USA Mitchell Cancer Institute - Lalita Shevde-Samant, Ph.D.

Lalita Shevde-Samant, Ph.D.

Assistant Professor, Department of Oncologic Sciences

Contact Information:

Medical Sciences Building, Room 2332, Mitchell Cancer Institute, USA
307 N. University Blvd, Mobile AL 36688-0002
Telephone: (251) 460-6118
Fax: (251) 460-6994
Email: lsamant@usouthal.edu

Positions Held :

1994-1995                 Research Assistant (Fungal Screening Laboratory), Hoechst Marion-Roussell (India) Ltd.
1995-1999                 Junior Research Fellow, Cancer Research Institute, University of Bombay, India.
08/1999-09/2002      Postdoctoral Scholar (Jake Gittlen Cancer Research Institute), The Pennsylvania State University College of Medicine, Hershey, PA.
10/2002-06/2003      Research Associate (Department of Pathology / Molecular and Cellular Pathology) University of Alabama at Birmingham, AL
10/2002-05/2004      Associate Scientist, Womens Cancer Section, Comprehensive Cancer Center, UAB
06/2003-05/2004      Research Instructor (Department of Pathology/ Molecular and Cellular Pathology) University of Alabama, Birmingham, AL
06/2004-08/2007      Staff Scientist (Tenure track), Mitchell Cancer Institute, University of South Alabama, Mobile, AL
06/2004-08/2007      Assistant Professor (Tenure track), Department of Pathology, University of South Alabama, Mobile, AL
08/2007-present       Assistant professor (Tenure track), Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL
08/2007-present       Assistant Professor, (Department of Cell Biology & Neurosciences), University of South Alabama, Mobile, AL

Honors and Awards :

Honors
1991-92           President, Ruia Microbiology Society, Ramanaraian Ruia College, Mumbai, India.
2001                Invited talk at the, 92nd Annual Meeting of the American Association of Cancer Research, March 24-28, 2001.
2007                Invited talk at the Gordon Research Conference on SIBLING proteins, University of New England, Biddeford, Maine, August 5-10, 2007

Awards
1992                Gold medal, Ranked 1st in B. S. (Microbiology) at R. Ruia College, Mumbai, India.
1992                Merit Award, Ranked 3rd in the University, B. S. (Microbiology), University of Mumbai, India
1994                Ranked 2nd in M. S. University, Baroda, India for M. S. (Microbiology).
2001                AACR- Genentech, Inc. Scholar-in-Training Award, 92nd Annual Meeting of the American Association of Cancer Research, March 24-28, 2001
2004                Travel award from the Susan G. Komen Breast Cancer Foundation for The 10th International Congress of the Metastasis Research Society, Genoa, Italy,                          September 17-21, 2004
2006                University Committee for Undergraduate Research (UCUR) Award from University of South Alabama, May-August 2006.
2007                University Committee for Undergraduate Research (UCUR) Award from University of South Alabama, May-August 2007.

Research Interests:

The role of the Hedgehog pathway and SPP1 (Osteopontin) in regulating metastasis of breast cancer to the bone.
The role of NUPR1 in determining chemoresistance of breast cancer.
Studies on the role of breast cancer stem cells in revealing characteristics of metastasis.
The role of epigenetic modification in regulating the expression of breast cancer metastasis suppressor gene 1.

Selected Recent Publications :

Shevde L.A., Rao N.M., Joshi N.N., Shinde S.R. , Ghosh S.N. and Nadkarni J.J. Natural killer cell function and genetic instability in unaffected members from cancer families. Eur J Cancer Prev 7: 141-148, 1998.
Shevde L.A., Joshi N.N., Shinde S.R. and Nadkarni J.J. Studies on functional status circulating lymphocytes in unaffected members from cancer families. Hum Immunol59: 373-381, 1998.
Shevde L.A., Joshi N.N., Advani S.H. and Nadkarni J.J. Impaired T lymphocyte function and differential cytokine response pattern in membranes from cancer families. Nat Imm16: 146-156, 1998.
Shevde L.A., Joshi N.N., Dudhat S.B., Hawaldar R.W. and Nadkarni J.J. Immune functions, clinical parameters and hormone receptor status in breast cancer patients. J Cancer Res Clin Oncol 125: 313-320, 1999.
Samant, R.S., Seraj, M.J., Saunders, M.M., Sakamaki, T., Shevde L.A., Harms, J.F., Leonard, T.O., Goldberg S.F., Budgeon, L., Meehan, W.J., Winter, C.R., Christensen, N.D., Verderame, M.F., Donahue, H.J., and Welch, D.R. Analysis of mechanisms underlying BRMS1 suppression of metastasis. Clin Exp Metas 18 (8): 683-693, 2001.
Samant, R.S., Shevde, L.A. and Welch, D.R. Role of BRMS1 in Breast Carcinoma Metastasis. Cancer Metastasis-related Genes. D.R. Welch ed. In: CANCER METASTASIS: BIOLOGY AND TREATMENT, edited by R.J. Ablin and W. G. Jiang, Kluwer Academic Publishers, Dorderecht, (2001).
Samant, R.S., Debies, M.T., Shevde, L.A, Verderame, M.F., and Welch, D.R. Identification and characterization of murine ortholog (brms1) of Breast Cancer Metastasis Suppressor 1 (BRMS1). Int J Cancer 97:15-20, 2002.
Shevde L.A., Samant R.S., Goldberg S.F., Sikaneta T, Alessandrini A, Donahue H.J., Mauger D.T., Welch D.R. Suppression of Human Melanoma Metastasis by the Metastasis Suppressor Gene, BRMS1. Exp Cell Res: 273(2), 229-239, 2002.
Shevde L.A. and Welch D.R. Metastasis suppressor pathways-an evolving paradigm Cancer Lett 198: 1-3, 2003.
Meehan W.J., Samant R.S., Hopper J.E., Carrozza M.J., Shevde L.A., Workman J.L, Eckert K.A., Verderame M.F., Welch D.R. The BRMS1 metastasis suppressor forms complexes with RBP1 and the mSin3 histone deacetylase complex and represses transcription. J Biol Chem 279(2): 1562-1569, 2004.
Harms J.F., Samant R.S., Shevde L.A., Babu G.R., Gay C.V., Mastro A.M., Donahue H.J., Griggs D.W., Kotyk J.J., Pagel M.D., Rader R.K., Westlin W.F., Welch D.R. The small molecule αvβ3 antagonist (S247) inhibits MDA-MB-435 breast cancer metastasis to bone. (Clin Exp Metastasis 21(2): 119-128, 2004.
Samant R.S. and Shevde L.A. “The molecular mechanisms for BRMS1 action in cancer metastasis” In: "DNA Methylation, Epigenetics and Metastasis” Chapter 10, P.P. 231-242, Edited by Manel Esteller, for Springer Life Sciences (2005).
Samant R.S., Debies M. T., Hurst D. R., Moore B. P., Shevde L. A., Welch D. R. Suppression of murine mammary carcinoma metastasis by the murine ortholog of Breast Cancer Metastasis Suppressor (Brms1). Cancer Letters 235(2): 260-265, 2006.
Hurst D.R., Mehta A., Moore B.P., Phadke P.A., Meehan W.J., Accavitti M.A., Shevde L.A., Hopper J.E., Xie Y., Welch D.R., Samant R.S. Breast Cancer Metastasis Suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone complex. Biochem Biophys Res Comm 348(4): 1429-35, 2006.
Shevde L. A., Samant R. S., Paik J. C., Metge B. J., Chambers A. F., Casey G., Frost A. R., Welch D. R. Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma. Clin Exp Metastasis 18(8): 683-93, 2006. (corresponding author)
Samant R.S., Clark D.W., Fillmore R.A., Cicek M., Metge B.J., Chandramouli K.H., Chambers A.F., Casey G., Welch D.R., Shevde L.A. Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-Kappa B activation. Molecular Cancer 6: 6, 2007, doi: 10.1186/1476-4598-6-6. (corresponding author)
Samant R.S. and Shevde L.A. “Insights into the signaling mechanisms of BRMS1” In “New Developments in Metastasis Suppressor Research” Chapter 1, Edited by Paul Jackson, PhD, for Nova Science Publishers, Inc. (2007).
Mbeunkui F., Metge B.M., Shevde L.A., Pannell L. K. Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancer. J Proteome Res 6(8): 2993-3002, 2007 (co-corresponding author)
Samant R.S., Fodstad O., Shevde L. A. “The genetic control of breast cancer metastasis” pp 7-30 In: “Metastasis of Breast Cancer” Edited by Robert E. Mansel, Oystein Fodstad and Wen G. Jiang for Springer Life Sciences (2007).
Shevde L.A. and King J. A. “Cell adhesion molecules in breast cancer invasion and metastasis” pp 111-136In: “Metastasis of Breast Cancer” Edited by Robert E. Mansel, Oystein Fodstad and Wen G. Jiang for Springer Life Sciences (2007).
King J. A., Shevde L. A., Ofori-Acquah S., Watkins G., Jiang, W.G. Is N-Cadherin Expression Important in Ductal Carcinoma? South Med J (In press).
Bauer N.N., Chen Y-W., Samant R.S., Shevde L.A., Fodstad O. Rac1 activity regulates proliferation of aggressive metastatic melanoma in part via NFκB signaling. Exp Cell Res (In press).
Samant R.S. and Shevde L.A. BRMS1. Targeted Protein Database (In press). (corresponding author).
Shevde L.A. and Riker A. I. Current concepts in biobanking: Development and implementation of a tissue repository. Accepted for publication in Frontiers in Biosciences (corresponding author).
Xi Y., Riker A., Shevde L.A., Samant R.S., Morris C., Gavin E., Fodstad O., Ju J, Global comparative gene expression analysis of melanoma patient sample, derived cell lines and corresponding tumor xenografts. Accepted for publication Cancer Genomics & Proteomics.

Grant Support:

ACTIVE

BC0601257
Department of Defense 06/01/2007-05/31/2010
Crosstalk between cancer cells and bone via the Hedgehog pathway determines bone metastasis of breast cancer
Goals: To investigate the role of the hedgehog pathway in mediating metastasis of breast cancer to bone.
Role: Principal Investigator

0655377B (King)
American Heart Association 07/01/2006-06/30/2008
Lung Endothelial ALCAM as a Determinant for Metastasis
Goals: To investigate the role of ALCAM in the lung endothelium in determining metastasis of breast cancer.
Role: Consultant