USA Mitchell Cancer Institute - Lewis K. Pannell, Ph.D.

Lewis K. Pannell, Ph.D.

Head Proteomics and Mass Spectrometry Research Laboratory
and Professor Biochemistry and Molecular Biology Center
for Basic and Translational Sciences

Contact Information:

Medical Sciences Building, Room 2310, Mitchell Cancer Institute, USA
307 N. University Blvd, Mobile AL 36688-0002
Telephone: (251) 414-8201
Fax: (251) 414-8281
Email: lpannell@usouthal.edu

Background:

Ph.D., University of Canterbury, New Zealand, 1975
Forensic Toxicologist, DSIR, Christchurch, New Zealand, December 1975 - August 1984
National Heart, Lung and Blood Institute, NIH, Bethesda MD on sabbatical, May 1983 - August 1984
Chief, Structural Mass Spectrometry Group, NIDDK, Bethesda MD, August 1984 - October 2002
Professor, University of South Alabama, Mobile AL, October 2002 - Present

Research Interests:

At USA, Dr Pannell's research work will be dominated by the projects within the new Cancer Research Institute, especially the identification of proteomic markers for cancer and their trace analysis within biological fluids and tissues. Undergraduate, graduate and postgraduate students from other research groups are encouraged to make use of the facility for their own research projects and they are trained how to prepare their own samples (e.g. to digest proteins on gels) and to characterize their digests using the available Mascot ( http://www.matrixscience.com ) and Waters Proteinlynx Global Server 2.0 software packages. Training is held for the students and faculty both on a formal (part of College of Medicine courses) and informal basis.

Selected Recent Publications :

A Novel Anti-HIV Macrocyclic Peptide from Palicourea condensate: Bokesch, H.R.; Pannell, L.K. ; Cochran, P.K.; Sowder, R.C.II; McKee, T.C.; Boyd, M.R.: J. Nat. Prod. 64(2), 249-250 (2001).

New Nitrogenous Constituents from the South African Marine Ascidian Pseudodistoma sp.: Rashid, M.A.; Gustafson, K.R.; Cartner, L.K.; Pannell, L.K. ; Boyd, M.R.: Tetrahedron 57, 5751-5755 (2001).

In Vivo Mechanism-based Inactivation of S-Adenosylmethionine Decarboxylases from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisia: Li, Y-F.; Hess, S.; Pannell, L.K. ; Tabor, C.W.; Tabor, H.: PNAS 98(19), 10578-10583 (2001).

Solid State NMR Data Support a Helix-loop-helix Structural Model for the N-terminal Half of HIV-1 Rev in Fibrillar Form: Blanco, F.J.; Hess, S.; Pannell, L.K. ; Rizzo, N.; Tycko, R.: J. Mol. Biol. 313, 845-859 (2001).

4 -Hydroxy-2-nonylquinoline: A Novel Iron Chelator Isolated from a Bacterial Cell Membrane: Royt, P.W.; Honeychuck, R.V.; Ravich, V.; Ponnaluri, P.; Pannell, L.K. ; Buyer, J.; Chandhoke, V.; Stalick, W.M.; DeSesso, L.C.; Donohue, S.; Ghei, R.; Relyea, J.D.; Ruiz, R.: Bioorganic Chemistry 29, 387-397 (2001).

Patterns of resistance to exonuclease digestion of oligonucleotides containing polycyclic aromatic hydrocarbon diol epoxide adducts at N6 of deoxyadenosine. Illankumara, P.; Pannell, L.K. ; Gebreselassie, P.; Pilcher, A.S.; Yagi, H.: Chem. Res. Toxicol. 14(9), 1330-1338 (2001).

A temperature-sensitive mutation of Crygs in the murine Opj cataract. Sinha, D.; Wyatt, M.K.; Sarra, R.; Jaworski, C.; Slingsby, C.; Thaung, C.; Pannell, L.K. ; Robinson, W.G.; Favor, J.; Lyon, M.; Wistow, G.: J. Biol. Chem. 276(12), 9308-9314 (2001).