USA Mitchell Cancer Institute - Jingfang Ju, Ph.D.

Jingfang Ju, Ph.D.

Head, Cancer Genomics Laboratory and Assistant Professor
of Pharmacology and Medicine

Contact Information:

Medical Sciences Building, Room 2316, Mitchell Cancer Institute, USA
307 N. University Blvd, Mobile AL 36688-0002
Telephone: (251) 460-7393
Fax: (251) 460-6994
Email: jju@usouthal.edu

Background:

Ph.D. University of Southern California, CA, September 1992- September 1996
Post-Doctoral Fellow, Yale University, CT, October 1996 - December 1999
Senior Research Scientist and Project Leader, CuraGen Corporation, CT, December 1999 -January 2004

Research Interests:

At the Cancer Genomics Laboratory in USA Cancer Research Institute, our main research interests include: 1.) Development of novel technologies for genomic and functional genomic research; 2.) Discovery of predictive and prognostic markers for various human cancers and treatments using clinical trial patient's samples; 3.) Investigate the molecular and cellular mechanism of newly discovered translational regulated genes related to tumor progression and drug resistance; 4.) Investigate non-coding RNA (microRNAs and siRNAs) functions in human cancer.

Selected Recent Publications :

Xi Y, Shalgi R, Fodstad O, Pilpel Y, Ju J . Differentially regulated miRNAs and actively translated mRNA transcripts by tumor suppressor p53 in colon cancer. Clinical Cancer Research. 2006; 12 (7): 2014-2024

Xi Y, Nakajima G, Schmitz, JC, Chu E, Ju J . Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006: 7: 68

Xi Y, Nakajima G, Hamil G, Fodstad O, Riker A, Ju J . IGFBP-3 expression is associated with tumor progression in melanoma. Cancer. 2006. (Revision)

Zhao M, Bi L, Bi W, Wang C, Yang Z, Ju J , Peng S. Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity. Bioorganic & Medicinal Chemistry . 2006. (in press)

Wu Y, Bi L, Bi W, Li Z, Zhao M, Wang C, Ju J , Peng S. Novel 2-substitutednitronyl nitroxides as free radical scavengers: synthesis, biological evaluation and structure-Activity relationship. Bioorganic & Medicinal Chemistry . 2006. (in press)

Ju J , Rastelli L, Malyanker M, Simons JF, Huang C, Herrmann J, MacDougall, and Taillon B. The melanoma vascular mimicry phenotype defined in gene expression and microsome sequencing analysis. Cancer Genomics & Proteomics. 2004; 1: 355-362.

Ju J , Huang C, Minskoff SA, Mayotte JE, Taillon BE, Simons JF. Simultaneous gene expression analysis of steady-state and actively translated mRNA populations from osteosarcoma MG-63 cells in response to IL-1alpha via an open expression analysis platform. Nucleic Acids Res. 2003; 31(17): 5157-66.

Schmittgen TD, Ju J , Danenberg KD, Lenz HJ, Danenberg PV. Inhibition of pre-mRNA splicing by cisplatin and platinum analogs. Int J Oncol. 2003; 23(3): 785-9.

Chu E, Copur SM, Ju J , Carey KL, Khleif S, Voeller DM, Mizunuma N, Patel M, Maley GF, Maley F, Allegra C. Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex. Mol. Cell. Biol. 1999; 19: 1582-1594.

Chu E, Schmitz, J., Ju J , Copur SM. An immunoprecipitation-RNA:rPCR method for the in vivo isolation of ribonucleoprotein complex. Methods of Molecular Biology (Humana Press Inc., Totowa, N. J.). 1999; 265-274.

Ju J , Lane J-P, Maley F, Chu E. Translational regulation of p53 expression by thymidylate synthase. Proc. Natl. Acad. Sci. USA 1999; 96: 3769-3774.

Chu E, Schmitz J, Ju J . Molecular regulation of expression of thymidylate synthase. Anticancer Drug Development Guide: Antifolate Drugs in Cancer Therapy (Humana Press Inc., Totowa, NJ). 1999; 397-408.

Liu M, Pelling JC, Ju J , Chu E, Brash DE. Antioxidant action via p53-mediated apoptosis. Cancer Research. 1998, 1723-1729.

Ju J , Lenz HJ, Banerjee D, Danenberg KD, Schmittgen T, Spears CP, Schonthal AH, Leichman L, Bertino JR, Danenberg PV. Restoration of wild-type p53 activity in p53-null HL-60 cells confers multi-drug sensitivity. Clinical Cancer Research. 1998; 4: 1315-1322.

Ju J , Kane SE, Lenz HJ, Chu E, Danenberg KD, Danenberg PV. Desensitization and sensitization of tumors to fluoropyrimidines with antisense against thymidylate synthase. Clinical Cancer Research. 1998; 9: 2229-2236.

Banerjee D, Lenz H-F, Schnieders B, Manno D, Ju J , Spears CP. Hochhauser D, Danenberg KD, Danenberg PV, Bertino JR. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL-60 cells and increases their sensitivity to stress. Cell Growth & Differentiation. 1995. 6(11):1405-13.

Patents :

1. Novel antibodies that bind to antigenic polypeptides, nucleic acids enconding the antigens, and methods of use. 20030185815

2. Antisnese modulation of protein expression. 20030176385

3. Method for analyzing a nucleic acid. 20020061526