Research Interests
A recent large scale clinical study demonstrated a 22% reduction in mortality of patients on mechanical ventilation for Acute Respiratory Distress Syndrome (ARDS) when tidal volume was reduced from the conventional 12 ml/kg to 6 ml/kg. This clinical study was based on previous animal experiments from our laboratory and others showing that alveolar overdistention produces microvascular injury and increased vascular permeability. While previous hypotheses have proposed a "stretched pore" effect forcing open intracellular junctions or a "stress failure" limited by the tensile strength of the basement membrane, recently studies from our laboratory suggest that an active endothelial cell response to mechanical stress contributes significantly to the fluid and protein leak observed at high vascular and airway pressures. We have proposed that calcium entry through non-selective stretch activated cation channels (SACC) produces a necessary increase in cell calcium that triggers a permeability response utilizing many of the signal pathways involved in ligand mediated permeability increases. The Ca++/calmodulin/myosin light chain kinase (MLCK) pathway has been implicated by studies showing that increased permeability in rat lungs due to lung overdistention was blocked by inhibition of either SACC, Ca++/calmodulin, or MLCK. Calcium transients in cultured pulmonary endothelial cells were also prevented by inhibition of SACC or MLCK. A possible role for tyrosine phosphorylation involved in focal adhesions has been suggested by isolated rat lung studies that demonstrate an enhanced susceptibility to mechanical injury after inhibition of protein tyrosine phosphatase and a reduced injury with inhibition of tyrosine kinase. Separation of epithelium and endothelium from basement membranes is a prominent feature of ventilator induced lung injury (VILI) in experimental animals suggesting a role of cell adhesion in this injury. During the tenure of a recently awarded 5 year grant, we will explore the role of SACC using cultured endothelial cells from each vascular segment in the rat lung; artery, vein and microcirculation, with new methods for evaluating monolayer permeability under strain and pressure. A state-of-the art confocal microscope with multiple fluorochrome capability will be used. In addition, we have obtained the plasmid containing the MID1 gene from yeast which codes for the only SACC gene product cloned to date. The responses of native and transfected endothelial cells will be studied using fluorescent analysis of intracellular Ca++ and electrophysiologic response using single channel patch clamp methods. With these studies we hope to characterize the events which initiate and propagate increased vascular permeability secondary to mechanical stress and identify potential targets for pharmacological intervention in patients.
An additional recent direction in my laboratory has been the development of a perfluorocarbon liquid ventilator in cojunction with Mallard Medical Co. of Redding, CA. This project is funded through the SBIR/STTR program of NIH and utilizes a patented method of liquid delivery through a bias flow mode that improves both gas exchange and fluid clearance from the lung compared to conventional tidal liquid ventilation. We are currently applying for Phase II funding and will finalize prototype designs for production. Controller algorithms are being developed for optimal control of tidal wave forms and automatic control of residual liquid volumes in the lung for efficient long term ventilation with minimal peak alveolar pressures.
EDUCATION |
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High School Education:
Metairie County Day School , Metairie , Louisiana -1957.
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Undergraduate Education:
B.S. - Biology & Chemistry - Washington and Lee University , Lexington , VA - 1961.
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Graduate Education:
Doctorate: Ph.D. - Physiology - University of Mississippi , Graduate School of Medical Sciences, Jackson , Mississippi - 1972.
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Honorary Awards:
Dean's List; Honor Roll - Washington and Lee University . Pharmacia Travel Award of the Microcirculatory Society, 198 - Funds for travel to European Research Laboratories.
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Fellowship Awards:
Mississippi Heart Association Research Fellowship, 1973-74.
NIH Predoctoral Fellowship, Cardiovascular Physiology, University of Mississippi Medical Center , 1968-72.
Mayo Research Foundation Fellowship, June-August 1963, Experimental Pathology.
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PROFESSIONAL QUALIFICATIONS |
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National Committees and Offices: |
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NIH CVA-AHR Cardiovascular and Pulmonary Study Section, Washington, D.C., February 13-15, 1979.
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Awards Committee, United States Microcirculatory Society, 1981-84, Chairman, 1983-84.
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Research Advisory Committee, Alabama Heart Association, 1983-86.
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NIH HLI Respiratory and Applied Physiology Study Section, Washington, D.C., 1984 - 1987.
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Editorial Board, J. Appl. Physiol., 1984-93.
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Reviewer: American Review of Respiratory Disease, Circulation Research, Microvascular Research, American Journal of Physiology.
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NIH Trauma and Burn Research Fellowship Review Committee, 1984.
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NIH NIGMS Site Visit Committee, 1986, 1987.
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NIH Program Project Review Site Visit, Seattle, WA, 1987.
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NIH Cancer Therapeutics Review Committee Site Visit, Richmond, VA., 1987.
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NIH ARDS SCOR Review Committee Site Visit, Seattle, WA, 1988.
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NIH NLS Review Committee Site Visit, San Francisco, CA, 1987.
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NIH Physiologic Sciences Study Section, Bethesda, MD March 1-3, 1995.
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NIH SBIR/STTR Study Section, Bethesda, MD 1999.
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NIH SBIR Study Section SSS-3, Chevy Chase, MD, Feb. 27-28, 2002
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Am. Heart Assoc. S. E. Region Peer Review Committee, Tampa, FL, April 7-9, 2002
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NIH NHLBI Program Project Review Committee, Bethesda, MD, May 8, 2002
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Professional Society Memberships: |
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American Physiological Society
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Circulation and Respiratory Sections of American Physiological Society
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Microcirculatory Society
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Sigma Xi
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Lung Water Club
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International Lymphology Society
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Alabama Heart Association
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American Heart Association, Circulation Council
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North American Vascular Biology Organization
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New York Academy of Sciences
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American Thoracic Society
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ACADEMIC QUALIFICATIONS |
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Present Appointment:
1983-Present - Professor, Department of Physiology
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Faculty Teaching Assignments:
Pulmonary Physiology: |
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1979 - Pres. |
COM I Medical Physiology course |
1980 |
Senior elective in Physiology |
1985 - Pres. |
Advanced Respiratory Physiology |
1981 - Pres. |
Advanced Cardiovascular Physiology |
1984 - Pres. |
BEAR Physiology course for minority students |
1990 - Pres. |
Journal Club |
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Hematology:
1978 - COM I Medical Physiology course
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Student Laboratories: |
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1978 - Pres. |
COM I Medical Physiology |
1985 - Pres. |
Intro. to Laboratory Physiology |
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Committee Assignments:
USAMC Research Advisory Committee, 1979-83
Graduate Student Promotions Committee, 1982-85
USAMC Medical School Admissions Committee, 1980-84, 1992-94 Ad Hoc
American Heart Association, Alabama Afficliate Research Advisory Committee, 1982-86
North American Microcirculatory Society Awards Committee, 1981-84; Chairman 1983-84
USAMC Animal Health and Welfare Committee, 1984-87
USAMC Radiation Safety Committee, 1984-87, 1996-1999
USAMC Medical Student Summer Research Committee, 1983-87, Chairman, 1985-86
USAMC Continuing Education Committee 1990-1991
USAMC Committee on Ethics in Research 1991-1992
USAMC Patent Committee 1993-1995
USAMC Faculty Committee on Appointments, Promotions, and Evaluations 1993-1995
USAMC Biomedical Library Committee 1993-1995
USAMC University Faculty Grievence Committee 1994-1997
USAMC Curriculum Committee 1995-1998
Alabama Regional Science Fair Judge 1992-1999
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Research Grants: |
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As Principal Investigator:
NIH 2 R42 HL57040 - 02 Phase II STTR,“Airway perfusion assisted liquid ventilator”, 7/1/01-6/31/03, $500,000, J.C. Parker, P.I., $250,000 annual
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NIH 1 P01 HL66299 Project 2, J. C. Parker, P.I.., $220,000 annual, In: “Lung endothelial cell phenotypes”, 12/01/01-11/31/06, $6,941,491, Troy Stevens, P.I.
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NIH 1 R01 HL66347 “Mechanical Injury to Lung Endothelium,” 12/1/2000-11/31/2005, $1,244,615, J.C. Parker, P.I., $248,923 annual.
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NIH 1 R41 HL57040-01A1 STTR, “Airway perfusion assisted liquid ventilator,” 2/1/99-1/30/00, $105,000, J.C. Parker, P.I.
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American Heart Association, Southeast Affiliate, 98101 80SE, "Mechanical ventilation induced lung injury, "7/1/98-6/30/00, $70,000, J.C.Parker,P.I.
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American Heart Association, #94013094, "Heterogeneity of pulmonary blood flow and injury". 7/1/94-6/30/97, $136,000, J.C.Parker, P.I.
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American Heart Association, #91011060, "Eosinophil and neutrophil effects on microvascular permeability in the lung," 7/1/91-6/30/94,$74,272, J.C.Parker, P.I.
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American Heart Association, Alabama Affiliate, AL-G-920030, "Tracheal blood flow during high frequency Jet Ventilation," 7/1/92-6/30/93, $25,000, J.C.Parker,P.I.
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NIH 1 RO1 HL37341, "Lung Microvascular Injury due to Airway Pressure", 4/1/87-3/31/90, $197,271
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NIH 2 RO1 HL24571, "Interstitial Fluid Pressure and Excluded Volume in the Lung"; 8/1/79-7/31/82, $186,268; Renewal 8/1/82-7/31/87, $316,000; Renewal 8/1/87-7/31/92, $526,000; J.C. Parker P.I.
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American Lung Association, "Interstitial Pressure and Excluded Volume in the Lung", 6/1/79-5/30/81, $25,666.
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American Heart Association, "Interstitial Pressure and Excluded Volume in the Lung", 7/1/79-6/30/82, $61,820.
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Intramural - University of South Alabama , 2/15/78-2/15/79, "Pulmonary Capillary and Interstitial Protein Transport", $5,000.
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Mississippi Heart Association, "Dynamics of Pulmonary Vascular and Extravascular Forces", 6/1/77-5/31/79, $18,974 (not transferred).
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Mississippi Heart Association, "Energy Metabolism in the Ischemic Myocardium", 6/1/75-5/31/77, $16,780.
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As Co-Investigator: |
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NIH R01 HL67461-01., ”Tlymphocyte role in lung ischemia - reperfusion injury.”, 4/1/01-2/28/05, $200,000/yr., (A. E. Taylor, P.I.; J.C. Parker, 20% effort).
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NIH R01 HL63302-01A2 “Airway submucosal glands and cystic fibrosis disease” 4/1/01-3/31/06, $1,486,263 (Stephen T. Ballard, P.I.; J.C. Parker, 5% effort)
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NIH 1 P01 HL66299 Project 2, J. C. Parker, P.I.., $220,000 annual, In: “Lung endothelial cell phenotypes”, 12/01/01-11/31/06, $6,941,491, Troy Stevens, P.I.
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American Lung Association, "Diaphragmatic function during mechanical ventilation in ewes.", $50,000 (Max Ferrigno, P.I., 7/1/95-6/30/97; J.C. Parker, 15%).
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American Heart Association, Alabama Affiliate, "Nitric Oxide Modulation of Oleic Acid Injured Lungs," 7/1/95-6/30/97, $55,450, (Michael M. Zayek, P.I; J.C.Parker, 10% effort.
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NIH, "Transport Across Alveolar Capillary Membrane", 9/1/77-8/31/82, $200,715; renewal 9/1/81-8/31/87, $545,000 (A.E. Taylor, P.I.). (Renewal 9/1/87-8/31/92, $640,000; J.C. Parker, 15%).
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Parker B. Francis Foundation Fellowship, 9/1/78-8/31/81, $72,000; renewal 9/1/81-8/31/83, $72,000 (A.E. Taylor, P.I.).
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American Lung Association, "Barotrauma and Microvascular Injury in the Immature Lung", $35,000 (Alicia Moise,P.I., 7/1/88-6/30/90; J.C. Parker, 15%).
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Patents Awarded: U. S. Patent No. 5,706,830 awarded on Jan. 13, 1998 , entitled “Liquid ventilator and use thereof ”, to J.C. Parker, ref. No. 87647.97R243.
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Ph.D Dissertation Committees:
Michelle Lynn Perry 1988
William Keith Adkins 1991
Peter S. Wilson 1993
Laura Trout 2001
Judy Creighton
Donna Cioffi
Diego Alverez
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Post-Doctoral Students:
Roger M. Pitt M.D.
Lucretia A. Hernandez M.D., Ph.D.
Toshishiga Shibamoto M.D., Ph.D.
Keisaku Fujimoto M.D.,Ph.D.
Sawako Yoshikawa M.D.,Ph.D.
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PUBLICATIONS |
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TEXTBOOKS:
Taylor , A.E., K. Rehder, R. Hyatt, and J.C. Parker. Clinical Pulmonary Physiology, Saunders Publishing Co: Philadelphia , PA , 1989.
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SCIENTIFIC PAPERS AND CHAPTERS:
1. Jones, C.E., J.C. Parker, and E.E. Smith. Determination of myocardial acid soluble adenine nucleotides on anion exchange thin layers. J. Chromatography 64:378-344, 1972.
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2. Parker, J.C., and E.E. Smith. Effects of xanthine oxidase inhibition in cardiac arrest. Surgery 71:339-344, 1972.
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3. Parker, J.C., C.E. Jones, and E.E. Smith. Determination of acid soluble nucleosides and bases in myocardium by thin layer methods. J. Chromatography 79:360-363, 1973.
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4. Guyton, A.C., A.E. Taylor, R.E. Drake, and J.C. Parker. Dynamics of subatmospheric pressure in pulmonary interstitial fluid. In: Lung Liquids, a CIBA Foundation Symposium. Elsevier, Amsterdam , 1976.
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5. Parker, J.C., C.E. Jones, and J.X. Thomas, Jr. Effect of ischemia and infarction on regional content of adenine nucleotides and derivatives in canine left ventricle. Cardiology 61:279-288, 1976.
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6. Parker, J.C., E.E. Smith, and C.E. Jones. The role of nucleoside and nucleobase metabolism in myocardial adenine nucleotide regeneration after cardiac arrest. Circulatory Shock 3(1):11-20, 1976.
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7. Jones, C.E., J.X. Thomas, J.C. Parker, and R.E. Parker. Acute changes in adenine nucleotides, nucleotide derivaties and contractile force in ischemic and non-ischemic and canine myocardium following coronary occlusion. Cardiovascular Research 10:275-282, 1976.
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8. Parker, J.C., and D.H. Pearce. Computation of indicator dilution flows and transit times with a pocket calculator. Am. Heart J. 91:826-827, 1976.
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9. Parker, J.C., C.E. Jones, J.X. Thomas, and H.J. Granger. A dynamic analysis of energy and contractility transients in ischemic myocardium. Proceedings of Summer Computer Simulation Conference, pp. 539-544, 1977.
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10. Parker, J.C., A.C. Guyton, and A.E. Taylor. Pulmonary transcapillary exchange and pulmonary edema. In: A.C. Guyton (ed.) International Review of Physiology, Cardiovascular Physiology III. University Park Press, Baltimore, 1978.
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11. Parker, J.C., A.C. Guyton, and A.E. Taylor. Pulmonary interstitial and capillary pressures estimated from intra-alveolar fluid pressures. J. Appl. Physiology 44:267-276, 1978.
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12. Guyton, A.C., J.C. Parker, A.E. Taylor, T.E. Jackson, and D.S. Moffatt. Forces governing water movement in the lung. In: Pulmonary edema. A.P. Fishman and E.M. Renkin, eds., Am. Physiological Society, Bethesda , MD , 1979.
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13. Parker, J.C., and A.E. Taylor. Pulmonary interstitial and capillary pressures estimated from intra-alveolar fluid pressures (Letter), J. Appl. Physiol. 47-643-644, 1979.
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14. Parker, J.C., A.E. Taylor, R.E. Parker, and D.N. Granger. Vertical gradient in regional vascular resistance and pre-to post-capillary resistance ratios in the dog lung. Lymphology 12:191-200, 1979.
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15. Parker, J.C., J.H. Falgout, R.E. Parker, D.N. Granger, and A.E. Taylor. The effect of volume loading on interstitial albumin exclusion and lymph flow in the lung. Circ. Res. 45:440-450, 1979.
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16. Granger, D.N., T. Miller, R.E. Allen, R.E. Parker, J.C. Parker, and A.E. Taylor. Permselectivity of the cat blood-lymph barrier to endogenous macromolecules. Gastroenterology 77:103-109, 1979.
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17. Granger, D.N., N.A. Mortillaro, P.R. Kvietys, G. Rutili, J.C. Parker, and A.E. Taylor. Role of the interstitial matrix during intestinal volume absorption. Am. J. Physiol. 238:G183-G189, 1980.
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18. Parker, J.C., R.E. Parker, D.N. Granger, and A.E. Taylor. Vascular permeability and transvascular fluid and proteins transport in the dog lung. Circ. Res. 48:549-561, 1981.
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19. Parker, J.C., H.J. Falgout, F.A. Grimbert, and A.E. Taylor. The effect of increased vascular pressure on albumin excluded volume and lymph flow in the dog lymph. Circ. Res. 47:866-875, 1980.
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20. Taylor , A.E., J.C. Parker, D.N. Granger, and G. Rutili. Pulmonary edema: Changes in Starling Forces and Lymph Flow. In: Tissue Fluid Pressure and Composition. (Ed.) Alan Hargens, Williams and Wilkins Co., pp. 135-143, 1981.
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21. Perry, M.A., and J.C. Parker. Indicator measurement of splanchnic blood flow. In: Measurement of Blood Flow. (Eds.) D.N. Granger and G.B. Bulkley, Williams and Wilkins Co., pp. 159-176, 1981.
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22. Parker, J.C., F. Grimbert, G. Rutili, and A.E. Taylor. Pulmonary lymph plasma oncotic pressure gradients after hemodilution, increased vascular pressures, and albumin infusion. In: Recent Advances in Microcirculatory Research (Ed.) P. Gaethtgens, S. Karger, Basel, pp. 251-254, 1981.
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23. Taylor , A.E., J.C. Parker, D.N. Granger, N.A. Motrillaro, and G.Rutili. Assessment of capillary permeability using lymphatic protein flux: Estimation of the osmotic reflection coefficient. In: The Microcirculation, (Ed.) R. Effros, H. Schmid-Schonbein, and J. Ditzel, Academic Press, pp. 19-32, 1981.
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24. Parker, J.C., R.C. Allison, and A.E. Taylor. Edema affects intralveolar fluid pressures and interdependence in dog lungs. J. Appl. Physiol. 51:911-921, 1981.
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25. Grimbert, F.A., J.C. Parker, and A.E. Taylor. Increased pulmonary vascular permeability following acid aspiration. J. Appl. Physiol. 51:335-345, 1981.
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26. Kinnebrew, P.S., J.C. Parker, J.J. Falgout, and A.E. Taylor. Pulmonary microvascular permeability following E. coli endotoxin and hemorrhage. J. Appl. Physiol. 52:403-409, 1982.
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27. Rutili, G., P. Kvietys, J.C. Parker, and A.E. Taylor. Increased microvascular permeability induced by ANTU. J. Appl. Physiol. 52:1316-1323, 1982.
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28. Rutili, G., D.N. Granger, A.E. Taylor, J.C. Parker, and N.A. Mortillaro. Analysis of lymphatic protein data IV. Comparison of the different methods used to estimate reflection coefficients and permeability-surface area products. Microvasc. Res. 23:347-360, 1982.
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29. Parker, J.C., M. Crain, F. Grimbert, G. Rutili, and A.E. Taylor. Total lung lymph flow and fluid compartmentation in edematous dog lungs. J. Appl. Physiol. 51:1268-1277, 1981.
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30. Taylor , A.E., J.C. Parker, P.R. Kvietys, and M. Perry. Pulmonary interstitium in capillary exchange. In: Mechanisms of Lung Microvascular Injury. (Ed.) N.C. Staub and A. Malik , N.Y. Acad. Sci. 384:146-165, 1982.
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31. Taylor , A.E., J.C. Parker, and R.C. Allison. Capillary exchange of fluid and protein. In: Critical Care Vol. 3. (Ed.) W.C. Shoemaker and W.L. Thompson. Soc. Crit. Care, Fullerton , CA , pp. III B 1-26, 1982.
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32. Parker, J.C., and A.E. Taylor. Comparison of capsular and intra-alveolar fluid pressures in the lung. J. Appl. Physiol. 52:1444-1454, 1982.
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33. Martin, D.J., J.C. Parker, and A.E. Taylor. Simultaneous comparison of tracheobronchial and right duct lymph dynamics in dogs. J. Appl. Physiol. 54:199-207, 1983.
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34. Holloway, H.M. Perry, J. Downey, J.C. Parker, and A.E. Taylor. Estimation of effective capillary pressure in intact lungs. J. Appl. Physiol. 54:846-851, 1983.
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35. Parker, J.C., D. Martin, and A.E. Taylor. Extravascular fluid compartmentation and lymph flow in edematous lungs. In: Advances in Lympholosy. (Ed.) V. Bartos and J.W. Davidson, Avicenum , Czech. , Medical Press, Prague , pp. 192-202, 1982.
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36. Parker, J.C., P.R. Kvietys, K.P. Ryan, and A.E. Taylor. Comparison of isogravimetric and venous occlusion pressures in isolated dog. J. Appl. Physiol. 55:964-968, 1983.
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37. Parker, J.C., L. Campbell, S. Gilchrist, G. Longenecker, and A.E. Taylor. Failure of myocardial ischemia to increase pulmonary microvascular permeability in dogs. J. Appl. Physiol. 56:691-699, 1984.
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38. Taylor , A.E., D. Martin, and J.C. Parker. The effects of oxygen radicals on pulmonary edema formation. Surgery 94:433-438, 1983.
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39. Parker, J.C., D. Martin, G. Rutili, and A.E. Taylor. Prevention of Free Radical Mediated Vascular Permeability Increases in Lung Using Superoxide Dismutase. Chest 83:52S-54S, 1983.
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40. Rutili, G., J.C. Parker, and A.E. Taylor. Fluid balance in ANTU-injured lungs during crystalloid and colloid infusions. J. Appl. Physiol. 56:983-998, 1984.
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41. Perry, M.A. , C.A. Navia, D.N. Granger, J.C. Parker, and A.E. Taylor. Calculation of equivalent pore radii in dog hind paw capillaries using endogenous lymph and plasma proteins. Microvasc. Res. 26:250-253, 1983.
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42. Allison, R.C., J.C. Parker, C.E. Duncan, and A.E. Taylor. Effect of air embolism on the measurement of extravascular lung thermal volume. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 54(4):943-949, 1983.
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43. Martin, D., K. Rehder, J.C. Parker, and A.E. Taylor. High-frequency ventilation: lymph protein flux, and lung water. J Appl. Physiol.: Respirat. Environ. Exercise Physiol. 57(1):240-245, 1984.
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44. Rippe, B., R.C. Allison, J.C. Parker, and A.E. Taylor. Effects of histamine serotonin, and norepinephrine on circulation of dog lungs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 57(1):223-232, 1984.
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45. Rippe, B., M. Townsley, J. Thigpen, J.C. Parker, R.J. Korthuis, and A.E. Taylor. Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 57(1):233-239, 1984.
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46. Parker, J.C., M.A. Perry, and A.E. Taylor. Permeability of the microvascular barrier. In: Edema. Eds. N.C. Staub and A.E. Taylor. Chap. 7. Raven Press, New York , 1984, pp. 143-187.
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47. Parker, J.C., J. Ryan, and A.E. Taylor. Plasma-lymph albumin kinetics, total lymph flow and tissue hematocrit in normally hydrated dog lungs. Microvasc. Res. 28:254-269, 1984.
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48. Parker, J.C., M.I. Townsley, B. Rippe, and J. Thigpen. Increased microvascular permeability in dog lungs due to high peak airway pressures. J. Appl. Physiol. 57:1809-1816, 1984.
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49. Taylor , A.E., B. Rippe, M. Townsley, R. Korthuis, and J.C. Parker. Interstitial lung tissue fluid resistance. In: Frontiers in Physiology Research, ed., by D.G. Garlick and P.I. Korner. Australian Academy of Science, pp. 120-161, 1984.
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50. Gilchrist , S.A. , and J.C. Parker. Exclusion of charged macromolecules in the pulmonary interstitium. Microvasc. Res. 30:88-98, 1985.
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51. Taylor , A.E., and J.C. Parker. The interstitial spaces in lymph flow. In: Handbook of Physiology: Respiration, Vol. 4, A.P. Fishman and A.B. Fisher (eds.), Am. Physiol. Soc., Bethesda, MD 1985, pp. 167-320.
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52. Rippe, B., M. Townsley, J.C. Parker, and A.E. Taylor. The osmotic reflection coefficient for total plasma protein in lung microvessels. J. Appl. Physiol. 58:436-442, 1985.
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53. Parker, J.C., S. Gilchrist, and A.E. Taylor. Plasma-lymph exchange and interstitial distribution volumes of charged macromolecules. J. Appl. Physiol. 59:1128-1136, 1985.
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54. Parker, J.C., B. Rippe, and A.E. Taylor. Fluid filtration and protein clearances through large and small pore populations in dog lung capillaries. Microvas. Res. 31:1-17, 1986.
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55. Parker, J.C. Transvascular clearance and distribution of charged macromolecules in ANTU lung injury. J. Appl. Physiol. 60:1221-1229, 1986.
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56. Taylor , A.E., J.C. Parker, and B. Rippe. Edema and the tissue resistance safety factor. Chapter 9. In: Tissue Nutrition and Viability, Ed. by A.R. Hargens. Springer-Verlag , New York , NY, 1986. pp. 185-196.
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57. Rippe, B., J.C. Parker, M.I. Townsley, N.A. Mortillaro, and A.E. Taylor. Segmental vascular resistances and compliances in dog lung. J. Appl. Physiol. 62:1206-1215, 1987.
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58. Parker, J.C., M. Miniati, R. Pitt, and A.E. Taylor. Interstitial distribution of charged macromolecules in the dog lung: A kinetic model. Ann. Biomed. Eng. 15:157-172, 1987.
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59. Townsley, M.I., R.J. Korthuis, B. Rippe, J.C. Parker, and A.E. Taylor. Validation of double vascular occlusion method for Pc,i in lung and skeletal muscle. J. Appl. Physiol. 61:127-132, 1986.
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60. Pitt, R.M., J.C. Parker, G.J. Jurkovich, A.E. Taylor, and P.W. Curreri. Analysis of altered capillary pressure and permeability after thermal injury. J. Surg. Res. 42:693-702, 1987.
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61. Townsley, M.I., J.C. Parker, R.J. Korthuis, and A.E. Taylor. Alterations in hemodynamics and Kf,c during lung mass resection. J. Appl. Physiol. 63:2460-2466, 1987.
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62. Parker, J.C. Transport and distribution of charged macromolecules in lungs. Adv. Microcirc. 13:150-159, 1987.
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63. Miniati, M., J.C. Parker, M. Pistolesi, J. Cartledge, C. Giuntini, and A.E. Taylor. Albumin reabsorption kinetics from the pleural spaces of dogs. Am. J. Physiol. 255:H375-H385, 1988.
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64. Parker, J.C. Transvascular transport and distribution volumes of charged macromolecules in normal and injured lungs. In: Interstitial Fluid Dynamics, ed. by N.C. Staub and A. Hargens. S. Karger, Basel , 1988.
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65. Parker, J.C., M. Miniati, A.E. Taylor, and R. Pitt. Pulmonary microvascular permeability of charged isozymes of lactate dehydrogenase (LDH) in isolated dog lungs. In: M. Tsuchiya (Ed.) Microcirculation - An Update, Vol. 1 (1987).
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66. Taylor , A.E., J.C. Parker, R.C. Allison, and M. Perry. Capillary exchange of fluid and protein. In: Textbook of Critical Care, ed. by W. Shoemaker, W.L. Thompson, and P.R. Holbrook. Saunders Publishing Co: Philadelphia , PA , 1988.
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67. Grimbert, F.A., D. Martin, J.C. Parker, and A.E. Taylor. Pulmonary blood flow vs. microvascular pressure effects on lung lymph flow in dogs. Am. J. Physiol. 255:H1149-H1155, 1988.
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68. Townsley, M.I., J.C. Parker, G.L. Longenecker, M.L. Perry, R.M. Pitt, and A.E. Taylor. Pulmonary embolism: Analysis of endothelial pore sizes in canine lung. Am. J. Physiol. 255:H1075-H1083, 1988.
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69. Taylor , A.E., K. Rehder, R. Hyatt, and J.C. Parker. Clinical Pulmonary Physiology, Saunders Publishing Co: Philadelphia , PA , 1989.
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70. Cope, D.K., J.C. Parker, R.C. Allison, and A.E. Taylor. The Gaar equation is not a reliable predictor of pulmonary capillary pressure. Critical Care Medicine 17:300, 1989.
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71. Parker, J.C., M.I. Townsley, and J.T. Cartledge. Edema increases transvascular filtration rate but not filtration coefficient in dog lungs. J. Appl. Physiol. 66:1553-1560, 1989.
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72. Hernandez, L.A. , K.J. Peevy, A.A. Moise, and J.C. Parker. Chest wall restriction limits high airway pressure-induced lung injury in young rabbits. J. Appl. Physiol. 66:2364-2368, 1989.
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73. Barman, Scott A., Jeffrey L. Ardell, J.C. Parker, Michele L. Perry, and A.E. Taylor. Pulmonary and systemic blood flow contributions to upper airways in canine lung. Am J. Physiol. 255 (Heart Circ. Physiol. 24): H1130-H1135, 1988.
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74. Allison, Ronald C., Bengt Rippe, V. Ravi Prasad, J.C. Parker, and A.E. Taylor. Pulmonary vascular permeability and resistance measurements in control and ANTU-injured dog lungs. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H1711-1718, 1989.
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75. Cope, D.K., J.C. Parker, M.D. Taylor, M. Houston, and A.E. Taylor. Pulmonary capillary pressures during hypoxia and hypoxemia: Experimental and clinical studies. Crit. Care Med. 17:853-857, 1989.
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76. Peevy, K.J., L.A. Hernandez, A.A. Moise, J.C. Parker. Barotrauma and microvascular injury in lungs of non-adult rabbits: Effect of ventilation pattern. Critical Care Medicine 18:634-637, 1990.
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77. Shibamoto, T., J.C. Parker, A.E. Taylor, and M.I. Townsley. Derecruitment of filtration surface area in paraquat-injured isolated dog lungs. J. Appl. Physiol. 68:1581-1589, 1990.
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78. Shibamoto, T., A.E. Taylor, and J.C. Parker. PO2 modulation of paraquat-induced microvascular injury in isolated dog lungs. J. Appl. Physiol. 68:2119-2127, 1990.
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79. Parker, J.C., L.A. Hernandez, G.L. Longenecker, K. Peevy, and W. Johnson. Lung edema due to high peak inspiration pressures in dogs: Role of increased microvascular filtration pressure and permeability. Am. Rev. Respir. Dis. 142:321-328, 1990.
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80. Fujimoto, K., J.C. Parker, and S.G. Kayes. Activated eosinophils increase vascular permeability and resistance in isolated perfused rat lungs. Am. Rev. Respir. Dis. 142:1414-1421, 1990.
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81. Hernandez, L.A. , P.J. Coker, S. May, A.L. Thompson, and J.C. Parker. Mechanical ventilation increases microvascular permeability in oleic acid injured lungs. J. Appl. Physiol. 69:2057-2061, 1990.
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82. Adkins, W.K., L.A. Hernandez, P.J. Coker, B. Buchanan, and J.C. Parker. Age affects susceptibility to pulmonary barotrauma in rabbits. Critical Care Medicine 19:390-393, 1991.
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83. Ishibashi, M., R.K. Reed, M.I. Townsley, J.C. Parker, and A.E. Taylor. Albumin transport across pulmonary capillary interstitial barrier in anesthetized dogs. J. Appl. Physiol. 70(5):2104-2110, 1991.
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84. Cope, D.K., R.C. Allison, J.N. Miller, J.C. Parker, and A.E. Taylor. Estimation of pulmonary capillary pressure in intact dog lungs using the arterial occlusion technique [letter; comment]. Am. Rev. Respir. Dis. 141(6):1602-1603, 1990.
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85. Parker, J.C., D.K. Cope, and M.P. Houston. Regional pulmonary vascular pressures and resistances during unilateral hypoxia. [letter] Crit. Care Med. 18:1493-1494, 1990.
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86. Parker, J.C., L.A. Hernandez, and K. Peevy. What is the mechanism of pulmonary edema during high volume ventilation? [letter, reply] Am. Rev. Respir. Dis. 143:1198-1200, 1991.
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87. Fujimoto, K., J.C. Parker, and S.G. Kayes. O2 radical scavengers protect against eosinophil-induced injury in isolated perfused rat lungs. J. Appl. Physiol. 73:687-694,1992.
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88. Shibamoto, T. and J.C. Parker. Fructose 1,6-diphosphate augments paraquat injury in isolated dog lungs. J. Appl. Physiol. 71(5):1830-36, 1991.
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89. Parker, J.C., L.A. Hernandez, and K.J. Peevy. High Volume Stress Failure of Pulmonary Capillaries. In: High Altitude Medicine. Eds. G. Ueda, J.T. Reeves, and M. Sekiguchi. Shinshu Univ. Press, Matsumoto , Japan , pp.139-144,1992.
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90. Coker, P.J., L.A. Hernandez, K.J. Peevy, W.K. Adkins, and J.C. Parker. Increased sensitivity to mechanical ventilation in non-compliant young rabbit lungs. Crit. Care Med. 20:635-40,1992.
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91. Shibamoto, T. and J.C.Parker. Effects of hyperoxia, hypoxia and fructose-1,6-diphosphate on paraquat induced pulmonary injury in isolated dog lungs. In: Pulmonary Circulation Research, Eds. H. Nagano, T. Nakada, Y. Sagawa. Kieio Univ. Press. 1991, pp.43-50.
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92. Parker, J.C., L.A. Hernandez, and K.J. Peevy. Mechanisms of ventilator-induced lung injury. Crit. Care Med. 21:131-143, 1993.
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93. Yoshikawa, S., S.G. Kayes, and J.C. Parker. Eosinophils increase lung microvascular permeability via the peroxidase-hydrogen peroxide-halide system. Am. Rev. Respir. Dis. 147:914-920, 1993.
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94. Parker, J.C., R. Prasad, R.C. Allison, W.V. Wojchiechowski, and S.L. Martin. Capillary filtration coefficient (Kf,c) using laser densitometry in isolated dog lungs. J. Appl. Physiol. 74:1981-1987, 1993.
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95. Reed, R.K., M. Ishibashi, M.I. Townsley, J.C. Parker, and A.E. Taylor. Blood-to-lymph clearance vs. Lymph analysis in determinating capillary transport characteristics for albumin in skin. Am. J. Physiol. 264:H1394-401, 1993.
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96. Parker, J.C. Ventilator-induced injury. ITACCS Newsletter 4:12-14,1994.
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97. Townsley, M.I., R. K. Reed, M. Ishibashi, J.C. Parker, T.C. Laurent, and A. E. Taylor. Hyaluronan efflux from canine lung with increased hydrostatic presssure and saline loading. Am. J. Respir. Crit Care Med. 150:1606-11,1994.
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98. Parker, J.C., J.A. Ardell, C.R. Hamm, S. A. Barman, and P.A. Coker. Regional pulmonary blood flow during rest, tilt, and exercise in unanesthetized dogs. J. Appl. Physiol. 78:838-846, 1995.
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99. Cavanagh,K.A., H.F. Hill, W. Wojciechowski, and J.C. Parker. Regional tracheal blood flow during conventional and high-frequency ventilation in sucking pigs. Crit. Care Med. 24: 280-286, 1996.
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100. Yoshikawa, S., S.G. Kayes, S. L. Martin, and J.C. Parker. Eosinophilia induced vascular and airway remodeling and hyperresponsiveness in rat lungs. J. Appl. Physiol. 81(3): 1279-1287, 1996.
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101. Parker, J.C., C.B. Cave , J.L. Ardell, C. R. Hamm, and S. G. Williams. Vascular tree structure affects lung blood flow heterogeneity simulated in three dimensions. J. Appl. Physiol. 83(4):1370-82, 1997.
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102. Parker, J.C., E.A. Breen, and J.B. West. High vascular and airway pressures increase interstitial protein mRNA expression in isolated rat lungs. J. Appl. Physiol. 83(5):1697-1705, 1997.
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103. Parker, J.C., and C. Ivey. Isoproterenol attenulates and edema augments high vascular pressure induced permeability increases in lung. J. Appl. Physiol. 83(6): 1962-1967, 1997.
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104. 2. Anglade, D.J., M. Corboz, S. Nazir, A. Menaquar, J.C. Parker, and F. A. Grimbert. Blood flow vs venous pressure effects on filtration coefficient in oleic acid injured lung. J. Appl. Physiol. 84 (3): 1011-1023, 1998.
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105. Parker, J.C., C. Ivey and J. Allan Tucker. Gadolinium prevents high airway pressure induced permeability increases in isolated rat lungs. J. Appl. Physiol. 84(4): 1113-1118, 1998.
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106. Parker, J.C., C. L. Ivey and J.A. Tucker. Phosphotyrosine phosphatase inhibition increases airway pressure induced lung injury. J. Appl. Physiol. 85:1753-1761, 1998.
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107. Parker, J.C., M.I. Townsley, and T. Stevens. Ca2+ dependence of mechanical injury in lung capillaries (letter). J. Appl. Physiol. 86: 775-6, 1999.
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108. Parker, J.C., and A. E. Taylor. Oxygen toxicity. In: The lung at depth. Eds. C.E.G. Lundgren and J.N. Miller. Vol 132: Lung biology in health and disease. Series Ed. C. Lenfant. Marcel Dekker, Inc. New York . Pages 165-210, 1999.
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109. Parker, J.C., M.N. Gillespie, A.E. Taylor, and S. L. Martin. Capillary filtration coefficient, vascular resistance and compliance in isolated mouse lungs. J. Appl. Physiol. 87:1421-1427, 1999.
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110. Parker, J.C.. Inhibitors of myosin light chain kinase, phosphodiesterase and calmodulin attenuate ventilator induced lung injury. J. Appl. Physiol. 89: 2241-2248, 2000.
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PAPERS ACCEPTED, IN PRESS, AND SUBMITTED FOR PUBLICATION: |
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1. Parker, J. C and S. Yoshikawa. Vascular segmental permeabilities at high peak inflation pressure in isolated rat lungs. Am. J. Physiol.: Lung Cell. Mol. Physiol. In Press.
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2. Yoshikawa, S., J. King, R. Lausch, C. Sybert, A. Penton, F. Eyal and J.C. Parker. Microvascular albumin leak is independent of Tumor Necrosis Factor -α during acute ventilator induced lung injury in mice. A. J. Respir. Crit. Care Med. Submitted.
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3. Parker, R.N. Lausch, X.T. Yan, F.G. Eyal, C.R. Hamm, and Sherri L. Martin. High airway pressure induced cytokine and chemokine release from perfused mouse lungs. Crit. Care Med. (Submitted).
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4. Parker, J.C., T.Stevens, J.Randall, C. Sybert, S. Yoshikawa, and A. Penton. Hydraulic conductance of segmental endothelial phenotypes in pulmonary circulation. Submitted.
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ABSTRACTS: |
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1. Smith, E.E., J.C. Parker, and D. Hinton. Intestinal enteritis and fluid loss associated with hemorrhagic shock. Fed. Proc., 1969.
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2. Parker, J.C., and E.E. Smith. Serum uric acid levels during cardiac arrest. J. Miss. Aca. Sci. 15, 1970.
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3. Parker, J.C., C.E. Jones, and E.E. Smith. Determination of myocardial purines during cardiac arrest and recovery. J. Miss. Acad. Sci. 16, 1971.
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4. Parker, J.C. and E.E. Smith. Myocardial free energy purines during cardiac arrest and recovery. The Physiologist 14:206, 1971.
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5. Parker, J.C. and E.E. Smith. Adenosine nucleotide substrate depletion and survival in cardiac arrest. Fed. Proc., 1972.
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6. Parker, J.C., C.E. Jones, and E.E. Smith. A concept of adenosine nucleotide substrate washout in cardiac arrest. J. Miss. Acad. Sci. 17, 1972.
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7. Ferguson , J.D., J.C. Parker, C.E. Jones, and E.E. Smith. Effect of allopurinol on adenine nucleotide degradation in cardiac arrest. J. Miss. Acad. Sci. 17, 1972.
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8. Parker, J.C. Computer stimulation of adenine nucleotide kinetics in the arrested myocardium. J. Miss. Acad. Sci. 18, 1973.
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9. Parker, J.C., and C.E. Jones. Changes in energy conservation in ischemic and non-ischemic myocardium following coronary occlusion. J. Miss. Acad. Sci. 18, 1973.
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10. Thomas, J.X., C.E. Jones, and J.C. Parker. Studies of adenine nucleotides and metabolites following coronary occlusion. Fed. Proc. 33:262, 1974.
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11. Thomas, J.X., C.E. Jones, and J.C. Parker. Acute and chronic studies of adenine nucleotides and metabolites following coronary occlusion. J. Miss. Acad. Sci. 19, 1974.
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12. Parker, J.C., C.E. Jones, and J.X. Thomas, Jr. Regional contractility studies in left ventricular following coronary occlusion. J. Miss. Acad. Sci., 1974.
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13. Thomas, J.X., C.E. Jones, and J.C. Parker. Acute changes in adenine nucleotides and contractile force in ischemic and non-ischemic myocardium following coronary occlusion. The Physiologist 17:344, 1974.
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14. Parker, J.C., C.E. Jones, and J.X. Thomas. Inotropic effects of nucleoside infusion on ischemic and non-ischemic myocardium. J. Miss. Acad. Sci. 20 (Suppl), 1975.
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15. Parker, J.C., A.C. Guyton, and A.E. Taylor. Estimation of pulmonary interstitial fluid pressures. The Physiologist 19:322, 1976.
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16. Parker, J.C., A.E. Taylor, and A.C. Guyton. Relationship of capillary, interstitial and interdependance forces in the lung. Fed. Proc. 36:536, 1977.
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17. Parker, J.C., and A.E. Taylor. Determinants of the vertical gradient in pulmonary extravascular fluid volume. The Physiologist 20:71, 1977.
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18. Parker, J.C., and A.E. Taylor. Vertical distribution of pre- to post-capillary resistance ratios in the lung. Microvasc. Res., 1978.
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19. Parker, J.C., A.E. Taylor, and A.C. Guyton. Measurement of pulmonary extravascular and vascular fluid volumes by constant infusion of a thermal indicator. Fed. Proc. 37:635, 1978.
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20. Parker, J.C. Physiology of pulmonary capillary fluid exchange. Hydrostatic pressure in the capillaries and tissues. Proc. Postgraduate Assembly, NY Soc. of Anesth., 1978.
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21. Taylor , A.E., R.E. Parker, J.C. Parker, and D.N. Granger. Pre- and post-capillary resistances in isolated dog lungs during alveolar hypoxia. The Physiologist 21:119, 1978.
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22. Parker, J.C., R.E. Parker, D.N. Granger, and A.E. Taylor. Vertical gradient in pulmonary interstitial fluid pressure. The Physiologist 21:89, 1978.
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23. Shackleford, J.S., D.N. Granger, A.E. Taylor, and J.C. Parker. Mechanism of PGE induced transmucosal protein efflux in the cat ileum. The Physiologist 21:108, 1978.
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24. Granger, D.N., J.C. Parker, and A.E. Taylor. Permselectivity of visceral exchange vessels to endogenous macromolecules. Microvasc. Res. 17:5105, 1979.
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25. Parker, J.C., R.E. Parker, D.N. Granger, and A.E. Taylor. Effect of volume loading on interstitial albumin exclusion in the lung. Fed. Proc. 38:1264, 1979.
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26. Parker, J.C., R.E. Parker, D.N. Granger, and A.E. Taylor. Effect of volume loading on interstitial albumin exclusion in the lung. Fed. Proc. 38:1264, 1979.
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27. Taylor , A.E., J.C. Parker, R.E. Parker, and D.N. Granger. Permselectivity of pulmonary capillaries to endogenous macromolecules. Fed. Proc. 38:1327, 1979.
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28. Moffatt, D.S., J.C. Parker, and A.C. Guyton. Measurement of pulmonary extravascular volume by constant infusion thermadilution technique. Fed. Proc. 38:1327, 1979.
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29. Falgout, H.J., and J.C. Parker. The effect of volume loading on interstitial albumin excluded volume in the lung. Ala. J. Med. Sci. 16:43, 1979.
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30. Parker, J.C., and A.E. Taylor. Effect of increased pulmonary vascular pressure on albumin excluded volume in the lung. Physiologist 22:98, 1979.
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31. Rutili, G., D.N. Granger, N.A. Mortillaro, J.C. Parker, and A.E. Taylor. Analysis of blood-lymph transport in resting and passively flexed dog hing leg. Physiologist 22:110, 1979.
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32. Taylor , A.E., J.C. Parker, and D.N. Granger. Convective and diffusive transport of endogenous proteins in lung lymph. Physiologist 22:122, 1979.
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33. Grimbert, F.A., J.C. Parker, D.N., Granger, and A.E. Taylor. Lung vascular permeability changes following acid aspiration: Effect of altering plasma protein concentration. Physiologist 22:48 , 1979.
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34. Granger, D.N., N.A., Mortillaro, P.R. Kvietys, and J.C. Parker. Effects of volume absorption on intestinal exclusion of albumin in the small bowel. Physiologist 22:47 , 1979.
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35. Rutili, G., P. Kvietys, J.C. Parker, and A.E. Taylor. Studies of lung protein flux and water content in ANTU-induced pulmonary edema. Microvascular Research 20:125, 1980.
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36. Parker, J.C., G. Rutili, D.N. Granger, and A.E. Taylor. Endogenous protein composition of right duct (RD) and prenodal (TB) lung lymph in the dog. Microvascular Research 20:123, 1980.
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37. Parker, J.C., G. Rutili, and A.E. Taylor. Relationship of interstitial fluid volume to lymph flow in edematous lungs. Fed. Proc. 39(3):485, 1980.
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38. Rutili, G., D.N. Granger, N.A. Mortillaro, J.C. Parker, and A.E. Taylor. Analysis of blood-lymph transport in resting and passively flexed dog hing leg. Physiologist 22:110, 1979.
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39. Ryan, K., P. Kvietys, J.C. Parker, and A.E. Taylor. Comparison of venous occlusion and isogravimetric capillary pressures in isolated dog lungs. Physiologist 23:76, 1980.
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40. Parker, J.C., and A.E. Taylor. Effect of fluid volume expansion on intralobar interdependance. Physiologist 23:77, 1980.
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41. Holloway, H., P. Kvietys, J. Downey, J.C. Parker, and A.E. Taylor. Estimation of pulmonary capillary pressure in intact dog lungs. Fed. Proc. 40:449, 1981.
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42. Parker, J.C., P.S. Kinnebrew, R. Allison, and A.E. Taylor. Effect of hemorrhage and E. coli endotoxin on pulmonary vascular permeability. Fed. Proc. 40:449, 1981.
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43. Parker, J.C., R. Allison, and A.E. Taylor. Partitioning of filtration and protein transport between capillary pore populations in the lung. Microvasc. Res. 21:253, 1981.
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44. Parker, J.C., and A.E. Taylor. Extravascular fluid compartmentation and lymph flow in edematous lungs. Proc. Int. Lymphology Soc., 1981.
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45. Taylor , A.E., R.C. Allison, and J.C. Parker. Estimation of total protein diffusive flux across pulmonary capillaries. Physiologist 24:19, 1981.
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46. Parker, J.C., R.C. Allison, and A.E. Taylor. Total lung lymph flow in normally hydrated dog lungs. The Physiologist 24:17, 1981.
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47. Allison, R., J.C. Parker, and A.E. Taylor. Effect of air embolization on termal dye estimates of extravascular lung water. The Physiologist 24:18, 1981.
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48. Taylor , A.E., M.A. Perry, D.W. Shin, D.N. Granger, and J.C. Parker. Calculation of the effective pore radii in dog hind-paw capillaries using lymph endogenous proteins. Microvasc. Res. 23:276, 1982.
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49. Parker, J.C., F. Grimbert, G. Rutili, and A.E. Taylor. Pulmonary lymph plasma oncotic pressure gradients after hemodilution, increased vascular pressures, and albumin infusion. In: Recent Advances in Microcirculatory Research (Ed.) P. Gaethtgens, S. Karger, Basel., pp. 251-254, 1981.
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50. Martin, D., D.N. Granger, J. McCord, J.C. Parker, and A.E. Taylor. The protective effects of superoxide dismutase on pulmonary endothelial damage associated with ANTU. Microvasc. Res. 23:265, 1982.
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51. Martin, D., J.C. Parker, and A.E. Taylor. Comparison of right duct (RD) and tracheobronchial (TB) lymphatic flows and protein concentrations in the dog. Fed. Proc. 41:1245, 1982.
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52. Allison, R.C., R. Parker, J.C. Parker, and A.E. Taylor. Thermal volume estimates of total lung mass in isolated dog lobes. Fed Proc. 41:1362, 1982.
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53. Parker, J.C., D. Martin, and A.E. Taylor. Interstitial exclusion of albumin and globulin in the dog lung. Microvasc. Res. 23:268, 1982.
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54. Parker, J.C., M.P. Houston, D. Martin, and A.E. Taylor. Effect of hypoxia on the distribution of pulmonary vascular resistance in the lung. Fed. Proc. 41:1246, 1982.
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55. Taylor , A.E., J.C. Parker, M. Perry, and D.W. Shin. Estimation of pore dimensions in lung capillaries following ANTU challenge. Fed. Proc. 41:1246, 1982.
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56. Parker, J.C., D. Martin, G. Rutili, and A.E. Taylor. Prevention of free radical mediated vascular permeability increases in lung using superoxide dismutase. Chest 83:525-535, 1983.
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57. Parker, J.C., B. Rippe, and A.E. Taylor. Interstitial distribution of charged macromolecules in the lung. Microvasc. Res. 3:251, 1983.
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58. Parker, J.C., G. Rutili, and A.E. Taylor. Comparison of crystalloid and colloid infusion on pulmonary fluid balance during increased pulmonary vascular permeability. Physiologist 25:205, 1982.
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59. Martin, D., J.C. Parker, and A.E. Taylor. Effects of dimethylsulfoxide (DMSO) and catalase on the protein permeability of dog lung capillaries damaged with a-naphthylthiourea (ANTU). Physiologist 25:204, 1982.
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60. Taylor , A.E., D. Martin, and J.C. Parker. Effects of leukocyte reduction on lung vascular permeability changes associated with a-naphthylthiourea (ANTU) endothelial damage. Physiologist 25:204, 1982.
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61. Taylor , A.E.., B. Rippe, R.C. Allison, and J.C. Parker. Osmotic reflection coefficient for total protein in an isolated dog lung lobe. Fed. Proc. 42:1273, 1983.
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62. Allison, R.C., B. Rippe, J.C. Parker, and A.E. Taylor. ANTU increased permeability in isolated dog lung lobes. Fed. Proc. 42:1108, 1983.
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63. Martin, D.J., J.C. Parker, and A.E. Taylor. Effect of fructose 1-6, diphosphate (FDP) on the pulmonary vascular damage associated with alpha-naphthylthiourea (ANTU). Fed. Proc. 42:1108, 1983.
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64. Davidson, L., A.E. Taylor, D. Martin, and J.C. Parker. The effect of ibuprofen on lung vascular permeability associated with ANTU damage. Fed. Proc. 42:1108, 1983.
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65. Parker, J.C., L.H. Campbell, and A.E. Taylor. Failure of myocardial ischemia to acutely increased microvascular permeability in the lung. Fed. Proc. 42:1106, 1983.
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66. Rippe, B., R.C. Allison, J.C. Parker, and A.E. Taylor. Effects of histamine, serotonin, and norepinephrine on vascular resistances, pressures, and volumes and on capillary permeability in isolated left lower lung lobes. Fed. Proc. 42:733, 1983.
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67. Parker, J.C., D. Martin, D.N. Granger, and A.E. Taylor. Estimates of interstitial "equivalent pore" dimensions in normal and edematous dog lungs. Int. J. of Microcirc. 2(3):271, 1983.
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68. Parker, J.C., B. Rippe, and A.E. Taylor. A mathematical model of the pulmonary circulation: effect of histamine (H), serotonin (5HT), norepinephrine (NE), and increased vascular pressure (IP). Physiologist 26:36, 1983.
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69. Rippe, B., J. Parker, and A.E. Taylor. Effects of reduced plasma proteins on capillary filtration coefficients and isogravimetric capillary pressures in isolated dog lungs. Physiologist 26:8, 1983.
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70. Parker, J.C. and A.E. Taylor. Plasma-lymph transport and interstitial distribution volumes of charged macromolecules. Proc. Int. U. Physiol. Sci. 15:487, 1983.
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71. Gilchrist , S.A. , J.C. Parker, and A.E. Taylor. Extravascular distribution volumes (VA) of charged macromolecules in the lung. Microvasc. Res. 27:244, 1984.
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72. Rippe, B., J.C. Parker, J. Thigpen, R.J. Korthuis, M. Townsley, and A.E. Taylor. Effect of high vascular pressures on capillary filtration coefficient (Kf,c) in the lung. Microvas. Res. 27:260, 1984.
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73. Parker, J.C., B. Rippe, M. Townsley, and A.E. Taylor. Effect of peak airway pressure (PAW) on microvascular permeability in the lung. Fed. Proc. 43:513, 1984.
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74. Allison, R.C., J.C. Parker, and A.E. Taylor. Effect of air microemboli on pulmonary vascular permeability in dogs. Fed. Proc. 43:1028, 1984.
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75. Parker, J.S. Exclusion and charge effects in lung interstitium. Int. J. Microcirc. 3:459, 1984.
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76. Parker, J.C., J.T. Cartledge, and G. Longnecker. Periods of high peak airway pressure (PAW) can decrease protein sieving by pulmonary capillaries. Fed. Proc. 44:1905, 1985.
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77. Parker, J.C., J.T. Cartledge, and A.E. Taylor. Edema affects interstitial resistance to fluid filtration in the lung. Microvasc. Res. 29:245, 1985.
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78. Premen, A.J., P.R. Kvietys, and D.N. Granger. Effects of intestinal hormones on jejunal blood flow. Fed. Proc. 44:205, 1985.
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79. Rippe, B., J.C. Parker, M. Townsley, R.J. Korthuis, and A.E. Taylor. High left atrial pressures, marked plasma protein reductions and oleic acid or ANTU infusions cause increases in pulmonary hydraulic conductivity; histamine and 5-HT do not. Int. J. Microcirc. 3:302, 1984.
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80. Townsley, M.I., J.C. Parker, R.J. Korthuis, and A.E. Taylor. The effect of decreases in lung mass on the pulmonary capillary filtration coefficient (Kf,c) and hemodynamics. Microvasc. Res. 29:254, 1985.
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81. Townsley, M., R. Korthuis, J.C. Parker, and A.E. Taylor. Effects of methylprednisolone on pulmonary vascular resistance and capillary pressure in isolated lungs during active vasoconstriction. Int. J. Microcirc. 4:214, 1985.
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82. Parker, J.C., J.A. Cartledge, A.E. Taylor, and M.I. Townsley. Hydraulic conductivity of subcutaneous and pulmonary interstitium during edema. The Physiologist 28:349, 1985.
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83. Pitt, R. and J.C. Parker. Decreased capillary protein sieving after scald burn. Proc. Am. Burn Assn., 1986.
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84. Barman , S.A. , P.J. Coker, J.C. Parker, J.L. Ardell, and A.E. Taylor. Measurement of upper airway regional blood flow in the isolated canine lung. Fed. Proc. 46:516, 1987.
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85. Parker, J.C. Theoretical effect of molecular charge on microvascular permeability to lactate dehydrogenase (LDH) isozymes in dog lungs. Microvasc. Res. 33:111, 1987.
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86. Cope, D.K., J.C. Parker, M.D. Taylor, K.T. Marble, and A.E. Taylor. Site of hypoxic pulmonary vasoconstriction in dog and human lungs. Southern Soc. Anesth, 1988.
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87. Parker, J.C., T. Leach, P. Coker, L. Hernandez, A. Taylor, S. Barman, and R. Pitt. Pulmonary capillary filtration coefficients during edema and varied perfusate protein concentration (CP). Physiologist 30(4):145, 1987.
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88. Parker, J.C., T. Leach, L. Hernandez, K. Adkins, K. Peevy, and P. Coker. Protamine increases pulmonary microvascular permeability in the presence and absence of albumin and leukocytes. FASEB J. 2:A1293, 1988.
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89. Peevy, K.J., L.A. Hernandez, and J.C. Parker. Barotrauma-associated microvascular injury after ventilation with short inspiratory times and high flow rates. J. Clin. Res. 36:80A, 1988.
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90. Pitt, R.M., J.C. Parker, and A.E. Taylor. Starling force changes in burned tissue. Physiologist 30:218, 1987.
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91. Parker, J.C., L.A. Hernandez, T. Shibamoto, P. Coker, and B. Buchanan. Leukocyte mediation of protamine microvascular damage in dog lungs. The Physiologist 31:A58, 1988.
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92. Shibamoto, T., L.A. Hernandez, A. Moise, K. Peevy, A.E. Taylor, and J.C. Parker. Effect of hyperoxia and hypoxia on paraquat-induced increases in pulmonary vascular permeability. The Physiologist 31:A59, 1988.
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93. Adkins, K., L. Hernandez, A. Moise, K. Peevy, B. Buchanan, and J.C. Parker. High peak airway pressures increase microvascular permeability in adult rabbit lungs. The Physiologist 31:A59, 1988.
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94. Hernandez, L.A. , K. Peevy, and J.C. Parker. Effect of high peak airway pressure on the normal rabbit lung. FASEB J. 20:A1184, 1988.
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95. Parker, J.C., L.A. Hernandez, and K. Peevy. Increased hydraulic conductivity in pulmonary and subcutaneous interstitium induced by free radical injury and edema. Free Rad. Res. Comm. 5:204, 1988.
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96. Shibamoto, T., M. Ishibashi, V.R. Prasad, A.E. Taylor and J.C. Parker. Effect of blood flow on capillary filtration coefficient (Kf,c) after paraquat injury (PQ) in isolated dog lungs. FASEB J. 3:A375, 1989.
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97. Adkins, W.K., M.I. Townsley, and J.C. Parker. Estimation of the reflection coefficient in isolated rabbit lungs. FASEB J. 3:A1141, 1989.
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98. Coker, P.J., L.A. Hernandez, K.J. Peevy, and J.C. Parker. Effect of pulmonary surfactant depletion and mechanical ventilation in the isolated rabbit lung. FASEB J. 3:A1141, 1989.
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99. Parker, J.C., M.I. Townsley, L.A. Hernandez, B. Twohig, M. Perry, K. Adkins, and A.E. Taylor. Allometric study of pulmonary capillary filtration coefficient (Kf,c). FASEB J. 3:A1141, 1989.
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100. Hernandez, L.A. , K.J. Peevy, and J.C. Parker. Response to mechanical ventilation after oleic acid induced lung injury. FASEB J. 3:A1141, 1989.
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101. Ishibashi, M., R.K. Reed, M.I. Townsley, J.C. Parker, and A.E. Taylor. Permeability surface area (PS) products and reflection coefficient (σ) at maximal protein diffusion in pulmonary capillaries. The Physiologist 32:A201, 1989.
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102. Parker, J., M. Miniati, T. Shibamoto, and A. Taylor. Transcapillary Influx, Efflux, and Interstitial Equilibration of Albumin in Dog Lungs. Proc. IUPS XVII:178, 1989.
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103. Johnson, W.H., J.A. Young, L.A. Hernandez, J.C. Parker, and K.J. Peevy. Positive End-Expiratory Pressure (PEEP) Prevents Barotrauma-Induced Microvascular Injury due to High Peak Inspiratory Pressure (PIP). Ped. Res. 25:367A, 1989.
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104. Johnson, W.H., J.A. Young, J.C. Parker, and K.J. Peevy. High mean airway pressure exacerbates barotrauma-induced microvascular injury in isolated perfused rabbit lungs. FASEB J. 4:A970, 1990.
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105. Coker, P.J., W.K. Adkins, L.A. Hernandez, and J.C. Parker. Lung maturity affects susceptibility to pulmonary barotrauma in rabbits. FASEB J. 4:A970, 1990.
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106. Hernandez, L.A. , P. Coker, S. May, and J.C. Parker. Oleic acid induced changes in pulmonary blood flow effects of ventilation. FASEB J. 4:A970, 1990.
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107. Ishibashi, M., R.K. Reed, M.I. Townsley, J.C. Parker, and A.E. Taylor. Capillary-interstitial barrier properties to albumin in the canine lung. FASEB J. 4:A589 (1990).
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108. Fujimoto, K., J.C. Parker, and S.G. Kayes. Effects of activated eosinophils on isolated perfused rat lungs. Am. Rev. Resp. Dis. 141:A641, 1990.
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109. Parker, J.C., P.J. Coker, L.A. Hernandez, and J.A. Freeman. Perfusion Heterogeneity in Injured Lungs Estimated Using Fluorescent Zinc-Cadmium Sulfide (ZCS) Aggregates. Physiologist. 33:A101, 1990.
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110. Shibamoto, T., S. Yoshikawa, and J.C. Parker. Fructose-1, 6-diphosphate augments paraquat-induced increases in microvascular permeability in isolated dog lungs. Am. Rev. Respir. Dis. 143:A224, 1991.
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111. Parker, J.C., S. Roohparvar, J. Foster, L. Hernandez, and P. Coker. High peak inspiratory pressures (PIP) affect the rate of bacterial clearance from rabbit lungs. Am. Rev. Respir. Dis. 143:A570, 1991.
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112. Fujimoto, K., J.C. Parker, S.G. Kayes, and S. Yoshikawa. O2 radical scavengers protect against eosinophil-induced lung injury. Am. Rev. Respir. Dis. 143:A40, 1991.
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113. Fujimoto, K., J.C. Parker, S. Yoshikawa, and S.G. Kayes. Eosinophils and supernatant injure isolated perfused rat lungs. Proc. Fifth World Congress for Microcirc., p. 29, 1991.
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114. Parker, J.C., R. Prasad, and W.V. Wojchiechowski. Capillary filtration coefficient (Kf,c) using laser densitometry in isolated dog lungs. Proc. Fifth World Congress for Microcirc., p. 84, 1991.
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115. Reed, R.K., M. Ishibashi, M.I. Townsley, J.C. Parker, and A.E. Taylor. Comparison of blood-to-tissue clearance of tracer and endogenous albumin fluxes to determine PS product and reflection coefficient (σ). Proc. Fifth World Congress for Microcirc., p. 90, 1991.
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116. Whitehurst, R., K. Peevy, P. Coker, J. Parker, and W. Johnson. Overdistention, not high peak airway pressure, produces pulmonary microvascular injury. J. Clin. Res. 38:93, 1990.
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117. Fujimoto, K., J.C.Parker, S.G. Kayes, and S. Yoshikawa. O2 radical scavengers protect against eosinophil-induced lung injury. Am. Rev. Respir. Dis. 143:A40,1991.
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118. Shibamoto, T., S. Yoshikawa, and J.C. Parker. Fructose-1,6-diphosphate augments paraquat induced increases in microvascular permeability in isolated dog lungs. Am. Rev. Respir. Dis. 143:A224, 1991.
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119. Parker, J.C., S. Roohparvar, J. Foster, L. Hernandez, and P. Coker. High peak inspiratory pressures (PIP) affect the rate of bacterial clearance from rabbit lungs. Am. Rev. Respir. Dis. 143:A570.1991.
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120. Yoshikawa,S., J.C. Parker, A.F. Seibert, and S.G. Kayes. The peroxide H2O2-halide system contributes to eosinophil induced injury in isolated perfused rat lungs. FASEB J. 6:A1058, 1992.
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121. Parker, J.C., S. Yoshikawa, S.G. Kayes, A.G. Brady, and S. Martin. sialodacryoadenitis virus increases eosinophil induced damage in isolated rat lungs. FASEB J. 6:A1612, 1992.
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122. Cavanagh, K., J.C. Parker, F. Hill, and W.V. Wojceichowski. Regional tracheal blood flow during high frequency jet ventilation (HFJV) in juvenile pigs. FASEB J. 6:A2043, 1992.
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123. Yoshikawa,S., J.C. Parker, and S.G. Kayes. Eosinophil p | |
