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Professional Profile
Research Interests: -Cancer chemoprevention and anti-cancer drug development -Phosphodiesterases and cAMP/cGMP signaling in cancer biology -Intracellular signaling compartmentalization in anti-cancer therapy -Angiogenesis between cancer and normal tissues in lung cancer chemotherapy Honors, Professional Organizations, and Achievements: -Member, American Association for Cancer Research, 2002-2007 -Member, The American Physiological Society, 2005-present -Ad hoc Reviewer, Medical Science Monitor, 2006-present Education: -Postdoctoral Fellow, University of South Alabama College of Medicine, 1997-2002 -Ph.D., Pharmacology, Peking Union Medical College and Chinese Academy of Medical Science, 1991-1996 -B.S., Pharmacy, Beijing Medical University, 1987-1991 Professional Appointments: -Assistant Professor, Beijing Medical University, National Key Laboratory, P. R. China, 1996-1997 -Research Associate, Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama, 2002-2005 -Instructor, Department of Pharmacology, University of South Alabama College of Medicine, 2005-2008 -Assistant Professor, Center for Lung Biology, Department of Pharmacology, University of South Alabama College of Medicine, 2008-2011 -Assistant Professor of Oncologic Sciences, Drug Discovery, Mitchell Cancer Institute, University of South Alabama, 2011-present Scientific Focus: The novel targets of intracellular signaling of cyclic nucleotides and phosphodiesterases in cancer therapy, chemoprevention, and new drug development. Selected Publications: 1. Feinstein, W., Zhu, B., Leavesley, S.J., Sayner, S.L., Thomas, C.R. (2011) Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells. Am J Physiol Cell Physiol. In press. 2. Zhu, B., Zhang, L., Creighton, J., Alexeyev, M., Strada, S.J., Stevens, T. (2010) Protein kinase A phosphorylation of Tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrier. Am J Physiol Lung Cell Mol Physiol. 299: L493-L501. 3. Zhu, B., Zhang, L., Alexeyev, M., Alvarez, D., Strada, S.J., Stevens, T. (2009) Type 5 phosphodiesterase is a critical determinant of the lung endothelial cell angiogenic phenotype. Am J Physiol Lung Cell Mol Physiol. 296: L220-L228. 4. Ji, D.B., Zhu, M.C., Zhu, B., Zhu, Y.Z., Li, C.L., Zhu, H.B. (2008) Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1a-VEGF pathway and regulation of Bcl-2/Bax. J Cardiovasc Pharmacol. 52: 191–202. 5. Schmidt, E.P., Damarla, M., Rentsendorj, O., Servinsky, L.E., Zhu, B., Moldobaeva, A., Gonzalez, A., Hassoun, P.M., Pearse, D.B. (2008) Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 295: L1056-L1065. 6. Creighton, J., Zhu, B., Alexeyev, M., Stevens, T. (2008) Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation. J Cell Sci. 121: 110-119. 7. Zhu, B., Strada, S.J. The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma and pulmonary/cardiovascular vessels (Review). (2007) Curr Top Med Chem. 7: 437-454. 8. Zhu, B., Liu, G.T., Wu, R.S., Strada, S.J. (2006) Chemoprevention of Bicyclol against hepatic preneoplastic lesions. Cancer Biol Ther. 5: 1665-1673. 9. Zhu, B., Liu, G.T., Zhao, Y.M., Wu, R.S., Strada, S.J. (2006) Chemosensitizing multiple drug resistance of human carcinoma by Bicyclol involves attenuated P-glycoprotein, GST-P and Bcl-2. Cancer Biol Ther. 5: 536-543. 10. Zhu, B., Zhang, L.H., Zhao, Y.M., Cui, J.R., Strada, S.J.(2006) 8-Chloroadenosine induced HL-60 cell growth inhibition, differentiation and G1 arrest involves attenuated cyclin D1 and telomerase but up-regulated p21WAF1/CIP1. J Cell Biochem. 97: 166-177. 11. Zhu, B., Strada, S.J., Stevens, T. (2005) Cyclic GMP-specific phosphodiesterase 5 regulates cell growth and apoptosis of pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 289: L196-L206. 12. Zhu, B., Vemavarapu, L., Thompson, W.J., Strada, S.J. (2005) Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cell. J Cell Biochem. 94: 336-350. 13. Zhu, B., Kelly, J.J., Vemavarapu, L., Strada, S.J., Thompson, W.J. (2004) Activation and induction of cyclic AMP phosphodiesterase (PDE 4) in rat pulmonary microvascular endothelial cells. Biochem Pharmacol. 68: 479-491. 14. Thompson, W.J., Ashikaga, T., Kelly, J.J., Liu, L., Zhu, B., Vemavarapu, L., Strada, S.J. (2002) Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4). Biochem Pharmacol. 63: 797-807. 15. Thompson, W.J., Piazza, G.A., Li, H., Liu, L., Fetter, J., Zhu, B., Sperl, G., Ahnen, D., Pamukcu, R. (2000) Exisulind induction of apoptosis involves guanosine 3’,5’-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated ß -catenin. Cancer Res 60: 3338-3342. Grant Records: -1 R01 HL094455-01A1 Period: 09/01/09-08/31/11 Provider: NIH Title: cAMP Phosphodiesterase and Lung Endothelial Cell Permeability Role: Co-Investigator (PI: RICH, T) -0865356E Beginning Grant-in-Aid Period: 07/01/08-06/30/10 Provider: American Heart Association, Southeast Title: PDE5 and Endothelial Cell Angiogenesis Role: Principal Investigator -0665169 Beginning Grant-in-Aid Period: 07/01/06-06/30/08 Provider: American Heart Association, Southeast Title: Cyclic GMP phosphodiesterase 5 in control of apoptosis and growth inhibition in lung endothelium Role: Principal Investigator |
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University of South Alabama - Mobile Alabama 36688-0002 Appointments: Medical, Surgical and Gynecologic Oncology: (251) 665-8000 Radiation Oncology: (251) 445-9615 Administration: (251) 460-6993 For questions or comments Contact Us Date last changed: February 1, 2012 3:33 PM http://www.southalabama.edu/mci/zhu.html |
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