USA Mitchell Cancer Institute - Rajeev Samant, Ph.D.

Rajeev Samant, Ph.D.

Assistant Professor, Department of Oncologic Sciences

Contact Information:

Medical Sciences Building, Room 2015, Mitchell Cancer Institute, USA
307 N. University Blvd, Mobile AL 36688-0002
Telephone: (251) 460-6993
Fax: (251) 460-6994
Email: rsamant@usouthal.edu

Background:

05/04-present Assistant Professor, (Tenure Track), Basic and Clinical Translational research, Department of Oncologic sciences, Mitchell Cancer Institute, Mobile, AL
05/04-present Assistant Professor, (Tenure Track), Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL
10/2003-05/2004 Associate Scientist (Women's Cancer Program) Comprehensive Cancer Center, University of Alabama at Birmingham, AL
06/2003-05/2004 Research Instructor (Department of Pathology/ Molecular and Cellular Pathology) University of Alabama at Birmingham, AL
10/2002 -6/2003 Research Associate (Department of Pathology/ Molecular and Cellular Pathology) University of Alabama at Birmingham, AL
8/1998-9/2002 Post Doctoral Scholar (Jake Gittlen Cancer Research Institute) Department of Pharmacology, Pennsylvania State University College of Medicine
6/1995-7/1998 Senior Research Fellow (Bacterial gene regulation) Indian Institute of Technology, Bombay, India
6/1993-5/1995 Junior Research Fellow (Bacterial gene regulation) Indian Institute of Technology, Bombay, India

Research Interests:

1. Heat shock proteins (HSP40) in cancer progression and metastasis.
2. Role of myc interactors in cancer progression and metastasis.
3. Understanding role of novel multi-protein complexes in modulation of gene expression and tumor progression.

Selected Recent Publications :

Samant, R.S. *, Seraj, M.J.*, Verderame, M.F., Welch, D.R. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Research 60: 2764-2769 (2000)

Samant, R.S., Welch, D.R.: BRMS1. In: Schwab, M., (Ed) Cancer Research: an encyclopedic reference. Springer, Berlin, 2000. (http://claim.springer.de/EncRef/CancerResearch/default.htm)

Jaeger, E.B, Samant, R.S., Rinker-Schaeffer, C.W. Metastasis Suppression In Prostate Cancer. Cancer Metastasis Rev;20(3-4): 279-86, 2001.

Samant, R.S., Seraj, M.J., Saunders, M.M., Sakamaki, T., Shevde L.A., Harms, J.F., Leonard, T.O., Goldberg S.F., Budgeon, L., Meehan, W.J., Winter, C.R., Christensen, N.D., Verderame, M.F., Donahue, H.J., Welch, D.R. Analysis of mechanisms underlying BRMS1 suppression of metastasis. Clin Exp Metastas. 18 (8): 683-693, 2001.

Samant, R.S., Shevde, L.A. and Welch, D.R. Role of BRMS1 in Breast Carcinoma Metastasis. In: D.R. Welch, R.J. Ablin, W. G. Jiang (Eds) Cancer Metastasis-related Genes. CANCER METASTASIS: BIOLOGY AND TREATMENT, Kluwer Academic Publishers, Dorderecht, 2001.

Manni, A., Washington, S., Griffith, J.W., Verderame, M.F., Mauger, D., Demers, L.M., Samant, R.S., Welch D.R. Polyamine involvement in invasion and metastasis by human breast carcinoma cells. Clinical and Experimental Metastasis, 19 (2), 95-105, 2002.

Shevde, L.A., Samant, R.S., Goldberg, S.F., Sikaneta, T., Alessandrini, A., Donahue, H.J., Mauger, D.T., Welch, D.R. Suppression of Human Melanoma Metastasis by the Metastasis Suppressor Gene, BRMS1. Exp Cell Res: 273(2), 229-239, 2002.

Park Y.G., Lukes L., Yang H., Debies M.T., Samant R.S., Welch D.R., Lee M., Hunter K.W. Comparative sequence Analysis in Eight Inbred Strains of the Metastasis Modifier QTL Candidate Gene Brms1. Mammalian Genome, 13 (6), 289-292, 2002.

Samant, R.S., Debies, M.T., Shevde, L.A, Verderame, M.F., and Welch, D.R. Identification and characterization of murine ortholog (brms1) of Breast Cancer Metastasis Suppressor 1 (BRMS1). Int. J. Cancer: 97, 15-20, 2002.

Samant, R.S., Meehan, W.J.*, Hopper, J.E., Workman, J.L., Carrozza, M.J., Shevde, L.S., Verderame, M.F., Eckert, K.E., Welch, D.R. Interaction of the BRMS1 metastasis suppressor with RBP1 and mSin3 histone deacetylase complex. J Biol Chem. 279(2):1562-1569, 2004.

Jaeger, E.B., Chekmareva, M.A., Tennant, T.R., Luu, H.H., Hickson, J.A., Chen, S.L., Samant, R.S., Sokoloff, M.H., Rinker-Schaeffer, C.W. Inhibition of prostate cancer metastatic colonization by approximately 4.2 Mb of human chromosome 12.Int J Cancer., 108(1):15-22, 2004.

Harms, J.F., Welch, D.R., Samant, R.S., Shevde, L.A., Babu, et al , The small molecule antagonist of the αvβ3 integrin suppresses MDA-MB-435 skelatel metastasis. Clinical and Experimental Metastasis, 21 (2), 119-128, 2004.

Cicek, M., Samant, R.S., Kinter, M., Welch, D.R., Casey, G. Identification of metastasis associated proteins through protein analysis of metastatic MDA-MB-435 and Metastasis Suppressed BRMS1 transfected MDA-MB-435 cells. Clinical and Experimental Metastasis, 21 (2), 149-157, 2004.

Kapoor, P., Saunders, M.M., Li, Z., Zhou, Z., Schaeffer, N., Kunze, E.L., Samant, R.S., Welch, D.R., Donahue, H.J. Breast cancer metastatic potential: Correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells. Int J Cancer. 111(5):693-697, 2004.

Dewald, D.B., Torabinejad, J., Samant, R.S., Johnston, D., Erin, N., Shope, J.C., Xie, Y., Welch, D.R. Metastasis Suppression by Breast Cancer Metastasis Suppressor 1 Involves Reduction of Phosphoinositide Signaling in MDA-MB-435 Breast Carcinoma Cells. Cancer Res. 65(3):713-7, 2005.

Samant, R.S., Debies, M. T., Hurst, D.R., Moore, B.P., Shevde, L.A., Welch, D.R. Suppression of murine mammary carcinoma metastasis by the murine ortholog of Breast Cancer Metastasis Suppressor (Brms1). Cancer Lett 235(2): 260-265, 2006.

Shevde, L.A., Samant, R.S., Paik, J.C., Metge, B.J., Chambers, A.F., Casey, G., Frost, A.R., Welch, D.R. Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma.Clin Exp Metastasis. 23(2):123-33, 2006.

Hurst, D.R., Mehta, A., Moore, B.P., Phadke, P.A., Meehan, W.J., Accavitti, M.A., Shevde, L.A., Hopper, J.E., Xie, Y., Welch, D.R., Samant, R.S. Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. Biochem Biophys Res Commun.348 1429–1435, 2006

Samant, R.S., Clark, D.W., Fillmore, R.A., Cicek, M., Metge, B.J., Chandramouli, K.H., Chambers, A.F., Casey, G., Welch, D.R., Shevde, L.A. Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-Kappa B activation. Molecular Cancer 6:6 doi:10.1186/1476-4598-6-6

Samant, R.S. Shevde, L.A.: The molecular mechanisms for BRMS1 action in cancer metastasis In: Esteller, M. (Ed) DNA Methylation, Epigenetics and Metastasis. Springer Life Sciences. Chapter 10, pp. 231-242, 2005

Samant, R.S., Shevde, L.A. Insights into the signaling mechanisms of BRMS1 In: Paul Jackson, PhD., (Ed) Developments in metastasis Suppressors. Nova Science Publishers, Inc.

Samant, R.S., Fodstad, O., Shevde, L. A.: The genetic control of breast cancer metastasis” In: Robert E. Mansel, Oystein Fodstad and Wen G. Jiang (Ed). Metastasis of Breast Cancer Springer Life Sciences. PP 1-30

Bauer N.N., Chen Y-W., Samant R.S., Shevde L.A., Fodstad O. Rac1 activity regulates proliferation of aggressive metastatic melanoma. Exp Cell Res (In press).

Samant R. S., Shevde L.A. ”BRMS1” Target assessment for Targeted Proteins database. (In press)