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    NIH - Funded Training in Cell Signaling & Lung Pathobiology
    		 

    Townsley, Mary I., Ph.D.
    Professor
    Phone: (251) 460-6815
    Fax: (251) 460-6464
    mtownsley@usouthal.edu


    Research Interests

    My laboratory is focused on understanding two facets of lung endothelial cell biology: 1) structural and functional adaptations in lung to heart failure and 2) factors which dictate the spatial heterogeneity in endothelial targets for acute lung injury. Currently funded work relates to identifying a role for the vanilloid transient receptor potential channel TRPV4 in regulation of calcium entry into endothelial cells, which impacts endothelial permeability. Further, we are evaluating the hypothesis that endothelial injury “fingerprints” in the lung are dictated by the spatial distribution of specific TRP channels. This work utilizes a variety of techniques ranging from specific measures of endothelial permeability in whole lung, microscopy and vascular corrosion casting, immunohistochemistry, and knockout or transient knockdown of TRPV4 in lung.
     
    EDUCATION
    B.A., Biology, Lycoming College, Williamsport, Pennsylvania, 1972
    Ph.D., Physiology, University of California, Davis, California, 1982
    Postdoctoral training, University of South Alabama, Mobile, Alabama, 1983-1986
    PROFESSIONAL EXPERIENCE
    Assistant Professor, Department of Physiology, 1986-1988, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio
     
    Assistant Professor, Department of Physiology, 1988-1991, University of South Alabama   College of Medicine, Mobile, Alabama
     
    Associate Professor, Department of Physiology, 1991-1995, University of South Alabama College of Medicine, Mobile, Alabama (Promotion and tenure granted in 1991)
    Professor, Department of Physiology, 1995-present, University of South Alabama College of Medicine, Mobile, Alabama
     
    Director, Interdisciplinary Graduate Program in Basic Medical Sciences, 2001-2004, University of South Alabama College of Medicine, Mobile, Alabama
     
    Director, Training Programs, Center for Lung Biology, 2002-present, University of South  Alabama College of Medicine, Mobile, Alabama 
    Assistant Dean, Office of Faculty Affairs, 2004-present, University of South Alabama College of  Medicine, Mobile, Alabama
     
    HONORS
    NIH Predoctoral Fellowship, University of California, Davis, 1979-1982
    Loren D. Carlsen Award in Physiology, University of California, Davis, 1983
    Parker B. Francis Pulmonary Fellow, 1983-1984
    NIH Postdoctoral Fellowship, 1984-1986
    Draco Award, Microcirculation Society, 1987 
    Travel Award for 31st IUPS, American Physiological Society, 1989
    American Physiological Society, Elected Fellow of the Cardiovascular Section, 1993
    1999-2000 Class of Fellows in the Hedwig van Ameringen Executive Leadership in Academic Medicine (ELAM) Program for Women
    Alpha Omega Alpha Medical Honor Society, Elected 2000 
    American Heart Association, Elected Fellow, AHA Council on Cardiopulmonary, Perioperative and Critical Care, 2003
     
    EDITORIAL BOARDS
    Clinical Science, 2000-2001
    Microcirculation, 1999-2002
    American Journal of Physiology, Heart and Circulatory Physiology, 1997-1998
    Microvascular Research, 1997-present
     
    STUDY SECTION SERVICE
    Alabama Heart Association Grant Review Board, 1991-1994; Co-Chair, 1994
    NIH Clinical Sciences Study Section; Ad Hoc 1990, 1992; Member 1992-1994
    NIH Physiological Sciences Study Section, 1994
    NIH General Medicine A Study Section, 1994
    AHA Lung and Development Study Committee, 1994-1997
    NIH Physiological and Biological Sciences Special Emphasis Study Section, 1996
    Chair, Committee 4 AHA Southern Research Consortium, 1997-1998
    VA Merit Review Subcommittee for Respiration, 1998-2000 
    AHA Lung, Respiration and Resuscitation National Study Committee, Chair, 2001-2003; 
    Co-Chair, 1997-1998, 2000
    NIH ZRG1 RES B (02), October, 2004; Chair
     
    NATIONAL SERVICE
    Mentor, NIDDK/APS Minority Fellows Program, 1988, 1989, 1997
    APS, Career Opportunities in Physiology Committee, 1988-1991
    Microcirculatory Society, Executive Council, 1993-1996
    APS, Women in Physiology Committee, 1996-1998
    AHA Southeast Affiliate, Vice Chair, Research Committee, 2000-2002
    AHA National Research Committee, 2000-2005
    AHA Council Delegate, Delegate Assembly, 2001
    Chair, Review Team for Department of Veterinary Physiology & Pharmacology, Texas A&M
    University, Review of Doctoral Programs, 2001
    Gulf Coast Physiological Society, President, 2002-2004 
    AHA Southeast Affiliate, Chair, Research Committee, 2002-2004
    AHA Southeast Affiliate, Board of Directors, 2002-2004
    APS, Cardiovascular Section Nominating Committee (elected), 2002-2005
    AHA Steering Committee, 2004-2005
    Chair, AHA Council on Cardiopulmonary, Perioperative and Critical Care, 2005-2007
     
    GRANT FUNDING - Current 
    NIH/NHLBI (R01 HL081851): "TRPV4 in regulation of lung endothelial permeability”, 2005-2009; Total direct costs $1,000,000; Principal investigator 
    NIH/NHLBI (T32 HL076125): "Training in cell signaling and lung pathobiology"; 2004-2009; Total direct costs $796,231; Program director.
    NIH/NHLBI (R01 HL39045): "T-lymphocyte involvement in lung ischemia-reperfusion injury”, 2003-2005; Total direct costs $400,000; Principal investigator
    AHA Southeast Affiliate, Predoctoral Fellowship (0315049B): “Role of P450 arachidonic acid metabolites in regulation of pulmonary endothelial cell permeability”; 2003-2005; Total direct costs $36,000; Sponsor for Diego Alvarez
     
    GRANT FUNDING - Previous Awards
    NIH/NHLBI (RO1 HL61955): “Heart failure-induced alterations in regulation of pulmonary endothelial permeability”, 1999-2003; Total direct costs $680,274; Principal investigator 
    NIH/NHLBI (R01 HL39045): "Lung microcirculation with high vascular pressures", 1996-2000; Total direct costs $560,984; Principal investigator
    AHA Southeast Affiliate Grant-in-Aid (9810109): “Peripheral microvascular permeability response to autocoids in heart failure: role of catecholamines and prostanoids”, 1998-2000; Total direct costs $66,071; Collaborating investigator; D. Lynn Dyess, M.D., Principal investigator
    AHA National Center Grant-in-Aid (96015130): "Lung microcirculation with high vascular pressures”, 1996-1999; Total direct costs $120,000; Principal investigator (awarded but declined)
    APS Porter Physiology Development Program; Predoctoral Fellowship for Ron McMillon, 1994-1996; Total direct costs $13,500; Faculty mentor 
    AHA Established Investigatorship (92001990): "Lung remodeling in chronic pulmonary venous hypertension", 1992-1997; Total direct costs $265,000; Principal investigator
    NIH Research Career Development Award (K04 HL02732): "Lung adaptation to chronic pulmonary hypertension", 1992-1997; Total direct costs $247,700; Principal investigator; relinquished April, 1992 to accept Established Investigatorship
    NIH/NHLBI (R01 HL39045): "Lung microcirculation with high vascular pressures", 1992-1995; Total direct costs $324,498; Principal investigator
    AHA National Center Grant-in-Aid (91006760): "The pulmonary circulation in congestive heart failure", 1991-1994; Total direct costs $120,000; Principal investigator
    NATO Travel Grant for Research Collaboration : "Measurement of microvascular permeability in skin, lung, and ileum", 1989-1993; Total direct costs $15,500; Co-investigator with Dr. Rolf K. Reed, University of Bergen, Norway
    ECFMG Foreign Faculty Fellowship for Dr. Vijay Devi Mathur, Professor of Physiology Kakatiya Medical College, Warangal, India, 1989-1990; Total direct costs $4,004; Co-director
    NIH/NHLBI FIRST Award (R29 HL39045): "Lung capillary permeability with high vascular pressure", 1987-1992; Total direct costs $343,083; Principal investigator
    AHA Alabama Affiliate:  "Lung permeability: mechanical stress in traumatized lungs", 1986-1987; Total direct costs $15,125; Principal investigator 
    NIH/NHLBI New Investigator Award (R23 HL36332): "Lung capillary permeability with high vascular pressure", 1986-1987; Total direct costs $33,250; Principal investigator 
    TRAINEE AWARDS
    Vijay Mathur, M.D. – postdoctoral fellow (1988-1989): ECFMG Foreign Faculty Fellowship 
    Svein Åge Rodt, M.D. - postdoctoral fellow (1991-1992): fellowship support Norwegian Research Council 
    Ron McMillon – predoctoral student (1994-1998): APS Porter Physiology Development Program Predoctoral Fellowship; APS/NIDDK Travel Awards
    Diego Alvarez, M.D.– predoctoral student (2001-2005): AHA Southeast Affiliate, Predoctoral Fellowship; Caroline Tum Sudem-Frances Hellebrandt Professional Opportunity Award; Presidential Student Award, Microscopy Society of America; APS Respiration Section Research Recognition Award; Travel Award, Southeast Microscopy Society 
    Eli-Anne Gjerde, Ph.D.- postdoctoral fellow (2002-2003): fellowship support Norwegian Research Council 
     
    INVOLVEMENT IN TRAINING

    Undergraduate Honor’s Program (Biology and University)
              Emile Addison, 2005-2006

    Master's degree in Biology
              Margery Halstead (M.S., 1993); Pulmonary vascular      responses to ACh and bradykinin in pacing-induced heart failure  

    Mentor, Ph.D. in Physiology
              Diego Alvarez (2001-projected completion spring 2005)
              Ronald McMillon (Ph.D., 1998)
              Allen Lee (1994-1995)
     
    Service on other Ph.D. Committees 

    Patti Sadowsky (Pharmacology), current
    Qining Qin (Physiology, Ph.D. 2004)
    Wesley Denny (Pharmacology, Ph.D. 2003)
    Kathy Ault-Ziel (Pharmacology, Ph.D., 2002) 
    Natalie Norwood (Pharmacology, Ph.D., 2001) 
    David Killilea (Pharmacology, Ph.D., 2000)
    Cherry Ballard (Pharmacology, Ph.D., 1998)
    Peter Wilson (Physiology, Ph.D., 1998)
    Ling Zhao (Pharmacology, Ph.D., 1997)
    Hafeez Diwan (Pharmacology, Ph.D., 1997)
    Tim Moore (Physiology, Ph.D., 1996) 
    Todd Engerson ( Biochemistry, Ph.D., 1991)
    Keith Adkins (Physiology, Ph.D., 1991) 

    Postdoctoral Fellows

    Eli-Anne Gjerde, Ph.D. (2002-2003)
    Siobhan Tarpey, Ph.D. (1999-2003) 
    Darryl Sawmiller, Ph.D. (1999)
    Claire Ivey, Ph.D. (1996-1998) 
    Bev Roy, M.D. (1992-1996)
    Svein Åge Rodt, M.D. (1991-92) 
    DaChang Liu, M.D. (1991) 
    Zhuodao Zhao, M.D. (1990-1992) 
    Vijay Mathur, M.D. (1988-89) 
    PUBLICATIONS

    1.         Riordan KK, Weiskopf RB, Townsley MI, Chadwick KR.  Oxygen-linked hydrogen ion binding of canine blood. Pflüegers Arch. 1981; 390:99-101.

     2.        Weiskopf RB, Townsley MI, Riordan KK, Chadwick K. Comparison of cardiopulmonary responses to graded hemorrhage during enflurane, halothane, isoflurane, and ketamine anesthesia. Anes. Analg. 1981; 60:481-491.

     3.        Jones TA, Townsley MI, Weidner WJ. Effects of intracranial and left atrial hypertension on lung fluid balance in sheep. J. Appl. Physiol. 1982; 52:1324-1329.

     4.        Weiskopf RB, Townsley MI, Riordan KK, Harris D, Chadwick K.  Acid-base curve and alignment nomograms for swine blood. J. Appl. Physiol. 1983; 54:978-983.

     5.        Townsley MI, McClure DE, Weidner WJ. Assessment of pulmonary microvascular permeability in acutely prepared sheep. J. Appl. Physiol. 1984; 56:857-861.

     6.        Rippe B, Townsley M, Thigpen J, Parker JC, Korthuis RJ, Taylor AE.  Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs. J. Appl. Physiol.1984; 57:233-239.

     7.        Parker JC, Townsley MI, Rippe B, Taylor AE, Allison RC. Increased microvascular permeability in dog lungs due to high peak airway pressures. J. Appl. Physiol. 1984; 57:1809-1816.

     8.        Korthuis RJ, Townsley MI, Rippe B, Taylor AE. Estimation of isogravimetric capillary pressure by a filtration method in skeletal muscle and lung. J. Appl. Physiol. 1984; 57:1817-1823.

     9.        Rippe B, Townsley M, Parker JC, Taylor AE. Osmotic reflection coefficient for total plasma protein in lung microvessels. J. Appl. Physiol. 1985; 58:436-442.

    10.        Townsley MI, Korthuis RJ, Taylor AE. Effect of arachidonic acid on the distribution of vascular resistance in the canine lung. J. Appl. Physiol. 1985; 58:206-210.

    11.        Korthuis RJ, Granger DN, Townsley MI, Taylor AE. Autoregulation of capillary pressure and filtration rate in isolated rat hindquarters. Am. J. Physiol. 1985; 248:H835-H842.

    12.        Townsley MI, Korthuis RJ, Taylor AE. Specific hemodynamic effects of PGE2 and PGF1 in the canine lung. Prostagl. Leukotr. Med. 1985; 20:275-282.

    13.        Korthuis RJ, Kerr CR, Townsley MI, Taylor AE. Microvascular pressure, surface area, and permeability in isolated hindquarters of SHR. Am. J. Physiol. 1985; 249:H498-H504.

    14.        Korthuis RJ, Granger DN, Townsley MI, Taylor AE. The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability. Circ. Res. 1985; 57:599-609.

    15.        Taylor AE, Townsley MI, Korthuis RJ. Macromolecule transport across the pulmonary microvessel walls. Exp. Lung Res. 1985; 8:95-121. (INVITED)

    16.        Townsley MI, Taylor GE, Korthuis RJ, Taylor AE. Promethazine or DPPD pretreatment attenuates oleic acid-induced injury in isolated canine lungs. J. Appl. Physiol. 1985; 59:39-46.

    17.        Rippe B, Townsley MI, Taylor AE. Effects of plasma- and cell-free perfusates on filtration coefficient of perfused isolated canine lungs.  J. Appl. Physiol. 1985; 58:1521-1527.

    18.        Taylor AE, Korthuis R, Townsley M. Use of lymphatic protein fluxes to assess vascular endothelial selectivity to macromolecules. Prog. Appl. Microcirc. 1985; 9:100-115.

    19.        Korthuis RJ, Benoit JN, Kvietys PR, Townsley MI, Taylor AE, Granger DN. Humoral factors may mediate increased rat hindquarter blood flow in portal hypertension. Am. J. Physiol. 1985; 249:H827-H833.

    20.        Townsley MI, Korthuis RJ, Rippe B, Parker JC, Taylor AE.  Validation of double vascular occlusion method for Pc,i in lung and skeletal muscle. J. Appl. Physiol. 1986; 61:127-132.

    21.        Martin D, Korthuis RJ, Perry M, Townsley MI, Taylor AE. Oxygen radical-mediated lung damage associated with -napthylthiourea.  Acta Physiol. Scand. 1986; 126 (Suppl. 548):119-125.

    22.        Allison RC, Marble KT, Hernandez EM, Townsley MI, Taylor AE.  Attenuation of permeability lung injury after phorbol myristate acetate by verapamil and OKY-046. Am. Rev. Resp. Dis. 1986; 134:93-100.

    23.        Rippe B, Parker JC, Townsley MI, Mortillaro NA, Taylor AE.  Segmental vascular resistances and compliances in dog lung. J. Appl. Physiol. 1987; 62:1206-1215.

    24.        Townsley MI, Parker JC, Korthuis RJ, Taylor AE. Alterations in hemodynamics and Kf,c during lung mass resection. J. Appl. Physiol. 1987; 63:2460-2466.

    25.        Weidner WJ, Jones TA, Townsley MI, DeFouw DO. Ultrastructural analysis of sheep lungs after increased intracranial pressure and development of pulmonary edema. Microcirc. Endoth. Lymphatics 1987; 3:397-410.

    26.        Taylor AE, Townsley MI. Evaluation of the Starling fluid flux equation. News in Physiol. Sci. 1987; 2:48 -52.  (INVITED)

    27.        Townsley MI, Parker JC, Longenecker GL, Perry ML, Pitt RM, Taylor AE. Pulmonary embolism: analysis of endothelial pore sizes in canine lung. Am. J. Physiol. 1988; 255:H1075-H1083.

    28.        Parker JC, Townsley MI, Cartledge JT. Lung edema increases transvascular filtration rate but not filtration coefficient. J. Appl. Physiol. 1989; 66:1553-1560.

    29.        Reed RK, Townsley MI, Taylor AE. Estimation of capillary reflection coefficient and unique PS products in dog paw. Am. J. Physiol. 1989; 257:H1037-H1041.

    30.        Townsley MI, Barman SA, Taylor AE. Pulmonary embolism: emboli and fibrinolysis inhibition in isolated canine lungs. Am. J. Physiol. 1990; 258:H754-H758.

    31.        Shibamoto T, Parker JC, Taylor AE, Townsley MI. Derecruitment of filtration surface area in paraquat-injured dog lungs. J. Appl. Physiol. 1990; 68:1581-1589.

    32.        Negrini D, Townsley MI, Taylor AE. Hydraulic conductivity of canine parietal pleura in vivo. J. Appl. Physiol. 1990; 69:438-442.

    33.        Townsley MI, Lim EH, Sahawneh TM, Song W. Interaction of chemical and high vascular pressure injury in isolated canine lung. J. Appl. Physiol. 1990; 69:1657-1664.

    34.        Townsley MI, Negrini D, Ardell JL. Regional blood flow to canine parietal pleura and internal intercostal muscle. J. Appl. Physiol. 1991; 70:97-102.

    35.        Reed RK, Townsley MI, Korthuis RJ, Taylor AE.  Analysis of lymphatic protein flux data. V. Unique PS products and d's at low lymph flows. Am. J. Physiol. 1991; 261:H728-H740.

    36.        Ishibashi M, Reed RK, Townsley MI, Parker JC, Taylor AE. Albumin transport across pulmonary capillary-interstitial barrier in anesthetized dogs. J. Appl. Physiol. 1991; 70:2104-2110.

    37.        Ferrara JJ, Reed RK, Dyess DL, Townsley MI, Onarheim H, Laurent TC, Taylor AE. Increased hyaluronan flux from skin following burn injury. J. Surg. Res. 1991; 50:240-244.

    38.        Townsley MI, Smith SM, Reed RK, Pitts VH, Taylor AE. Ileal microvascular permeability: a comparison of PS and d using lymphatic and isotopic protein clearances. Am. J. Physiol. 1992; 262:G572-G580.

    39.        Reed RK, Townsley MI, Laurent TC, Taylor AE. Hyaluronan flux from cat intestine: changes with lymph flow. Am. J. Physiol. 1992; 262:H457-H462.

    40.        Dyess DL, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ. Effects of hypertonic saline and dextran 70 resuscitation on microvascular permeability after burn. Am. J. Physiol. 1992; 262:H1832-H1837.

    41.        Reed RK, Townsley MI, Korthuis R, Taylor AE. Letter to the Editor.  Am. J. Physiol. 1992; 263:H1972-H1973.

    42.        Reed RK, Townsley MI, Smith SM, Laurent TC, Taylor AE.  Increased lymphatic flux of hyaluronan from cat intestine during fat absorption. Am. J. Physiol. 1992; 263:G6-G11.

    43.        Laurent TC, Alston-Smith J, Allen SJ, Asplund T, Berg S, Dahl IMS, Dahl LB, Edelstam GAB, Forsberg N, Engström-Laurent A, Fraser JRE, Gustafson S, Heldin P, Henriksen JH, Johnsson H, Laurent C, Laurent UBG, Lebel L, Lilja K, Lindqvist U, McCourt PAG, Pertoft H, Reed RK, Rodén L, Smedsröd B, Tengblad A, Townsley MI, Wells A, Wikström T, Ytterberg D.  Turnover of hyaluronan. In: Proceedings of the 2nd Joint Meeting on Carbohydrates, Grado, Italy. 1992; p. 11-14.

    44.        Reed RK, Ishibashi M, Townsley MI, Parker JC, Taylor AE.  Blood-to-tissue clearance vs. lymph analysis in determining capillary transport characteristics for albumin in skin. Am. J. Physiol. 1993; 264:H1394-H1401.

    45.        Ferrara JJ, Dyess DL, Collins JN, Fish JM, Ardell JL, Townsley MI, Taylor AE, Flint LM. Effects of pentafraction administration on microvascular permeability alterations induced by graded thermal injury. Surgery 1994; 115:182-189.

    46.        Collins JN, Dyess DL, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ.  The effects of albumin administration on microvascular permeability at the site of burn injury. J. Trauma 1994; 36:27-33.

    47.        Reed RK, Townsley MI, Zhao Z, Ishibashi M, Laurent TC, Taylor AE.  Lymphatic hyaluronan flux from skin increases during increased lymph flow induced by intravenous saline loading. Int. J. Microcirc. 1994; 14:56 -61.

    48.        Negrini, D, Venturoli D, Townsley MI, Reed RK. Permeability of the parietal pleura to liquid and proteins. J. Appl. Physiol. 1994; 76:627-633.

    49.        Townsley MI, Pitts VH, Ardell JL, Zhao Z, Johnson WH Jr.  Altered pulmonary microvascular reactivity to norepinephrine in canine pacing-induced heart failure. Circ. Res. 1994; 75:347-356.

    50.        Ferrara JJ, Dyess DL, Collins JN, Fish JM, Markert AJ, Ardell JL, Townsley MI, Flint LM, Taylor AE. Effects of graded thermal injury on microvascular permeability at the site of injury. J. Surg. Res. 1994; 57:420-426.

    51.        Rodt SÅ, Reed RK, Townsley MI. Increased hyaluronan flux in canine paw lymph induced by histamine and the histamine-releasing agent C48-80. Int. J. Microcirc. 1994; 14:212-217.

    52.        Townsley MI, Reed RK, Ishibashi M, Parker JC, Laurent TC, Taylor AE. Hyaluronan efflux from canine lung: effects of increased hydrostatic pressure and saline loading. Am. J. Resp. Crit. Care Med. 1994; 150:1605-1611.

    53.        Townsley MI, Fu Z, Mathieu-Costello O, West JB. Pulmonary microvascular permeability: responses to high vascular pressure after induction of pacing-induced heart failure in dogs. Circ. Res. 1995; 77:317-325.

    54.        Rizzo A, Taylor AE, Townsley MI, Logsdon P, Khimenko P, Fletcher JR. Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2. Am. J. Physiol. 1995; 268:H1954-H1958. 

    55.        Townsley MI, McMillon RK, Lee AK. Regulation of tissue oxygenation. Sem. Resp. Crit. Care Med. 1995; 16:361-371.  (INVITED)

    56.        Townsley MI, Erlanson-Albertsson C, Olsson A, Reed RK.  Enterostatin flux in cat intestinal lymph: relation to lymph flow, hyaluronan, and fat absorption. Am. J. Physiol. 1996; 271:G714-G721.

    57.        Roy B, Townsley MI. Pulmonary vascular responses to angiotensin II in canine pacing-induced heart failure. Am. J. Physiol. 1996; 271:H222-H227. 

    58.        Taylor AE, Moore TM, Townsley MI.  Evaluation of endothelial barrier damage in lungs. Pathophysiology 1998; 5:85-90

    59.        Ivey CL, Roy BJ, Townsley MI. Ablation of lung endothelial injury after pacing-induced heart failure is related to alterations in calcium signaling. Am. J. Physiol. 1998; 275:H844-H851.

    60.        Ivey CL, Stephenson AH, Townsley MI. Involvement of cytochrome P450 enzyme activity in the control of microvascular permeability in canine lung. Am. J. Physiol. 1998; 275:L756-L763.

    61.        Parker JC, Townsley MI, Stevens T. Calcium dependence of mechanical injury to lung capillaries. Letter to the Editor. J. Appl. Physiol. 1999; 86:775-776.

    62.        McMillon RK, Townsley MI. -Adrenergic vasoreactivity of canine intrapulmonary bronchial arteries in pacing-induced heart failure Am. J. Physiol. 1999; 277:H1392-H1402.

    63.        Townsley MI, Snell KS, Ivey CL, Culberson DE, Liu D, Reed RK, Mathieu-Costello O. Remodeling of interstitium but not extra-alveolar resistance vessels in canine pacing-induced heart failure. J. Appl. Physiol. 1999; 87:1823-1830.

    64.        Zhu D, Bousamra M, Zeldin DC, Falck JR, Townsley MI, Harder DR, Roman RJ, Jacobs ER. Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries. Am. J. Physiol. 2000; 278:L335-L343.      

    65.        Dyess DL, Collins JN, Ardell JL, Townsley MI, Taylor AE, Ferrara JJ.  Modulation of microvascular permeability after burn injury by 21-aminosteroids. J. Burn Care Rehabil. 2000; 21:406-413.

    66.        Dyess DL, Hunter JL, Lakey JR, Moyer D, Dougherty FG, Townsley MI. Attenuation of histamine-induced endothelial permeability responses after pacing-induced heart failure: role for endogenous catecholamines. Microcirculation 2000;7:307-316.

    67.        Townsley MI. Successful grantsmanship: Navigating the AHA granting process. Newsletter of the Council on Cardiopulmonary and Critical Care 2001; Fall. (INVITED)

    68.        Tarpey SB, Sawmiller DR, Kelly CI, Thompson WJ, Townsley MI.  Phosphodiesterase 3 (PDE 3) activity is reduced in dog lung following pacing-induced heart failure. Am. J. Physiol. Lung Cell Mol. Physiol. 2003; 283: L766-L773.

    69.        Trout L, Townsley MI, Bowden AL, Ballard ST. Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lungs. J. Physiol. 2003; 549: 845-853.

    70.        Dougherty FC, Donovan FM, Townsley MI. Harmonic analysis of perfusion pumps. J. Biomech. Eng. 2003; 125: 814-822.         

    71.        Parker JC, Townsley MI.  Evaluation of lung injury in rats and mice.  Am. J. Physiol. Lung Cell Mol. Physiol 2004; 286: L231-L246.  INVITED REVIEW

    72.        Alvarez DF, Gjerde EB, Townsley MI.  Role of EETs in regulation of endothelial permeability in rat lung. Am. J. Physiol. Lung Cell Mol. Physiol. 2004; 286: L445-L451. 

    73.        Hsia C, Berberich MA, Driscoll B, Laubach VE, Lillehei CW, Massaro DJ, Perkett EA, Pierce RA, Rannels DE, Ryan RM, Tepper RS, Townsley MI, Veness-Meehan KA, Wang N, Warburton D. ATS Document: Mechanisms and limits of induced postnatal lung growth.  Am. J. Respir. Crit. Care Med. 2004; 170: 319-343.

    74.        Wu S, Cioffi EA, Alvarez D, Sayner SL, Chen H, Cioffi DL, King J, Creighton JR, Townsley M, Goodman SR, Stevens T. Essential role of a Ca2+ selective, store operated current (ISOC) in endothelial cell permeability. Determinants of the vascular leak site. Circ. Res. 2005; 96: 856-863.

    75.        Alvarez DF, King JA, Townsley MI.  Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. Am. J. Resp. Crit. Care Med. 2005; submitted.

    BOOK CHAPTERS

     1.        Taylor AE, Rippe B, Townsley M, Korthuis R, Parker JC. Interstitial lung tissue fluid resistance. In: Frontiers in Physiological Research.  Garlick DG, Korner PI, eds. Canberra: Australian Academy of Sciences. 1984; p. 147-154.

     2.        Taylor AE, Martin D, Townsley MI. Oxygen radicals and pulmonary edema. In: The pulmonary circulation and acute lung injury. Said SI, ed. Mount Kisco, NY: Futura Publishing, 1985; p. 307-320.

     3.        Taylor AE, Cope DK, Allison RC, Townsley MI, Holloway H.  Estimation of pulmonary capillary pressure using Swan-Ganz catheters. In: Update in intensive care and emergency medicine.  Vincent JL, ed. Berlin: Springer-Verlag, 1985; p.127-132.

     4.        Townsley MI, Taylor AE. Role of oxygen radicals in free fatty acid-induced lung injury. In: Physiology of oxygen radicals. Taylor AE, Matalon S, Ward P, eds. Bethesda: American Physiological Society, 1986; p.169-186.

     5.        Taylor AE, Townsley MI. Assessment of oxygen radical tissue damage. In: Physiology of oxygen radicals. Taylor AE, Matalon S, Ward P, eds. Bethesda: American Physiological Society, 1986; p.19-38.

     6.        Townsley MI, Taylor AE. Involvement of oxygen radicals in pulmonary edema. In: Handbook of free radicals and antioxidants in biomedicine, Vol. 1. Miquel J, Quintanilha AT, Weber H, Eds. Boca Raton: CRC Press, Inc., 1989; p. 297-314.

     7.        Townsley MI, Lee AK, McMillon RK, Roy BJ. Pulmonary microvascular adaptations to heart failure and pulmonary venous hypertension. In: The pathophysiology of tachycardia induced heart failure. Spinale FG, Ed. Mount Kisco, NY: Futura Publishing Co. 1996; 173-192. 

     8.        Townsley MI, Neal C, Michel CC. High vascular pressure injury. In: Connective Tissue Biology: Integration and Reductionism. Reed RK, Rubin K, Eds., Portland Press, London, 1998, pp. 207-220.

     9.        Townsley MI. Hydrostatic pulmonary edema. In: Pulmonary Edema.  Matthay M, Ingbar D, Eds., Marcel Dekker, New York, 1998, pp. 163-202.