NIH has provided many resources for investigators to help them navigate these changes.

Resources

As of May 20, 2010, the NIH has updated its SF424 (R&R) application guide. A description of the more notable edits is attached
http://grants.nih.gov/grants/funding/424/appl_guide_changes_20100520.doc

Interacting Electronically with NIH - Power Point Presentation
http://www.southalabama.edu/hsgrants/pdf/interactingelectronically.ppt

Quick Overview of NIH Electronic Submission - Power Point Presentation
http://www.southalabama.edu/hsgrants/pdf/submissionoverview.ppt

Details of Application Changes for Fellowships - March 18, 2010
http://www.southalabama.edu/hsgrants/pdf/appchangesforfellowships.pdf

Overall Impact Versus Significance
http://www.southalabama.edu/hsgrants/pdf/impactvssignifcance.pdf

Clarification on the Extended Error Correction Window and Format of the Research Strategy Section for Restructured Applications Intended for Due Dates on or After January 25, 2010
(NOT-OD-10-050)
National Institutes of Health
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-10-050.html

Details of Application Changes - May 20, 2010
http://enhancing-peer-review.nih.gov/docs/application_changes.pdf

Sample Biosketch
http://grants.nih.gov/grants/funding/2590/biosketchsample.pdf

Confirming the Correct Electronic Forms Choice
http://enhancing-peer-review.nih.gov/docs/confirming_the_correct_electronic_forms_choice.pdf

SBIR/STTR: Upcoming Changes to the Submission of Grant Applications (includes shorter page limits)
http://grants.nih.gov/grants/funding/sbirsttr_news.htm

NOT-HS-10-002: AHRQ Announces Changes to Peer Review Processes, Evaluation Review Criteria, and New Application Forms for Grant Applications
http://grants.nih.gov/grants/guide/notice-files/NOT-HS-10-002.html

Shorter Page Limits
http://enhancing-peer-review.nih.gov/page_limits.html

Details of Career Development Application Changes
http://enhancing-peer-review.nih.gov/docs/Details_of_Career_Development_Application_Changes.pdf

Availability of Reissued Parent Announcements
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-10-031.html

What Applicants Need to Know Now - PowerPoint Presentation, November 19, 2009
http://www.southalabama.edu/hsgrants/applicationchanges.ppt

Video - What Applicants Need to Know Now, November 19, 2009
http://enhancing-peer-review.nih.gov/application_changes_video.html

Title: NIH Notice NOT-OD-10-016
Now Available: Restructured Application Forms and Instructions
http://grants1.nih.gov/grants/guide/notice-files/not-od-10-016.html

Enhancing Peer Review Website
http://enhancing-peer-review.nih.gov/index.html

Training and Communication Resources
http://enhancing-peer-review.nih.gov/training_communication.html

Details of Application Changes for Research Grants and Cooperative Agreements (for due dates on or after January 25, 2010) November 5, 2009
http://enhancing-peer-review.nih.gov/docs/application_changes.pdf

NIH Flyer for Application Changes
http://enhancing-peer-review.nih.gov/docs/flyer_for_application_changes.pdf

NIH One Page Update
http://enhancing-peer-review.nih.gov/docs/information_for_applicants.pdf

In-Depth Overview - Power Point Presentation
http://www.southalabama.edu/hsgrants/enhancingpeerreview.ppt

NIH Frequently Asked Questions
http://enhancing-peer-review.nih.gov/faqs.html

NIH Policy Notices
http://enhancing-peer-review.nih.gov/policy_announcements.html