Research with the Yet Group

 Teaching Philosophy

It is my mission at the general undergraduate to the specialized graduate level chemistry courses to not only teach the basic ideas of chemistry, but to show students the valuable applications of the fundamental science in the applied research. I believe in promoting the understanding of basic concepts rather than presenting material and memorizing. It is important that in the undergraduate teaching environment these students acquire the basic chemistry knowledge that will build a solid foundation for them to enter a career as a chemist or as a prerequisite to other disciplines. At the graduate level, students must learn the critical thinking of the advanced and specialized chemistry level courses so they can have a successful career in the academic, pharmaceutical, petroleum, specialty chemical, or polymer fields. The illustration of real world case studies will be most useful at the graduate level courses. Students will see that learning chemistry is not just a field of study but a creative venue to working as a team, encourages lifelong learning, self-exploration, ethics, and applications to real world issues affecting mankind.

 Research
Our group is interested in the synthesis and structure-activity relationships (SAR) of biologically active heterocyclic natural products in the anticancer area. Our research involves the state of the art development of transition metal-catalyzed reactions which significantly shortens a chemical synthetic route compared to classical organic chemistry schemes. We are interested in the development of ligands for metal-catalyzed cross-coupling and C-H activation reactions as a proof of principle methodology and then we apply these new reactions to selected heterocyclic biological targets. We use the techniques of organic chemistry to prepare biologically active compounds which we submit for assays, and then we use our skills as a medicinal chemist to synthesize more potent analogs of the compounds based on the available data obtained from the assays. Our group is exposed to how we can do “real world” research in an academic environment.
 Recent Publications & Collaborations

1.      The Olefin Ring-Closing Metathesis Reaction”, Larry Yet, Chapter Contribution for Organic Reactions, John Wiley & Sons, Inc., New York, 2015, In Press.

2.      “Progress in the Development of Fatty Acid Synthase Inhibitors as Anticancer Agents”, Genevieve E. Mullen and Larry Yet, Bioorg. Med. Chem. Lett. 2015, 25, 4363–4369.

3.      “Five-Membered Ring Systems: With More than One N Atom”, Larry Yet In Progress in Heterocyclic Chemistry: Gordon W. Gribble and John Joule, Eds.; Pergamon: Oxford, 2015, Volume 27, 247–285.

4.      Interleukin-1 Receptor Associated Kinase 4”, W. Michael Seganish, William T. McElroy, R. Jason Herr, Stephanie Brumfield, William J. Greenlee, James Harding, Venukrishnan Komanduri, Julius Matasi, Koraboina Chandra Prakash, Deen Tulshian, Jinhai Yang, Larry Yet, Kristine Devito, James Fossetta, Charles G. Garlisi, Daniel Lundell, Xiaoda Niu, Christopher Sondey, Bioorg. Med. Chem. Lett. 2015, 25, 3203–3207.

5.      Discovery and Hit-to-Lead Optimization of 2,6-Diaminopyrimidine Inhibitors of Interleukin Receptor-Associated Kinase 4”,  William T. McElroy, W. Michael Seganish, R. Jason Herr, James Harding, Jinhai Yang, Larry Yet, Venukrishnan Komanduri, Koraboina Chandra Prakash, Brian Lavey, Deen Tulshian, William J. Greenlee, Christopher Sondey, Thierry Fischmann and Xiaoda Niu, Bioorg. Med. Chem. Lett. 2015, 25, 1836–1841.

6.      “Phosphodiesterase 10A: a Novel Target for Selective Inhibition of Colon Tumor Cell Growth and β-Catenin-Dependent TCF Transcriptional Activity”, Kevin Lee, Nan Li, Y. Xi, Bing Zhu, Bernard D. Gary, V. Ramirez-Alcantara, E. Gurpinar, J. C. Canzoneri, A. Fajardo, S. Sigler, John T. Piazza, Xi Chen, J. Andrews, M. Thomas, W. Lu, Y. Li, D. J. Laan, M. P. Moyer, S. Russo, Brian T. Eberhardt, Larry Yet, Adam B. Keeton, William E. Grizzle, Gary A. Piazza, Oncogene, 2015, 34, 1499–1509.

7.      Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors”, Shuang Liu, Congxiang Zha, Kassoum Nacro, Min Hu, Wenge Cui, Yuh-Lin Yang, Ulhas Bhatt,Aruna Sambandam, Matthew Isherwood, Larry Yet, Michael T. Herr, Sarah Ebeltoft, Carla Hassler,Linda Fleming, Anthony D. Pechulis, Anne Payen-Fornicola, Nicholas Holman, Dennis Milanowski,Ian Cotterill, Vadim Mozhaev, Yuri Khmelnitsky, Peter R. Guzzo, Bruce J. Sargent, and Bruce F. Molino, ACS Med. Chem. Lett. 2014, 5, 760–765.

8.      “Five-Membered Ring Systems: With More than One N Atom”, Larry Yet In Progress in Heterocyclic Chemistry: Gordon W. Gribble and John Joule, Eds.; Pergamon: Oxford, 2014, Volume 26, 237–277.

9.      “Five-Membered Ring Systems: With More than One N Atom”, Larry Yet In Progress in Heterocyclic Chemistry: Gordon W. Gribble and John Joule, Eds.; Pergamon: Oxford, 2013, Volume 25, 217–256.

10.      “Five-Membered Ring Systems: With More than One N Atom”, Larry Yet In Progress in Heterocyclic Chemistry: Gordon W. Gribble and John Joule, Eds.; Pergamon: Oxford, 2012, Volume 24, 243–279.

11.  “Six-Membered Ring Systems: Diazenes and Benzo Derivatives”, Larry Yet In Progress in Heterocyclic Chemistry: Gordon W. Gribble and John Joule, Eds.; Pergamon: Oxford, 2012, Volume 24, 393–420.