtry I. Chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature. (invited point/counterpoint) J Appl Physiol, in press, 2007.
190. Oka M, Homma N, Taraseviciene-Stewart L, Morris KG, Kraskauskas D, Voelkel NF, McMurtry IF. Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res, in press, 2007.
191. Laudi S, Trump S, Schmitz V, West J, McMurtry I, Mutlak H, Christians U, Weimann J, Kaisers U, Steudel W. Serotonin transporter protein in pulmonary hypertensive lungs treated with atorvastatin. Submitted, 2006.
192. Natalie R. Bauer, Timothy M. Moore, and Ivan F. McMurtry. Rodent Models of PAH: Are We There Yet?

1. McMurtry IF, Will DH. Cardiorespiratory responses of male and female miniature swine to hypobaria. Fed Proc 30:427, 1971.
2. Hall P, Fitch JW, McMurtry IF. The miniature pig as a model for the study of decompression. Annual Scientific Meeting, Aerospace Medical Association, 1972.
3. Tucker A. Reeves JT, McMurtry IF, Alexander AF, Will DH, Grover RF. Interspecies variation in altitude-induced pulmonary hypertension and cardiac hypertrophy. Fed Proc 33:308, 1974.
4. McMurtry IF, Reeves JT, Grover RF. Inhibition by verapamil of pulmonary vasoconstrictive response to alveolar hypoxia. Physiologist 17:285, 1974.
5. Reeves JT, Tucker A. McMurtry IF, Alexander AF, Will DH, Grover RF. Lung mast cell hyperplasia at high altitude. Circulation 50:III-50, 1974.
6. McMurtry IF, Tucker A, Reeves JT, Grover RF. Hyperreactivity of normotensive and hypertensive pulmonary vasculature in spontaneously hypertensive rats. Proc Second Int Symposium on SHR, 1975.
7. Davidson AB, McMurtry IF. Pulmonary pressor response to hypoxia but not prostaglandin F2a is inhibited by verapamil. Clin Res 23:116A, 1975.
8. Will DH, McMurtry IF, Reeves JT, Grover RF. Cold-induced pulmonary hypertension. Physiologist 18:450, 1975,
9. McMurtry IF, Tucker A, Reeves JT, Grover RF. Pulmonary vascular reactivity in spontaneously hypertensive rats (SHR). Physiologist 18:314, 1975.
10. Weir EK, McMurtry IF, Reeves JT, Will DH, Grover RF. Prostaglandins and pulmonary hypertension in cattle. Fed Proc 34:437, 1975.
11. McMurtry IF, Hiser WW, Reeves JT, Grover RF. Disassociation of hypoxia- and angiotensin II-induced pulmonary vasoconstriction by saralasin. Fed Proc 34:438, 1975.
12. McMurtry IF, Tucker A, Davidson AB, Reeves JT, Grover RF. Blunted hypoxic pressor response in lungs from high altitude rats. Fed Proc 35:453, 1976.
13. McMurtry IF, Reeves JT. Blunted hypoxic pressor response in lungs from acute high altitude rats. Fed Proc 36:611, 1977.
14. McMurtry IF, Reeves JT, Grover RF. Blunted pressor responses to hypoxia, DNP, and KCl inlungs from rats exposed to high altitude. Proc Int Union Physiol Sci 13:496, 1977.
15. McMurtry IF, Petrun MD, Reeves JT. Metabolic inhibitors do not reverse blunted hypoxic pressor response in lungs from high altitude rats. Fed Proc 37:293, 1978.
16. Voelkel NF, McMurtry IF, Reeves JT. Increased perfusate calcium blunts hypoxic pressor response in lungs from low-altitude rats, but potentiates it in lungs from high-altitude rats. Physiologist 21:124, 1978.
17. Voelkel NF, McMurtry IF, Reeves JT, Grover RF. Lungs from rats treated chronically with propranolol have a blunted hypoxic pressor response. Circulation 58:II-108, 1978.
18. Rounds S, Hookway B, McMurtry IF. Energy metabolism influences hypoxic pulmonary vasoconstriction. Am Rev Resp Dis 117:387, 1978.
19. Gerber JG, Voelkel NF, Nies AS, Kadowitz PJ, McMurtry IF, Reeves JT. Pulmonary vasodilation during hypoxia with infusion of arachidonic acid (AA). Physiologist 21:43, 1978.
20. Voelkel NF, McMurtry IF, Reeves JT, Grover RF. Hypoxia delays vasodilation following angiotensin II induced pressor response in isolated rat lungs. Fed Proc 38:1379, 1979.
21. McMurtry IF, Morris KG, Reeves JT. Aortas from diabetic rats are hyporesponsive to angiotensin II. Fed Proc 38:1136, 1979.
22. Voelkel NF, Gerber JG, McMurtry IF, Reeves JT, Nies AS. Release of dilator prostaglandins (PG) from rat lung during angiotensin II (AII) vasoconstriction. Adv Prostaglandin Thromboxane Res 7:957, 1979.
23. Rounds S, McMurtry IF, Reeves JT. Inhibitors of oxidative phosphorylation cause pulmonary vasoconstriction. Am Rev Resp Dis 119:386, 1979.
24. Gerber JG, Voelkel NF, Nies AS, McMurtry IF, Reeves JT. Isolated rat lungs release prostaglandin I2 (PGI2) during hypoxic vasconstriction. Physiologist 22:43, 1979.
25. Voelkel NF, Hegstrand L, McMurtry IF, Molinoff P, Reeves JT. Decreased number of b-receptors in right ventricles of chronically hypoxic rats. Proc 3rd Prague Int Symp on Pulm Circ, 1979.
26. McMurtry IF, Rounds SS, Voelkel NF. Studies of hypoxic vasoconstriction in rat lungs. Proc 3rd Prague Int Sym on Pulm Circ, 1979.
27. Newman JH, McMurtry IF, Reeves JT. Oxygen toxicity blunts hypoxic vasoconstriction in rat lungs: possible role of prostaglandins. Am Rev Resp Dis 121:383, 1980.
28. Voelkel NF, McMurtry IF, Reeves JT. High extracellular calcium causes pulmonary vasodilation by stimulating Na+, K+ATPase. Blood Vessels 17:168, 1980.
29. Voelkel NF, Olson RD, McMurtry IF, Reeves JT. Vanadate potentiates hypoxic pulmonary vasoconstriction. Fed Proc 39:766, 1980.
30. Redding GJ, McMurtry IF, Reeves JT. Effects of meclofenamate on pulmonary hemodynamics decrease with postnaal age in anesthetized piglets. Physiologist 23:900, 1980.
31. McMurtry IF, Keatinge WR. Hypoxia contracts vascular smooth muscle treated with tetra-ethylammonium. Physiologist 23:61, 1980.
32. Voelkel NF, Walker BR, McMurtry IF, Adams M. Blunted hypoxic pressor response in the isolated hamster lung. Physiologist 23:154, 1980.
33. Stanbrook H, McMurtry IF. Inhibitors of glycolysis potentiate the hpoxic pressor response in isolated rat lungs. Fed Proc 40;504, 1981.
34. Vanbenthuysen KM, Shasby DM, Tate RM, Repine JE, McMurtry IF. Indomethacin and tetracaine inhibit polymorphonuclear leukocyte dependent acute pulmonary vascular injury. Am Rev Resp Dis 123:243, 1981.
35. VanBenthuysen KM, Shasby DM, Dauber IM, Repine JE, McMurtry IF. Indomethacin inhibits polymorphonuclear leukocyte (PMN)-dependent acute pulmonary vascular injury. Clin Res 29:101A, 1981.
36. Shasby DM, VanBenthuysen KM, Tate RM, McMurtry IF, Repine JE. Oxygen radicals released from phorbol myristate acetate (PMA) stimulated granulocytes cause acute pulmonary vascular injury. Am Rev Resp Dis 123:248, 1981.
37. Tate RM, VanBenthuysen KM, Shasby DM, McMurtry IF, Bowman CM, Harada RN, Fox RB, Repine JE. Dimethylthiourea, a hydroxyl radical scavenger, blocks oxygen radical-induced acute edematous lung injury in an isolated perfused lung. Am Rev Resp Dis 123:244, 1981.
38. Tate R, Shasby DM, VanBenthuysen KM, McMurtry IF, Repine JE. Hydroxyl radical scavengers dimethylsulfoxide (DMSO) or dimethylthiourea (DMTU), block oxygen radical-induced acute edematous lung injury in an isolated perfuse lung. Chest 81:57s-59s, 1982.
39. VanBenthuysen KM, Shasby D, Tate R, Repine JE, McMurtry IF. Inhibitors of arachidonic acid metabolism prevent neutrophil-dependent acute edematous lung injury in isolated, perfused rabbit lungs. Chest 81: 60s-61s, 1982.
40. Stanbrook HS, McMurtry IF. Inhibition of glycolysis increases sensitivity of rat lungs to hypoxic vasoconstriction. In: Oxygen Transport to Human Tissues, ed., J. Loeppky and M. Riedesel, New York: Elsevier, p370, 1982.
41. Heffner JE, Tate RM, Canham EM, Shoemaker SA, Patel MN, McMurtry IF, Repine JE. Platelet activating factor (PAF) stimulates platelets to produce pulmonary hypertension and edematous lung injury in isolated perfused rabbit lungs. Am Rev Resp Dis 125:277, 1982.
42. Canham EM, Shoemaker SA, Tate RM, Heffner JE, McMurtry IF, Repine JE. Mepacrine inhibits neutrophil mediated acute edematous injury in isolated perfused lungs. Am Rev Resp Dis 125:274, 1982.
43. Canham EM, Shoemaker SA, Tate RM, Heffner JE, McMurtry IF, Repine JE. High dose corticosteroids do not prevent neutrophil mediated acute edematous lung injury in two models of adult respiratory distress syndrome. Am Rev Resp Dis 125:131, 1982.
44. Heffner JE, McMurtry IF, Repine JE. Platelet activating factor stimulates platelets to produce pulmonary hypertension and edematous lung injury in isolated perfused rabbit lungs. Clin Res 30:430A, 1982.
45. Heffner J, Shoemaker S, Patel M, Canham M, McMurtry IF, Repine JE. Platelet activating factor and platelets produce pulmonary hypertension and hydrostatic edema in isolated perfused rabbit lungs: role of thromboxane A2. Am Rev Resp Dis 125:277, 1982.
46. VanBenthuysen KM, Tate RM, Morris KG, Reeves JT, Repine JE, McMurtry IF. Oxygen radical-induced contracton of isolated pulmonary vascular smooth muscle: role of arachidonic acid metabolism. Clin Res 30:76A, 1982.
47. McMurtry IF. Vasoactive agents other than angiotensin enable hypoxic vasoconstriction in rat lungs perfused with salt-albumin solution. Fed Proc 41:1686, 1982.
48. Stanbrook HS, Morris KG, McMurtry IF. Inhibition of the hypoxic pulmonary pressor response by vasodilator drugs in the conscious rat. Physiologist 25:276, 1982.
49. White CW, Bowman CM, Berger EM, Clifford DP, Jackson JH, McMurtry IF, Repine JE. Preexposure to hypoxia increases lung catalase activity and decreases hydrogen peroxide dependent permeability pulmonary edema in isolated perfused rat lungs. Clin Res 31:423A, 1983.
50. Herget J, McMurtry IF. Ouabain blunts hypoxic vasoconstriction in isolated rat lungs. Fed Proc 42:595, 1983.
51. Burghuber O, Mathias MM, McMurtry IF, Tate RM, Reeves JT, Voelkel NF. Chemically produced hydrogen peroxides (H202) in isolated rat lungs cause edema: modification by catalase and meclofenamate. Am Rev Resp Dis 127;304, 1983.
52. Clifford DP, White CW, Jackson JH, Berger EM, McMurtry IF, Repine JE. Erythrocytes protect against toxic O2 metabolite mediated acute edematous lung injury in isolated rat lungs. Am Rev Resp Dis 127:285, 1983.
53. White CW, Bowman CM, Berger EM, Clifford DP, Jackson JH, McMurtry IF, Repine JE. Endogenous mechanisms of antioxidant against toxic oxygen-metabolite mediated permeability pulmonary edema. Am Rev Resp Dis 127:208, 1983.
54. Stanbrook HS, Morris KG, McMurtry IF. Chronic hypoxic pulmonary hypertension in rats is reduced by calcium channel blockers. Fed Proc 42:596, 1983.
55. Jackson JH, White CW, Schroeder WR, McMurtry IF, Anderson WH, Repine JE. High-dose phorbol myristate acetate (PMA) and oxygen metabolit (O2) deficient chronic granulomatous disease (CGD) neutrophils cause acute edematous lung injury (ARDS) and leukotriene (LT) increases in isolated perfused rabbit lungs (IPRL). Clin Res 32:62A, 1984.
56. O'Brien RF, McMurtry IF. Endothelial cell (EC) supernates contract bovine pulmonary artery (PA) rings. Am Rev Resp Dis 129:A337, 1984.
57. Feddersen CO, McMurtry IF, Voelkel NF. Acetylcholine (ACH) induced pulmonary vasodilation is partially inhibited by meclofenamate (MECLO). Fed Proc 43:809, 1984.
58. Herget J, McMurtry IF. Possible mechanisms of hypoxic pulmonary vasoconstriction. Proc 4th Prague Int Symposium on Pulm Circ, p51, 1984.
59. VanBenthuysen KM, McMurtry IF, Horwitz LD. Reperfusion following myocardial ischemia increases vascular reactivity: a coronary endothelial reperfusion injury. Clin Res 33:91A, 1985.
60. VanBenthuysen KM, McMurtry IF, Horwitz LD. Reperfusion following myocardial ischemia increases vascular reactivity: a cornonary endothelial reperfusion injury. Clin Res 33:523A, 1985.
61. O'Brien RF, Owasoyo J, McMurtry IF, Gillespie M. Sustained coronary vasoconstriction in isolated hearts caused by endothelial cell conditioned media. Fed Proc 44:1479. 1985.
62. McMurtry IF. Bay K 8644, a Ca++ channel facilitator, potentiates hypoxic vasoconstriction in isolated rat lungs. Fed Proc 44:820, 1985.
63. Herget J, McMurtry IF. Energy metabolism in hypoxic pulmonary vasoconstriction (HPV). Bull Eur Physiopath Resp 21 (suppl):52L, 1985.
64. McMurtry IF, Herget J. Dexamethasone (DEX) increases hypoxic pressor reactivity of salt solution-perfused rat lungs. Fed Proc 45:552, 1986.
65. Herget J, McMurtry IF. Glucocorticoids increases hypoxic pressor reactivity of isolated rat lungs. Bull Eur Physiopath Respir 22(suppl 8):165, 1986.
66. O'Brien RF, Morris KG, McMurtry IF. Protamine inhibits monocrotaline-induced pulmonary hypertension in rats. Fed Proc 45:552, 1986.
67. Raffestin B, McMurtry IF. Phorbol myristate acetate (PMA) and NH4Cl potentiate hypoxic pressor response in isolated rat lung. Fed Proc 45:1004, 1986.
68. Welsh CH, McMurtry IF, Weil JV. Endotoxin (Etx) induced lung protein leak and loss of endothelial dependent relaxation. Fed Proc 45:525, 1986.
69. Welsh CH, McMurtry IF, Weil JV. Dimethylsulfoxide prevents endotoxin induced lung protein leak and attenuates loss of endothelial dependent relaxation. Am Rev Resp Dis 133:A276, 1986.
70. McMurtry IF, Morris KG. Platelet activating factor causes pulmonary vasodilation in the rat. Am Rev Resp Dis 133:A227, 1986.
71. O'Brien RF, Walchak SJ, Morris KG, McMurtry IF. Protamine inhibits chronic hypoxic pulmonary hypertension in rats. Am Rev Resp Dis 133:A398, 1986.
72. VanBenthuysen KM, Lesnefsky E, Morris KG, Horwitz LD, McMurtry IF. Oxygen radical mediated endothelial injury and vascular reactivity. Clin Res 34:90A, 1986.
73. VanBenthuysen KM, Lesnefsky E, Morris KG, Horwitz LD, McMurtry IF. Oxygen radical mediated endothelial injury and vascular raectivity. Clin Res 34:350A, 1986.
74. White CW, McMurtry IF, Repine JE. Increased glutathione re-dox activity in lungs of rats following preexposure to hypoxia partially accounts for their subsequent tolerance to oxidants. Clin Res 34:587A, 1986.
75. Lesnefsky EJ, VanBenthuysen KM, McMurtry IF, Fennessey PM, Travis VL, Horwitz LD. Superoxide dismutase prevents myocardial release of conjugated dienes during early reperfusion. Circulation 74:II-347, 1986.
76. VanBenthuysen KM, Portz SJ, McMurtry IF, Horwitz LD. Myocardial ischemia and reperfusion blunt endothelium dependent vasodilation and augment vasoconstriction in canine coronary resistance arteries. Clin Res 35:114A, 1987.
77. VanBenthuysen KM, Portz SJ, McMurtry IF, Horwitz LD. Myocardia ischemia and reperfusion blunt endothelium-dependent vasodilation and augment vasoconstriction in canine coronary resistance arteries. Clin Res 35:330A, 1987.
78. Lesnefsky EJ, VanBenthuysen KM, McMurtry IF, Johnston RBJr, Shikes RH, Horwitz LD. Lidocaine reduces canine infarct size: protection from myocardial lipid peroxidation. Clin Res 35:110A, 1987.
79. Lesnefsky EJ, Van Benthuysen KM, McMurtry IF, Johnston RB Jr, Shikes RH, Horwitz LD. Lidocaine reduces canine infarct size: protection from myocardial lipid peroxidation. Clin Res 35:573A, 1987.
80. Portz SJ, Van Benthuysen KM, McMurtry IF, Horwitz LD. Dimethylthiourea, a diffusible oxygen radical scavenger, reduces myocardial infarct size. Clin Res 35:315A, 1987.
81. White CW, Ghezzi P, Dinarello CA, Caldwell SA, McMahon S, McMurtry IF, Repine JE. Single dose treatment with recombinant tumor necrosis factor/cachectin (TNF/C) and interleukin-1 (IL-1) decreases oxygen toxicity and oxidized glutathione (GSSG) accumulation in rat lungs. Clin Res 35:633A, 1987.
82. Rhodes RA, Packer CS, McMurtry IF, Kurzhal SI, Wagner WW Jr, Patterson CE, Meiss RA. Free radicals cause pulmonary arterial smooth muscle contraction. Fed Proc 46:663, 1987.
83. O'Brien RF, McMurtry IF. Cyclic GMP inhibits vascular smooth muscle cell proliferation in vitro. Clin Res 35:310A, 1987.
84. Yamaguchi T, Rodman DM, O'Brien RF, McMurtry IF. Potentiation of pulmonary vasoconstriction by inhibitors of endothelium derived relaxing factor. Am Rev Resp Dis 135:A131, 1987.
85. Rodman DM, Yamaguchi T, O'Brien RF, McMurtry IF. Hypoxic contraction of isolated pulmonary artery is reduced by endothelial denudation, hemoglobin, and methylene blue. Am Rev Resp Dis 135:A131, 1987.
86. Portz SJ, VanBenthuysen KM, Lesnefsky EJ, McMurtry IF, Horwitz LD. Dimethylthiourea but not dimethylsulfoxide reduces canine myocardial infarct size. Circulation 76, supp IV-196, 1987.
87. VanBenthuysen KM, Ashmore RC, Dauber IM, McMurtry IF, Horwitz LD. Contractile hyperreactivity to aggregating platelets following ischemia and reperfusion. Clin Res 36:115A, 1988.
88. VanBenuysen KM, Dauber IM, McMurtry IF, Lesnefsky EJ, Portz SJ, Horwitz LD. Superoxide dismutase protects coronary arteries from ischemia-reperfusion-induced endothelial dysfunction. Clin Res 36:115A, 1988.
89. Yamaguchi T, O'Brien RF, Hanson WL, Wagner WW, McMurtry IF. Alkalosis may inhibit hypoxic pulmonary vasoconstriction by stimulation of prostacyclin synthesis. Am Rev Resp Dis 137:104, 1988.
90. Orton EC, Raffestin B, McMurtry IF. Protein kinase C activation alters pulmonary vasoreactivity. FASEB J 2:A1504, 1988.
91. Dempsey EC, McMurtry IF, O'Brien RF. Hypoxia blocks phorbol ester-induced proliferation of cultured bovine pulmonary artery smooth muscle cells. FASEB J 2:A1578, 1988.
92. McMurtry IF, Raffestin B, Orton EC, O'Brien RF. Protein kinase C activation increases pulmonary vascular tone and reactivity. Am Rev Resp Dis 37:103, 1988.
93. Rodman DM, Yamaguchi T, O'Brien RF, McMurtry IF. Bay K8644 potentiates and nifedipine inhibits hypoxic contraction of isolated rat PA. Am Rev Resp Dis 137:109, 1988.
94. Rodman DM, Yamaguchi T, O'Brien RF, McMurtry IF. Decreased pulmonary artery (PA) cGMP content during hypoxia is due to decreased endothelium-derived relaxing factor (EDRF) activity. Circulation 78:II-320, 1988.
95. Ashomore RC, O'Brien RF, Stelzner TJ, Dauber IM, Horwitz LD, McMurtry IF,Van Benthuysen KM. Platelet-derived adenine nucleotides stimulate a calcium signal in endothelial cells. Circulation 78:II-337, 1988.
96. O'Brien RF, Dempsey EC, McMurtry IF. G-proteins are involved in pulmonary vascular smooth muscle cell proliferation. FASEB J 3:A304, 1989.
97. Hasunuma K, Yamaguchi T, O'Brien RF, McMurtry IF, Rodman DM. L-canavanine potentiates vasoconstriction in perfused rat lungs and pulmonary artery rings. Am Rev Resp Dis 139:A53, 1989.
98. Sato K, Tucker A, O'Brien RF, McMurtry IF, Stelzner TJ. The fawn hooded rat: a model of spontaneous pulmonary hypertension. Am Rev Resp Dis 139:A167, 1989.
99. Rodman DM, Sato K, Stelzner TJ, McMurtry IF, O'Brien RF. Endothelin causes pulmonary vasoconstriction and lung edema. Am Rev Resp Dis 139:A51, 1989.
100. Dempsey EC, McMurtry IF, O'Brien RF. Protein kinase C activation allows quiescent bovine pulmonary artery smooth muscle cells to proliferate in response to moderate hypoxia. Am Rev Resp Dis 139:A171, 1989.
101. Yuan BH, McMurtry IF, Conger JD. Effect of endothelin on isolated perused rat afferent and efferent arterioles. Clin Res 37:586A, 1989.
102. Ashmore RC, Sato K, O'Brien RF, Rodman DM, McMurtry IF, Stelzner TJ. Paradoxical pulmonary artery constriction to aggregating platelets in rats with spontaneous pulmonary hypertension. Circulation 80:II-87, 1989.
103. Rodman DM, Hasunuma K, Peach J, Walchak S, O'Brien RF, McMurtry IF. Decreases in cAMP do not mediate the hypoxic contraction of rat pulmonary artery. Circulation 80:II-287, 1989.
104. Dauber IM, McMurtry IF, Horwitz LD, Weil JV. Endotoxin augments endothelium-dependent vasodilation and increases coronary permeability. Circulation 80:II-434, 1989.
105. Sheridan FM, Horwitz LD, McMurtry IF. Protein kinase C and canine coronary artery reactivity. Circulation 80:II-546, 1989.
106. Abman SH, Chatfield BA, Rodman DM, Hall SL, McMurtry IF. Ontogeny of ovine pulmonary vascular responses to endothelium-dependent and -independent dilators in vitro. Physiologist 32:153, 1989.
107. Lippton H, McMurtry IF, Hyman A. Pulmonary vasodilation by endothelin is mediated by potassium channels. FASEB J 4:A813, 1990.
108. Hasunuma K, Rodman DM, O'Brien RF, McMurtry IF. Endothelin-1 causes pulmonary vasodilation in the rat. FASEB J 4:A814, 1990.
109. Stelzner TJ, Yanagisawa M, Sakurai T, Sato K, Webb S, Zamora M, McMurtry IF, Fisher JH, O'Brien RF. Increased lung preproendothelin (preET-1) mRNA expression in rats with pulmonary hypertension. FASEB J 4:A1147, 1990.
110. Dempsey EC, Stenmark KR, McMurtry IF, O'Brien RF, Voelkel NF, Badesch DB. Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate and synergistic pathways. Am Rev Respir Dis 141:A184, 1990.
111. Dempsey EC, McMurtry IF, Badesch DB, O'Brien RF. Activation of protein kinase C (PKC) is required for bovine pulmonary artery (PA) smooth muscle cell (SMC) proliferative response to hypoxia in vitro. Am Rev Respir Dis 141:A184, 1990.
112. Mallet JE, McMurtry IF, Rodman DM. Rat pulmonary artery EDRF is resistant to inhibition by antimycin A and rotenone. Am Rev Respir Dis 141:A481, 1990.
113. Hasunuma K, Yamaguchi T, O'Brien RF, Rodman DM, McMurtry IF. Effects of inhibitors of EDRF and EDHF on pulmonary vascular control. Am Rev Respir Dis 141:A481, 1990.
114. Rodman DM, Peach JL, McMurtry IF. Chronic hypoxia decreases cGMP-mediated relaxation of rat pulmonary artery in vitro. Am Rev Respir Dis 141:A185, 1990.
115. Chatfield BA, McMurtry IF, O'Brien RF, Hall SL, Abman SH. In vitro and in vivo effects of endothelin-1 on the fetal pulmonary circulation. Am Rev Respir Dis 141:A483, 1990.
116. Sheridan FM, Horwitz LD, McMurtry IF. Protein kinase C activation attenuates coronary artery vasodilation in vitro. Clin Res 38:593A, 1990.
117. Chatfield BA, McMurtry IF, O'Brien RF, Hall SL, Abman SH. Fetal hemodynamic responses to intrapulmonry and systemic infusions of endothelin-1. Pediatric Res 27:353A, 1990.
118. Abman SH, Chatfield BA, Rodamn DM, Hall SL, McMurtry IF. Diminished endothelium-derived relaxant factor (EDRF) release by fetal pulmonary arteries in vitro. Pediatric Res 351A, 1990.
119. Abman SH, Chatfield BA, Hall SL, McMurtry IF. Role of endothelium-derived relaxing factor (EDRF) in transition of the pulmonary circulation. Circulation 82:III-101, 1990.
120. Hasunuma K, Rodman DM, O'Brien RF, McMurtry IF, Kira S. Endothelin-1 has biphasic effect on pulmonary circulation in rats. J Vascular Med Biol 2:206, 1990.
121. Webb S, Ashmore R, McMurtry IF, Stelzner T. Perfused lung responses to platelets, ADP and sertonin (5-HT) in pulmonary hypertensive rats. FASEB J 5:A1429, 1991.
122. Hasunuma K, Oka M, Webb S, Rodman D, McMurtry I, Kira S. Nitro-L-arginine increases normoxic pulmonary vascular resistance in chronically hypoxic rats. Am Rev Resp Dis 143:A185, 1991.
123. Cornfield DN, McQueston JA, Chatfield BA, Rodman DM, McMurtry IF, Abman SH. BRL 34195, an ATP-sensitive potasium channel agonist, causes fetal pulmonary vasodilation. Pediatric Res 29:58A, 1991.
124. Cornfield DN, Chatfield BA, McMurtry IF, Abman SH. Effects of endothelium-derived relaxing factor (EDRF) inhibition on the fetal pulmonary vascular response to partial compression of the ductus arteriosus. Pediatric Res 29:311A, 1991.
125. Cornfield DN, Chatfield BA, McQueston JA, McMurtry IF, Abman SH. Effects of endothelium-derived relaxing factor (EDRF) inhibition on birth-related stimuli in the ovine fetal lung. Pediatric Res 29:311A, 1991.
126. McMurtry IF, Yamaguchi T, Hasunuma K, Oka M, Webb S, Rodman D. Role of EDRF in control of normoxic and hypoxic pulmonary vacular tone. The 4th Int Symp on High Altitude Med Sci p37, 1991.
127. McQueston JA, Cornfield DN, McMurtry IF, Abman SH. Role of endothelium-direved relaxing factor (EDRF) in O2-induced fetal pulmonary vasodilation. Pediatric Res 31:316A, 1992.
128. Cornfield DN, Rodman DM, Stevens T, McMurtry IF, Abman SH. Hypoxia alters basal and stimulated cytosolic calcium in ovine fetal pulmonary artery smooth muscle cells. Pediatric Res 31:304A, 1992.
129. Oka M, Hasunuma K, Rodman D, McMurtry I. Inhibition of endothelium-derived relaxing factor causes vasoconstriction in hypertensive rat lungs. Am Rev Respir Dis 145:A208, 1992.
130. Stevens T, Morris K, McMurtry IF, Tucker A. Acute tumor necrosis factor-a administration decreases pulmonary vascular reactivity and depresses myocardial function in conscious rats. Am Rev Respir Dis 145:A628, 1992.
131. Bonvallet ST, Oka M, Yano M, McMurtry IF, Stelzner TJ. An endothelin receptor antagonist attenuates endothelin-1 (ET-1) induced vasoconstriction in the rat pulmonary circulation. Am Rev Respir Dis 145:A642, 1992.
132. Atanasova I, Morris K, McMurtry I, Burke TJ, Schrier RW. Nitric oxide inhibition (NOI) and acute renal ischemia (ARI): cardiovascular consequences. J Am Soc Nephrol 3:539, 1992.
133. Stevens T, Cornfield D, McMurtry IF, Rodman D. Hypoxia inhibits calcium influx and decreases basal calcium in pulmonary artery endothelial cells. FASEB J 7:A405, 1993.
134. Rodman D, Cornfield DN, McMurtry IF, Stevens T. Hypoxia increases the peak calcium response to bradykinin and thapsigargin in pulmonary artery endothelial cells. FASEB J 7:A405, 1993.
135. Oka M, Morris KG, McMurtry IF. Acute hemodynamic effects of NIP-121, a potassium channel activator, in the chronically hypoxic, pulmonary hypertensive rat. FASEB J 7:A533, 1993.
136. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Hypoxia-induced increase in fetal pulmonary artery smooth muscle cell [Ca++]i is mediated by entry of Ca++ through voltage-operated Ca++ channels. Pediatric Res 32:320A, 1993.
137. McQueston JA, Kinsella JP, Ivy DD, McMurtry IF, Abman SH. Changes in endothelium-dependent and -independent vasodilation during chronic intrauterine pulmonary hypertension in fetal lambs. Pediatric Res 32:337A, 1993.
138. Bonvallet ST, Morris KG, Yano M, Zamora MR, McMurtry IF, Stelzner TJ. A selective ETA receptor antagonist (BQ 123) attenuates the development of hypoxic pulmonary hypertension in vivo. Am Rev Respir Dis 147:A493, 1993.
139. Stevens T, Cooper DMF, Cornfield DN, McMurtry IF, Rodman DM. Adenylyl cyclase activity in pulmonary artery endothelial cells is inhibited by calcium. FASEB J 8:A36, 1994.
140. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Thapsigargin, but not ryanodine, elicits EDRF-mediated vasodilation in hypertensive rat lungs. Am J Respir Crit Care Med 149:A293, 1994.
141. Zamora MR, Oka M, Tyler RC, Morris KG, McMurtry IF, Stelzner TJ. Inhibition of endothelium-derived relaxing factor exacerbates pulmonary hypertension in fawn-hooded rats. Am J Respir Crit Care Med 149:A22, 1994.
142. Cornfield DN, Stevens T, McMurtry IF, Abman SH, Rodman DM. Acute hypoxia causes membrane depolarization in fetal pulmonary artery smooth muscle cells. Pediatric Res
143. Tyler RC, Muramatsu M, Cohen AH, Rodman DM, McMurtry IF. Amiloride but not dichlorobenzamil attenuates nitro-L-arginine induced vasoconstriction in hypertensive rat lungs. Hypertension 24: 391, 1994.
144. Stevens T, Nakahashi Y, McMurtry IF, Cooper DMF, Rodman DM. Calcium modulates adenosine 3',5'-cyclic monophosphate production in lung endothelial cells via a calcium inhibitable cyclase. Circulation 90: I-150, 1994.
145. Weigert A, Higa E, McMurtry IF, Raynolds M, Perryman B, Schrier RW. Expression of inducible nitric oxide synthase (iNOS) in the aorta of rats treated with endotoxin and reversal of endotoxin-induced vasodilation by aminoguanidine (AG), a selective inhibitor of iNOS. Clin Res 42: 256A, 1994.
146. Tyler RC, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF. Hypoxic and monocrotaline but not fawn-hooded hypertensive rat lungs express increased mRNA for endothelial nitric oxide synthase. FASEB J 9: A131, 1995.
147. Rodman DM, Tyler RC, Gorman C, Tudoe R, McClarrion M, McMurtry IF. Cationic liposome-mediated gene transfer to lungs of normal and pulmonary hypertensive mice in vivo. FASEB J 9: A857, 1995.
148. Stevens T, Brough G, Rodman DM, McMurtry IF, Majack RA, Schwartz PE. PA endothelial cell expression of proteins which bind to cAMP response elements dependent and independent of cAMP. FASEB J 9: A719, 1995.
149. Fouty B, Geraci M, Girod C, Cook R, Miller Y, McMurtry I, Rodman D. Messenger RNA for a cyclic nucleotide-gated ion channel detected by reverse transcriptase/polymerase chain reaction of lung and pulmonary artery. Am J Respir Crit Care Med 151: A526, 1995.
150. Cohen AH, Morris K, McMurtry IF, Rodman DM. The cyclic guanylate monophosphate phosphodiesterase inhibitor E4021 is a pulmonary vasodilator in vitro and in vivo. Am J Respir Crit Care Med 151: A626, 1995.
151. Rodman DM, Fouty B, Stevens T, Hepler L, Richardson D, McMurtry IF. Differing effects of ATP on pulmonary microvascular and conduit endothelial cell membrane potential and [Ca++]i. Am J Respir Crit Care Med 151: A628, 1995.
152. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF. Neither receptor-operated Ca++ entry nor reverse Na+/Ca++ exchange mediate nitro-L-arginine vasoconstriction in hypertensive rat lungs. Am J Respir Crit Care Med 151: A735, 1995.
153. Rodman DM, Stevens T, Fouty B, Hepler L, Richardson D, McMurtry IF. Reduced agonist-induced calcium influx in pulmonary microvascular endothelial cells. Clin Res 1995.
154. Chetham PM, Stevens T, McMurtry IF. Ischemia reperfusion-induced lung injury: effect of perfusate calcium concentration. Anesthesiology 83: A540,1995.
155. Stevens T, Brough G, Shasby S, McMurtry I, Rodman D, Shasby M. Inhibition of cAMP by intracellular calcium corresponds with myosin phosphorylation in pulmonary artery endothelial cells. FASEB J 10: A110, 1996.
156. Veit A, Brough G, McMurtry I, Rodman D, Stevens T. Protein kinase C stimulates adenylyl cyclase and cAMP in human pulmonary microvascular endothelial cells. FASEB J 10: A110, 1996.
157. Muramatsu M, Oka M, Rodman DM, McMurtry IF. Endothelin-1 contributes to nitro-L-arginine induced vasoconstriction in hypertensive rat lungs. FASEB J 10: A307, 1996.
158. McMurtry I, Zeng X, Gebb S, Szabo, Greenberg J, Wispe J. Nitric oxide (NO) increases expression of vascular endothelium growth factor (VEGF) in cultured cells. FASEB J 10: A545, 1996.
159. Muramatsu M, Tyler RC, Cohen AH, Gutkowska Y, Rodman DM, McMurtry IF. Atrial natriuretic peptide (ANP) activity contributes to enhanced perfusate level of cGMP in hypertensive rat lungs. Am J Respir Crit Care Med 153: A189, 1996.
160. Tyler RC, Muramatsu M, Hepler LK, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF. Variability in endothelial nitric oxide synthase gene expression in hypoxic, monocrotaline, and fawn-hooded hypertensive rat lungs. Circulation 94: I-647, 1996.
161. McMurtry IF, Muramatsu M, Tyler RC, Rodman DM, Oka M. Roles of endothelin-1 and T-type Ca2+ channels in nitro-L-arginine vasoconstriction of hypertensive rat lungs. J Physiol 499P: S11-S12, 1997.
162. Le Cras TD, Tyler RC, Horan MP, Morris KG, McMurtry IF, Johns RA, Abman SH. Chronic hypoxia increases endothelial nitric oxide synthase expression in rat lung despite reduced blood flow due to left pulmonary artery stenosis. FASEB J 11: A134, 1997.
163. Fagan KA, Sato K, Tyler RC, Morris KG, Huang PL, McMurtry IF, Rodman DM. Endothelial nitric oxide synthase knock-out mice develop pulmonary hypertension. Circulation 96: I-61, 1997.
164. Chetham PM, Bridges JP, Stevens T, McMurtry IF. Acute hypoxia attenuates thapsigargin-induced permeability in the isolated rat lung. Circulation 96: I-244, 1997.
165. Li KX, McMurtry IF, Rodman D. The endothelin-1 effect on Kv current in pulmonary artery myocytes is mediated by both ETA and ETB receptors. FASEB J 12: A386, 1998.
166. Sato K, Rodman DM, McMurtry IF. Hypoxia inhibits nitric oxide production in chronically-hypoxic rat lungs. FASEB J 12: A493, 1998.
167. Fagan K, Huang P, McMurtry IF, Rodman D. Endothelial nitric oxide synthase (eNOS) deficient mice have increased sensitivity to hypoxia. Am J Respir Crit Care Med 157: A588, 1998.
168. Le Cras TD, Richter G, Sato K, Abman SH, McMurtry IF. Rapid decrease in lung preproendothelin-1 mRNA in rats with chronic hypoxic pulmonary hypertension after brief exposure to normoxia. Am J Respir Crit Care Med 157: A725, 1998.
169. Tottempudi PK, Reyland ME, Hoagland KD, Das M, McMurtry IF, Dempsey EC. Regulation of PKC- gene expression in bovine pulmonary artery smooth muscle cells. ASBMB Fall Symposia Program 71, 1998.
170. Carter EP, Sato K, Le Cras LE, McMurtry IF. Decreased lung endothelin-1 gene expression in rats with liver cirrhosis. Circulation 98: I-34, 1998.
171. Le Cras TD, Sato K, Oliver-Pickett CK, Abman SH, McMurtry IF. Increased oxygen tension rather than decreased perfusion pressure causes a rapid decrease in preproendothelin-1 mRNA in chronically-hypoxic rat lungs during brief exposure to normoxia. FASEB J 13: A826, 1999.
172. Ruff LI, Grever KF, Fagan KA, McMurtry IF, Kraft AS, Pettit GR, Dempsey EC. Attenuating effects of bryostatin-1 in an adult murine model of chronic hypoxic pulmonary hypertension. Am J Respir Crit Care Med 159: A163, 1999.
173. Tottempudi PK, Reyland Me, Das M, Hoagland KD, McMurtry IF, Stenmark KR, Dempsey EC. Regulation of protein kinase C- gene expression in bovine pulmonary artery smooth muscle cells. Am J Respir Crit Care Med 159: A346, 1999.
174. Sato K, Morris KG, Rodman DM, McMurtry IF. Endothelin receptor blockers inhibit acute hypoxic pulmonary vasoconstriction in both intact rats and isolated rat lungs. Am J Respir Crit Care Med 159: A566, 1999.
175. Ivy D, McMurtry IF, Yanagisawa M, Gariepy CE, Morris KG, Le Cras TD, Abman S. Exaggerated pulmonary vasoconstrictor response to acute hypoxia in the endothelin B receptor deficient rat. Pediatric Res 45: 24A, 1999.
176. Malik AB, Matthay MA, McMurtry IF, Pitt BR, Schumacker PT, Ye RD. January 2000! Am J Physiol Lung Cellular Molec Physiol 278: L1-L2, 2000.
177. Li KX, McMurtry IF, Rodman DM. Endothelin-1 induces intracellular Ca2+ mobilization in bovine pulmonary artery endothelial cells. FASEB J 14: A695, 2000.
178. Tottempudi PK, Tseng P, Reylan ME, McMurtry IF, Stenmark KR, Dempsey EC. Early signaling events in PDGF-induced growth of neonatal bovine pulmonary artery smooth muscle cells. Am J Respir Crit Care Med 161: A143, 2000.
179. Carter EP, Hartsfield CL, McMurtry IF. Lung heme oxygenase-1 (HO-1) induction during hepatopulmonary syndrome is prevented by nitric oxide inhibition. Am J Respir Crit Care Med 161: A628, 2000.
180. Morio Y, McMurtry IF. Inhibitors of sarcoplasmic reticulum Ca2+ uptake augment hypoxic vasoconstriction in rat lungs. Am J Respir Crit Care Med 161: A629, 2000.
181. Fagan KA, Morissey B, Fouty BW, Satp K, Wright-Harral J, Morris KG, Miller M, Vidmar S, McMurtry IF, Rodman DM. Upregulation of NOS in lungs of mice with severe hypoxic pulmonary hypertension. Am J Respir Crit Care Med 163: A117, 2001.
182. Morio Y, McMurtry IF. A blocker of gap junction intercellular communication, 18-glycyrrhetinic acid, inhibits hypoxic vasoconstriction in rat lungs. Am J Respir Crit Care Med 163: A395, 2001.
183. Kohli P, Jakkula M, McMurtry IF, Carter EP. Increased function and expression of small conductance KCa channels in lung during cirrhosis. Am J Respir Crit Care Med 163: A395, 2001.
184. Nagaoka T, Muramatsu M, Sato K, Morio Y, Oka M, McMurtry IF, Fukuchi Y. Mild hypoxia causes severe pulmonary hypertension in the fawn-hooded but not in the Tester Moriyama rat. Am J Respir Crit Care Med 163: A401, 2001.
185. Hartsfield CL, Fagan KA, Vidmar S, Morris K, McMurtry IF. Blockade of heme oxygenase by tin protoporphyrin is cardioprotective during development of hypoxia-induced pulmonary hypertension. Am J Crit Care Med 163: A402, 2001.
186. Oka M, Morio Y, Morris KG, McMurtry IF. Acute hemodynamic effects of Y-37632, a selective Rho-kinase inhibitor, in chronically hypoxic rats. FASEB J 16: A74, 2002.
187. Morio Y, Oka M, McMurtry IF. A selective Rho-kinase inhibitor, Y-27632, is an effective vasodilator of chronically hypoxic hypertensive rat lungs. FASEB J 16: A74, 2002.
188. Fagan KA, McMurtry IF, Oka, M. Rho-kinase inhibitor (Y-27632) attenuates the development of hypoxia-induced pulmonary hypertension in mice. Am J Med Crit Care 165: B53, 2002.
189. Gebb S, Bauer N, Oka M, Morio Y, Fagan K, McMurtry I. Rho/Rho-kinase signaling mediates increased vascular tone in hypoxic pulmonary hypertension. Grover Conference on Proinflammatory Signaling Mechanisms in the Pulmonary Circulation, 2002.
190. McMurtry IF, Bauer NR, Nagaoka T, Gebb SA, Oka M. Hypoxia and Rho-kinase: lung development versus hypoxic pulmonary hypertension. 13th International Hypoxia Symposium, Banff, Alberta, Canada, 2003.
191. Nagaoka T, Morio Y, Oka M, McMurtry IF. Endothelin-1 and serotonin are involved in Rho-kinase-mediated augmented pressor response to KCl in chronically hypoxic hypertensive rat lungs. Am J Respir Crit Care Med 167: A697, 2003.
192. Oka M, Nagaoka T, Morris KG, McMurtry IF. Dehydroepiandrosterone markedly reduces the development of hypoxic pulmonary hypertension in rats. Am Respir Crit Care Med 167: A824, 2003.
193. Morio Y, Carter EP, Oka M, Fukuchi Y, McMurtry IF. Endothelium-derived hyperpolarizing factor-mediated vasodilation occurs by different mechanisms in normotensive and hypoxia-induced hypertensive rat lungs. Am J Respir Crit Care Med 167: A697, 2003.
194. Imamura M, Oka M, McMurtry IF, Carter EP. High altitude pulmonary hypertension is prevented in cirrhotic rats. Am J Respir Crit Care Med 167: A925, 2003.
195. Tang JR, Markham NE, Lin YJ, McMurtry IF, Kinsella JP, Abman SH. Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth after treatment with a VEGF receptor inhibitor in neonatal rats. Pediatr Res 53: 439A, 2003.
196. Nagaoka T, Fagan KA, Morris KG, McMurtry IF, Oka M. Inhaled Rho-kinase inhibitor is more effective than inhaled nitric oxide as a selective vasodilator in hypoxic pulmonary hypertensive rats. Circulation 108: IV-10, 2003.
197. Ling X, Crockett SK, Oka M, McMurtry I, Flores S. Role of oxidant stress in endothelial dysfunction in type-1 diabetes.
198. McMurtry IF, Bauer NR, Fagan KA, Gebb SA, Nagaoka T, Oka M. Role of RhoA/Rho-kinase signaling in hypoxic pulmonary hypertension. Keystone Hypoxia Meeting, 2004.
199. Kaufman J, Sakao E, Oka M, Nagaoka T, Oliver-Pickett C, Jones PL, McMurtry IF, Gebb SA. Rho GTPases in lung development and pulmonary hypertension. Aspen Lung Conference, 2004.
200. Majka SM, McNiece IK, Roedersheimer M, McMurtry IF, Gebb SA. Adult pulmonary vascular endothelial precursors reside within the mesenchymal lung side population of cells. FASEB J 2005.
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204. Beutz MA, Gebb SA, West JD, McMurtry IF. Differential effect of sphingosine-1-phosphate on cell survival in human pulmonary artery vs. microvascular endothelial cells. Proc Am Thoracic Soc 2: A606, 2005.
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Last update: Mar. 15, 2007