EDUCATIONAL HISTORY

RESEARCH AND PROFESSIONAL EXPERIENCE

HONORS

• Graduated top 10%, Chadron State College, 1986.

• Captain, Intercollegiate Basketball, Chadron State College, 1983-1986.

• Academic All-American Nominee, Intercollegiate Basketball, Chadron State College, 1986.

• NHLBI Postdoctoral Fellowship through the Cardiovascular-Pulmonary Research Laboratory, University of Colorado Health Sciences Center, 1991-1994.

• Parker B. Francis Fellowship Award for Research in Pulmonary Medicine, 1995-1998.

• Giles Filley Memorial Award for Research in Pulmonary Medicine, 1995.

• Editorial Board of American Journal of Physiology: Lung Cellular and Molecular Physiology, 1999-present.

• Medical Education Teaching Recognition, University of South Alabama College of Medicine Graduating Classes of 2000-2002.

• Chair and Organizer, NIH Workshop on Endothelial Cell Phenotypes in Heart, Lung and Blood Diseases, Bethesda MD, 2000.

• US Delegate for US-Russia Symposium on Basic Research in Cardiovascular and Pulmonary Diseases, Moscow Russia, 2001.

• US Delegate for US-Italy Symposium on Pathophysiology and Therapeutic Approaches for Vascular Remodeling, Atlanta GA, 2002.

• Associate Editor of "Microvascular Research" for Elsevier Science, 2003 - present.

• At-Large Member for Leadership Committee, Council on Cardiopulmonary and Critical Care for the American Heart Association National Center, 2003 - present.

• Fellow of Council on Cardiopulmonary, Perioperative and Critical Care for the American Heart Association National Center, 2003-present.

• Student Trainee Awards
  Timothy M. Moore, Ph.D. Postdoctoral Fellow, 1996-1999. Recipient of an American Heart Association Fellowship, 1997-1999 and of the Henry Christian Award for excellence in research by the American Federation of Medical Research, 1999.
  
  Songwei Wu, M.D. Postdoctoral Fellow, 1998-2001. Recipient of an American Heart Association Fellowship, 1999-2001 and National Scientist Training Grant Award, 2002-2006.
  
  Judy Creighton, B.S. Graduate Student, 1996-1998. Abstract selected for Special Topics presentation by the Respiration Section of the American Physiological Society, Experimental Biology, 1999.
  
  Natalie N. Norwood, Ph.D. Doctoral Candidate, 1996-2001. Recipient of the Procter & Gamble Professional Opportunity Award for Meritorious Research, presented by The American Physiological Society, 2000.
  
  Donna Cioffi, M.S. Doctoral Candidate, 1999-present. Abstract selected for Special Topics presentation by the Respiration Section of the American Physiological Society, Experimental Biology, 2001 and 2002. Recipient of an American Heart Association Predoctoral Fellowship Award, 2002-2004, and of the Young Investigator Award from the American Physiological Society Respiration Section, 2003.
  
  Prya Bhat, B.S. Medical Student, 2001. Summer student, abstract selected as best poster, University of South Alabama College of Medicine, 2001.
  
  Sarah Sayner, B.S. Doctoral Candidate, 2001-present. Abstract selected for Special Topics presentation by the Respiration Section of the American Physiological Society, Experimental Biology, 2002. Recipient of an American Heart Association Predoctoral Fellowship Award, 2003-2005.

ACTIVE GRANT SUPPORT

1. NIH PO1 HL66299, 2001-2006
   TITLE: Lung endothelial cell phenotypes
   Principal Investigator: T. Stevens 
   Funded: $6,620,000
   
   Project 1: Calcium inhibition of cAMP in endothelial permeability
   Project Leader: T. Stevens, Ph.D.
   
   Project 2: Stretch-induced Ca²⁺ entry in pulmonary endothelium
   Project Leader: J. Parker, Ph.D.
   
   Project 3: Mitochondrial DNA integrity and endothelial cell free radical stress
   Project Leader: M. Gillespie, Ph.D.
   
   Core 1: Administrative 
   Core Leader: T. Stevens, Ph.D.
   
   Core 2: Cell isolation, culture and characterization
   Core Leaders: T. Stevens, Ph.D. and J. King, M.D.
   
   Core 3: Gene Delivery
   Core Leader: J. Olson, Ph.D. and Mikhail Alexeyev, Ph.D.

2. NIH RO1 HL56050, 1996-2001
   TITLE: Calcium inhibition of cAMP in endothelial permeability
   Principal Investigator: T. Stevens (50%) 
   Co-Investigator: D. Cooper
   Funded: $752,000 
   
   NIH 2 RO1 HL56050-06, 2001-2006 [Competitive Renewal]
   TITLE: Calcium inhibition of cAMP in endothelial permeability
   Principal Investigator: T. Stevens (40%) 
   Co-Investigator: S. Goodman, J. King
   Funded: $1,446,000
   NOTE: Returned to accept PO1 listed above.

3. NIH RO1 HL60024, 1998-2002
   TITLE: Store operated Ca²⁺ entry: Lung endothelial permeability
   Principal Investigator: T. Stevens (30%) 
   Co-Investigator: M. Alexeyev, S. Wu
   Funded: $1,208,000
   
   NIH 2 RO1 HL60024-05, 2002-2006 [Competitive Renewal]
   Principal Investigator: T. Stevens (30%) 
   Co-Investigator: S. Goodman, M. Alexeyev, S. Wu
   TITLE: Store operated calcium entry: Lung endothelial permeability
   Funded: $1,498,548

4. NIH RO1 HL66347, 2000-2005
   TITLE: Mechanical injury to lung endothelium
   Principal Investigator: J. Parker 
   Co-Investigator: T. Stevens (10%)
   Funded: $1,244,615
   NOTE: Returned to accept PO1 listed above.

5. American Heart Association, Southeastern Affiliate, 2002-2004 [Predoctoral Fellowship]
   TITLE: Regulation of endothelial barrier integrity by protein 4.1-dependent store operated Ca entry
   Principal Investigator: D. Cioffi 
   Sponsor: T. Stevens
   Funded: $36,000

6. American Heart Association, Southeastern Affiliate, 2003-2005 [Predoctoral Fellowship]
   TITLE: Pseudomonas aeruginosa adenylyl cyclase synthesizes a cAMP pool that induces pulmonary microvascular endothelial gap formation
   Principal Investigator: S. Sayner 
   Sponsor: T. Stevens
   Funded: $36,000

7. NIH R13 HL075254 Conference Grant, 2004
   TITLE: Genetic and environmental determinants of pulmonary endothelial cell function conference (2004 Grover Conference)
   Principal Investigator: T. Stevens
   Funded: $35,000

8. NIH RO1, 2003-2008
   TITLE: Cytoskeletal activity in pulmonary microvascular cells
   Principal Investigator: R. Balczon 
   Co-Investigator: T. Stevens
   Pending: $1,640,200

9. NIH RO1, 2004-2009
   TITLE: Endothelial mitochondria under flow and ischemia
   Principal Investigator: A. Al-Mehdi 
   Co-Investigator: T. Stevens
   Pending: $912,500

10. NIH T32 HL076125, 2004-2009
    TITLE: Training in cell signaling and lung pathobiology
    Principal Investigator: M. Townsley 
    Co-Investigator: T. Stevens
    Pending: $849,023

PAST GRANT SUPPORT

1. Biomedical Research Supply Grant, 1989-1990
   TITLE: Rheumatoid arthritis: role of TNF-a 
   Principal Investigator: A. Tucker 
   Co-Investigator: T. Stevens
   Funded: $20,000

2. American Heart Association, Colorado Affiliate, 1990-1991
   TITLE: The effect of acute and chronic TNF-a administration on pulmonary 
   vascular reactivity in conscious rats
   Principal Investigator: A. Tucker 
   Co-Investigator: T. Stevens
   Funded: $19,000

3. American Lung Association, Research Grant, 1993-1995
   TITLE: Hypoxia and mechanisms of pulmonary endothelial vasodilator production
   Principal Investigator: T. Stevens 
   Co-Investigator: D. Cooper
   Funded: $50,000

4. American Heart Association-Colorado, Research Grant-in-Aid, 1994-1995
   TITLE: The role of adenylyl cyclases in endothelial permeability
   Principal Investigator: T. Stevens 
   Co-Investigator: D. Cooper
   Funded: $25,000

5. Society of Cardiovascular Anesthesiologists, 1995-1997
   TITLE: Intracellular Ca²⁺ release modulates ischemia-reperfusion pulmonary edema
   Principal Investigator: P. Chetham 
   Co-Investigator: T. Stevens
   Funded: $50,000 (Declined)

6. Parker B. Francis Pulmonary Fellowship, 1995-1998
   TITLE: The role of Ca²⁺ inhibitable adenylyl cyclase in pulmonary endothelial permeability
   Principal Investigator: T. Stevens 
   Sponsor: I.F. McMurtry and M.N. Gillespie
   Funded: $108,000

7. Giles Filley Memorial Award in Respiratory Physiology and Medicine, 1995-1996
   TITLE: The role of Ca²⁺ inhibitable adenylyl cyclase in pulmonary endothelial permeability
   Principal Investigator: T. Stevens
   Funded: $12,000

8. American Heart Association, Research Grant-in-Aid, 1995-1998
   TITLE: The role of Ca²⁺ inhibitable adenylyl cyclase in pulmonary endothelial permeability
   Principal Investigator: T. Stevens 
   Co-Investigator: D. Cooper
   Funded: $140,000 (Returned)

9. American Heart Association, Fellowship, 1996-1998
   TITLE: Regulation of pulmonary microvascular endothelial function by avb 3 integrins: Roles of Ca²⁺ and cyclic AMP
   Principal Investigator: T. Stevens 
   Fellow: T. Moore
   Funded: $45,000

10. American Heart Association, Fellowship, 1999-2001
    TITLE: Control of lung endothelial cell membrane potential by novel cyclic nucleotide-gated 
    channel: response to inflammation
    Principal Investigator: T. Stevens 
    Fellow: S. Wu
    Funded: $50,000

11. NIH RO1 HL61955, 1999-2003
    TITLE: Lung permeability in congestive heart failure
    Principal Investigator: M. Townsley 
    Co-Investigator: T. Stevens (10%)
    Funded: $1,496,000

12. NIH RO1 HL62489, 1999-2004
    TITLE: Regulation of pulmonary resistance vessels
    Principal Investigator: J. Aschner 
    Co-Investigator: T. Stevens 
    Funded: $1,296,262
    NOTE: This project is sub-contracted with Wake Forest Universit

ORIGINAL PUBLICATIONS

1. Stevens T, Janssen P, and Tucker A. Acute and long-term TNF-a  administration increases pulmonary vascular reactivity in isolated-perfused rat lungs. J. Appl. Physiol., 73: 708-712, 1992.

2. Selland M, Stevens T, McCullough R, Stelzner T, McCullough R, Mazzeo R, and Reeves J. Pulmonary function and hypoxic ventilatory response in subjects susceptible to high altitude pulmonary edema. Chest, 103: 111-116, 1993.

3. Stevens T, Morris K, McMurtry I, Zamora M, and Tucker A. Pulmonary and systemic vascular responsiveness to TNF-a in conscious rats. J. Appl. Physiol., 74: 1905-1910, 1993.

4. Cornfield D, Stevens T, Abman S, McMurtry I, and Rodman D. Hypoxia increases basal and stimulated cytosolic Ca²⁺ in ovine fetal pulmonary artery smooth muscle cells. Am. J. Physiol., 265: L53-L56, 1993.

5. Stevens T, Cornfield D, McMurtry I, and Rodman D. Acute reductions in pO2 depolarize pulmonary artery endothelial cells and decrease intracellular free Ca²⁺. Am. J. Physiol., 266: H1416-H1421, 1994.

6. Cornfield D, Stevens T, McMurtry I, Abman S, and Rodman D. Acute hypoxia causes membrane depolarization and Ca²⁺ influx in fetal pulmonary artery smooth muscle cells. Am. J. Physiol., 266: L469-L475, 1994.

7. Yohn J, Smith C, Stevens T, Hoffman T, Morelli J, Hurt D, Yanagisawa M, Kane M, and Zamora M. Human melanoma cells express functional endothelin-1 receptors. Biochem. Biophys. Res. Comm., 201: 449-457, 1994.

8. Yohn J, Smith C, Stevens T, Morelli J, Dormish J, Kane M, and Zamora M. Evidence for an endothelin-1 autocrine system in normal human keratinocytes. Biochim. Biophys. Acta., 1224: 454-458, 1994.

9. Stevens T, Fouty B, Cornfield D, and Rodman D. Reduced pO₂ alters the behavior of Fura-2 and Indo-1 in bovine pulmonary artery endothelial cells. Cell Calcium, 16: 404-412, 1994.

10. Stevens T, Nakahashi Y, Cornfield D, McMurtry I, Cooper D, and Rodman D. Calcium inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function. Proc. Natl. Acad. Sci. USA, 92: 2696-2700, 1995.

11. Stevens T and Rodman D. The effect of hypoxia on endothelial cell function. Endothelium, 3: 1-11, 1995. [Invited Review]

12. White M, Zamudio S, Stevens T, Tyler R, Lindenfield J, Leslie K, and Moore L. Estrogen, progesterone and vascular reactivity: Potential cellular mechanisms. Endocrinol. Rev., 16: 739-751, 1995.

13. Dempsey E, Stevens T, Durmowitz A, and Stenmark K. Mechanisms of hypoxia-induced change in contraction, growth, and matrix synthetic properties of pulmonary vascular cells. In: Lung Biology Series - Tissue Oxygen Deprivation: Developmental, Molecular and Integrated Function (Eds. Haddad, G. and Lister, G.), Marcel Dekker, Inc., New York, New York, 1996.

14. Abman S and Stevens T. Oxygen and perinatal pulmonary vasoregulation: Implications for the pathophysiology and treatment of neonatal pulmonary hypertension. In: Lung Biology Series - Tissue Oxygen Deprivation: Developmental, Molecular and Integrated Function (Eds. Haddad, G. and Lister, G.), Marcel Dekker, Inc., New York, New York, 1996.

15. Stevens T, Fouty B, Hepler L, Richardson D, Brough G, McMurtry I, Rodman D. Cytosolic Ca²⁺ and adenylyl cyclase responses in phenotypically distinct endothelial cells. Am. J. Physiol, 272: L51-L59, 1997.

16. Shasby D, Stevens T, Ries D, Moy A, Kamath J, Kamath A, and Shasby S. Thrombin inhibits myosin light chain dephosphorylation in endothelial cells. Am. J. Physiol., 272: L311-L319, 1997.

17. Chetham P, Bridges J, Stevens T, and McMurtry I. Inhaled nitric oxide prevents ischemia/reperfusion-induced pulmonary microvascular dysfunction. Anesthesiology, 86: 895-902, 1997.

18. Chetham P, Brough G, Mons N, Cooper D, and Stevens T. Ca²⁺ inhibitable adenylyl cyclase and pulmonary microvascular permeability. Am. J. Physiol., 273: L22-L30, 1997.

19. Stevens T, Brough G, Moore T, Babal, P, and Thompson W. Endothelial cells. In: Methods in Pulmonary Research (Eds. Gerlach, P. and Taylor A.), Birkhauser Verlag AG. 1997.

20. Kelly J, Stevens T, and Thompson W. Adenylate and guanylate cyclases. In: Current Protocols in Pharmacology (Eds. Williams, M. and Enna, S.), John Wiley & Sons, Inc. 1998.

21. Kelly J, Moore T, Babal P, Diwan H, Stevens T, and Thompson W. Pulmonary microvascular and macrovascular endothelial cells: Differential regulation of Ca²⁺ and permeability. Am. J. Physiol., 274: L810-L819, 1998.

22. Moore T, Chetham P, Kelly J, and Stevens T. Signal transduction and regulation of endothelial cell function. Interaction between Ca²⁺ and cyclic AMP. Am. J. Physiol., 275: L203-L222, 1998. [Invited Review]

23. Weil J, Stevens T, Pickett C, Tatsumi K, Dickinson M, Jacoby C, and Rodman D. Strain-associated differences in hypoxic chemosensitivity of the carotid body in rats. Am. J. Physiol., 274: L767-L774, 1998.

24. Moore T, Brough G, Babal P, Kelly J, Li M, and Stevens T. Store operated Ca²⁺ entry promotes shape change in pulmonary endothelial cells expressing Trp-1. Am. J. Physiol., 275: L574-L582, 1998.

25. Chetham P, Babal P, Bridges J, Moore T, and Stevens T. Segmental regulation of pulmonary vascular permeability by store operated Ca²⁺ entry. Am. J. Physiol., 276: L41-L50, 1999. 

26. Parker J, Townsley M, and Stevens T. Calcium dependence of mechanical injury in lung capillaries. J. Appl. Physiol., 86: 775-776, 1999. [Letter to the Editor]

27. Guldemeester H, Stenmark K, Brough G, and Stevens T. Mechanisms regulating cAMP-mediated growth of bovine neonatal pulmonary artery smooth muscle cells. Am. J. Physiol., 276: L1010-L1017, 1999.

28. Haynes J, Obiako B, Babal P, Brough G, and Stevens T. 5’-(N-ethylcarboxamido)adenosine rapidly desensitizes the A2 adenosine receptor in lung circulation. Am. J. Physiol., 276: H1877-H1883, 1999.

29. Stevens T, Creighton J, and Thompson W. Distinct mechanisms regulate rat pulmonary macro- and microvascular endothelial cell cyclic AMP. Implications for control of barrier function. Am. J. Physiol., 277: L119-L126, 1999.

30. Wu S, Moore TM, Brough G, Li M, and Stevens T. Cyclic nucleotide gated channels mediate membrane depolarization following activation of store operated Ca²⁺ entry in endothelial cells. J. Biol. Chem., 275: 18887-18896, 2000.

31. Stevens T, Garcia JGN, Shasby DM, Bhattacharya J, and Malik AB. Mechanisms regulating endothelial cell barrier function. Am. J. Physiol., 279: L419-L422, 2000. [Invited Review]

32. Moore T, Norwood N, Creighton J, Babal P, Brough G, Shasby D, and Stevens T. Receptor-dependent activation of store-operated Ca²⁺ entry increases endothelial cell permeability. Am. J. Physiol., 279: L691-L699, 2000.

33. Norwood N, Moore TM, Dean D, Bhattacharjee R, Creighton J, Babal P, and Stevens T. Store operated Ca²⁺ entry and endothelial cell permeability. Am. J. Physiol., 279: L815-L824, 2000.

34. Stevens T. Pulmonary vasoconstriction induced by Gq agonists. Is there a role for store operated calcium entry? Am. J. Physiol., 280: L866-L869, 2001. [Invited Editorial]

35. Brough G, Wu S, Moore TM, Li M, Dean N, and Stevens T. Contribution of endogenously expressed Trp-1 to a Ca²⁺ selective store operated Ca²⁺ entry pathway. FASEB J., 15: 1727-1738, 2001.

36. Wu S, Sangerman J, Li M, Brough G, Goodman S, and Stevens T. Essential control of an endothelial cell I_SOC by the spectrin membrane skeleton. J. Cell Biol., 154: 1225-1233, 2001.

37. Stevens T, Rosenberg B, Aird W, Quertermous T, Garcia JGN, Hebbel R, Tuder R, Garfinkel S. Endothelial cell phenotypes in heart, lung and blood diseases. Am. J. Physiol., 281: C1422-C1433, 2001.

38. Parker J, Stevens T, Randall J, Sybert C, Yoshikawa S, and Penton A. Hydraulic conductance of segmental endothelial phenotypes in pulmonary circulation. Proc. 7^th World Cong. Microcirc., pp. 505-511, 2002.

39. Cioffi D, Moore TM, Schaack J, Creighton J, Cooper DMF and Stevens T. Dominant regulation of inter-endothelial cell gap formation by the calcium-inhibited type 6 adenylyl cyclase. J. Cell Biol., 157: 1267-1278, 2002.

40. Stevens T. Bronchial endothelial cell phenotypes and the form:function relationship. Am. J. Physiol. 283: L518-L519, 2002. [Invited Editorial]

41. Wang Q, Pfeiffer GR, Stevens T, and Doerschuk CM. Pulmonary microvascular and arterial endothelial cells differ in their responses to ICAM-1 ligation. Am. Rev. Resp. Crit. Care Med., 166: 872-877, 2002.

42. Norwood N and Stevens T. Molecular motors in control of store operated Ca²⁺ entry. Cell Biochem. Biophys., 37: 53-70, 2002. [Invited Review]

43. Creighton J, Masada N, Cooper DMF, and Stevens T. Coordinate regulation of membrane cAMP by calcium inhibited adenylyl cyclase (type 6) and phosphodiesterase (type 4) activities. Am. J. Physiol., 284: L100-L107, 2003.

44. Wu S, Cioffi D, and Stevens T. On the endothelial cell I_SOC channel. Cell Calcium. 33: 323-336, 2003. [Invited Review].

45. Wu S, Haynes J, Taylor J, Brough GH, Li M, and Stevens T. Cav3.1 (a_1G) T-type Ca²⁺ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation. Circ. Res., 93: 346-353, 2003.

46. Chatterjee S, Al-Mehdi A, Levitan I, Stevens T, and Fisher AB. Shear stress increases expression of a K_ATP channel in rat pulmonary microvascular endothelial cells. Am. J. Physiol., 285: C959-967, 2003.

47. Stevens T. Calcium inhibited adenylyl cyclase (AC₆) controls endothelial cell barrier function. In: Proinflammatory Signaling Mechanism in the Pulmonary Circulation. In Press.

48. Wu S, Cioffi D, and Stevens T. Receptor-operated and ligand-gated Ca²⁺ channels. In: Ion Channels in the Pulmonary Vasculature. In Press [Invited Review]

49. Cioffi D, Wu S, and Stevens T. Transient receptor potential cation channels and store-operated Ca²⁺ channels. In: Ion Channels in the Pulmonary Vasculature. In Press [Invited Review].

50. Stevens T, Kasper M, Carlyne Cool, and Voelkel NF. Pulmonary circulation and pulmonary hypertension. In: EC Phenotypes in Health and Disease. In Press. [Invited Review]

51. King J, Weathington T, Creighton J, Wu S, McDonald F, and Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc. Res., In Press.

52. Cioffi D, Goodman SR, Zhu M, and Stevens T. Protein 4.1 mediates interaction between TRPC4 and the actin-based membrane skeleton. J. Biol. Chem., Submitted.

53. Sayner SL, Frank D, King J, VandeWaa J, and Stevens T. Paradoxical cAMP-induced endothelial hyperpermeability revealed by P. aeruginosa ExoY. J. Clin. Invest., Submitted.

54. Ihida-Stansbury K, Gebb SA, McKean DM, Martin JF, Stevens T, Kaplan-Alburquerque N, and Jones PL. The paired-related homeobox gene transcription factor Prx1 is required for lung vascularization and normal alveolar development. J. Clin. Invest., Submitted.

55. Gebb SA and Stevens T. On lung endothelial cell heterogeneity. In: Microvascular Research. Submitted [Invited Review].

56. Sayner S and Stevens T. Adenylyl cyclases in control of endothelial barrier properties. In: Lung Endothelial in Health and Disease. Submitted.

57. Norwood N, Wu S, Dudek S, Garcia JGN and Stevens T. Calcium store depletion induces tyrosine phosphorylation of myosin light chain kinase. Implications for calcium signaling. Am. J. Physiol., In Preparation.

58. Wu S, Cioffi E, Sayner S, Cioffi D, King J, and Stevens T. Selective disruption of adhesion by activation of endothelial cell ISOC. J. Cell Biol., In Preparation.

59. Al-Mehdi A and Stevens T. Lung endothelial heterogeneity. In: Encyclopedia of the Microvasculature. In Preparation.

ABSTRACTS

1. Stevens T, Sockler J, Tucker A, and Cordain L. Metabolic consequences of submaximal exercise during altitude and cold stress. Med. Sci. Sport Ex., 21: S62, 1989.

2. Stevens T, Diesel D, Janssen P, and Tucker A. TNF-a increases pulmonary vascular reactivity in rats. Physiologist, 33: A-103, 1990.

3. Stevens T, Janssen P, and Tucker A. Sub-pressor doses of TNF-a increase vascular reactivity in isolated rat lungs. FASEB J, 5: A-1432, 1991.

4. Stevens T, Morris K, McMurtry I, and Tucker A. Chronic TNF-a administration decreases pulmonary vascular reactivity in conscious rats independently of EDRF and ET-1. Presented, American Heart Association, Snowbird, Utah, 1992.

5. Stevens T, Morris K, McMurtry I, and Tucker A. Acute TNF-a administration decreases pulmonary vascular reactivity and depresses myocardial function in conscious rats. Am. Rev. Resp. Dis., 145: A628, 1992.

6. Cornfield D, Rodman D, Stevens T, McMurtry I, and Abman S. Hypoxia alters basal and stimulated cytosolic Ca²⁺ in ovine fetal pulmonary artery smooth muscle cells. Ped. Res., 31: 304A, 1992.

7. Yohn J, Smith C, Stevens T, Morelli J, Dormish J, Kane M, and Zamora M. Identification of functional endothelin-1 receptors in cultured human malignant melanoma cells. J. Dermatol. Res., 1993.

8. Smith C, Yohn J, Stevens T, Morelli J, Dormish J, Kane M, and Zamora M. Evidence for an endothelin-1 autocrine system in normal human keratinocytes. J. Dermatol. Res., 1993.

9. Rodman D, Cornfield D, McMurtry I, and Stevens T. Hypoxia increases the peak Ca²⁺ response to bradykinin and thapsigargin in pulmonary artery endothelial cells. FASEB J., 7: A405, 1993.

10. Stevens T, Cornfield D, McMurtry I, and Rodman D. Hypoxia inhibits Ca²⁺ influx and decreases basal Ca²⁺ in pulmonary artery endothelial cells. FASEB J., 7: A405, 1993.

11. Zamudio S, Moore L, Rodman D, and Stevens T. Estradiol-17 decreases basal and stimulated Ca²⁺ in pulmonary artery endothelial cells. FASEB J., 7: A669, 1993.

12. Cornfield D, Stevens T, McMurtry I, Abman S, and Rodman D. Hypoxia-induced increase in fetal pulmonary artery smooth muscle cell [Ca²⁺]i is mediated by entry of Ca²⁺ through voltage-operated Ca²⁺ channels. Ped. Res., 33: 320A, 1993.

13. Stevens T , Cooper D, Cornfield D, McMurtry I, and Rodman D. Adenylyl cyclase activity in pulmonary artery endothelial cells is inhibited by Ca²⁺. FASEB J., 8: A36, 1994. 

14. Fouty B, Cornfield D, Stevens T, and Rodman D. Cellular hypoxia alters the behavior of Ca²⁺-sensitive fluorophores in PA endothelial cells. Am. J. Resp. Crit. Care Med., 149: A23, 1994.

15. Cornfield D, Stevens T, McMurtry I, Abman S, and Rodman D. Hypoxia causes membrane depolarization in fetal pulmonary artery smooth muscle cells. Ped. Res., 35: 329A, 1994.

16. Stevens T, Nakahashi Y, McMurtry I, Cooper D, and Rodman D. Ca²⁺ modulates adenosine 3',5'-cyclic monophosphate production in lung endothelial cells via a Ca²⁺ inhibitable adenylyl cyclase. Circulation, 90: I-150, 1994.

17. Stevens T, Brough G, Rodman D, McMurtry I, Majack R, and Schwartz P. PA endothelial cell expression of proteins which bind to cAMP response elements dependent and independent of cAMP. FASEB J., 9: A719, 1995.

18. Stevens T, Brough G, Shasby S, Chetham P, Rodman D, Dempsey E, and Shasby D. Phosphorylation of endothelial myosin light chain by distinct intracellular signals. Circulation, 92: I-374, 1995.

19. Stevens T, Brough G, Shasby S, McMurtry I, Rodman D, and Shasby D. Inhibition of cAMP by intracellular Ca²⁺ corresponds with myosin phosphorylation in pulmonary artery endothelial cells. FASEB J., 7: A110, 1996.

20. Veit A, Brough G, McMurtry I, Rodman D, and Stevens T. Protein kinase C stimulates adenylyl cyclase and cAMP in human pulmonary microvascular endothelial cells. FASEB J., 10: A110, 1996.

21. Chetham P, Guldemeester A, Brough G, Bridges J, Thompson W, and Stevens T. Lung microvascular permeability regulation: Ca²⁺ inhibitable adenylyl cyclase. Circulation, 94: I-701, 1996.

22. Guldemeester H, Stenmark K, Brough G, Walchak S, and Stevens T. Protein kinase C stimulation of adenylyl cyclase and cyclic AMP promotes the neonatal smooth muscle proliferation. Circulation, 94: I-49, 1996.

23. Chetham P, Bridges J, Stevens T and McMurtry I. Acute hypoxia attenuates thapsigargin-induced permeability in the isolated rat lung. Circulation, 96: I-244, 1997.

24. Moore T, Norwood N, Brough G, and Stevens T. F-actin gates thapsigargin-sensitive store operated Ca²⁺ channels in pulmonary endothelial cells. FASEB J., 12: A777, 1998.

25. Kelly J, Moore T, Babal P, Diwan H, Stevens T, and Thompson W. Differential Ca²⁺ signaling and permeability in pulmonary microvascular and macrovascular endothelial cells. FASEB J., 12: A14, 1998.

26. Bhattacharjee A, Stevens T, and Li M. The role of basal intracellular Ca²⁺ channel activity in insulin-secreting cells. FASEB J., 12: A439, 1998.

27. Guldemeester A, Stenmark K, Brough G, Tudor R, and Stevens T. Site-specific expression of adenylyl cyclase isoforms in normotensive and hypoxic hypertensive pulmonary circulations of the calf. Chest, 114: 38S-39S, 1998.

28. Moore T, Brough G, Kelly J, Babal P, and Stevens T. Regulation of pulmonary endothelial cell shape by Trp-mediated Ca²⁺ entry. Chest, 114: 36S-38S, 1998. [Extended Abstract]

29. Guldemeester A, Brough G, Stenmark K, and Stevens T. Site-specific expression of adenylyl cyclase unmasks distinct populations of smooth muscle cells in the pulmonary arterial media. Am. J. Resp. Crit. Care Med., 157: A211, 1999.

30. Stevens T, and Thompson W. Regulation of pulmonary microvascular endothelial cAMP by adenylyl cyclase. Implications for endothelial barrier function. Chest, 116: 32S, 1999.

31. Norwood N, Moore, TM, Creighton J, Babal P, Bhattacharjee R, and Stevens T. Myosin light chain kinase regulates activation of store-operated caclium entry in pulmonary artery endothelial cells. FASEB J., 13: A502, 1999.

32. Norwood N, Dean D, Moore TM, Creighton J, Babal P. and Stevens T. Inhibition of myosin light chain kinase stimulates Ca²⁺ release in pulmonary artery endothelial cells. FASEB J., 13: A502, 1999.

33. Creighton J, Thompson WJ, and Stevens T. Regulation of cAMP in lung micro- and macrovascular endothelial cells: Mechanisms of enhanced microvascular barrier function. FASEB J., 13: A502, 1999.

34. Wu S, Moore TM, Brough G, Li M, and Stevens T. Activation of store operated Ca²⁺ entry causes lung endothelial cell membrane depolarization via a Ca²⁺-inhibited, cAMP activated K+ conducting channel. FASEB J., 13: A502, 1999.

35. Moore T, Norwood N, Creighton J, Babal P, Brough G, and Stevens T. Calcium influx is sufficient but not required for thrombin-induced endothelial cell shape change. FASEB J., 13: A501, 1999.

36. Haynes J, Obiako B, Babal P, Brough G, and Stevens T. 5’-(N-ethylcarboxamido)adenosine rapidly desensitizes the A2 adenosine receptor in lung circulation. Am. J. Resp. Crit. Care Med., 159: A574, 1999.

37. Norwood N, Moore T, and Stevens T. Use of the myosin light chain kinase inhibitor, ML-9, reveals a mechanism for increased pulmonary artery endothelial permeability. FASEB J., 14: A693, 2000.

38. Norwood N, Cioffi D, Moore T, and Stevens T. Distinct regulation of endothelial cell permeability by proteolytic and direct activation of the thrombin receptor. FASEB J., 14: A693, 2000.

39. El-Menshawi M, Moore T, Norwood N, and Stevens T. Transcytosis through lung endothelium. Implications for inflammation. FASEB J., 14: A129, 2000.

40. Creighton J, and Stevens T. cAMP accumulation dictates Ca²⁺ inhibition of adenylyl cyclase 6 necessary to increase gap formation in lung microvascular endothelial cells. FASEB J., 14: A693, 2000.

41. Wu S, Goodman S, and Stevens T. Binding of non-erythroid spectrin to protein band 4.1 physically links store depletion to activation of Ca²⁺ entry in endothelial cells. FASEB J., 14: A411, 2000.

42. Wu S, Brough G, Creighton J, El-Menshawi M, Goodman S, and Stevens T. Disruption of F-actin binding to non-erythroid spectrin induces focal inter-endothelial cell gaps. FASEB J., 14: A694, 2000.

43. Brough G, Moore T, Wu S, Dean D, Dean N, and Stevens T. Endogenously expressed Trp-1 mediates store operated Ca²⁺ entry in lung cells. FASEB J., 14: A694, 2000.

44. Parker JC, and Stevens T. Mechanical stress induced Ca²⁺ transients in pulmonary artery and microvascular endothelial cells. FASEB J., 14: A693, 2000.

45. Parker JC, Stevens T, and Martin SL. Vascular segmental permeability after high peak inflation pressure (PIP) injury in isolated rat lungs. FASEB J., 14: A605, 2000.

46. Ruchko M, Stevens T, Gillespie MN, and Olson JW. Thrombin-regulated VE-cadherin expression in rat pulmonary endothelial cells: Role of -catenin and phosphatidylinositol 3-kinase. FASEB J., 14: A692, 2000.

47. Bonness K, Durcova I, Capley G, Stevens T, Gillespie MN, and Olson JW. Thrombin stimulates sub-cellular trafficking of active ornithine decarboxylase in rat pulmonary endothelial cells. FASEB J., 14: A692, 2000.

48. King J, Weathington T, Creighton J, McDonald F, Gillespie MN, Olson J, Parker J, and Stevens T. Characterization of phenotypically distinct endothelial cell populations from rat lung. FASEB J., 15: A492, 2001.

49. Creighton J, and Stevens T. Calcium inhibition of adenylyl cyclase 6 is regulated by cAMP in lung microvascular endothelial cells. FASEB J., 15: A161, 2001.

50. Cioffi D, Creighton J, Canales K, Cooper DMF, and Stevens T. Expression of a calcium-stimulated adenylyl cyclase prevents thrombin-induced gap formation in microvascular endothelium. FASEB J., 15: A161, 2001.

51. Cioffi EA, Wu S, Wallace B, and Stevens T. Modulation of fura-2 luminescence by alkaline earth cations both in vitro and in vivo in pulmonary macro- and microvascular endothelial cells. FASEB J., 15: A492, 2001.

52. Wu S, Cioffi E, and Stevens T. Distinct store operated calcium entry pathways in pulmonary macro- and microvascular endothelial cells. FASEB J., 15: A161, 2001.

53. Norwood N, Wu S, Dudek S, Garcia JGN, and Stevens T. Endothelial cell myosin light chain kinase-1 and activation of store operated calcium entry. FASEB J., 15: A492, 2001.

54. Cioffi D, Zhu M, Goodman SR, and Stevens T. Association of Trp-1 and –4 store operated calcium entry channels with the spectrin membrane skeleton in endothelium. FASEB J., 15: A161, 2001.

55. Wu S, Brough GH, Dean N, and Stevens T. Contribution of endogenously expressed Trp-1 to a calcium selective store operated calcium entry pathway in endothelium. FASEB J., 15: A161, 2001.

56. Taylor J, Wu S, Brough GH, Li M, and Stevens T. Selective endothelial expression of T-type voltage gated calcium channels in lung microvascular cells. FASEB J., 15: A492, 2001.

57. Morales RE, Babal P, Khimenko PL, Stevens T, Obiako B, and Haynes J. A₂ adenosine receptor (A₂AR) distribution in the rat pulmonary circulation. Am. J. Resp. Crit. Care Med., 165: A336, 2002.

58. King J, Weathington T, Sangerman J, McDonald F, Pace B, and Stevens T. Communication between cultured lung macro- and microvascular endothelia: Role of stem cells. FASEB J., 16: A406, 2002.

59. Wu S, Haynes J, Obiako B, Li M, and Stevens T. T-type Ca²⁺ channel activation contributes to vaso-occlusion of sickled erythrocytes in inflamed lung. FASEB J., 16: A407, 2002.

60. Wu S, Creighton J, King J, and Stevens T. Selective disruption of endothelial cell adhesion by activation of a Ca²⁺ selective store operated current, I_SOC. FASEB J., 16: A406, 2002.

61. Norwood N, Cioffi D, Wu S, Dudek S, Garcia JGN, and Stevens T. Ca²⁺ store depletion promotes tyrosine phosphorylation of myosin light chain kinase. FASEB J., 16: A467, 2002.

62. Cioffi EA, Cioffi DL, and Stevens T. cAMP resolution in endothelia using ³¹P nuclear magnetic resonance spectroscopy. FASEB J., 16: A407, 2002.

63. Weathington T, Bhat P, Voelkel N, and Stevens T. Lung microvascular endothelial cells exhibit a unique proliferative phenotype. FASEB J., 16: A406, 2002.

64. Cioffi D, Zhu M, Goodman SR, and Stevens T. Association of Trp-1 and –4 store operated Ca²⁺ entry channels with protein 4.1 in endothelium. FASEB J., 16: A406, 2002.

65. Sayner S, Frank D, VandeWaa J, and Stevens T. P. aeruginosa adenylyl cyclase (ExoY) increases cAMP causing intercellular gap formation in pulmonary microvascular endothelium. FASEB J., 17: A412, 2003.

66. Sayner S, Frank D, VandeWaa J, and Stevens T. Functional association of endogenous adenylyl cyclases and phosphodiesterases in pulmonary microvascular endothelial cells revealed by P. aeruginos adenylyl cyclase, ExoY. FASEB J., 17: A412, 2003.

67. Cioffi D, Zhu M, Goodman SR, and Stevens T. Protein 4.1 provides the functional scaffold linking Trp4 calcium channels to the membrane skeleton. FASEB J., 17: A413, 2003.

68. King J, Wu S, Cioffi D, Sayner S, and Stevens T. Inhibition of type 4 phosphodiesterase induces abluminal translocation of endoplasmic reticulum tubules in lung microvascular endothelial cells. FASEB J., 17: A413, 2003.

69. Wu S, King JAC, Stevens T, and Balczon R. Close coupling of endoplasmic reticulum to the plasma membrane is required for ISOC activation in lung microvascular endothelial cells. FASEB J., 17: A411, 2003.

70. Bauer NN, Stevens T, Gebb SA, and McMurtry IF. Hypoxia stimulates Rho A/Rho kinase signaling and stress fiber formation in pulmonary microvascular, but not macrovascular endothelial cells. FASEB J., 17: A411, 2003.

71. Cioffi E, Wallace B, Cioffi DL, Wu S, and Stevens T. Molecular modeling of Fura-2-Be²⁺ complexes reveals a distorted π aromatic network that modulates its fluorescence detection: implications for use in living endothelia. FASEB J., 17: A414, 2003.

72. Gjerde EB, Stevens T, and Townsley MI. 14,15-Epoxyeicosatrienoic acid activates store-operated calcium channels in rat pulmonary microvascular endothelial cells. FASEB J., late-breaking abstracts, 2003.

73. Ofori-Acquah SF, Durcova I, Pace BS, and Stevens T. Molecular basis for the heterogeneity of paracellular transport by pulmonary macro- and microvascular endothelial cells. Am. J. Resp. Crit. Care Med. 167(7):A566, 2003.

74. Ofori-Acquah SF, Olson JW, Durcova I, Ying F, Qian X, Sviridov D, Pace BS, and Stevens T. HB2/ALCAM distributes in inter-endothelial junctions of the lung microvasculature. Am. J. Resp. Crit. Care Med. 167(7):A566, 2003.

75. King J, Ofori-Acquah S, Stevens T, and Al-Mehdi A. Potential role for ALCAM and N-cadherin in metastasis to the lung microcirculation. Chest, In press.

76. Gjerde EB, Alvarez DF, Stevens T, and Townsley MI. Role of 14,15- and 11,12-epoxyeicosatrienoic acids in activation of store-operated calcium channels in rat pulmonary microvascular endothelial cells. In press.

77. Zhu B. and Stevens T. Regulation of endothelial cell growth and apoptosis by cGMP-specific phosphodiesterase 5. FASEB J., In Press.

78. Zhu B. and Stevens T. Expression of cone-type inhibitory and γ-subunit of PDE6 in rat pulmonary endothelium. FASEB J., In Press.

79. Sayner S. and Stevens T. Soluble adenylyl cyclase generates a cAMP pool that disrupts the pulmonary microvascular endothelial barrier. FASEB J., In Press.

80. Clark J. and Stevens T. Pulmonary microvascular endothelial cells possess greater amounts of heterochromatin than do pulmonary artery endothelial cells. FASEB J., In Press.

81. Wu S. and Stevens T. Disruption of the dynein motor promotes endoplasmic reticulum-plasmalemma coupling important for activation of the Ca²⁺-selective store-operated current in pulmonary microvascular endothelium. FASEB J., In Press.

82. Cioffi D. and Stevens T. Activation of endothelial I_SOC requires interaction between TRPC4 and protein 4.1. FASEB J., In Press.

83. Creighton J. and Stevens T. Functional co-localization of calcium inhibited adenylyl cyclase and type 4 phosphodiesterase precisely controls membrane-associated cAMP concentrations in lung microvascular endothelium. FASEB J., In Press.

84. King J. and Stevens T. Role of ALCAM in interaction of breast cancer metastases and the endothelium of the lung. FASEB J., In Press.

INVITED LECTURES

1. National Jewish Hospital, Denver CO, 1992. Acute hypoxia reduces intracellular free Ca²⁺ in pulmonary artery endothelial cells.

2. Division of Cardiology, Department of Medicine, University Colorado Health Sciences Center, Denver CO, 1992. Acute hypoxia reduces intracellular free Ca²⁺ in pulmonary artery endothelial cells.

3. Webb Waring Lung Institute, University Colorado Health Sciences Center, Denver CO, 1992. Acute hypoxia reduces intracellular free Ca²⁺ in pulmonary artery endothelial cells.

4. Department of Pediatrics, Southwestern University, Dallas TX, 1993. Acute hypoxia reduces intracellular free Ca²⁺ in pulmonary artery endothelial cells.

5. Experimental Biology, International Convention, New Orleans LA, 1994. Hypoxia increases the peak Ca²⁺ response to bradykinin and thapsigargin in pulmonary artery endothelial cells.

6. Experimental Biology, International Convention, New Orleans LA, 1994. Hypoxia inhibits Ca²⁺ influx and decreases basal Ca²⁺ in pulmonary artery endothelial cells.

7. National Jewish Hospital, Denver CO, 1994. The role of adenylyl cyclases in endothelial permeability.

8. Department of Physiology and Biophysics, Colorado State University, Ft. Collins CO, 1995. Control of endothelial barrier properties by cyclic AMP.

9. Department of Pharmacology, University of South Alabama, Mobile AL, 1995. Ca²⁺ inhibitable adenylyl cyclase mediates pulmonary macro- and microvascular endothelial cell cAMP content and barrier properties.

10. Division of Cardiology, Department of Medicine, University of Colorado Health Sciences Center, Denver CO, 1995. Ca²⁺ inhibitable adenylyl cyclase mediates pulmonary macro- and microvascular endothelial cell cAMP content and barrier properties.

11. American Heart Association, International Convention, Anaheim CA, 1995. Activation of endothelial myosin phosphorylation by distinct intracellular signals.

12. American Heart Association, International Convention, New Orleans LA, 1996. Calcium and cAMP in endothelial cell cultures.

13. Department of Pharmacology, University of South Alabama, Mobile AL, 1996. Calcium regulation of endothelial cell cAMP content in control of permeability.

14. Grand Rounds, Department of Medicine, University of South Alabama, Mobile AL, 1997. Adult Respiratory Distress Syndrome: Is the endothelial injury reversible?

15. CVP Research Lab, Department of Medicine, University of Colorado, Denver CO, 1997. Regulation of pulmonary endothelial permeability by store operated Ca²⁺ entry; Role of Trp proteins.

16. Grand Rounds, Department of Pediatrics, University of Minnesota, Minneapolis MN, 1997. Acute Lung Injury: Is the endothelial injury reversible?

17. Department of Physiology, University of Minnesota, Minneapolis MN, 1997. Regulation of pulmonary endothelial permeability by store operated Ca²⁺ entry; Role of Trp proteins.

18. Eye Research Group, University of South Alabama, Mobile AL, 1998. Regulation of lung endothelial cell shape in response to inflammation.

19. Grand Rounds, Department of Surgery, University of South Alabama, Mobile AL, 1998. Control of endothelial permeability in adult respiratory distress syndrome.

20. Emerging Technology Partners, Inc., Birmingham AL, 1998. Inhibition of Trp-1 as an anti-inflammatory paradigm.

21. ICOS Pharmaceuticals, Seattle WA, 1999. Calcium regulation of cyclic nucleotide metabolism. Control of endothelial cell permeability in inflammation.

22. International Symposium on the Pulmonary Circulation VII, Prague, Czech Republic, 1999. Adenovirus-mediated transgene transfer of type 8 adenylyl cyclase increases cAMP and prevents barrier disruption in response to activation of store operated Ca²⁺ entry.

23. Sophia’s Children’s Hospital, Rotterdam, The Netherlands, 1999. Trp Ca²⁺ channels and lung permeability. 

24. Sophia’s Children’s Hospital, Rotterdam, The Netherlands, 1999. Calcium sensitive adenylyl cyclase in lung permeability.

25. Gordon Research Conference, Henniker NH, 1999. Regulation of store operated Ca²⁺ entry by myosin light chain kinase. [Poster Presenter]

26. Cardiovascular Biology Institute, Albany Medical College, 1999. Control of endothelial barrier function by Ca²⁺ and cAMP.

27. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1999. Segmental control pulmonary endothelial cell permeability.

28. Department of Pharmacology, University of Illinois at Chicago, 2000. Control of endothelial cell barrier function by Ca²⁺ and cAMP.

29. Experimental Biology, International Convention, San Diego CA, 2000. Calcium regulation of cAMP: Control of endothelial permeability.

30. National Institutes of Health, Workshop, Bethesda MD, 2000. Signal transduction in control of macro- and microvascular endothelial cell function.

31. Physiological Society, The King’s College, London England, 2000. Regulation of endothelial cell function by the coordination between Ca²⁺ and cAMP signals.

32. Grand Rounds, Department of Surgery, University of South Alabama, Mobile AL, 2000. Role of endothelium in lung inflammation.

33. Joy Goodwin Distinguished Scientist Lecture Series, College of Veterinary Medicine, Auburn University, Auburn AL, 2001. Role of endothelium in lung inflammation.

34. Cardiovascular Research, Department of Surgery, College of Veterinary Medicine, Auburn University, Auburn AL, 2001. Calcium signaling in control of endothelial cell function.

35. Symposium on Molecular regulation of vascular permeability: Novel mechanisms and therapies Johns Hopkins University, Baltimore MD, 2001. Calcium, cAMP and endothelial barrier regulation.

36. Distinguished Scientist Seminar Series, Institute for Environmental Medicine, The University of Pennsylvania, Philadelphia PA, 2001. Regulation of endothelial cell adhesion by calcium and cAMP signal transduction.

37. US-Russia Symposium on Basic Research in Cardiovascular and Pulmonary Diseases, Moscow Russia, 2001. Biomechanics and intracellular signaling in the pulmonary system.

38. US-Italy Symposium on Pathophysiology and Therapeutic Approaches for Vascular Remodeling, Atlanta GA, 2002. Signaling in distinct lung endothelial cell phenotypes.

39. Invited Speaker, Robert Grover Conference on the Pulmonary Circulation, Deckers CO, 2002. Calcium sensitive and insensitive adenyl cyclases in control of lung endothelial cell function. 

40. American Heart Association, International Convention, Chicago IL, 2002. Endothelial cell Trp Channels in pulmonary hypertension. 

41. Division of Pulmonary and Critical Care Medicine, University of Iowa, 2002. Epigenetic origin of lung endothelium. 

42. Department of Physiology, Texas A&M University, 2002. Signaling in lung macro- and microvascular endothelium. 

43. Armed Forces Institute of Pathology, Bethesda, MD, 2003. On the Origins of Lung Vascular Endothelium. Implications for Development of Pulmonary Hypertension.

44. National Institutes of Health, Working Group on Translational Research in Primary Pulmonary Hypertension, Bethesda, MD, 2003. Biological Modifiers of Pulmonary Hypertension.

45. American Thoracic Society, Postgraduate Course on Acute Lung Injury and Ventilator Induced Lung Injury, Orlando, FL, 2004. The Role of Calcium in Endothelial Cell Barrier Function.

46. Distinguished Scientist Seminar Speaker, University of Arizona, 2003. On the Endothelial Cell ISOC.

47. Distinguished Scientist Seminar Speaker, St. Louis University, 2004. Calcium Regulation of Lung Vascular Function.

48. Department of Surgery Grand Rounds, University of South Alabama, 2004. Biomechanics Intracellular Signaling in the Pulmonary System.

49. Distinguished Scientist Seminar Speaker, Loyola University, 2004. Calcium Regulation of Lung Vascular Function.

50. American Thoracic Society Postgraduate Course, 2004. The Role of the Calcium and Endothelial Barrier Function.

51. Aspen Lung Conference, 2004. Cellular and Molecular Heterogeneity of Pulmonary Endothelium.

52. Gordon Research Conference, 2004. Pulmonary Endothelium in Health and Disease.

53. Grover Conference, 2004. Introduction to Endothelial Heterogeneity.

MANUSCRIPT REVIEW

1. American Journal of Physiology

2. American Journal of Respiratory Cell and Molecular Biology

3. American Review of Respiratory and Critical Care Medicine

4. Biochemical Pharmacology

5. Clinical Science

6. Developmental Dynamics

7. Endothelium

8. European Journal of Respiratory Physiology

9. FASEB Journal

10. Journal of Applied Physiology

11. Journal of Clinical Investigation 

12. Journal of Physiology 

13. Microvascular Research

MEMBERSHIPS

1. American Association for the Advancement of Science
2. American Heart Association
3. American Physiological Society
4. American Society for Pharmacology and Experimental Therapeutics
5. American Thoracic Society
6. Microcirculatory Society
  

GRANT REVIEW

1. Standing Member, Nebraska Cancer and Smoking Disease Research Program, 1995-2002.

2. Ad Hoc, Veterans Administration Merit Awards, 1995-present.

3. Ad Hoc, National Heart, Lung and Blood Institutes, Lung Biology and Pathology (LBPA) Study Section, 1997-present.

4. Ad Hoc, National Heart, Lung and Blood Institutes, Respiratory and Applied Physiology (RAP) Study Section, 1998-present.

5. Ad Hoc Program Project Grants, National Heart, Lung and Blood Institutes, Lung Biology and Pathology (LBPA) Study Section, 1999-present.

6. Ad Hoc, National Heart, Lung and Blood Institutes, Experimental Cardiovascular Sciences (ECS) Study Section, 2001-present.

7. Standing Member Grant Review, American Heart Association, Cardiopulmonary Section, 2000-2003.

8. Member, Respiratory Physiology Study Section, Center for Scientific Review for the National Institutes of Health, 2003-present

PATENTS FILED

1. U.S. Provisional Patent Application Number 87647.98R215, Filed 1998, Entitled Inhibition of
   Trp-1.

2. U.S. Patent Application Number 09/360,396, Filed July 23, 1999, Entitled Use of Decreasing Levels of Functional Transient Receptor Potential Gene Product.

3. International Patent Application Number PCT/US99/16822, Filed July 23, 1999, Entitled Use of Decreasing Levels of Functional Transient Receptor Potential Gene Product.

INDUSTRIAL COLLABORATIONS

1. ISIS Pharmaceuticals. Supply of anti-sense oligonucleotides to inhibit expression of mammalian transient receptor potential-1 gene product.

2. ICOS Pharmaceuticals. Consultation in development of surface inhibitor(s) of mammalian transient receptor potential-1.

SYMPOSIA

1. American Thoracic Society, 1999. TITLE: Regulatory mechanisms of lung permeability.
   ROLE: Co-Chair.

2. Experimental Biology, 2000. TITLE: Mechanisms regulating endothelial cell barrier function. 
   ROLE: Co-Chair.

3. National Institutes of Health Workshop, National Heart, Lung and Blood Institutes, 2000. TITLE: Endothelial cell phenotypes in heart, lung and blood diseases. 
   ROLE: Chair of the overall meeting, Co-Chair of the lung session.

4. American Thoracic Society, 2002. TITLE: Lung Permeability and Edema.
   ROLE: Co-Chair

TEACHING EXPERIENCE

TRAINEES

1. Andrew Veit, M.D. Research Fellow, Department of Anesthesiology University of Colorado Health Sciences Center, Denver CO, USA, 1995-96. Current Position: Anesthesiologist, The Children's Hospital, Denver CO.

2. H. Alexandra Guldemeester, M.D., Ph.D. Research Fellow (Funded by: The Ter Meulen Fund, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands), 1995-1997. Current Position: Assistant Professor, Department of Pediatric Surgery, Sophia Children's Hospital, Rotterdam, The Netherlands.

3. Timothy Moore, M.D., Ph.D. Postdoctoral Fellow (Funded by: American Heart Association-Southeastern Consortium), 1996-1999. Department of Pharmacology, University of South Alabama College of Medicine, Mobile AL. Current Position: Medical Student, University of South Alabama.

4. Natalie Norwood, Ph.D. Doctoral Candidate (Funded by: NIH RO1 HL56050), 1997-present. Department of Pharmacology, University of South Alabama College of Medicine, Mobile AL.

5. Songwei Wu, M.D. Postdoctoral Fellow (Funded by: American Heart Association-Southeastern Consortium), 1998-present. Department of Pharmacology, University of South Alabama College of Medicine, Mobile AL.

6. Rakesh Bhattacharjee, B.S. Summer Student (Funded by: NIH RO1 HL56050), 1998. Department of Pharmacology, University of South Alabama College of Medicine, Mobile AL.

7. Donna Cioffi, M.S. Doctoral Candidate (Funded by: NIH RO1 HL60024), 1999-present. Department of Pharmacology, University of South Alabama College of Medicine, Mobile AL.

8. Marwa El-Menshawi, B.S. Undergraduate Student, 1999-2000. Department of Pharmacology, University of South Alabama, Mobile AL.

9. Tray Weathington, M.S. Master's Student, 2001-2003. Department of Biology, University of South Alabama, Mobile AL.

10. Priya Bhat, B.S. Medical Summer Student, 2001. Department of Pharmacology, University of South Alabama, Mobile AL.

11. Sarah Sayner, B.S. Doctoral Candidate (Funded by: NIH RO1 HL60024), 2002-present. Department of Pharmacology, University of South Alabama College of Medicine, Mobile AL.

12. Jennifer Clark, B.S. Doctoral Student, 2003-present. Center for Lung Biology, University of South Alabama, Mobile, AL.

DOCTORAL COMMITTEES

1. Mark Taylor, Ph.D. Doctoral Candidate with Dr. Joey Benoit, Department of Physiology, 1996-1999.

2. John K. Hawkins, M.S. Doctoral Candidate with Dr. June Ayling, Department of Pharmacology, 1997-present.

3. Kathy Ault-Ziel, B.S. Doctoral Candidate with Dr. Mark Gillespie, Department Pharmacology, 1998-present.

4. Heather Foley, B.S. Doctoral Candidate with Dr. Betty Pace, Department of Structural and Cellular Biology and Comprehensive Sickle Cell Center, 1999-present. 

5. Guofei Zhou, B.S. Doctoral Student with Dr. Richard Honkanen, Department of Biochemistry, 2000-present.

6. Kathy Gross, B.S. Doctoral Student with Dr. Jonathan Scammell, Department of Pharmacology, 2000-present.

7. Jeffrey Breit, B.S. Doctoral Student with Dr. Mark Gillespie, Department of Pharmacology, 2000-present.

8. Diego Alvarez, M.D. Doctoral Student with Dr. Mary Townsley, Department of Physiology, 2001-present.

9. Brad Swiger, B.S. Doctoral Student with Dr. Mark Gillespie, Department of Pharmacology, 2003- present.

SERVICE

National:

1. Curriculum Development in Human Physiology for Disabled American Veterans Career Training, 1994.
   

2. American Thoracic Society:
   • Pulmonary Circulation Assembly Planning Committee, 1998-present.
   • Pulmonary Circulation Assembly Long-Range Planning Committee, 2000-present.
   • Chair, Nominating and Steering Committee, Pulmonary Circulation Assembly, 2001-2002.
   • Editor, Journal Club on Pulmonary Edema, Pulmonary Circulation Assembly, 2002-present

3. American Physiological Society
   • Program Committee, 2002-present.

4. National Institutes of Health
   • Participant, Workshop on Translational Research in Primary Pulmonary Hypertension, 2003.

Local, Department Level:

1. Resident Selection Committee, Department of Anesthesiology, University of Colorado, 1994-1995.

2. Director, Distinguished Scientist Seminar Series, Department of Pharmacology, University of South Alabama College of Medicine, 1996-2003.

3. Director, Departmental Seminar Series, Department of Pharmacology, University of South Alabama College of Medicine, 1996-2000.

4. Sponsor, Minority High School Research Program, University of South Alabama College of Medicine, summer of 1997.

5. Course Director, Medical Pharmacology, Department of Pharmacology, University of South Alabama College of Medicine, 1998-2000.

6. Director, Graduate Program, Department of Pharmacology, University of South Alabama College of Medicine, 2001-2002.

Local, College Level:

1. Member, Medical Student Selection Committee, University of South Alabama College of Medicine, 1997-2001.

2. Member, Curriculum Development, Interdisciplinary Cancer Training Program, University of South Alabama College of Medicine, 1998.

3. Member, Distinguished Scientist Selection Committee, University of South Alabama College of Medicine, 1999-2003; Chair 1999-2000.

4. Member, Basic Medical Sciences Graduate Program Curriculum Committee, College of Medicine, University of South Alabama, 1999-2003.

5. Member, Student Promotions and Evaluation Committee, University of South Alabama College of Medicine, 2000-2001.

6. At-Large Member, Executive Council, University of South Alabama College of Medicine, 2000-2002.

7. Ex Officio Member, Ad-Hoc Committee on MD/PhD proposal, University of South Alabama College of Medicine, 2001.

8. Member, Graduate Education in the Science Basic to Medicine subcommittee, University of South Alabama College of Medicine, 2001-2003.

9. Member, Ad-Hoc Committee on Clinical Research, University of South Alabama College of Medicine, 2001.

10. Member, Research Cytometry Core Advisory Committee, University of South Alabama College of Medicine, 2001-2003.

11. Member, Committee on Committees, University of South Alabama College of Medicine, 2001-2004; Chair 2003-2004.

12. Member, Research Advisory Committee, University of South Alabama College of Medicine, 2001-2004.

13. Member, Student Research Committee, University of South Alabama College of Medicine, 2001-2004; Chair, 2002-2003.

14. Member, Executive Council, University of South Alabama College of Medicine, 2002-present.

15. Member, Search Committee for Departmental Chair, Department of Pediatrics, University of South Alabama College of Medicine, 2003.

16. Secretary, Faculty Assembly Committee, University of South Alabama College of Medicine, 2003-2004.

17. Member, Faculty Committee on Appointments, Promotions, and Evaluations, University of South Alabama College of Medicine, 2003-2006.

18. Member, Patent Committee, University of South Alabama College of Medicine, 2003-2006.

Local, University Level:

1. Member, Research and Technology Corporation Advisory Committee, University of South Alabama, 2002-present.