A fine balance exists between productive immune responses generating protection from pathogens, and counter-productive responses that lead to autoimmune disease. My lab focuses on understanding the cellular and molecular pathways responsible for directing B cell fate decisions that ultimately result in antibody production. We utilize genetic mouse strains to explore more efficient vaccine design and to model human autoimmune disease.

Recent Publications

1. Barrington RA, Schneider TJ, Pitcher, LA, Mempel T, Ma M, Schuerpf F, Barteneva N and Carrol MC. 2009. Uncoupling CD21 and CD21 of the B cell co-receptor. Proc Nat’l Acad Sci USA 106 (34):14490-5. PMID:19706534

2. Zhang H, Li J, Barrington RA, Liang G, Qin G, Liu DX. 2007. An anti-endotoxin peptide that generates from the amino-terminal domain of complement regulatory protein C1 inhibitor. Biochem Biophys Res Commun 359(2):285-91.
 

3. Zhang H, Qin G, Liang G, Li J, Chiu I, Barrington RA, Liu D. 2007. Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1. Biochem Biophys Res Commun 358(4):1120-7.

4. Zhang H, Qin G, Liang G, Li J, Barrington RA, Liu DX. 2007. C5aR-mediated myocardial C5aR-mediated myocardial ischemia/reperfusion injury. Biochem Biophys Res Com 357(2):446-52.

5. Barrington RA, Borde M, Rao A, and Carroll MC. 2006. Involvement of NFAT1 in B cell self-tolerance. J Immunol 177(3):1510-1515.

6. Barrington RA, Zhang M, Zhong X, Jonsson H, Holodick N, Cherukuri A, Pierce S, Rothstein TL, and Carroll MC. 2005. CD21/CD35 co-receptor signaling promotes B cell survival during primary immune responses. J Immunol 175(5): 2859-2867.

7. Morra M, Barrington RA, Abadina-Molina A, Okamuto S, Julien A, Gullo C, Spolski R, Satoskar A, Carroll MC, and Terhorst C. 2005. Defective early B cell responses in the absence of the XLP-gene SAP. Proc Nat’l Acad. Sci. USA 102 (13): 4819-4823.

8. Barrington RA, Pozdnyakova O, Zafari MR, Benjamin CD and Carroll MC. 2002. B lymphocyte memory: Role of stromal cell complement and FcRIIB receptors. J Exp Med 196(6):1189-1199.

9. Barrington RA, Fasullo M and Knight KL. 1999. A role for RAD51 in the generation of immunoglobulin gene diversity in rabbits. J  Immunol 162(2):911-919.