My research interest is to prevent and treat cardiovascular disease. We employ a combination of traditional engineering approaches (solid mechanics and fluid mechanics) and biological techniques (tissue engineering and physiology) to develop models to better understand the pathology of cardiovascular disease and characterize the failure of cardiovascular devices.
Ph.D. Biomedical Engineering, Wake Forest University
M.S. Engineering Mechanics, Virginia Tech
B.S. Engineering Science and Mechanics, Virginia Tech
Malve M, Gharib AM, Yazdani SK, Finet G, Martinez MA, Pettigrew R, Ohayon J. Tortuosity of coronary bifurcation as a potential local risk factor for atherosclerosis: CFD steady state study based on in vivo dynamic CT measurements. Accepted to Annals of Biomedical Engineering.
Yazdani SK, Pacheco E, Nakano M, Otsuka F, Naisbitt S, Kolodgie FD, Ladich E, Rousselle S, Virmani R. Vascular, downstream, and pharmacokinetic responses to treatment with a low dose drug-coated balloon in a swine femoral artery model. Catheter Cardiovasc Interv. 2014; 83(1):132-140.Bouvier A, Deleaval F, Doyley MM, Yazdani SK, Finet G, Le Floc'h S, Cloutier G, Pettigrew RI, Ohayon J. A direct vulnerable atherosclerotic plaque elasticity reconstruction method based on an original material-finite element formulation: theoretical framework. Phys Med Biol. 2013; 58(23):8457-8476. See More
Yazdani SK, Nakano M, Otsuka F, Kolodgie FD, Virmani R. Animal models of vascular repair and re-endothelialization. Rev Esp Cardiol Supl. 2013; 13(E):20-28.
Yazdani SK, Sheehy A, Nakano M, Nakazawa G, Vorphal M, Outsuka F, Donn RS, Perkins LE, Simonton CA, Kolodgie FD, Virmani R. Preclinical evaluation of 2nd generation everolimus and zotarolimus eluting coronary stents. Journal of Invasive Cardiology. 2013; 25 (8):383-90.
Deleaval F, Bouvier A, Finet G, Cloutier G, Yazdani SK, Le Floc'h S, Clarysse P, Pettigrew RI, Ohayon J. The Intravascular Ultrasound Elasticity-Palpography Technique Revisited: A reliable Tool for the in vivo Detection of Vulnerable Coronary Atherosclerotic Plaques. Ultrasound in Medicine & Biology. 2013; 39(8):1469-81.
Yazdani SK, Otsuka F, Nakano M, Ladich E, Virmani R. Pathology of Saphenous Vein Grafts. Interventional Cardiology Clinics. 2013; 2(2):242-249.
Habib A, Karmali V, Polavarapu R, Akahori H, Nakano M, Yazdani S, Otsuka F, Pachura K, Davis T, Narula J, Kolodgie FD, Virmani R, Finn AV. Metformin impairs vascular endothelial recovery after stent placement in the setting of local eluted mammalian target of rapamycin inhibitors via s6 kinase-dependent inhibition of cell proliferation. JACC. 2013; 61 (9):971-80.
Le Floc'h S, Cloutier G, Saijo Y, Finet G, Yazdani SK, Deleaval F, Rioufol G, Pettigrew RI, Ohayon J. A Four-Criterion Selection Procedure for Atherosclerotic Plaque Elasticity Reconstruction Based on In Vivo Coronary Intravascular Ultrasound Radial Strain Sequences. Ultrasound in Medicine & Biology. 2012; 38(12):2084-2097.
Tillman BW, Yazdani SK, Neff LP, Corriere MA, Christ GJ, Soker S, Geary RL, Yoo JJ. Bioengineered Vascular Access Maintains Structural Integrity in Response to Arteriovenous Graft Flow and Repeated Needle Puncture. Journal of Vascular Surgery. 2012; 56(3):783-93.
Yazdani SK, Farb A, Nakano M, Vorpahl M, Ladich E, Finn AV, Kolodgie FD, Virmani R. Pathology of drug-eluting versus bare metal stents in saphenous vein graft lesions. JACC Cardiovascular Intervention. 2012; 5(6):666-74.
Otsuka F, Finn AV, Yazdani SK, Nakano M, Kolodgie FD, Virmani R. The Importance of the Endothelium in Atherothrombosis and Coronary Stenting . Nature Reviews Cardiology. 2012; 9(8): 439-53.
Yazdani SK, Nakano M, Otsuka F, Kolodgie FD, Virmani R. Accelerating Endothelialization of Coronary Stents by Capturing Circulating Endothelial Progenitor Cells with CD34 antibody. Interventional Cardiology. 2012;4(2): 168-181.
Yazdani SK, Kolodgie FD, Virmani R. Ex vivo and preclinical assessment of an endothelial progenitor cell capturing bioengineering stent. Minerva Cardioangiologica. 2012; 60(1):11-22.
Nakano M, Vorpahl M, Otsuka F, Taniwaki M, Yazdani SK, Finn AV, Ladich ER, Kolodgie FD, Virmani R. Ex vivo assessment of vascular response to coronary stents by optical frequency domain imaging. JACC Cardiovascular Imaging. 2012; 5(1):71-82.
Finn AV, Nakano M, Polavarapu R, Karmali V, Zhao X, Yazdani S, Davis T, Habib A, Saeed O, Narula J, Kolodgie FD, Virmani R. Hemoglobin directs macrophage differentiation and determines lipid uptake in human atherosclerotic plaques. Journal of American College of Cardiology. 2012; 59(2):166-77.
Larsen K, Cheng C, Tempel D, Parker S, Yazdani S, den Dekker WK, Houtgraaf JH, de Jong R, Hoor SS, Ligtenberg E, Kolodgie FD, Serruys PW, Virmani R, Duckers HJ. Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bioengineered stent in human ex vivo shunt and rabbit denudation model. European Heart Journal. 2012; 33(1):120-8.
Otsuka F, Nakano M, Yazdani SK, Ladich E, Kolodgie F, Virmani R. Pathology of fist-generation drug eluting stents. Interventional Cardiology. 2011; 6(1):28-35.
Yazdani SK, Vorpahl M, Nakano M, Shih-Horng S, Kolodgie FD, Virmani R. In vitro and in vivo characterization of biodegradable polymer-based drug eluting stent. Euro Intervention. 2011; 7(7):835-43.
Sheehy A, Hsu S, Sinn I, Tai J, Kolodgie FD, Nakazawa G, Yazdani SK, Quee SC, Virmani R, Polyakov I. Vascular response to coronary artery stenting in mature and juvenile swine. Cardiovascular Revascularization Medicine. 2011; 12(6):375-84.
Ohayon J, Gharib AM, Garcia A, Heroux J, Yazdani SK, Valve M, Tracqui P, Martinez MA, Doblare M, Finet G, Pettigrew RI. Is Arterial Wall-Strain Stiffening an Additional Process Responsible for Atherosclerosis in Coronary Bifurcations: in vivo Study Based on Dynamic CT and MRI. American Journal of Physiology – Heart and Circulatory Physiology. 2011; 301(3): H1097-107.
Nakazawa G, Otsuka F, Nakano M, Vorpahl M, Yazdani SK, Ladich E, Kolodgie FD, Finn AV, Virmani R. The pathology of neoatherosclerosis in human coronary implants: bare metal and drug-eluting stents. Journal of the American College of Cardiology. 2011; 57(11), 1314-1322.
Neff LP, Tillman BW, Yazdani SK, Machingal M, Yoo JJ, Soker S, Bernish B, Geary RL, Christ GJ. Vascular smooth muscle enhances functionality of tissue engineered blood vessels in vivo. Journal of Vascular Surgery. 2011; 53(2), 426-434.
Yazdani SK, Nakano M, Otsuka F, Kolodgie FD, Virmani R. Atheroma and coronary bifurcations: before and after stenting. EuroIntervention. 2010; 6, J24-30.
Vorpahl M, Yazdani SK, Nakano M, Ladich E, Kolodgie FD, Finn AV, Virmani R. Pathobiology of stent thrombosis after drug-eluting stent implantation. Current Pharmaceutical Design. 2010; 16(36), 4064-4071.
Reifart N, Gyongyosi M, Hauptmann KE, Rabe A, Enayat D, Giokoglu K, Kolodgie FD, Vorpahl M, Yazdani SK, Hemetsberger R, Samaha E, Pavo IJ, Virmani R. Pre-clinical and clinical study results for the CoractoTM Rapamycin-eluting stent – A new-generation drug-eluting stent. Interventional Cardiology. 2010; 5, 39-42.
Yazdani SK, Vorpahl M, Ladich E, Virmani R. Pathology and vulnerability of atherosclerotic plaque: Identification, treatment options, and individual patient differences for prevention of stroke. Current Treatment Options in Cardiovascular Medicine. 2010; 12, 297-314.
Nakazawa G, Yazdani SK, Finn AV, Kolodgie FD, Virmani R. Pathological findings at bifurcation lesions: The impact of flow distribution on atherosclerosis and arterial healing following stent implantation. Journal of the American College of Cardiology. 2010; 55, 1679-1687.
Bekkers S, Yazdani SK, Virmani R, Waltenberger J. Microvascular obstruction: Underlying pathophysiology and clinical diagnosis. Journal of the American College of Cardiology. 2010; 55, 1649-1660.
Yazdani SK, Tillman BW, Berry JL, Soker S, Geary RL. The fate of an endothelium layer after preconditioning: An in vitro and in vivo analysis. Journal of Vascular Surgery. 2010; 51, 174-183.
Yazdani SK, Watts B, Machingal M, Jarajapu Y, Van Dyke ME, Christ GJ. Smooth muscle cell seeding of decellularized scaffolds: The importance of bioreactor preconditioning to development of a more native architecture for tissue engineered blood vessels. Tissue Engineering Part A. 2009; 15, 827-840.
Tillman BW, Yazdani SK, Corriere M, Geary RL, Atala A, Yoo JJ. Efficient recovery of endothelial progenitors for clinical translation. Tissue Engineering Part C. 2009; 15, 213-221.
Yazdani SK, Berry JL. The development of an in vitro system to assess stent induced smooth muscle cell proliferation: a feasibility study. Journal of Vascular Interventional Radiology. 2009; 20, 101-106.
Tillman BW, Yazdani SK, Lee SJ, Geary RL, Atala A, Yoo JJ. The in vivo stability of electrospun polycaprolactone-collagen scaffolds in vascular reconstruction. Biomaterials. 2009; 30, 583-588.
Whitlow CT, Geer CP, Mattern CW, Mussat-Whitlow BJ, Yazdani SK, Berry JL, Lalli JH, Claus RO, Challa VR, Morris PP. Endovascular histologic effects of ultrathin gold-or vitronectin-coated platinum aneurysm coils in a rodent arterial occlusion model: a preliminary investigation. American Journal of Neuroradiology. 2009; 30, 85-90.
Whitlow CT, Yazdani SK, Reedy ML, Kaminsky SE, Berry JL, Morris PP. Investigating sacroplasty: Technical considerations and biomechanical properties of polymethylmethacrylate infusion into cadaveric sacrum. American Journal of Neuroradiology. 2007; 28, 1036-1041.
Amiel G, Komura M, Shapira O, Yoo J, Yazdani S, Berry JL, Kaushal S, Bischoff J, Atala A, Soker S. Engineering of Blood Vessels from Acellular Collagen Matrices Coated with Human Endothelial Cells. Tissue Engineering. 2006; 12, 2355-2365.
Yazdani SK, Berry JL, Moore J, Vlachos PP. DPIV Measurements of Flow Disturbances in Stented Artery Models: Importance of Compliance Mismatch. Journal of Biomechanical Engineering. 2004; 126, 559-566.
EG 101 Introduction to Engineering
EG 284 Dynamics
ME 316 Instrumentation& Exp Method Lab
EG 621 Biomedical Engineering II
Faculty Advisor: Biomedical Engineering Society (BMES) Student Chapter