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    NIH - Funded Training in Cell Signaling & Lung Pathobiology
    		 
     

    Jennifer Clark
    Phone: (251) 461-1669
    Fax: (251) 460-6798 jec301@jaguar1.usouthal.edu

     
    EDUCATIONAL HISTORY
    Institution/Location Degree Year Conferred Field of Study
    University of South Alabama Ph.D. In Progress Lung Biology
    Mobile,AL      
    University of South Alabama B.S. 2002  Biomedical Science
    Mobile, AL      
     

    RESEARCH EXPERIENCE
    Honors Research Thesis:  Detection of proliferation in normal adult rat cardiomyocytes. University of South Alabama, 2001-2002.
     
    ABSTRACTS
    Jennifer Clark and Troy Stevens.  Nucleosome assembly protein acts as an important epigenetic determinant of phenotype in pulmonary microvascular endothelial cells.  FASEB J, 2005.
    Jennifer Clark, Solomon Ofori-Acquah, YM Bhatnagar and Troy Stevens. Pulmonary microvascular endothelial cells possess greater amounts of heterochromatin than do pulmonary artery endothelial cells.  FASEB J, 2004.
    Jennifer Clark, Solomon Ofori-Acquah, YM Bhatnagar and Troy Stevens. Pulmonary microvascular endothelial cells possess greater amounts of heterochromatin than do pulmonary artery endothelial cells.   Gulf Coast Physiological Society, 2003.
     
    COURSES TAKEN
    Fundamentals I/II
    Methods
    Lung Biology
    Lung Pathobiology
    Advanced Signal Transduction
    Biostatistics
    Literature Reports
    Directed Studies
     
    JOURNAL CLUB PRESENTATIONS

    Chromatin compaction by human MeCP2.  Assembly of novel secondary chromatin structures in the absence of DNA methylation.  J Biol Chem. 2003 Aug 22;  278(34):32181-8.  Georgel PT, Horowitz-Scherer RA, Adkins N, Woodcock CL, Wade, PA , Hansen, JC.
    Xenopus nucleosome assembly protein becomes tissue-restricted during development and can alter the expression of specific genes Steer, W., Anita Abu-Daya, Sarah J. Brickwood, Katherine L. Mumford, Niove Jordanaires, Julian Mitchell , Carl Robinson, Alan W. Thorne, and Matthew J. Guille. Mechanisms of Development 120 (2003) 1045-1057.
    VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature Tomomi Kamba, Betty Y. Y. Tam, Hiroya Hashizume, Amy Haskell, Barbara Sennino, Michael R. Mancuso, Scott M. Norberg, Shaun M. O’Brien, Rachel B. Davis, Lori C. Gowen, Keith D. Anderson, Gavin Thurston, Shuji Joho, Matthew L. Springer,Calvin J. Kuo, and Donald M. McDonald.  Am J Physiol Heart Circ Physiol (September 19, 2005).
    UNIVERSITY SERVICE

    Student Representative for the Center for Lung Biology 2004-2005.
    Secretary Basic Medical Sciences Student Organization 2005-2006.
     
    TEACHING EXPERIENCE

    BEAR Program-oxidative metabolism, electron transport chain, citric acid cycle.
    Summer Scrubs
    Science Olympiad Judge-Chemical Identification
    BMD 323 Biochemistry Laboratory
     
    RESEARCH INTERESTS

    Basic research interests are related to lung endothelial cell function in development and disease.  Themes of lung endothelial cell heterogeneity of phenotype with respect to developmental origins, proliferative capacity, disease response and plasticity run rampantly through our research aims.  Current projects are focused on the fundamental differences in proliferative capacity of cultured pulmonary microvascular endothelial cells compared to cultured pulmonary artery endothelial cells.
     
     
    Last Update: Aug. 24, 2006