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Dr. Adel L. Barsoum, Assistant Professor, received his Ph.D. from Christian Albrechts University, Kiel, Germany in 1965. He joined the Faculty at the Heinrich Heine University Medical Center in Düsseldorf,
and at the University of Essen. He was also a visiting scientist at the Chester Beatty Cancer Research Institute in London. He did his postdoctoral studies at The Milton S. Hershey Medical Center, Pennsylvania State University.
My laboratory is studying the immunochemistry and expression of the Oncofetal antigen in different types of murine and human tumors. This antigen has been recently identified by us as immature laminin receptor protein, which is conserved in rodents and humans. It plays a role in tumor invasion and metastasis and is autoimmunogenic in the tumor bearing host.
Currently we are monitoring B- and T-Cell immune response of breast cancer patients immunized with recombinant pure OFA/iLRP loaded on their autologous dendritic cells in an FDA-approved Phase I / II clinical trial. |
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Recent
Publications
Friedricks B, S. Siegel, M Kloess, A. Barsoum, J. Coggin, Jr., J. Rohrer, I. Jakob, M. Tiemann, K. Heidorn, C. Shulte, D. Kabelitz, J. Steinmann, N. Schmitz and M. Zeis. Humoral immune responses against the immature laminin receptor protein show prognostic significance in patients with chronic lymphocytic leukemia. J Immunol:180, 6374-6384, 2008.
Rohrer J. W., A. L. Baroum, J. H. Coggin, Jr. Identification of Oncofetal Antigen/ Immature Laminin Receptor Protein epitopes that activate BALB/c mouse OFA/iLRP-specific effector and regulatory T cell clones. J. Immunol 176, 2844-2856, 2006.
Coggin J. H. Jr., A. L. Barsoum, J. W. Rohrer, M. Thurnher and M. Zeis. Contemporary definitions of tumor specific antigens, immunogens, and markers as related to the adaptive responses of the cancer-bearing host. Anticancer Res. 25, 2345-2356, 2005
Höltl L., C. Zelle-Rieser, H. Gander, C. Papesh, R. Ramoner, G. Bartsch, H. Rogatsch, A. L. Barsoum, Joseph H. Coggin, Jr. and Martin Thurnher. Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. Clin. Cancer Res. 8 (11) 3369-3376, 2002.
Barsoum A.L., J. W. Rohrer and J. H. Coggin, Jr. 37kDa Oncofetal antigen is an autoimmunogenic homologue of the 37kDa laminin receptor precursor. Cellular & Molecular Biology Letters 5: 207-203, 2000.
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