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NIH - Funded Training in Cell Signaling & Lung Pathobiology
 

Timothy Moore Ph.D., M.D.
Assistant Professor
Phone: (251) 460-6790 
Fax: (251) 460-7452
tmoore@jaguar1.usouthal.edu

 
EDUCATION
1998-2002 M.D. Univ. of South Alabama College of Medicine
  Mobile, AL
1991-1996 Ph.D. Univ. of South Alabama College of Medicine
  Mobile, AL
1987-1991 B.S., Auburn University
  Auburn, AL

                        

POSTGRADUATE TRAINING AND CLINICAL/RESEARCH FELLOWSHIP APPOINTMENS
2003-2006 Resident/Research Fellow, ACCM
  Johns Hopkins Medical Institutions
  Baltimore, MD
2002-2003 Intern, Internal Medicine
  Mercy Medical Center
  Baltimore, MD
2001-2002 Post-Doctoral, Physiology
  Univ. South Alabama COM
  Mobile, AL
1996-1999 Post-Doctoral, Pharmacology
  Univ. South Alabama COM
  Mobile, AL

                                                      

FACULTY APPOINTMENTS (including Secondary Appointments)
9/06-  Assistant Professor
  Dept. of Internal Medicine and CLB
  University of South Alabama
  Mobile, AL
6/98-9/98  Part-time, Temporary Assistant Professor
  College of Arts and Sciences, Dept. of Biology
  University of South Alabama
  Mobile, AL
9/97-12/97   Part-time, Temporary Assistant Professor
  College of Arts and Sciences, Dept. of Biology
  University of South Alabama
  Mobile, AL
1/97-3/97 Part-time, Temporary Assistant Professor
  College of Allied Health, Dept. Biomedical Sci.
  University of South Alabama
  Mobile, AL
6/96-8/96 Part-time, Temporary Assistant Professor
  College of Allied Heath, Dept. Biomedical Sci.
  University of South Alabama
  Mobile, AL
 
ADMINISTRATIVE APPOINTMENTS
None Currently

           

SPECIALTY BOARDS AND CERTIFICATION
USMLE Steps I, II, and III
            (Alabama licensure pending)

           

AWARDS AND HONORS
2002  Charles W. Urschel Award in Physiology, USA COM
2002 Alpha Omega Alpha
2001

Warquis Who'sWho in America and Who'sWho in the World®

2000  Trainee Travel Award, American Federation for Medical Research
2000 Trainee Award. American Federation for Medical Research, Southern Section/Southern Society for Clinical Investigation
1999   Henry Christian Award, American Federation for Medical Research
1996  Outstanding Poster Presentation (2nd Place), 22nd Eastern Student Research Forum
1995 Proctor and Gamble Professional Opportunity Student Award
1989  Alpha Epsilon Delta
 
MEMBERSHIPS IN PROFESSIONAL AND HONORARY SOCIETIES
2006 Alpha Omega Alpha Medical Honor Society (Johns Hopkins and USA Chapter)
2006 American Heart Association Council on Cardiopulmonary, Perioperative & Critical Care
2006  American Federation for Medical Research (AFMR)
2006  American Lung Association

         

UNVERSITY SERVICE
Department Committees or Responsibilities
2006-  Director Critical Care Conference Series at Center for Lung Biology
 
College of Medicine Committees
2001-2002    Univ. South Alabama COM Admissions Committee
1995-1996 Univ. South Alabama Basic Medical Sciences Admissions Committee
 
University and/or Health System Committees
None Currently
 

EXTRAMURAL SUPPPORT

Research Grants, Contracts, Awards, Projects
Current Support:
Title:   Soluble CD40 Ligand Increases Pulmonary Microvascular Permeability.
Source: Parker B. Francis Foundation
Role:  PI
Dates:  2007-2010
Total Funds: $144,000.00
   
Title: Soluble CD40 Ligand Increases Pulmonary Microvascular Permeability.
Source:  American Heart Association Beginning Grant-in-Aid
Role:  PI
Dates: 2007-2009
Total Funds:  $110,000.00 (direct + indirect)
   
Pending Support:
Title:  Use of Soluble CD40 Ligand Levels to Guide Perioperative Risk Assessment and Therapeutic Management in Obstructive Sleep Apnea.
Source: ResMed Foundation
Role:  PI
Dates:   2007-2008
Total Funds: $28,034.00 (direct + indirect)
   
Title:  Redefining the Alveolar-capillary Membrane: a Dynamic Environmental Interface
Source: NIH/NIGMS
Role:  PI
Dates:  2007-2012
Total Funds: $2,205,000.00 (direct + indirect)
   
Past Support:
Title:  T-Lymphocyte involvement in lung ischemia-reperfusion injury.
Source:    NIH/NHLBI R01 HL/AI67461-01 A.E. Taylor, PI
Role: Postdoctoral (25% effort)
Dates: 2001-2005
Total Funds: $800,000.00
   
Title:  Regulation of Pulmonary Microvascular Endothelial Function by αvb3 Integrins: Roles of Calcium and cAMP.
Source:   American Heart Association Southern Research Consortium
Role:  Postdoctoral Fellow
Dates: 7/01/1997-6/30/1999
Total Funds: $45,000.00
 
Other Funding:
None Currently
 
PROFESSIONAL SERVICE
Leadership and Committee Positions:
None Currently
 
Editorial Boards:
None Currently
 
Peer Review (Study Sections, Ad Hoc Grant or Journal Review, Site Visits):
1998-1999  Journal of Clinical Science
1998-1999 Inflammation Research
2006-2007  American Journal of Lung Cell and Respiratory Physiology
 
INVITED LECTURES/WORKSHOUPS/PRESENTATIONS

“Soluble CD40 ligand induces co-localization of CD40 with Rab5 in pulmonary microvascular endothelial cells” AFMR, Washington, DC, 2007.

“Studies in Acute Lung Injury and ARDS” Center for Lung Biology Special Seminar, Mobile, AL, 2006.

“Immunohistochemical identification of CGRP and adenosine A2A intrinsic neurons in hamster cheek pouch” Johns Hopkins ACCM Research Day, Baltimore, MD 2006.

“Immunohistochemical identification of CGRP and adenosine A2A intrinsic neurons in hamster cheek pouch” Joint US/UK Microcirculatory Conference, Durham, NH 2005.

“Association between obesity and cancer in the United States.” Mercy Medical Center, Dept. Of Medicine Seminar Series, Baltimore, MD, 2003.

“Involvement of IL-10, MIP-2, and CD40 signaling in lung ischemia-reperfusion injury.” University of South Alabama COM Physiology Seminar Series, Mobile, AL, 2000

“Calcium influx is not required for thrombin-induced endothelial barrier disruption.” University of South Alabama COM Physiology Seminar Series, Mobile AL 1999.

“Quantitative assessment of solute flux across cultured pulmonary arterial endothelial monolayers: comparison of different stimuli.” University of South Alabama COM Pharmacology Seminar Series, Mobile, AL 1999.

“Pulmonary endothelium and Mardi Gras: laissez les bon temp roulers!” University of South Alabama COM Pharmacology Seminar Series, Mobile, AL 1998.

“Respiratory, renal, gastrointestinal, and acid-base physiology.” Masters in Nursing Program Physiology Workshop, Mobile, AL, 1998.

“Pulmonary endothelial calcium regulation: role of trp gene products.” University of South Alabama COM Physiology Seminar Series, Mobile, AL 1997.

“Respiratory, renal, gastrointestinal, and acid-base physiology.” Masters in Nursing Program Physiology Workshop, Mobile, AL 1997.

“Mechanisms of ischemia-reperfusion injury in the lung.” AHA/ATS/Pulmonary Circulation Foundation 8th Pulmonary Circulation Conference, Denver, CO, 1996.

“Endothelial damage caused by ischemia and reperfusion and different ventilatory strategies in the lung.” University of South Alabama COM Advanced Respiratory Physiology Course, Mobile, AL, 1996.
“Ischemia and reperfusion injury in lung endothelial barrier.” Subcommittee on Cardiovascular Seminars 69th Scientific Sessions of the AHA, New Orleans, LA, 1996.

“Inflammation and nitric oxide in lung I/R injury.” University of South Alabama COM Pharmacology Seminar Series, Mobile, AL 1996.

“Mechanisms of microvascular damage associated with lung ischemia/reperfusion.” University of South Alabama COM Physiology Seminar Series, Mobile, AL 1996.

“Vascular permeability and epithelial transport effects on lung edema formation in ischemia and reperfusion.” University of South Alabama COM Physiology Seminar Series, Mobile, AL, 1994.

“A synopsis of PMA and ischemia-reperfusion induced lung injury.” University of South Alabama COM Physiology Seminar Series, Mobile, AL 1993.

 
CONTRIBUTIONS TO EDUCATION
College of Medicine Teaching Activities:
Medical Student Education:
2006-2007 Univ. South Alabama COM Medical Pharmacology
2005-2006  Johns Hopkins Hospital Anesthesiology
(resident intra-op student proctor)
1997-1998 Univ. South Alabama COM Dept. of Pharmacology (course proctor)
1992-1996 Univ. South Alabama COM Dept. of Physiology (course tutor)
1992-1996  Univ. South Alabama COM Dept. of Physiology (lab proctor)
 
Resident & Fellow Education:
None Currently
 
Faculty Development/CME:
None Currently
 
Community/Lay Public:
1994 Univ. of South Alabama School of Continuing Education and
  Special Courses: “Anatomy and Physiology for the Medical Office Manager”
 
Students, Faculty, Residents, or Fellows Mentored:

           Anjali Kumbla – Medical Student Summer Research Program: “CD40/CD40 ligand interactions and lung microvascular permeability.”

 
OTHER CONTRIBUTIONS TO SCHOLARSHIP OR SERVICE
Other Scholarly Contributions:
Univ. South Alabama College of Medicine Physician-Scientist Interest Group; 2001-2002
 
Community Service:

American Heart Association “Walk-the-Block” Campaign.

Hillsdale Middle School (Mobile, AL) Health Fair Oversight Committee.

Univ. of South Alabama College of Medicine “Relay for Life Team”; American Cancer Society

Volunteers of America Human Rights Committee (Member-at-large)

 

BIBLIOGRAPHY

Journal Publications/Original Papers:

Adkins, W.K., J.W. Barnard, T. M. Moore, R.C. Allison, V.R. Prasad, and A.E. Taylor. Adenosine prevents PMA-lung injury via an A2 receptor mechanism. J. Appl. Physiol. 74: 982-988, 1993.

Barnard, J., P.S. Wilson, T.M. Moore, W.J. Thompson, and A.E. Taylor. Effect of nitric oxide and cyclooxygenase products on vascular resistance in dog and rat lungs. J. Appl. Physiol. 74: 2940-2948, 1993.

Khimenko, P.L., J.W. Barnard, T.M. Moore, P.S. Wilson, S.T. Ballard, and A.E. Taylor. Vascular permeability and epithelial transport effects on lung edema formation in ischemia and reperfusion. J. Appl. Physiol. 77: 1116-1121, 1994.

P.L. Khimenko, T.M. Moore, Hill, L.W., P.S. Wilson, S. Coleman, A. Rizzo, and A.E. Taylor. Adenosine A2 receptors reverse ischemia- reperfusion lung injury independent of $ receptors. J. Appl. Physiol. 78: 990-996, 1995.

Wilson, P.S., P.L. Khimenko, J.W. Barnard, T.M. Moore, and A.E. Taylor. Muscarinic agonists and antagonists cause vasodilation in the isolated rat lung. J. Appl. Physiol. 78: 1404-1411, 1995.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. ATP-sensitive K+ channels are not involved in ischemia/reperfusion lung endothelial injury. J. Appl. Physiol. 79: 554-559, 1995.

Moore, T.M., P.L. Khimenko, W.K. Adkins, M. Miyasaka, and A.E. Taylor. Adhesion molecules contribute to ischemia and reperfusion injury in the isolated rat lung. J. Appl. Physiol. 78: 2245-2252, 1995.

Moore, T.M., P.L. Khimenko, and A.E. Taylor. Restoration of normal pH triggers ischemia-reperfusion injury in the lung by Na+/H+ exchange activation. Am. J. Physiol. 269: H1501-H1505 (rapid communication), 1995.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. Blocking ETA receptors prevents ischemia and reperfusion injury in rat lungs. J. Appl. Physiol. 80: 203-207, 1996.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. Role of calmodulin and myosin light-chain kinase in lung ischemia/reperfusion injury. Am. J. Physiol. 271: L121-L125, 1996.

Wilson, P.S., P.L. Khimenko, T.M. Moore, and A.E. Taylor. Perfusate viscosity and hematocrit determine pulmonary vascular responsiveness to NO synthase inhibitors. Am. J. Physiol. 270: H1757-H1765, 1996.

Moore, T.M., P.S. Wilson, P.L. Khimenko, and A.E. Taylor. The role of nitric oxide in lung ischemia and reperfusion injury. Am. J. Physiol. 271: H1970-H1977, 1996.
           
Wilson, P.S., W.J. Thompson, T.M. Moore, P.L. Khimenko, and A.E. Taylor. Vasoconstriction increases pulmonary nitric oxide synthesis and circulating cyclic GMP. J. Surg. Res. 70: 75-83, 1997.

Kelly, J.J., T.M. Moore, P. Babal, A.H. Diwan, T. Stevens, and W.J. Thompson. Pulmonary microvascular and macrovascular endothelial cells: Differential regulation of calcium and permeability. Am. J. Physiol. 274: L810-L819, 1998.

Moore, T.M., G. Brough, J.J. Kelly, P. Babal, M. Li, and T. Stevens. Store-operated calcium entry promotes shape change in pulmonary endothelial cells expressing Trp1. Am. J. Physiol. 275: L574-L582, 1998.

Chetham, P.M., P. Babal, J.P. Bridges, T.M. Moore, and T. Stevens. Segmental regulation of pulmonary vascular permeability by store-operated calcium entry. Am. J. Physiol. 276: L41-L50, 1999.

Moore, T.M., N.R. Norwood, J.R. Creighton, P. Babal, G.H. Brough, D.M. Shasby, and T. Stevens. Receptor-dependent activation of store-operated calcium entry increases end permeability. Am. J. Physiol Lung Cell. Mol. Physiol. 279(4): L691-L698, 2000.

Norwood, N., T.M. Moore, D.A. Dean, R. Bhattacharjee, M. Li, and T. Stevens. Store-operated calcium entry and increased endothelial cell permeability. Am. J. Physiol. Lung Cell Mol. Physiol. 279(5): L815-L824, 2000.

Wu, S., T.M. Moore, G.H. Brough, S.R. Whitt, M. Chinkers, M. Li, and T. Stevens. Cyclic nucleotide-gated channels mediate membrane depolarization following activation of store-operated calcium entry in endothelial cells. J. Biol. Chem 275(25): 18887-18896, 2000.

Brough, G.H., S. Wu, D. Cioffi, T.M. Moore, M. Li, N. Dean, and T. Stevens. Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathway. FASEB J. 15: 1727-1738, 2001.

Moore, T.M., W.B. Shirah, P.L. Khimenko, P. Paisley, R.N. Lausch, and A.E. Taylor. Involvement of CD40-CD40L signaling in postischemic lung injury.  Am. J. Physiol. Lung Cell. Mol. Physiol. 283(6): L1255-L1262, 2002.

Cioffi, D.L., T.M. Moore, J. Schaack, J.R. Creighton, D.M. Cooper, and T. Stevens. Dominant regulation of interendothelial cell gap formation by calcium-inhibited type 6 adenylyl cyclase. J Cell Biol. Jun 24;157(7): 1267-1278, 2002.

Ko, A.C., E. Hirsh, A.C. Wong, T.M. Moore, A.E. Taylor, R.B. Hirschl, and J.G. Younger. Segmental hemodynamics during partial liquid ventilation in isolated rat lungs. Resuscitation 57: 85 – 91, 2003.

Rivers, R.J., V.A. Miriel, Y. Chen, T.M. Moore, and N. Thengchaisri. Adenosine activation of intrinsic CGRP-ergic neurons: a novel mechanism for metabolic regulation of tissue blood flow. Circ. Res. In review, 2006.

Thengchaisri, N., T.M. Moore, and R.J. Rivers. Central role for adenosine A2A receptors in the adenosine neuro-vascular network response. Microcirculation In Prep., 2006.

Wu, S., H. Chen, M.F. Alexeyev, J.A.C. King, T.M. Moore, T. Stevens, and R. Balczon. Microtuble motors regulate Isoc activation necessary to increase endothelial cell permeability. J. Cell. Biol. Submitted, 5/2007.

 
Book Chapters and Reviews:

Taylor, A.E., W.K. Adkins, and T.M. Moore. Ischemia reperfusion lung injury: Repair of endothelial damage by adenosine and cAMP. In: Yearbook of Intensive Care and Emergency Medicine, J.L. Vincent (Ed.), Berlin, Germany: Springer-Verlag, pp. 12-20, 1993.

Taylor, A.E., P. Khimenko, J.W. Barnard, A. Rizzo, and T. Moore. Protection and reversal in ischemia-reperfusion tissue injury. In: Reperfusion Injuries and Clincal Capillary Leak Syndrome. Zikria, B.A., M.C. Oz, and R.W. Carlson (Eds.), Armonk, NY: Futura Publishing Company Inc., pp. 493-516, 1994.      

Taylor, A.E., T. Moore, and P. Khimenko. Microcirculatory exchange of fluid and protein and development of the third space. In: In: Reperfusion Injuries and Clincal Capillary Leak Syndrome. Zikria, B.A., M.C. Oz, and R.W. Carlson (Eds.), Armonk, NY: Futura Publishing Company Inc., pp. 59-92, 1994.

Taylor, A.E., T. Moore, A. Rizzo, and P. Khimenko. Lymphatic safety factor. In: Interstitium, Connective Tissue, and Lymphatics. Reed, R.K., G.A. Laine, J.L. Bert, P. Winlove, and N. McHale (Eds.), London, England: Portland Press, pp. 41-50, 1995.

Taylor, A.E., T. Moore, P. Khimenko, and K. Adkins. Fluid balance. In: The Lung: Scientific Foundations (2nd edition). Crystal, R.G. and J.B. West (Eds.), Philadelphia, Pennsylvania: Lippincott-Raven Press, pp. 1549-1566, 1996.
           
Moore, T.M., P.L. Khimenko, and A.E. Taylor. Endothelial damage caused by ischemia and reperfusion and different ventilatory strategies in the lung. Chin. J. Physiol. 39 (invited review): 65-81, 1996.

Taylor, A.E., P.L. Khimenko, and T.M. Moore. The endothelial barrier: What is its function? In: Connective Tissue Biology: Integration and Reductionism. Reed, R.K. and K. Rubin (Eds.), London, England: Wenner-Gren International Series, Portland Press, pp 14 - 16, 1998.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. Ischemia reperfusion and lung endothelial damage. In: The Failure of the Pulmonary Circulation - a Key Role in Acute Lung Injury. Taylor, A.E. and A. Goetz (Eds.), Basel, Switzerland: Karger, pp. 101 – 110, 1998.

Stevens, T., G.H. Brough, T.M. Moore, P. Babal, and W.J. Thompson. Endothelial cells. In: Methods in Pulmonary Research. Uhlig, S. and A.E. Taylor (Eds.), Basel, Switzerland: Birkhauser-Verlag, pp 37 - 48, 1998.

Taylor, A.E., T.M. Moore, and M.I. Townsley. Evaluation of endothelial damage in lungs. Pathophysiology (invited review), 1998.

Taylor, A., P. Khimenko, T. Moore, and B. Rippe. Overview of lung ischemia/reperfusion experimental models. Proceedings of the 20th European Conference on Microcirculation, Monduzzi Editore, Bologna, Italy, pp. 95-100, 1998.

Moore, T.M. and A.E. Taylor. Pathophysiology. In: Oxford Textbook of Critical Care. Webb, A., M.J. Shapiro, M. Singer, and P. Suter (Eds.), Oxford, England: Oxford University Press, pp. 1-5, 1998.

Moore, T.M., P.L. Khimenko, and A.E. Taylor. Mechanisms of ischemia-reperfusion injury in the lung. In: Pathogenesis and Treatment of Pulmonary Edema. Weir, E.K., S.L. Archer, and J.T. Reeves (Eds.), New York, New York: Futura Publishing Co., pp. 45 - 50, 1998. 

Moore, T.M., P. Chetham, J.J. Kelly, and T. Stevens. Signal transduction and regulation of lung endothelial permeability: Interaction between calcium and cAMP. Am. J. Physiol. 275 (invited review): L203-L222, 1998.

Taylor, A. E. and T. M. Moore. Capillary fluid exchange. Am. J. Physiol.  277 (Adv. Physiol. Educ. 22): S203-S210, 1999.

Taylor, A.E., T.M. Moore, W.B. Shirah, P.L. Khimenko, and P. Paisley. The Lung in Inflammation. In: Proceedings of the 7th World Congress for Microcirculation, Sydney, Australia, August 19-22. Monduzzi Editore International Proceedings Division, pp. 225-233, 2001.

Moore, T. and F. Zarfeshanfard.  Be aware that enteral feeds can lower phenytoin levels. (E1). In: Avoiding Common Errors in the ICU, In press, 2006.

Moore, T. Avoid concomitant use of steroids, neuromuscular blockade, and aminoglycosides to lessen the risk of critical illness myopathy. (E27). In: Avoiding Common Errors in the ICU, In press, 2006.

Moore, T. Check serial methemoglobin levels in patients on inhaled nitric oxide. (E31). In: Avoiding Common Errors in the ICU, In press, 2006.

Moore, T.M. and M.I. Townsley.  Pulmonary Edema. In: Encyclopedia of Molecular Mechanisms of Disease. Lang, F.  (Ed.); Springer-Verlag, Heildelberg, Germany, In press, 2006.

 

Editorials, Letters to Editor, Other:

None Currently
 
Abstracts:

Moore, T.M., W.K. Adkins, J.W. Barnard, P.S. Wilson, and A.E. Taylor. Adenosine attenuates PMA-induced injury to the dog lung via an A2 receptor mechanism. Circulation 86: I354, 1992.
           
Barnard, J., T.M. Moore, P.S. Wilson, W.J. Thompson, and A.E. Taylor. Effect of nitric oxide and cyclooxygenase products on vascular resistance in lung. Circulation 86: I603, 1992.

Adkins, W.K., J.W. Barnard, T. Moore, and A.E. Taylor. Cyclic AMP in PMA-induced endothelial injury in the isolated dog lung. FASEB J. 6: A1534, 1992.

Moore, T.M., J.W. Barnard, P.S. Wilson, and A.E. Taylor. Staurosporine and H7, PKC inhibitors, attenuate PMA-induced vascular changes in isolated dog lung. FASEB J. 7: A649, 1993.

Wilson, P.S., J.W. Barnard, T.M. Moore, and A.E. Taylor. Control of pulmonary vascular resistance and permeability by nitric oxide synthesis inhibitors. Proc. Congress Int’l. Union Physiol. Sci. p.51, 1993.

Adkins, W.K., W.K. Greene, T.M. Moore, and A.E. Taylor. Phalloidin attenuates PMA-induced permeability increase in isolated canine lung. FASEB J. 7: A545, 1993.

Wilson, P.S., J.W. Barnard, T.M. Moore, and A.E. Taylor. Inhibition of pulmonary vascular recruitment by L-NAME is dependent on blood elements. FASEB J. 7: A772, 1993.

Barnard, J.W., A.F. Seibert, W.J. Thompson, P.S. Wilson, T.M. Moore, and A.E. Taylor. Reversal of ischemia-reperfusion lung injury by phosphodiesterase inhibition. FASEB J. 7: A494, 1993.

Moore, T.M., C.S. Kirby, and A.E. Taylor. Polymyxin B prevents PMA injury in blood perfused dog lungs, but not buffer perfused dog lungs. FASEB J. 8: A2427, 1994.

Taylor, A.E., P.L. Khimenko, T.M. Moore, and D.L. Dyess. Fluid and protein balance in edema. In: Progress in Lymphology XIV: Proceedings of the 14th Intenational Congress of Lymphology. Witte, M.H. and C.L. White (Eds.), Zurich, Switzerland and Tucson, AZ., 1994.

Khimenko, P.L., J.W. Barnard, T.M. Moore, P.S. Wilson, S.T. Ballard, and A.E. Taylor. Effects of active Na+ transport on edema fluid accumulation in ischemia and reperfusion injury in rat lungs. Am. J. Respir. Crit. Care Med. 149: A821, 1994.

Khimenko, P.L., J.W. Barnard, T.M. Moore, P.S. Wilson, S.T. Ballard, and A.E. Taylor. Isoproterenol does not affect amiloride-sensitive Na+ channels after ischemia and reperfusion (I/R). FASEB J. 8: A143, 1994.

Hill, L., P.L. Khimenko, S. Coleman, T.M. Moore, P.S. Wilson, and A.E. Taylor. A2 adenosine receptor stimulation protects lung against ischemia and reperfusion (I/R) injury. FASEB J. 8: A898, 1994.

Moore, T.M., P.L. Khimenko, W.K. Adkins, and A.E. Taylor. Leukocyte and endothelial cell adhesion molecules contribute to ischemia and reperfusion-induced injury in the isolated rat lung. FASEB J. 9: A38, 1995.
           
Moore, T.M., P.L. Khimenko, and A.E. Taylor. L-NAME prevents ischemia and reperfusion injury in rat lungs due to pH alteration: evidence for the Na+/H+ co-transporter in the mechanism of injury. Circulation 92: I580, 1995.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. KATP channel activation protects lung endothelial barrier against ischemia/reperfusion injury. 42nd Ann. Conf. Microcirc. Soc. p. 38. 1995.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. KATP channels are not involved in reversal of ischemia/reperfusion lung injury. FASEB J. 9: A973, 1995.

Taylor, A.E., P.L. Khimenko, and T.M. Moore. Adenosine A2 receptors activate PKA independent of $-receptors to reverse ischemia/reperfusion lung injury. FASEB J. 9: A971, 1995.

Moore, T.M., P.L. Khimenko, P.S. Wilson, and A.E. Taylor. PAF antagonists attenuate I/R-induced microvascular injury in the isolated rat lung. FASEB J. 10: A109, 1996.

Moore, T.M., P.L. Khimenko, P.S. Wilson, and A.E. Taylor. Nitric oxide prevents ischemia/reperfusion-induced permeability increase in isolated rat lungs. Am. J. Respir. Crit. Care Med. 153:A391, 1996.

Moore, T.M., P.L. Khimenko, and A.E. Taylor. The effects of nitric oxide synthase inhibitors and nitric oxide donors on ischemia and reperfusion injury in isolated rat lungs. Int’l J. Microcirculation 16(S1): 170, 1996.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. Role of calmodulin and myosin light chain kinase in ischemia/reperfusion rat lung injury. Int’l J. Microcirculation 16(S1): 70, 1996.

Taylor, A.E., T.M. Moore, and P.L. Khimenko. Mechanisms of endothelial damage in inflammation. Int’l J. Microcirculation 16(S1): 17, 1996.
           
Khimenko, P.L., T.M. Moore, Wilson, P.S., and A.E. Taylor. Role of oxygen and flow cessation in ischemia-reperfusion injury in the rat lung.  FASEB J. 10: A583, 1996.
           
Khimenko, P.L., T.M. Moore, Wilson, P.S., and A.E. Taylor. Calcium ionophore damages rat lung independently of calmodulin system. 43rd Annual Conference of the Microcirculatory Society, p. 38, 1996.

Wilson, P.S., T.M. Moore, P.L. Khimenko, and A.E. Taylor. Shear stress increases NO synthesis in isolated rat lungs. FASEB J. 10: A96, 1996.

Khimenko, P.L., T.M. Moore, Wilson, P.S., and A.E. Taylor. Calcium ionophore does not mimic ischemia/reperfusion rat lung injury. Am. J. Respir. Crit. Care Med. 153: A574, 1996.

Taylor, A.E., P.L. Khimenko, and T.M. Moore. TNF-alpha is involved in ischemia, ventilation, and reperfusion injury in rat lungs. FASEB J. 10: A647, 1996.

Taylor, A.E., P.L. Khimenko, T.M. Moore, and P.S. Wilson. Role of calmodulin and myosin light-chain kinase in ischemia-reperfusion rat lung injury. Am. J. Respir. Crit. Care Med. 153: A574, 1996.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. Effects of the phospholipase A2-cyclooxygenase system on ischemia and reperfusion lung endothelial injury. FASEB J. 11: A106, 1997.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. Estimation of the filtration coefficient during ischemia in isolated rat lung. Am. J. Respir. Crit. Care Med. 155: A857, 1997.

Kelly, J.J., T.M. Moore, P. Babal, A.H. Diwan, T. Stevens, and W.J. Thompson. Differential calcium signaling and permeability in pulmonary microvascular and macrovascular endothelial cells. FASEB J. 12: A, 1998.

Moore, T.M., N. Norwood, G. Brough, and T. Stevens. F-actin gates thapsigargin-sensitive store-operated calcium channels in pulmonary endothelial cells. FASEB J. 12: A, 1998.

Moore, T.M., G. Brough, J.J. Kelly, P. Babal, and T. Stevens. Regulation of  pulmonary endothelial cell shape by Trp-mediated calcium entry. Chest 114 (1 Suppl): 36S-38S, 1998.

Norwood, N., D. Dean, T. Moore, J. Creighton, P. Babal, and T. Stevens. Inhibition of myosin light chain kinase stimulates calcium release in pulmonary artery endothelial cells. FASEB J. 13: A44, 1999.

Norwood, N., T. Moore, J. Creighton, P. Babal, R. Bhattacharjee, and T. Stevens. Myosin light chain kinase regulates activation of store-operated calcium entry in pulmonary artery endothelial cells. FASEB J. 13: A48, 1999.

Wu, S. T.M. Moore, G.H. Brough, M. Li, and T. Stevens. Activation of store-operated Ca2+ entry causes lung endothelial cell membrane depolarization via a Ca2+-inhibited, cAMP-activated K+ conducting channel. FASEB J. 13: A47, 1999.

Moore, T., N. Norwood, G. Brough, J. Creighton, L. Lee, P. Babal, and T. Stevens. Calcium influx is sufficient but not required for thrombin-induced endothelial cell shape change. FASEB J. 13: A44, 1999.

Moore, T. M., K. Fagan, J. Schaak, J. Creighton, D.M.F. Cooper, and T. Stevens. Adenovirus-mediated transgene transfer of Type 8 adenylyl cyclase increases cAMP and prevents endothelial barrier disruption in response to thapsigargin. Int’l Congress for Pulmonary Circulation VII, Prague, Czech Republic, 1999.

Moore, T.M., J.R. Creighton, and T. Stevens. Adenovirus-mediated transgene transfer of type VIII adenylyl cyclase increases cyclic AMP and prevents calcium-induced endothelial barrier disruption. Southern Regional AFMR Proceedings, 2000.

Moore, T.M. and A.E. Taylor. Anti-CD40 antibody reduces early ischemia/reperfusion-induced lung microvascular dysfunction. FASEB J. 14: A5, 2000.

Brough, G., T. Moore, S. Wu, D. Dean, N. Dean, and T. Stevens. Endogenously expressed TRP1 mediates store operated calcium entry in lung cells. FASEB J. 14: A157, 2000.

Moore, T., P. Khimenko, and A. Taylor. IL-10 prevents lung microvascular damage following ischemia-reperfusion without PKA activation. Am. J. Respir. Crit. Care Med. 158: A747, 2000.

Moore, T., B. Shirah, R. Nash, and A.E. Taylor. Acute lymphocytic involvement in ischemia/reperfusion-induced lung microvascular dysfunction. Am. J. Respir. Crit. Care Med. 158: A320, 2000.

Younger, J.G., A.C. Ko, E. Hirsh, T. Moore, R.B. Hirschl, A.E. Taylor, and P.A. Ward. Pulmonary hemodynamics and capillary filtration coefficient in isolated perfused rat lungs during liquid ventilation. FASEB J. 15(4): A494, 2001.

Khimenko, P.L., T.M. Moore, and A.E. Taylor. Activation of K+ATP channels is required for protective effect of cGMP in ischemia/reperfusion lung injury. Am. J. Resp. Crit. Care Med 163(5): A879, 2001.

Moore, T., B. Shirah, R. Nash, and A.E. Taylor. Acute lymphocytic involvement in ischemia/reperfusion-induced lung microvascular dysfunction.  Am. J. Resp. Crit. Care Med 163(5): A141, 2001.

Taylor, A.E., T.M. Moore, and P. Paisley. Permeability of the alveolar-capillary membrane. FASEB J.,  2002.

Taylor, A.E., T.M. Moore, and P. Paisley. The time has finally arrived: use of intravital microscopy in the airway circulation.  Am. J Physiol. Lung Cell Mol. Physiol. 282: L957 – L958, 2002.
           
Moore, T.M. and R. Rivers. Immunohistochemical identification of CGRP and adenosine A2A intrinsic neurons in hamster cheek pouch.  Microcirculation. 12(8): 655, 2005

Moore, T.M. Soluble CD40 ligand induces co-localization of CD40 with RAB5 in pulmonary microvascular endothelial cells. AFMR Eastern Regional Meeting April, 2007.

Moore, T.M. Pulmonary Microvascular endothelial cells expressing CD40 exhibit increased permeability in response to soluble CD40 ligand. 50th Annual Aspen Lung Conference, June, 2007.

 

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Last Updated: June 19, 2007