Paul J. Brett, Ph.D.

Paul J. Brett, Ph.D.
Assistant Professor
Phone: (251) 414-8179
FAX: (251) 460-7931
pbrett@jaguar1.usouthal.edu

Burkholderia pseudomallei and Burkholderia mallei Host-Pathogen Interactions

Dr. Paul J. Brett, assistant professor, received his Ph.D. in Bacterial Pathogenesis from the University of Calgary, Calgary, Alberta in 1998 and conducted his postdoctoral training at University College London, London, United Kingdom and Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana. Dr. Brett joined the University of South Alabama College of Medicine Microbiology and Immunology faculty in November 2008. Dr. Brett serves as an ad hoc reviewer for Microbiology, Infection and Immunity, Cellular Immunology and the Journal of Clinical Microbiology.

Research in our lab focuses on elucidating the molecular mechanisms used by Burkholderia pseudomallei (melioidosis) and Burkholderia mallei (glanders) to subvert host innate immune defenses. In particular, we are interested in determining how the type III secretion systems (T3SS) and type VI secretion systems (T6SS) expressed by these organisms influence the outcomes of interactions with human and murine macrophages.

Recent Publications

Brett PJ, Burtnick MN, Fenno JC, Gherardini FC. Treponema denticola TroR is a manganese- and iron-dependent transcriptional repressor. Mol Microbiol. 2008 Oct;70(2):396-409. Epub 2008 Aug 27.

Burtnick MN, Brett PJ, Nair V, Warawa JM, Woods DE, Gherardini FC. Burkholderia pseudomallei type III secretion system mutants exhibit delayed vacuolar escape phenotypes in RAW 264.7 murine macrophages. Infect Immun. 2008 Jul;76(7):2991-3000. Epub 2008 Apr 28.

Brett PJ, Burtnick MN, Su H, Nair V, Gherardini FC. iNOS activity is critical for the clearance of Burkholderia mallei from infected RAW 264.7 murine macrophages. Cell Microbiol. 2008 Feb;10(2):487-98. Epub 2007 Oct 28.

Burtnick MN, Downey JS, Brett PJ, Boylan JA, Frye JG, Hoover TR, Gherardini FC. Insights into the complex regulation of rpoS in Borrelia burgdorferi. Mol Microbiol. 2007 Jul;65(2):277-93. Epub 2007 Jun 21.

Brett PJ, Burtnick MN, Snyder DS, Shannon JG, Azadi P, Gherardini FC. Burkholderia mallei expresses a unique lipopolysaccharide mixture that is a potent activator of human Toll-like receptor 4 complexes. Mol Microbiol. 2007 Jan;63(2):379-90. Epub 2006 Dec 5.

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