CURRICULUM VITAE JAMES MERRITT DOWNEY BRIEF CHRONOLOGY OF TRAINING AND EMPLOYMENT: 1967 Bachelor of Science in Biology from Manchester College , North
Manchester , Indiana . HONORS Elected to Circulation Group Am. Physiological Society 1979) PROFESSIONAL SOCIETIES:
MILITARY SERVICE: U.S. Army Reservist, Honorably Discharged, 1962-1970. ADDRESS: James M. Downey, PhD jdowney@southalabama.edu RESEARCH SUPPORT PAST AND PRESENT Florida Heart Association, "Determinants of Coronary Blood
Flow", July 1973 - June 1974, EDITORIAL BOARD MEMBERSHIP: Circulation Research, 1978 - 1983, 1994 - 2012 MEDICAL SCHOOL COMMITTEES Admissions Committee (2 years). PEER REVIEW ACTIVITIES: Research Committee, Alabama Heart Assn.(1982 -
1984, 1995 - present).GLAXO Cardiovascular Discovery Grant Program (1988 -
1989) INDUSTRIAL CONSULTANTSHIPS: Contracted Consultant: Hoffman LaRoche; Dr. Ann Sullivan and Dr. Lawrence
Klevans (1984 - 1989) INVITED PRESENTATIONS: (1993-present) Mar 2018 Inflammation and myocardial infarction: Invited seminar, The
Hatter Institute, University College, London England. NIH CONSULTING: (1985-present) May 2012 Reviewer: Board of Scientific Councilors Site Visit COMMUNITY SERVICE: Program Advisory Committee, American Physiological Society (1985-1988) MEETINGS ORGANIZED: May 2009 Co-organizer Heart Protection Symposium, Amman, Jordan STUDENTS TRAINED
David E. Chambers (1983) "Pharmacologic modification of infarct
size" PhD Students: as Committee member Post-Doctoral Trainees: JOURNAL ARTICLES 1. Hermsmeyer , Kent , and James M. Downey. Audile monitor for microelectrode experiments. J. Appl. Physiol. 28:858-859, 1970. 2. Downey , James M. The Determinants of the Intramyocardial Distribution of the Coronary Blood Flow. Ph.D. thesis, University of Illinois , Urbana , Illinois ,1971. 3. Kirk, Edward S., James M. Downey, and H. Fred Downey. The determinants of the non-uniform distribution of coronary blood flow in systole. International Symposium on Myocardial Blood Flow in Man. Pisa , Italy , 1971. 4. Cohn, Peter, Edward Kirk, James Downey, Edmund Sonnenblick, and Richard Gorlin. Autoradiographic evaluation of myocardial collateral circulation in the canine heart. Cardiovascular Research 7:181-185, 1973. 5. Forman, Robert, Edward S. Kirk, James M. Downey, and Edmund H. Sonnenblick. Nitroglycerine and heterogeneity of myocardial blood flow: Reduced subendocardial blood flow and contractile force. J. Clin. Invest. 52:905-911, 1973. 6. Cohen, Michael V., James M. Downey, Edmund H. Sonnenblick, and Edward S. Kirk. The effects of Nitroglycerine on Coronary Collaterals and Myocardial Contractility. J. Clin. Invest. 52:2836-2847, 1973. 7. Downey , J.M., H.F. Downey, and E.S. Kirk. Effects of myocardial strains on coronary blood flow. Circulation Research 34:286-292, 1974. 8. Downey , J.M., and E.S. Kirk. The distribution of coronary blood flow across the canine heart wall during systole. Circulation Research 34:251-257, 1974. 9. Snyder, R., J.M. Downey, and E.S. Kirk. The active and passive components of extravascular coronary resistance. Cardiovascular Research 9:161-166, 1975. 10. Downey , J.M., and E.S. Kirk. Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ. Res. 36:753-760, 1975. 11. Downey , J.M., and E.S. Kirk. The transmural distribution of coronary blood flow during maximal vasodilation. Proc. Soc. 150:189-193, 1975. 12. Downey , J.M., D.F. Cowan, Edmund H. Sonnenblick, C.W. Urschel and E.S. Kirk. The adequacy of coronary blood flow during acute hypotension. Circulatory Shock 3:83-91, 1976. 13. Downey , J.M. Subendocardial contractile force as a function of coronary blood flow in the autoregulating dog heart. Am. J. Physiol. 230:1-6,1976. 14. Downey , J.M. Compression of the coronary arteries by the fibrillating canine heart. Circ. Res. 39:53-57, 1976. 15. Downey , J.M. and R. Chagrasulis. The effect of cardiac contraction on collateral resistance in the canine heart. Circ. Res. 39:797, 1976. 16. Longenecker, H.E. and J.M. Downey. Multitrace display for a single beam oscilloscope. J. Electrophysiological Techniques 5(2):57-60, 1976. 17. Chagrasulis, R.W. and J.M. Downey. Selective coronary embolization inclosed chest dogs. Am. J. Physiol. 232:335-337, 1977. 18. Singh, B.N., D.E. Jewitt, J.M. Downey, E.S. Kirk, and E.H. Sonnenblick. Effects of amiodarone and L8040, novel antianginal and antiarrhythmic drugs, on cardiac and coronary hemodynamics and on cardiac intracellular potentials. Clin.Exp. Pharm. and Physiol. 3:427-443, 1976. 19. Russell, R.E., R.W. Chagrasulis and J.M. Downey. The inhibitory effect of cardiac contraction on coronary collateral blood flow. Am. J. Physiol.233:H541, 1977. 20. Downey , J.M. The effect of propranolol on direct coronary vasomotion. European J. Pharm. 46:119-124, 1977. 21. Downey , J.M., R.W. Chagrasulis, D. Fore, and L. Parmley. Accumulation of technetium - 99m Stannous Pyrophosphate in contused myocardium. Journal of Nuclear Medicine 18:1171, 1977. 22. Trimble, J. and J.M. Downey. Contribution of myocardial contractility to myocardial perfusion. Am. J. Physiol. 236:H121-H126, 1979. 23. Downey , J.M., R.W. Chagrasulis, and V. Hemphill. Quantitative study of intramyocardial compression in the fibrillating heart. Am. J. Physiol. 237:H191-H196, 1979. 24. Wilkerson, R.D., and J.M. Downey. Ventricular arrhythmias resulting from coronary occlusion in closed chest dog. J. Pharmacol. Techniques 1:39-44,1978. 25. Downey , J.M. Sample the 6100 Killobaud, December:54-61, 1979. 26. Goodlett, M., K. Dowling and J.M. Downey. The failure of hydrogen peroxide to improve function in ischemically-depressed myocardium. European J.Pharm. 60:257-260, 1979. 27. Goodlett, M., K. Dowling, L.J. Eddy, and J.M. Downey. The direct metabolic effects of isoproterenol and propranolol in ischemic myocardium of the dog. Am. J. Physiol. 239:H469-H476, 1980. 28. Munch, D.F., and J.M. Downey. Prediction of regional myocardial blood flow in dogs. Am. J. Physiol. 239:H308-H315, 1980. 29. Munch, D.F., H.T. Comer, and J.M. Downey. Barium contracture: A systolic model. Am. J. Physiol. 239:H438-H442, 1980. 30. Downey , J.M. Make PET hard copy easy. Killobaud, September:100-103, 1979. 31. Eddy, L.J., D. Chambers, S. Honig, and J.M. Downey. Lack of a direct metabolic effect of Fructose-1,6-Diphosphate in ischemic myocardium. Am. J.Physiol. 241:576-582, 1981. 32. Lee, J., and J.M. Downey. A microcomputer based drop counter. Pharm. Techniques 6:255-260, 1981. 33. Wyatt, D., J. Lee, and J.M. Downey. Determination of coronary collateral flow by a load line analysis. Circ. Res. 50:663-670, 1982. 34. Downey , J.M., and R.D. Wilkerson. The inability of isoproterenol or propranolol to alter the lateral dimensions of experimentally induced myocardial infarcts. Basic Res. Cardiol. 77:486-498, 1982. 35. Chambers, D.E., D.M. Yellon, D.J. Hearse, and J.M. Downey. Flurbiprofen limits infarct size at 6 but not at 24 hours following coronary occlusion in the dog. Am. J. Cardiol. 51:884-891, 1983. 36. Downey , J.M. J. Lee, and D.E. Chambers. Location and magnitude of the coronary artery capacitance. In: Mechanics of the Coronary Circulation, R.E.Mates, R.N. Nerem, and P.D. Stein, Editors, A.M.S.E., New York, pp. 45-48, 1983. 37. Yellon, D.M., D.J. Hearse, M.P. Maxwell, D.E. Chambers, and J.M. Downey. Sustained limitation of myocardial necrosis 24 hours after coronary artery occlusion: Verapamil infusion in dogs with small infarcts. Am. J. Cardiol. 51:1409-1413, 1983. 38. Lee, J., J.M. Downey, D.E. Chambers, and S. Akizuki. The role of vascular capacitance in the coronary arteries. Circ. Res 55:751-762, 1984. 39. Yoshida, S., J.M. Downey, D.E. Friedman, F.R., Chambers, D.J. Hearse, and D.M. Yellon. Nifedipine limits infarct size in closed chest coronary embolized dogs. Basic Res.Cardiology 80:76-87, 1985. 40. Downey , J.M., D.J. Hearse, S. Yoshida, M.P. Maxwell, and D.M. Yellon. Verapamil and nifedipine limit infarct size in the dog. Advances in myocardiology N.S. Dhalla and D.J. Hearse, Ed., Plenum Press, London 529-543, 1985. 41. Yellon, D.M., M.P. Maxwell, D.J. Hearse, S. Yoshida, L.J. Eddy, and J.M. Downey. Infarct size limitation: Real or artifactual. Studies with Flurbiprofen using a reperfusion model. Advances in Myocardiology N.S. Dhalla and D.J. Hearse, Ed., Plenum Press, London , 1985. 42. Gardner , T.J., J.R. Stewart, A.S. Casale, J.M. Downey, and D.E. Chambers. Reduction of myocardial ischemic injury by free radical scavengers. Surgery 94:423-427, 1983. 43. Chang, C., J. Vargese, J. Downey, and S. Bloom. Magnesium deficiency and vulnerability to myocardial infarction. J. Am. Col. Cardiology 5:280-289, 1985. 44. Downey , J.M., D.J. Hearse, D.M. Yellon, and A.S. Manning. Xanthine oxidase as a source of free radicals in myocardial ischemia. In: Pathobiology of Cardiovascular Injury H.L. Stone and W.B. Weglicki, Editors, Nijhoff, Boston , 1985. 45. Chambers, D.E., D.A. Parks, G. Patterson, R. Roy, J. McCord, S. Yoshida, L.F. Parmley, and J.M. Downey. Xanthine oxidase as a source of free radical damage in myocardial ischemia. J. Mol. Cell Cardiol. 17:145-152,1985. 46. Downey , J.M. Letter to the Editor. Circ. Res. 52:614-615, 1983. 47. Bulkley, G.B., W.A. Womack, J.M. Downey, P.R. Kvietys, and D.N. Granger. Efficiency of collateral blood vessels in the small bowel. Am. J. Physiol. 244:G228-G235, 1985. 48. Kudoh, Y., M.P. Maxwell, D.J. Hearse, J.M. Downey, and D.M. Yellon. Inability of metaprolol to achieve a sustained limitation of infarct size 24 hrs. after coronary embolization in the closed chest dog. J. Cardiovasc. Pharm.6:1201-1209, 1984. 49. Downey , J.M. and D.M. Yellon. Drugs to limit infarcts: The status in the lab. Cardio 2(6): 34-37, 1985. 50. Yellon, D.M., D.J. Hearse and J.M. Downey. Myocardial salvage by pharmacological interventions. 10 Phar 9th International Congress of Pharmacology Proceedings, MacMillan Press, London , 3:251-256, 1984. 51. Yoshida, S., S. Akizuki and J.M. Downey. Discrepancy between microsphere and diffusible tracer estimates of perfusion to ischemic myocardium during retrograde flow diversion. Am. J. Physiol. 249:H244-H264,1985. 52. Akizuki, S., S. Yoshida, D.E. Chambers, L.J. Eddy, L.F. Parmley, D.M. Yellon, and J.M. Downey. Infarct size limitation by the xanthine oxidase inhibitor, allopurinol, in closed chest dogs. Cardiovasc.Res. 19:686-692, 1985. 53. Yoshida, S., D.M. Downey, D.M. Yellon, T. Miura and O. Iimura. Diltiazem reduced infarct size but not ventricular arrhythmias in 48 hour coronary embolized dogs. Can. J. Cardiol.1:346-353, 1985. 54. Hearse, D.J., A.S. Manning, J.M. Downey, and D.M. Yellon. Xanthine oxidase as a critical mediator of myocardial injury during ischemia and reperfusion. Acta Physiol Scand. 548:65-78, 1986. 55. Downey , J.M. A functional estimate of overlap between adjacent coronary circulations in the dog. Basic Res. Cardiol. 81:336-341, 1986. 56. Hearse, D.J., D.M. Yellon, and J.M. Downey. Can Beta Blockers limit infarct size? European Heart Journal 7:925-930, 1986. 57. Dennis, A.R., J.G. Kingma, D.J. Hearse, J.M. Downey, and D.M. Yellon. Anapamil limits myocardial necrosis in the closed chest dog during 24 hours of coronary artery occlusion. J. Mol. Cell. Cardiol. 18 (Suppl I):359, 1986. 58. Kudoh, Y., D.J. Hearse, M.P. Maxwell, S. Yoshida , J.M. Downey, and D.M. Yellon. Calcium antagonist and evolving myocardial infarction: Studies of the effects of nifedipine on tissue ATP, collateral flow, and infarct size in the closed chest dog. J. Mol. Cell. Cardiol. 18 (Suppl 4):77-92, 1986. 59. Bulkley, G.B., W.A. Womack, J.M. Downey, P.R. Kvietys, and D.N. Granger. Collateral blood flow in segmental intestinal ischemia: Effects of vasoactive agents. Surgery 100:157-166, 1986. 60. Downey , J.M., S. Yoshida, M.D. Harpen. A functional estimate of overlap between adjacent coronary circulations in the dog. Basic Res. Cardiol. 81:336-341, 1986. 61. Miura, T., D.M. Yellon, D.J. Hearse, and J.M. Downey. The determinants of infarct size during permanent occlusion of a coronary artery in the closed chest dog. J. Am. Coll. Cardiol. 9:647-656, 1987. 62. Eddy, L.J., J.R. Stewart, H.P. Jones, T.D. Engerson, J.M. McCord, and J.M. Downey. The free radical producing enzyme, xanthine oxidase is undetectable in human hearts. Am. J. Physiol. 253:H709-H711, 1987. 63. Kingma, J.G., A.R. Dennis, D.J. Hearse, J.M. Downey, and D.M. Yellon. Limitation of infarct size for 24 hours by combined treatment with allopurinol plus verapamil during acute myocardial infarction in the dog. Circulation 75:V25-V33, 1987. 64. Downey , J.M., T. Miura, L.J. Eddy, D.E. Chambers, D.J. Hearse, and D.M. Yellon. Xanthine oxidase: A source of free radicals in ischemic rat heart but not in the rabbit heart. J. Mol. Cell.Cardiol. 19:1053-1060, 1987. 65. Miura, T., J.M. Downey, D. Hotta, M. Inoue, S. Ogawa , S. Yoshida, and O. Iimura. Apparent Limitation of Myocardial Infarct Size by Superoxide Dismutase and Catalase was Lost During 3 Day Reperfusion in a Rabbit Ischemia/Reperfusion Model. In: Microcirculation, M. Tsuchiya et al ., Eds.,Elsevier Science Publishers, Vol. 1, 1987, pp. 687-689. 66. Miura, T., D.M. Yellon, J. Kingma, and J.M. Downey. Protection afforded by allopurinol in the first 24 hours of coronary occlusion is diminished after 48 hours. Free Radicals in Biology and Medicine 4:25-30, 1988. 67. Miura, T., S. Yoshida , O. Iimura, and J.M. Downey. Dobutamine modifies infarct size through supply/demand balance. Am. J. Physiol. 23:H855,1988. 68. Miura, T. and J.M. Downey. Collateral perfusion of ischemic myocardium is inversely related to the size of the ischemic zone. Basic Res.Cardiol. 83:128-136, 1988. 69. Miura, T. and J.M. Downey. The percentage of the ischemic zone infarcting following permanent coronary occlusion is independent of ischemic zone size. Japan Heart Journal 29:359-366, 1988. 70. Downey , J.M., D.J. Hearse, and D.M. Yellon. The role of xanthine oxidase during myocardial ischemic in several species including Man. J. Mol. Cell. Cardiol. 20(Supp II):55-63, 1988. 71. Cohen, M.V., T. Matsuki, and J.M. Downey. Pressure-flow characteristics and nutritional capacity of coronary veins and their collateral channels in dogs. Am.J. Physiol. 255:H834-H846, 1988. 72. Miura, T., J.M. Downey, D. Hotta, and O. Iimura. Effect of superoxide dismutase plus catalase on myocardial infarct size in rabbits. Can. J. Cardiol. 4, 407-411, 1988. 73. Kingma, J.G., T. Miura, J.M. Downey, D.J. Hearse and D.M. Yellon. Myocardial salvage with allopurinol during 24 hours of permanent coronary occlusion: importance of pretreatment. Can. J. Cardiol. 4:360-365, 1988. 74. Matsuki, T., M.V. Cohen, G. Holt, J. Ayling, D.J. Hearse and J.M. Downey. Chronic whole-body sympathectomy fails to protect the ischemic rabbit heart. Am. J. Physiol. 256:H1322-H1329, 1989. 75. Miura, T., J.M. Downey, H. Ooiwa, S. Ogawa, T. Adachi, T. Noto, Y Shizuka, O. Iimura. Progression of myocardial infarction in a collateral flow deficient species. Jap. Heart J. 30:695-708, 1989. 76. Miura, T, J.M. Downey. Critical collateral blood flow level for salvage of ischemic myocardium. Can. J. Cardiol. 4:201-205, 1989. 77. Maxwell, M.P., D.J. Hearse, D.M. Yellon and J.M. Downey. Inability of chronic chemical sympathectomy to induce coronary collateral growth or development: studies in the rat heart in vivo. Cardiovasc. Res. 23:821-824, 1989 78. Shirato, C., T. Miura, H. Ooiwa, T. Toyofuku, W.H. Wilborn and J.M. Downey. Tetrazolium artifactually indicates superoxide dismutase-induced salvage in reperfused rabbit heart. J. Mol. Cell. Cardiol. 21:1187-1193, 1989 79. Downey , J.M. Free radicals and their involvement during long term myocardial ischemia and reperfusion. Ann. Rev. Physiol. 52:487-504, 1990 80. Van Winkle, D.M., T. Matsuki, N.M. Gad, M.C. Jordan, J.M. Downey. Left ventricular unloading during reperfusion does not limit infarct size. Circulation 81:1374-1379, 1990 81. Matsuki, T., C. Shirato, M.V. Cohen, J.M. Downey. Oxypurinol limits infarct size in closed chest dogs without pretreatment. Can. J. Cardiol. 6:123-129, 1990 82. Ooiwa, H., T. Miura, J.M. Downey, T. Matsuki, Y. Shizukuda, T. Adachi, A. Tsuchida, T. Iwamoto, T. Owawa and O. Iimura. The effect of inotropic dose of dobutamine during reperfusion on myocardial infarct size. Jap. Circ. J. 53:1511-1520, 1989 83. Matsuki, T. M.V. Cohen and J.M. Downey. Free radical scavengers preserve wall motion in the xanthine oxidase-deficient rabbit heart. Coronary Artery Disease 1:383-389, 1990 84. Ooiwa, H., A. Stanley, A.C. Felaneous-Bylund, W. Wilborn and J.M. Downey. Superoxide dismutase conjugated to polyethylene glycol fails to limit infarct size after 30 minutes ischemia followed by 72 hours of reperfusion in the rabbit. J. Mol. Cell. Cardiol. 23:119-127, 1991 85. Downey , J.M., B. Omar, H. Ooiwa and J.M. McCord. Superoxide dismutase therapy for myocardial ischemia. Free Rad. Res. Comms 12: 703-720, 1990 86. Yellon, D.M., D.J. Hearse, D.E. Chamber, J.M. Downey. Diltiazem, Nifedipine, Verapamil reduced infarct size in coronary embolized dog hearts. Japanese Pharmacology & Therapeutics 13(6): 83-90, 1985. 87. Thornton, J., S. Striplin, G.S. Liu, A. Swafford, A.W.H. Stanley, D.M. VanWinkle and J.M. Downey. Inhibition of protein synthesis does not block myocardial protection during preconditioning. Am. J. Physiol. 259:H1822-H1825, 1990 88. Yellon, D.M. and J.M. Downey. Current research views on myocardial reperfusion and reperfusion injury. Cardioscience 1:89-98, 1990 89. Van Winkle, D.M., A.N. Swafford, and J.M. Downey. Subendocardial coronary compression in the beating dog heart is independent of pressure in the ventricular lumen. Am. J. Physiol. 261: H500-H505, 1991 90. Cohen, M.V. and J.M. Downey. Myocardial stunning in dogs: preconditioning effect and influence of collateral flow. Am. Heart J. 120:282-291, 1990 91. Omar, B.A., N.M. Gad, M.C. Jordan, S.P. Striplin, W.J. Russell, J.M. Downey, J.M. McCord. Cardioprotection by superoxide dismutase is lost at high doses in the reoxygenated heart. Free Rad Com 9:465-471, 1990 92. Ooiwa, H., D.R. Janero, A.W.H. Stanley and J.M. Downey. Examination of two small-molecule antiperoxidant agents in a rabbit model of post-ischemic myocardial infarction. J. Cardiovasc. Pharm. 17:761-767, 1991 93. Van Winkle, D.M., J. Thornton, D.M. Downey, J.M. Downey. The natural history of preconditioning. Cardioprotection depends on duration of transient ischemia and time to subsequent ischemia. Coronary Artery Disease 2:613-619, 1991 94. Cohen, M.V., G.S. Liu, J.M. Downey. Preconditioning causes improved wall motion as well as smaller infarcts after transient coronary occlusion in rabbits. Circulation 84:341-349, 1990 95. Liu, G. S., J. Thornton, D.M. Van Winkle, A.W.H. Stanley, R.A. Olsson, J.M. Downey Protection against infarction afforded by preconditioning is mediated by A1 adenosine receptors in rabbit heart. Circulation 84:350-356, 1991 Times Cited: > 1000 96. Turrens, J.F., J. Thornton, M. L. Barnard, S. Snyder, G. Liu, and J.M. Downey. Protection from reperfusion injury by preconditioning hearts does not involve increased antioxidant defenses. Am J. Physiol 262:H585-H589, 1992 97. Thornton , J,D., Liu, G.S., Olsson, R.A, Downey , J.M. Intravenous pretreatment with A1-selective adenosine analogs protects the heart against infarction. Circulation 85:659-665, 1992 Times Cited: 384 98. Parmley, L.F., A.G. Mufti, J.M. Downey. Allopurinol therapy of ischemic heart disease with infarct extension. Can J. Cardiol. 8:280-286, 1992 99. Liu, G.S., A.W.H. Stanley, J.M. Downey. Cyclooxygenase products are not involved the protection against myocardial infarction afforded by preconditioning in rabbit. Am. J. Cardiovasc. Path. 4:56-63, 1992 100. Liu, G.S., A.W.H. Stanley, J.M. Downey. Ischemic preconditioning is not dependent on neutrophils or glycolytic substrate at reperfusion in rabbit heart. Cardiovasc. Res. 26:1195-1198, 1992 101. Liu, Y. and J.M. Downey. Ischemic preconditioning protects against infarction in the rat heart. Am J. Physiol. 263:H1107-1112, 1992 Times Cited: 310 102. Downey , J.M. Ischemic preconditioning: Nature’s own cardioprotective intervention. Trends Cardiovasc. Res. 2:170-175, 1992 Times Cited: 107 103. Yellon, D.M., E. Iliodromitis, D.S. Latchman, D.M. Van Winkle, J.M. Downey, F.M. Williams, T.J. Williams: Whole body heat stress fails to limit infarct size in the reperfused rabbit heart. Cardiovasc Res 26:342-346, 1992 104. Downey , J.M. Review of "Coronary Blood Flow," by J.A.E. Spaan. Cardiovascular Research 26: 912, 1992. 105. Thornton, J.D., C.S. Thornton, D.L. Sterling, J.M. Downey. Blockade of ATP sensitive potassium channels increases infarct size but does not prevent preconditioning. Circ Res 72:44-49, 1993 Times Cited: 153 106. Bunch, F.T, J.D. Thornton, M.V. Cohen and J.M. Downey. Adenosine is an endogenous protectant against stunning during repetitive ischemic episodes in the heart. Am Heart J 124:1440-1446, 1992 107. Tsuchida, A. G.S. Liu, W.H. Wilborn, J.M. Downey. Pretreatment with the adenosine A1 selective agonist 2 chloro-N6-cyclopentyladenosine (CCPA) causes a sustained limitation of infarct size in rabbits. Cardiovasc Res 27:652-656, 1993 108. Downey , J.M., G.S. Liu, J.D. Thornton . Adenosine and the anti infarct effects of preconditioning. Cardiovasc Res 27:2-8, 1993 Times Cited: 145 109. Thornton,J.D., J.F. Daly, M.V. Cohen, X.M. Yang, J.M. Downey. Catecholamines can induce adenosine receptor-mediated protection of the myocardium but do not participate in ischemic preconditioning in the rabbit. Circ Res 73:649-655, 1993 110. Liu, Y., J.D. Thornton, M.V. Cohen, J.M. Downey, S.W. Schaffer. Streptozotocin-induced non-insulin dependent diabetes protects heart from infarction. Circulation 88:1273-1278, 1993 111. Yellon, D.M., J.M. Walker, R.A. Kloner, J.M. Downey, W.B. Pugsley. Unstable Angina. Lancet 341:1323-1327,1993 112. Ytrehus, K., J.M. Downey. Experimental Models assessing the physiology of myocardial ischemia. Current Opinion Cardiol 8:581-588, 1993 113. Thornton , J.D., Thornton , C.S., Downey , J.M. Effect of adenosine receptor blockade: preventing protective preconditioning depends on time of initiation. Am J Physiol 265:H504-508, 1993 114. Thornton, J.D., G.S. Liu, J.M. Downey. Pretreatment with pertussis toxin blocks the protective effect of preconditioning: evidence for a G-protein mechanism. J Mol Cell Cardiol 25:311-320, 1993 Times Cited: 159 115. Tsuchida, A., G.S. Liu, K. Mullane, J.M. Downey. Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning. Cardiovasc Res 27:116-120 1993 116. Liu, Y., J.M. Downey. Preconditioning against infarction in the rat heart does not involve a pertussis toxin sensitive G protein. Cardiovasc Res 27:608-611, 1993 117. Yang, X.M., S. Arnoult , A. Tsuchida, D. Cope, J.D. Thornton, J. Daly, M.V. Cohen, J.M. Downey. Ischemic Preconditioning's protection can be reinstated in the rabbit heart after the initial protection has waned. Cardiovasc Res 27:556-558, 1993 118. Lawson, C.S., J.M. Downey. Preconditioning: State of the art protection. Cardiovasc Res 27:542-550, 1993 Times Cited: 261 119. Ganote, C.E., S. Armstrong, J.M. Downey. Adenosine and A1-selective agonists offer minimal protection against ischemic injury to isolated rat cardiomyocytes. Cardiovasc Res 27:1670-1676, 1993 120. Tsuchida, A., R. Thompson, R.A. Olsson, J.M. Downey The anti-infarct effect of an adenosine A1-selective agonist is diminished after prolonged infusion as is the cardioprotective effect of preconditioning in rabbit heart. J Mol Cell Cardiol 26:303-311, 1994 121. Sterling, D., J. Thornton, A. Swafford, S. Gottleib, S.P. Bishop, A.W.H. Stanley and J.M. Downey. Hyperbaric oxygen limits infarct size in ischemic rabbit myocardium in vivo. Circulation 88:1931-1936, 1993 122. Cave , A.C., C.S. Collis, J.M. Downey, D.J. Hearse. Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic rat heart. Cardiovasc Res 27:663-668, 1993 Times Cited: 137 123. Cohen, M.V., J.M. Downey. Ischemic Preconditioning: Can the protection be bottled? Lancet 342: 6, 1993 124. Ytrehus, K., Y. Liu, J.M. Downey. Ischemic preconditioning protects the heart by protein kinase C activation. Am J Physiol 266:H1145-1152, 1994 Times Cited: 472 125. Cohen, M.V., X-M Yang, Y.Liu, K.S. Snell, J.M. Downey A new model of controlled coronary occlusion in conscious rabbits. Cardiovasc Res 28:61-65, 1994 126. Liu, G.S., S.C. Richards, R.A. Olsson, K.Mullane, R.S. Walsh, J.M. Downey Evidence that the adenosine A3 receptor can mediate preconditioning's protection in isolated rabbit hearts. Cardiovasc Res 28:1057-1061, 1994 Times Cited: 182 127. Liu, Y., Ytrehus, K., J.M. Downey. Evidence that translocation of protein kinase C into cell membranes is the key event in ischemic preconditioning in rabbit myocardium. J. Mol Cell Cardiol 26:661-668, 1994 Times Cited: 222 128. Walsh, R.S., A. Tsuchida, M.V. Cohen, J.M. Downey: Ketamine/xylazine anesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium. Cardiovasc Res 28:1337-1334, 1994 129. Armstrong, S., J.M. Downey, C.E. Ganote. Preconditioning of isolated rabbit cardiomyocytes: Induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, protein kinase C inhibitor. Cardiovasc Res 28: 72-77, 1994 Times Cited: 117 130. Tsuchida, A., X-M. Yang, B. Burckhartt, K.M. Mullane, M.V. Cohen, J.M. Downey. Acadesine extends the window of protection afforded by ischemic preconditioning. Cardiovasc Res 28:379-383, 1994 131. Tsuchida, A.,Y. Liu, G.S. Liu, M.V. Cohen, J,M. Downey. a1 adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C. Circ Res 75:576-585, 1994 Times Cited: 203 132. Liu, Y., Cohen, M.V., Downey, J.M. Chelerytherine, a highly selective protein kinase C inhibitor blocks the antiinfarct effect of ischemic preconditioning in rabbit hearts. Cardiovasc Drugs and Therapy 8:881-882, 1994 133. Ytrehus, K., Y. Liu, A. Tsuchida, T. Miura, S.S. Liu, X-M Yang, D. Herbert, M.V. Cohen and J.M. Downey Rat and Rabbit heart infarction: effects of anesthesia, perfusate, risk zone and method of infarct sizing. Am J Physiol 267:H2383-H2390, 1994 Times Cited: 89 134. Cohen, M.V., X-M Yang, J.M. Downey. Conscious rabbits become tolerant to multiple episodes of ischemic preconditioning. Circ Res 74:998-1004, 1994 Times Cited: 104 135. Gu, J., N. Agrawal, P-P Wang, M.V. Cohen, J.M. Downey. A primary-secondary antibody complex method of immunohistochemistry using rabbit polyclonal antibodies to detect antigens in rabbit tissue. Cell Vision 2:52-59, 1995 136. Goto, M., Y. Liu, X-M Yang, J.L. Ardell, M.V. Cohen, J.M. Downey. The role of bradykinin in the protection of ischemic preconditioning in rabbit hearts. Circ Res 77:611-621, 1995 Times Cited: 298 137. Liu, Y., A. Tsuchida, M.V. Cohen, J.M. Downey. Pretreatment with angiotensin II activates protein kinase C and limits infarct size in isolated rabbit hearts. J Mol Cell Cardiol 27:883-892, 1995 138. Walsh, R.S., M. Borges, J.D. Thornton, M.V. Cohen, J.M. Downey. Hypoxia preconditions rabbit myocardium by an adenosine receptor-mediated mechanism. Can J Cardiol 11:141-146 1995 139. Haynes, J. Jr., B. Obiako, W.J. Thompson, J.M. Downey. Adenosine-induced vasodilation: receptor characterization in pulmonary circulation. Am J Physiol 268:H1862-1868, 1995 140. Cohen, M.V., J.M. Downey Preconditioning during ischemia: basic mechanisms and potential clinical applications. Cardiology in Review 3:137-149 1995 141. Burckhartt, B., X-M Yang, A Tsuchida, K.M. Mullane, J.M. Downey, M.V. Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits. Cardiovasc Res 29:653-657, 1995 142. Cohen, M.V., K.S. Snell, A. Tsuchida, D.G.L. Van Wylen, J.M. Downey. Effects of anesthesia and KATP channel blockade on interstitial adenosine accumulation in ischemic rabbit myocardium. Basic Res Cardiol 90:410-417, 1995 143. Goto, M., A. Tsuchida, Y. Liu, M.V. Cohen, J.M. Downey. Transient inhibition of glucose uptake mimics ischaemic preconditioning by effectively salvaging ischaemic myocardium in rabbit heart. J Mol Cell Cardiol 27:1883-1894, 1995 144. Ytrehus, K., R.S. Walsh , S.C. Richards J.M. Downey. Hydrogen peroxide as a protective agent during reperfusion A study in the isolated rabbit heart subjected to regional ischemia. Cardiovasc Res 30:1033-1037, 1995 145. Downey , J.M., M.V. Cohen. Signal transduction in ischemic preconditioning. Zeitschrift Fur Kardiologi 84(sup 4):77-86, 1995 146. Cohen, M.V., R.S. Walsh, M. Goto, J.M. Downey. Hypoxia preconditions rabbit myocardium via adenosine and catecholamine release. J Mol Cell Cardiol 27:1527-1543, 1995 147. Armstrong , S.C. , G.S. Liu, J.M. Downey, C.E. Ganote. Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil. J Mol Cell Cardiol 27:1765-1774, 1995 148. Downey , J.M., M.V. Cohen. Preconditioning: Markers vs epiphenomenon. Basic Res Cardiol 91:35-37, 1996 149. Goto, M., M.V. Cohen, D.G.L. VanWylen, J.M. Downey. Attenuated purine production during subsequent ischemia in preconditioned rabbit myocardium is unrelated to the mechanism of protection. J Mol Cell Cardiol. 28:447-454, 1996 150. Cohen, M.V., J.M. Downey. Myocardial preconditioning promises to be a novel approach to the treatment of ischemic heart disease. Ann Rev Medicine 47:21-29, 1996 151. Ardell, J.L., X-M Yang, B.B. Barron, J.M. Downey, M.V. Cohen. Endogenous myocardial norepinephrine is not essential for ischemic preconditioning in rabbit heart. Am J Physiol 270: H1078-H1084, 1996 152 Wang, P., K.P. Gallagher, J.M. Downey, M.V. Cohen. Pretreatment with endothelin-1 mimics ischemic preconditioning against infarction in isolated rabbit heart. J Mol Cell Cardiol 28:579-588, 1996 153 Yang X-M, G.F. Baxter, R.J. Heads, D.M. Yellon, J.M. Downey, M.V. Cohen. Infarct limitation of the second window of protection in a conscious rabbit model. Cardiovasc Res 31:777-783, 1996 154 Liu, G.S., K.A. Jacobson, J.M. Downey. An irreversible A1-selective agonist preconditions rabbit heart. Canadian J Cardiol 12:517-521, 1996 155 Shattok, M.J., C.S. Lawson, D.J. Hearse, J.M. Downey. Electrophysiological charactoristics of repetitive ischemic preconditioning in the pig heart. J Mol Cell Cardiol 28:1339-1347, 1996 156. Weinbrenner, C.,P. Wang, J.M.Downey. Loss of Glycogen during preconditioning is not a prerequisite for protection of the rabbit heart. Basic Res Cardiol 91:374-381,1996 157. Cohen, M.V., Y.Liu, G.S. Liu, P.Wang, C. Weinbrenner, G.A.Cordis, D.K. Das, J.M. Downey. Phospholipase D plays a role in ischemic preconditioning in rabbit heart. Circulation 94:1713-1718, 1996 158. Wang, P., J.M. Downey, M.V. Cohen. Mast Cell degranulation does not contribute to ischemic preconditioning in isolated rabbit hearts. Basic Res Cardiol 91:458-467, 1996 159. Baines, C.P., M. Goto J.M. Downey. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in rabbit myocardium J Mol Cell Cardiol 29:207-216, 1997 Times Cited: 174 160. Cope, D.K., Impastato, W.K., Cohen, M.V., and Downey, J.M.: Volatile Anesthetics Protect the Ischemic Rabbit Myocardium from Infarction. Anesthesiology 86:699-709, 1997. Times Cited: 143 161. Yang, X.-M., Sato, H., Downey, J.M., and Cohen, M.V.: Protection of Ischemic Preconditioning Is Dependent Upon a Critical Timing Sequence of Protein Kinase C Activation. J Mol Cell Cardiol. 29:991-999, 1997. 162. Sato, H., Miki, T., Vallabhapurapu, R.P., Wang, P., Liu, G.-S., Cohen, M.V., and Downey, J.M.: The Mechanism of Protection from 5-(N-ethyl-N-isopropyl)-amiloride Differs from that of Ischemic Preconditioning in Rabbit Heart. Basic Research in Cardiology 92:339-350, 1997 163. Cohen, M.V., Thornton, J.D., Thornton, C.S., Sato, H., Miki, T., and Downey, J.M.: Intravenous Co-infusion of Adenosine and Norepinephrine Preconditions the Heart Without Adverse Hemodynamic Effects. Journal of Thoracic and Cardiovascular Surgery. 114:236-242, 1997. 164. Cohen, M.V., Yang, X-M, Downey, J.M. Attenuation of S-T segment during repetitive coronary occlusions truly reflects the protection of ischemic preconditioning and is not an epiphenomenon. Basic Res Cardiol 92:426-434, 1997 165. Critz, S.D., Liu, G.-S., Chujo, M., Downey, J.M. Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.J Mol Cell Cardiol 29: 1123-1130, 1997 166. Weinbrenner, C., Cohen, M.V., and Downey, J.M.: Phosphorylation of Tyrosine 182 of p38 Mitogen-activated Protein Kinase Correlates with the Protection of Preconditioning in the Rabbit Heart. J Mol Cell Cardiol. 29:2383-2391, 1997. Times Cited: 143 167. Baines, C.P., L. Wang, M.V. Cohen and J.M. Downey. Protein tyrosine kinase is downstream of protein kinase C for ischemic preconditioning's anti-infarct effect in rabbit heart. J Mol Cell Cardiol 30: 383-392,1998 Times Cited: 106 168. Downey , J.M., Cohen, M.V. Arguments in favor of protein kinase C playing an important role in ischemic preconditioning Basic Res Cardiol 92 (suppl 2): 37-39, 1997 169. Armstrong, S.C., Kao, R., Gao, W., Shivell, L.C., Downey, J.M., Honkanen, R.E., Ganote, C.E. Comparison of in vivo preconditioning responses of isolated pig and rabbit cardiomyocytes: effects of a protein phosphatase inhibitor, fostriecin. J Mol Cell Cardiol 29:3009-3024, 1997 170. Hashimi, M.W., Thornton, J.D., Downey, J.M., and Cohen, M.V.: Loss of Myocardial Protection From Ischemic Preconditioning Following Chronic Exposure to R(-)-N6-(2-Phenylisopropyl) Adenosine Is Related to Defect at the Adenosine A1Receptor. Molecular and Cellular Biochemistry 186: 19-25, 1998. 171. Miki, T., Liu, G.S., Cohen, M.V., and Downey, J.M.: Mild Hypothermia Reduces Infarct Size in the Beating Rabbit Heart: A Practical Intervention for Acute Myocardial Infarction? Basic Research in Cardiology 93: 372-383, 1998. 172. Miki, T., Cohen, M.V., and Downey, J.M.: Opioid Receptor Contributes to Ischemic Preconditioning Through Protein Kinase C Activation in Rabbits. Molecular and Cellular Biochemistry 186: 3-12, 1998. Times Cited: 89 173. Weinbrenner, C., Baines, C.P., Liu, G-S, Armstrong, S.C., Ganote C.E., Honkanen, R.E., Cohen M.V., Downey, J.M. Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia. Circulation 98:899-905, 1998 174. Weinbrenner, C., Liu, G.S., Downey, J.M., and Cohen, M.V.: Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia. Cardiovasc Res 38: 676-684, 1998 175. Cohen, M.V., and Downey, J.M.: The Warm-up Phenomenon and Ischemic Preconditioning: An Uncertain Relationship (Editorial). European Heart Journal 20:167-168, 1999. 176. Baines CP, Cohen MV, Downey JM. Signal Transduction in Ischemic Preconditioning: The Role of Kinases and Mitochondrial KATP Channels. Journal of Cardiovascular Electrophysiology 10:741-754, 1999. 177. Baines CP, Liu GS, Birincioglu M, Critz SD, Cohen MV, Downey JM. Ischemic Preconditioning Depends on Interaction Between Mitochondrial KATP Channels and Actin Cytoskeleton. American Journal of Physiology 276:H1361-H1368, 1999. Times Cited: 113 178. Iliodromitis, E.K., Miki, T., Liu, G.S., Downey, J.M., Cohen, M.V., and Kremastinos, D.T.: The PKC Activator PMA Preconditions Rabbit Heart in the Presence of Adenosine Receptor Blockade: Is 5'-Nucleotidase Important? J Mol Cell Cardiol. 30:2201-2211, 1998. 179. Baines CP, Wang L, Cohen MV, Downey JM. Myocardial Protection by Insulin Is Dependent on Phosphatidylinositol 3-Kinase but not Protein Kinase C or KATP Channels in the Isolated Rabbit Heart. Basic Research in Cardiology 94: 188-198, 1999. . 180. Miki T, Cohen MV, Downey JM. Failure of N-2-Mercaptopropionyl Glycine to Reduce Myocardial Infarction After 3 Days of Reperfusion in Rabbits. Basic Research in Cardiology 94:180-187, 1999. 181. Cohen MV, Yang XM, Downey JM Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart. Am. J. Physiol. 277:H1754-H1761, 1999. 182. Miki T, Swafford AN, Cohen MV, Downey JM. Second window of protection against infarction in conscious rabbits: real or artifactual? J. Mol. Cell Cardiol. 31:809-816, 1999 183. Kim SO, Baines CP, Critz SD, Pelech SL, Katz S, Downey JM, Cohen MV Ischemia induced activation of heat shock proteins 27 kinases and casein kinase 2 in the preconditioned rabbit heart. Biochemistry and Cell Biology 77:559-567,1999 184. Liu GS, Cohen MV, Mochly-Rosen D, Downey JM. Protein kinase C-e is responsible for the protection of preconditioning in rabbit cardiomyocytes. J. Mol. Cell Cardiol. 31:1937-1948, 1999 Times Cited: 110 185. Birincioglu M, Yang XM, Critz SD, Cohen MV, Downey JM. S-T segment voltage during sequential coronary occlusions is an unreliable marker of preconditioning. Am. J. Physiol. 277:H2435-2441, 1999 186. Nakano A, Baines CP, Kim SO, Pelech SL, Downey JM, Cohen MV, Critz SD. Ischemic preconditioning activates MAPKAPK2 in the isolated rabbit heart. Circ res 86:144-151, 2000 187 Cohen MV, Baines CP, Downey JM. Ischemic preconditioning: from adenosine receptor to Katp channel. Annu. Rev. Physiol. 62:79-109, 2000 Times Cited: 214 188. Nakano, A., Cohen, M.V., and Downey, J.M.: Ischemic preconditioning: from basic mechanisms to clinical applications. Pharmacology & Therapeutics, 86:263-275, 2000 189. Cohen MV, Yang XM, Neumann T, Heusch G, Downey JM.: Favorable Remodeling Enhances Recovery of Regional Myocardial Function in the Weeks Following Infarction in Ischemically Preconditioned Hearts. Circulation 102:579-583, 2000 190. Nakano A, Liu GS, Heusch G, Downey JM, Cohen MV. Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning. J Mol Cell Cardiol. 32:1159-1167, 2000. 191. Downey, J.M., and Cohen, M.V.: Do mitochondrial KATP channels serve as triggers rather than end-effectors of ischemic preconditioning's protection? Basic Research in Cardiology 95:272-4, 2000. 192. Downey , J.M. Anti-preconditioning (an editorial comment) Basic Res Cardiology 95:11, 2000 193. Pain T, Yang XM, Critz SD, Yue Y, Nakano A, Liu GS, Heusch G, Cohen MV, Downey JM. Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals. Circ Res. 87:460-6, 2000 Times Cited: 224 194. Nakano A, Cohen MV, Critz S, Downey JM. SB 203580, an inhibitor of p38 MAPK, abolishes infarct-limiting effect of ischemic preconditioning in isolated rabbit hearts. Basic Res Cardiol. 95: :466-71, 2000 195. Xu Z, Yang XM, Cohen MV, Neumann T, Heusch G, Downey JM. Limitation of infarct size in rabbit hearts by the novel adenosine receptor agonist AMP 579 administered at reperfusion. J Mol Cell Cardiol. 32: :2339-47, 2000 196. Heusch G, Liu GS, Rose J, Cohen MV, Downey JM. No confirmation for a causal role of volume-regulated chloride channels in ischemic preconditioning in rabbits. J Mol Cell Cardiol. 32: 2279-85, 2000 197. Krenz M, Baines CP, Yang XM, Heusch G, Cohen MV, Downey JM. Acute ethanol exposure fails to elicit preconditioning-like protection in in situ rabbit hearts because of its continued presence during ischemia. J Am Coll Cardiol. 37: 601-7, 2001 198. Baxter GF, Hale SL, Miki T, Kloner RA, Cohen MV, Downey JM, Yellon DM. Adenosine A1 agonist at reperfusion trial (AART): results of a three-center, blinded, randomized, controlled experimental infarct study. Cardiovasc Drugs Ther. 14(6):607-1,. 2000 199. Downey JM and Cohen MV. Mitochondrial K(ATP) channel opening during index ischemia and following myocardial reperfusion in ischemic rat hearts. (an editorial comment) J Mol Cell Cardiol. 33:651-3, 2001 200. Yue
Y, Krenz M, Cohen MV, Downey JM, Critz SD. Menadione mimics the
infarct-limiting effect of preconditioning in isolated rat hearts. 201. Cohen MV, Yang XM, Liu GS, Heusch G, Downey JM. Acetylcholine, bradykinin, opioids, and phenylephrine, but not adenosine, trigger preconditioning by generating free radicals and opening mitochondrial K(ATP) channels. Circ Res. 89:273-8, 2001 Times Cited: 99 202. Xu Z, Downey JM, Cohen MV. AMP 579 reduces contracture and limits infarction in rabbit heart by activating adenosine a2 receptors. J Cardiovasc Pharmacol. 38:474-8, 2001 203. Xu Z, Cohen MV, Downey JM, Vanden Hoek TL, Yao Z. Attenuation of oxidant stress during reoxygenation by AMP 579 in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2001, 281:H2585-H2589. 204. Krenz M, Baines CP, Heusch G, Downey JM, Cohen MV. Acute Alcohol-induced Protection against Infarction in Rabbit Hearts: Differences from and Similarities to Ischemic Preconditioning. J Mol Cell Cardiol. 33:2015-22, 2001 205. Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G. Signal transduction of ischemic preconditioning. Cardiovasc Res. 52:181-198, 2001Times Cited: 121 206. Heusch G, Liu GS, Rose J, Cohen MV, Downey JM. Swelling-activated chloride channels as effectors of ischemic preconditioning? J Cell Mol Cardiol 33:1891-2, 2001 207. Nakano A, Heusch G, Cohen MV, Downey JM. Preconditioning one myocardial region does not necessarily precondition the whole rabbit heart. Basic Res Cardiol 97: 35-39, 2002 208. Gelpi RJ, Morales C, Cohen MV, Downey JM.. Xanthine oxidase contributes to preconditioning’s preservation of left ventricular developed pressure in isolated rat heart: developed pressure may not be an appropriate end point for studies on preconditioning. Basic Res Cardiol 97: 40-46 2002 209. Oldenburg O, Qin Q, Sharma AR, Cohen MV, Downey JM, Benoit JN. Acetlycholine leads to free radical production dependent on KATP channels, Gi proteins, phosphatidylinositol-3, and Tyrosine kinases. Cardiovasc Res 55:544-52, 2002. 210. Krenz M, Oldenburg O, Wimpee H, Cohen MV, Garlid KD, Critz SD, Downey JM, Benoit JN. Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells. Basic Res Cardiol 97:365-73, 2002. 211. Krenz M, Yang XM, Qin Q, Downey JM, Cohen MV. Dose-response relationships of the protective and the anti-protective effects of acute ethanol exposure in isolated rabbit hearts. Heart Disease 4:276-81, 2002 212. Xu Z, Jiao Z, Cohen MV, Downey JM. Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart. J Cardiovasc Pharmacol.40:510-8, 2002 213. Krieg T, Qin Q, McIntosh EC, Cohen MV, Downey JM. ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases. Am J Physiol Heart Circ Physiol. 283:H2322-30, 2002 214. Qin Q, Downey JM, Cohen MV. Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase. Am J Physiol Heart Circ Physiol. 284:H727-34, 2003 215. Krieg T, Landsberger M, Alexeyev MF, Felix SB, Cohen MV, Downey JM. Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals. Cardiovasc Res. 58:196-202, 2003 216. Oldenburg O, Critz SD, Cohen MV, Downey JM. Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening. J Mol Cell Cardiol. 35: 653-660, 2003 217. Oldenburg O, Cohen MV, Downey JM. Mitochondrial K(ATP) channels in preconditioning. J Mol Cell Cardiol. 35: 569-75, 2003 218. Zhang SJ, Yang XM, Liu GS, Cohen MV, Pemberton K, Downey JM. CGX-1051, a peptide from Conus snail venom, attenuates infarction in rabbit hearts when administered at reperfusion. J Cardiovasc Pharmacol. 42:764-71. 2003 219. Xu Z, Downey JM, Cohen MV. Timing and Duration of
Administration Are Crucial for Antiinfarct Effect of AMP 579 Infused at
Reperfusion in Rabbit Heart. 220. Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev. 83:1113-51. 2003 Times Cited: 90 221. Oldenburg O, Yang XM, Krieg T, Garlid KD, Cohen MV, Grover GJ, Downey JM. P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. J Mol Cell Cardiol. 35:1035-42, 2003 222. Oldenburg O, Qin Q, Krieg T, Yang XM, Philipp S, Critz SD, Cohen MV, Downey JM. Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG , and mKATP channel opening and leads to cardioprotection. Am J Physiol Heart Circ Physiol. 286:H468-76, 2004 223. Krieg T, Cohen MV, Downey JM. Mitochondria and their role in preconditioning's trigger phase. Basic Res Cardiol. 98:228-34, 2003 224. Krenz M, Cohen MV, Downey JM. Protective and anti-protective effects of acute ethanol exposure in myocardial ischemia/reperfusion. Pathophysiology. 10:113-119, 2004 225. Yang XM, Krieg T, Cui L, Downey JM, Cohen MV. NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO. J Mol Cell Cardiol. 36: 411-21, 2004 226. Krieg T, Cui L, Qin Q, Cohen MV, Downey JM. Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF. J Mol Cell Cardiol. 36:435-43, 2004 227. Krieg T, Yang XM, Downey JM, Schaffer SW, Cohen MV. Augmented taurine release is not the mechanism of ischemic preconditioning's cardioprotection. Amino Acids. 3:263-6. 2004 228. Qin Q, Yang XM, Cui L, Critz SD, Cohen MV, Browner N, Lincoln TM, Downey JM. Exogenous NO triggers preconditioning by a cGMP- and mitoKATP-dependent mechanism. Am J Physiol Heart Circ Physiol. 287:H712-8 2004 229. Krieg T, Qin Q, Philipp S, Alexeyev MF, Cohen MV, Downey JM. Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS. Am J Physiol Heart Circ Physiol.287:H2606-11, 2004 230. Yang XM, Proctor JB, Cui L, Krieg T, Downey JM, Cohen MV. Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways. J Am Coll Cardiol. 44:1103-10, 2004 231. Krieg T, Philipp S, Cui L, Dostmann WR, Downey JM, Cohen MV. Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart. Am J Physiol Heart Circ Physiol. 288:H1976-81. 2005 232. Yang XM, Philipp S, Downey JM, Cohen MV. Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation. Basic Res Cardiol. 100(1):57-63, 2005 233. Downey JM, Cohen MV. We think we see a pattern emerging here (Editorial). Circulation. Jan 18;111(2):120-1, 2005 234. Critz SD, Cohen MV, Downey JM. Mechanisms of acetylcholine- and bradykinin-induced preconditioning. Vascul Pharmacol. 42:201-9, 2005 235. Costa AD, Garlid KD, West IC, Lincoln TM, Downey JM, Cohen MV, Critz SD. Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria. Circ Res. 97:329-36. 2005 236. Solenkova NV, Solodushko V, Cohen MV, Downey JM. Endogenous adenosine protects the preconditioned heart during the early minutes of reperfusion by activating Akt. Am J Physiol Heart Circ Physiol. Am J Physiol Heart Circ Physiol. 290:H441-9. 2006 237. Philipp S, Cui L, Ludolph B, Kelm M, Schulz R, Cohen MV, Downey JM. Desferoxamine and ethyl-3,4 dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS . Am J Physiol Heart Circ Physiol. 290:H450-7. 2006 238. Downey JM, Cohen MV. Unraveling the mysteries of
classical preconditioning. 239. Philipp S, Critz SD, Cui L, Solodushko V, Cohen MV, Downey JM. Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway. Basic Res Cardiol. 101:159-67. 2006 240. Xu Z, Mueller RA, Park SS, Boysen PG, Cohen MV, Downey JM. Cardioprotection with adenosine A2 receptor activation at reperfusion. J Cardiovasc Pharmacol. 46:794-802. 2005 241. Cohen MV, Yang XM, Downey JM. Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies. Cardiovasc Res. 70:231-9. 2006 242. Downey JM, Cohen MV. A really radical observation (Editorial) Basic Res Cardiol. 101:190-1. 2006 243. Philipp S, Yang XM, Cui L, Davis AM, Downey JM, Cohen MV. Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade. Cardiovasc Res. 70:308-14. 2006 244. Cohen MV, Downey JM. AMISTAD trials: possible reasons for lack of success.(Letter to the editor) J Am Coll Cardiol. 47:1236. 2006 245. Forster K, Paul I, Solenkova N, Staudt A, Cohen MV, Downey JM, Felix SB, Krieg T. NECA at reperfusion limits infarction and inhibits formation of the mitochondrial permeability transition pore by activating p70S6 kinase. Basic Res Cardiol.101:319-26. 2006 246. Yang XM, Philipp S, Downey JM, Cohen MV. Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts. Basic Res Cardiol. 101:311-8. 2006 247. Downey JM, Cohen MV. Reducing infarct size in the setting of acute myocardial infarction. Prog Cardiovasc Dis. 48:363-71. 2006 248. Iliodromitis EK, Georgiadis M, Cohen MV, Downey JM, Bofilis E, Kremastinos DT. Protection from postconditioning depends on the number of short ischemic insults in anesthetized pigs. Basic Res Cardiol. 101:502-7. 2006 249. Solenkova NV, Maslov LN, Downey JM. ATP-dependent K+channels and the regulation of cardiac resistance to ischemic and reperfusion injuries. Patol Fiziol Eksp Ter. 2:28-31. 2006 250. Downey JM and Cohen MV. (Revascularization) Summaries of Ten Seminal Papers. Dialogues in Cardiovascular Medicine 11:319-330, 2006 251. Cohen MV, Yang XM, Downey JM. The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis. Circulation.115:1895-903. 2007 252. Cohen MV, Philipp S, Krieg T, Cui L, Kuno A, Solodushko V, Downey JM. Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways. J Mol Cell Cardiol. 42:842-51. 2007 253. Tissier R, Hamanaka K, Kuno A, Parker JC, Cohen MV, Downey JM. Total liquid ventilation provides ultra-fast cardioprotective cooling. 49:601-5. J Am Coll Cardiol. 2007 254. Kuno A, Critz SD, Cohen MV, Downey JM. Nicorandil opens mitochondrial K(ATP) channels not only directly but also through a NO- PKG -dependent pathway. Basic Res Cardiol. 102:73-9. 2007 255. Downey JM, Davis AM, Cohen MV. Signaling pathways in ischemic preconditioning. Heart Fail Rev. 12(3-4):181-8. 2007 256. Kuno A, Critz SD, Cui L, Solodushko V, Yang XM, Krahn T, Albrecht B, Philipp S, Cohen MV, Downey JM. Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity to adenosine during early reperfusion. J Mol Cell Cardiol 43:262-71. 2007 257. Tissier R, Cohen MV, Downey JM. Protecting the acutely ischemic myocardium beyond reperfusion therapies: Are we any closer to realizing the dream of infarct size elimination? Archives de Maladies du Coer et des Vaisseaux 100:794-802. 2007 258. Tissier R, Berdeaux A, Ghaleh B, Couvreur N, Krieg T, Cohen MV, Downey JM. Making the heart resistant to infarction: How can we further decrease infarct size? Frontiers of Bioscience 13:284-301. 2007 259. Dost T, Cohen MV, Downey JM. Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning. Basic Res Cardiol. 103:378-84, 2008 260. Liu Y, Yang XM, Iliodromitis EK, Kremastinos DT, Dost T, Cohen MV, Downey JM. Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator. Basic Res Cardiol. 103:54-9. 2008 261. Costa AD, Pierre SV, Cohen MV, Downey JM, Garlid KD. cGMP signalling in pre- and post-conditioning: the role of mitochondria. Cardiovasc Res. 77:344-52, 2008 262. Cohen MV, Downey JM. Adenosine: trigger and mediator of cardioprotection. Basic Res Cardiol.103:203-15, 2008 263. Downey JM, Cohen MV. Bypassing big pharma.(Editorial) Circulation. 116:1344-5, 2007 264. Downey JM, Cohen MV. Free radicals in the heart: friend or foe? Expert Rev Cardiovasc Ther. 6:589-91, 2008 265. Downey JM, Krieg T, Cohen MV. Mapping preconditioning's signaling pathways: an engineering approach. Ann N Y Acad Sci. 1123:187-96, 2008 266. Cohen MV, Yang XM, Downey JM. Acidosis, oxygen, and interference with mitochondrial permeability transition pore formation in the early minutes of reperfusion are critical to postconditioning's success. Basic Res Cardiol. 103:464-71. 2008 267. Cohen MV, Downey JM. Oestrogen plays a permissive role in cardioprotection.(Editorial) Cardiovasc Res. 1;79(3):353-4 2008 266. Downey JM, Cohen MV. Free radicals in the heart: friend or foe? Expert Rev Cardiovasc Ther. 2008 Jun;6(5):589-91. 267. Downey JM, Krieg T, Cohen MV. Mapping preconditioning's signaling pathways: an engineering approach. Ann N Y Acad Sci. 1123:187-96. 2008 268. Dost T, Cohen MV, Downey JM. Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning. Basic Res Cardiol. 103:378-84. 2008 269. Downey JM, Cohen MV. O-linked beta-N-acetylglucosamine: a new piece of the cardioprotection puzzle? Circ Res.104:7-8. 2009 270. Tissier R, Couvreur N, Ghaleh B, Bruneval P, Lidouren F, Morin D, Zini R, Bize A, Chenoune M, Belair MF, Mandet C, Douheret M, Dubois-Rande JL, Parker JC, Cohen MV, Downey JM, Berdeaux A. Rapid cooling preserves the ischaemic myocardium against mitochondrial damage and left ventricular dysfunction. Cardiovasc Res. 83:345-53. 2009 271. Cohen MV, Downey JM. Adenosine at reperfusion: a conundrum ready to be resolved. J Am Coll Cardiol. 53:718-9. 2009 272. Cohen MV, Downey JM. Modulation of receptor sensitivity: possible therapeutic target? Br J Pharmacol. 156:899-900. 2009 273. Krieg T, Liu Y, Rütz T, Methner C, Yang XM, Dost T, Felix SB, Stasch JP, Cohen MV, Downey JM. BAY 58-2667, a nitric oxide-independent guanylyl cyclase activator, pharmacologically post-conditions rabbit and rat hearts. Eur Heart J.30:1607-13. 2009 274. Downey JM, Cohen MV. Why do we still not have cardioprotective drugs? Circ J. 73:1171-7. 2009 275. Yang XM, Liu Y, Liu Y, Tandon N, Kambayashi J, Downey JM, Cohen MV. Attenuation of infarction in cynomolgus monkeys: preconditioning and postconditioning. Basic Res Cardiol. 2010 Jan;105(1):119-28. 276. Iliodromitis EK, Downey JM, Heusch G, Kremastinos DT. What Is the Optimal Postconditioning Algorithm? J Cardiovasc Pharmacol Ther. 2009 Dec;14(4):269-73. 277. Cohen MV, Yang X, Downey JM. A(2b) adenosine receptors can change their spots. Br J Pharmacol. 2010 Apr;159(8):1595-7. 278. Yang X, Cohen MV, Downey JM. Mechanism of cardioprotection by early ischemic preconditioning. Cardiovasc Drugs Ther. 2010 Jun;24(3):225-34. 279. Liu Y, Yang X, Yang XM, Walker S, Förster K, Cohen MV, Krieg T, Downey JM. AMP579 is revealed to be a potent A2b-adenosine receptor agonist in human 293 cells and rabbit hearts. Basic Res Cardiol. 2010 Jan;105(1):129-37 280. Cohen MV, Downey JM. Ischemic Postconditioning: From Receptor to End-Effector. Antioxid Redox Signal. 2011, Mar 1;14(5):821-31 281. Tissier R, Chenoune M, Ghaleh B, Cohen MV, Downey JM, Berdeaux A. The small chill: mild hypothermia for cardioprotection? Cardiovasc Res. 2010 Dec 1;88(3):406-14 282. Methner C, Schmidt K, Cohen MV, Downey JM, Krieg T. Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1262-4. 283. Cohen MV, Yang XM, Liu Y, Solenkova NV, Downey JM. Cardioprotective PKG -independent NO signaling at reperfusion. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H2028-36. 284. Grube K, Rüdebusch J, Xu Z, Böckenholt T, Methner C, Müller T, Cuello F, Zimmermann K, Yang X, Felix SB, Cohen MV, Downey JM, Krieg T. Evidence for an intracellular localization of the adenosine A(2B) receptor in rat cardiomyocytes. Basic Res Cardiol. 2011 May;106(3):385-96. 285. Yang X, Xin W, Yang XM, Kuno A, Rich TC, Cohen MV, Downey JM. A(2B) adenosine receptors
inhibit superoxide production from mitochondrial complex I in rabbit
cardiomyocytes via a mechanism sensitive to Pertussis toxin. Br J
Pharmacol. 2011, Jul;163(5):995-1006. 288. Cohen MV, Downey JM. Is it time to translate ischemic preconditioning's mechanism of cardioprotection into clinical practice? J Cardiovasc Pharmacol Ther. 2011 Sep-Dec;16(3-4):273-80 289. Darbera L, Chenoune M, Lidouren F, Ghaleh B, Cohen MV, Downey JM, Berdeaux A, Tissier R. Adenosine and Opioid Receptors Do Not Trigger the Cardioprotective Effect of Mild Hypothermia. J Cardiovasc Pharmacol Ther. 2012, 17:173-80 290. Tissier R, Cohen MV, Downey JM. Does mild hypothermia protect against reperfusion injury? The debate continues. Basic Res Cardiol. 2012 May 1;94(2):217-25 291. Xin W, Yang X, Rich TC, Krieg T, Barrington R, Cohen MV, Downey JM. All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte. J Cardiovasc Pharmacol Ther.2012 Jun;17(2):190-8 292. Tissier R, Ghaleh B, Cohen MV, Downey JM, Berdeaux A. Myocardial protection with mild hypothermia. Cardiovasc Res. 2012 May 1;94(2):217-25. 293. Yang XM, Liu Y, Cui L, Yang X, Liu Y, Tandon N, Kambayashi J, Downey JM, Cohen MV. Platelet P2Y12 blockers confer direct postconditioning-like protection in reperfused rabbit hearts. Cardiovasc Pharmacol Ther. 2013 18:251-62 294. Yang XM, Liu Y, Cui L, Yang X, Liu Y, Tandon N, Kambayashi J, Downey JM, Cohen MV. Two classes of anti-platelet drugs reduce anatomical infarct size in monkey hearts. Cardiovasc Drugs Ther. 2013, 27:109-15 295. Yang XM, Cui L, Alhammouri A, Downey JM, Cohen MV. Triple Therapy Greatly Increases Myocardial Salvage During Ischemia/Reperfusion in the in situ Rat Heart. Cardiovasc Drugs Ther. 2013, Oct;27(5):403-12. 296. Cohen MV, Downey JM. Combined cardioprotectant and antithrombotic actions of platelet P2Y12 receptor antagonists in acute coronary syndrome: just what the doctor ordered. J Cardiovasc Pharmacol Ther. 19:179-90 2014 297. Cohen MV, Downey JM. Signalling pathways and mechanisms of protection in pre- and postconditioning: historical perspective and lessons for the future. Br J Pharmacol. 2015, 172:1913-32. 298. Yang XM, Cui L, White J, Kuck J, Ruchko MV, Wilson GL, Alexeyev M, Gillespie MN, Downey JM, Cohen MV. Mitochondrially targeted Endonuclease III has a powerful anti-infarct effect in an in vivo rat model of myocardial ischemia/reperfusion. Basic Res Cardiol. 2015, 110:459. 299. Iliodromitis EK, Cohen MV, Dagres N, Andreadou I, Kremastinos DT, Downey JM. What is Wrong With Cardiac Conditioning? We May be Shooting at Moving Targets. J Cardiovasc Pharmacol Ther. 2015, 20:357-69. 300. Bell RM, Sivaraman V, Kunuthur SP, Cohen MV, Downey JM, Yellon DM. Cardioprotective Properties of the Platelet P2Y12 Receptor Inhibitor, Cangrelor: Protective in Diabetics and Reliant Upon the Presence of Blood. Cardiovasc Drugs Ther. 2015, 29:415-8. 301. Cohen MV, Downey JM. Status of P2Y12 treatment must be considered in evaluation of myocardial ischaemia/reperfusion injury. Cardiovasc Res. 2015, 106:8 302. Maslov LN, Khaliulin I, Zhang Y, Krylatov AV, Naryzhnaya NV, Mechoulam R, De Petrocellis L, Downey JM. Prospects for Creation of Cardioprotective Drugs Based on Cannabinoid Receptor Agonists. J Cardiovasc Pharmacol Ther. 2016, 21:262-72 303. Cohen MV, Yang XM, White J, Yellon DM, Bell RM, Downey JM. Cangrelor-Mediated Cardioprotection Requires Platelets and Sphingosine Phosphorylation. Cardiovasc Drugs Ther. 2016, 30:229-32 304. Bell RM, Bøtker HE, Carr RD, Davidson SM, Downey JM, Dutka DP, Heusch G, Ibanez B, Macallister R, Stoppe C, Ovize M, Redington A, Walker JM, Yellon DM. 9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection. Basic Res Cardiol. 2016, 111(4):41 305. Maslov LN, Khaliulin I, Oeltgen PR, Naryzhnaya NV, Pei JM, Brown SA, Lishmanov YB, Downey JM. Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists. Med Res Rev. 2016, 36:871-923 306. Yang XM, Downey JM, CohenMV, Housley NA, Alvarez DF, Audia JP. The Highly Selective Caspase-1 Inhibitor VX-765 Provides Additive Protection Against Myocardial Infarction In Rat Hearts When Combined With A Platelet Inhibitor. J Cardiovasc Pharmacol Ther. 2017 Nov;22(6):574-578 307. Downey JM, Cohen MV. Letter by Downey and Cohen Regarding Article, "Protective Effects of Ticagrelor on Myocardial Injury After Infarction". Circulation. 2017 Apr 25;135(17):e1000-e1001 308. Kloner RA, Brown DA, Csete M, Dai W, Downey JM, Gottlieb RA, Hale SL, Shi J. New and revisited approaches to preserving the reperfused myocardium. Nat Rev Cardiol. 2017 Nov;14(11):679-693. 309. Hausenloy DJ, Barrabes JA, Bøtker HE, Davidson SM, Di Lisa F, Downey J, Engstrom T, Ferdinandy P, Carbrera-Fuentes HA, Heusch G, Ibanez B, Iliodromitis EK, Inserte J, Jennings R, Kalia N, Kharbanda R, Lecour S, Marber M, Miura T, Ovize M, Perez-Pinzon MA, Piper HM, Przyklenk K, Schmidt MR, Redington A, Ruiz-Meana M, Vilahur G, Vinten-Johansen J, Yellon DM, Garcia-Dorado D. Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery. Basic Res Cardiol. 2016; 111(6):70. 310. Hausenloy DJ, Garcia-Dorado D, Bøtker HE, Davidson SM, Downey J, Engel FB, Jennings R, Lecour S, Leor J, Madonna R, Ovize M, Perrino C, Prunier F, Schulz R, Sluijter JPG, Van Laake LW, Vinten-Johansen J, Yellon DM, Ytrehus K, Heusch G, Ferdinandy P. Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart. Cardiovasc Res. 2017;113(6):564-585 311. Cohen MV, Downey JM. The impact of irreproducibility and competing protection from P2Y12 antagonists on the discovery of cardioprotective interventions. Basic Res Cardiol. 2017 Sep 26;112(6):64. 312. Nelson DA, Leavesley SJ, Zirlott CD, Yang XM, Downey JM. Feasibility of using thermal response to Ka band millimeter wave heating to assess skin blood flow. Physiol Meas. 2018, 39:045001. doi: 10.1088/1361-6579/aab4d4. 313. Audia JP, Yang XM, Crockett ES, Housley N, Haq EU, O'Donnell K, Cohen MV, Downey JM, Alvarez. DF. Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function. Basic Res Cardiol. 2018, 113(5):32 314. Krylatov AV, Maslov LN, Voronkov NS, Boshchenko AA, Popov SV, Gomez L, Wang H, Jaggi AS, Downey JM. Reactive Oxygen Species as Intracellular Signaling Molecules in the Cardiovascular System. Curr Cardiol Rev. 2018;14(4):290-300 315. Zuurbier CJ, Abbate A, Cabrera-Fuentes HA, Cohen MV, Collino M, De Kleijn DPV, Downey JM, Pagliaro P, Preissner KT, Takahashi M, Davidson SM. Innate immunity as a target for acute cardioprotection. Cardiovasc Res. 2019 ;115(7):1131-1142 316. Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, Pernow J, Preissner KT, Ferdinandy P. Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res;. 2019; 115(7):1156-1166 317: Yang XM, Gadde S, Audia JP, Alvarez DF, Downey JM, Cohen MV. Ticagrelor Does Not Protect Isolated Rat Hearts, Thus Clouding Its Proposed Cardioprotective Role Through ENT 1 in Heart Tissue. J Cardiovasc Pharmacol Ther. 2019; 24(4):371-376 318. Tsibulnikov SY, Maslov LN, Gorbunov AS, Voronkov NS, Boshchenko AA,
Popov SV, Prokudina ES, Singh N, Downey JM. A Review of Humoral Factors in Remote Preconditioning
of the Heart. J Cardiovasc Pharmacol Ther.
2019; 24(5):403-421 319. Mishra PK, Adameová A, Hill JA, Baines CP, Kang PM, Downey J, Narula
J, Takahashi M, Abbate A, Piristine HC, Kar S, Su S, Higa JK, Kawasaki NK,
Matsui T. Guidelines for evaluating myocardial cell death. Am J Physiol Heart Circ Physiol. Am J
Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H891-H922. 320. Cohen MV, Downey JM. What Are Optimal P2Y12 Inhibitor and Schedule of
Administration in Patients With Acute Coronary Syndrome? J Cardiovasc Pharmacol Ther. 2020
Mar;25(2):121-130. 321. Popov SV, Maslov LN, Naryzhnaya NV, Mukhomezyanov AV, Krylatov AV, Tsibulnikov SY, Ryabov VV, Cohen MV, Downey JM. The Role of Pyroptosis in Ischemic and Reperfusion Injury of the Heart. J Cardiovasc Pharmacol Ther. (in Press) BOOKS AND BOOK CHAPTERS 1. Munch, Douglas F., and James M. Downey. Regulation of Myocardial Contractility. In: Cardiac Pharmacology R.D. Wilkerson, ed., Academic Press, New York, 1981. 2. Downey, James M. and Douglas F. Munch. Evaluation of Drug Effects on Coronary Blood Flow and Oxygen Consumption. In: Cardiac Pharmacology, R.D. Wilkerson, ed., Academic Press, New York, 1981. 3. Downey, James M. The Extravascular Coronary Resistance. In: The Coronary Artery, Stanley Kalsner, ed., Croom-Helm, London, 1982. 4. Downey, James, and Steven Rogers. Interfacing the PET Computer, Howard Sams, Indianapolis, 1981. 5. Downey, James M. and Don Rindsburg. Interfacing Projects for the Sinclair Computers, Prentice-Hall, Englewood Cliffs, NJ (1983). 6. Downey, James M., D. Rindsburg, and W. Ischerwood. Easy Interfacing Projects for the VIC 20, Prentice-Hall, Englewood Cliffs, NJ, 1984. 7. Downey, James M., D. Rindsburg, and W. Ischerwood. Easy Interfacing Projects for the Commodore 64, Prentice_Hall, Englewood Cliffs, NJ, 1984. 8. Downey, James M. Why the endocardium? In: Therapeutic approaches to Myocardial Infarction, Hearse and Yellon, ed., Raven Press, London, 1984. 9. Miura, T., D.M. Yellon, and J.M. Downey. Myocardial Infarction. In: Physiology and Pathophysiology of the Heart, 2nd Ed. Nicholas Sperelakis, ed., pp 955-974, Kluwer Academic Publishers, Norwell, MA, 1989. 10. Downey, J.M. Extravascular coronary resistance. In: Physiology and Pathophysiology of the Heart, 2nd Ed. Nicholas Sperlakis, ed., pp 939-955, Kluwer Academic Publishers, Norwell, MA, 1989. 11. Hearse, D.J., A.S. Manning, J.M. Downey, and D.M. Yellon. Allopurinol,xanthine oxidase and myocardial injury. In: Superoxide and Superoxide Dismutase in Chemistry, Biology, and Medicine, Giuseppe Rotilio, ed., Elsevier, New York,1986. 12. Downey, J.M., L.J. Eddy, C. Shirato, P. Molina, and M. Molina. Xanthine oxidase is an unlikely source of free radicals in the ischemic human heart. In: Oxygen Radicals in the Pathophysiology of Heart Disease, Pawan Singal, ed., Martinus Nijhoff, NY (1988). 13. Hearse, D.J., A.S. Manning, J.M. Downey, D.M. Yellon. Oxygen derived free radicals and myocardial injury. A critical role for xanthine oxidase? in Oxygen Free Radicals in Shock. Karger: Basil 1986. 14. Downey, J.M. The extravascular coronary resistance. In: Coronary Circulation from Basic Mechanisms to Clinical Implications, J.A.E. Spaan, A.V.G.Brushke, and A.C. Gittenberger, eds., Marinus Nijhoff, NY, CIP-GEGEVENS, The Haag, 1987. 15. Downey, J.M. and M.V. Cohen. Nutrition of ischemic myocardium through venous level collaterals. In: Imaging Analysis and Simulation of the Cardiovascular System. (Proceedings of the Henry Goldberg Workshop), S. Sideman and R. Beyer eds., Freund London 1990. 16. Omar, B., J.M. McCord and J.M. Downey. Ischemia and Reperfusion. in: Oxidative Stress, Helmut Sies, ed. Academic Press, London 1991 17. Seven chapters on cardiovascular physiology in: Essential Medical Physiology, Leonard Johnson, Editor, Raven Press, New York, pp 151-230, 1992 18. Cohen, M.V., and J.M. Downey Venous level collaterals in the coronary system. in: Collateral Circulation, W. Schaper, ed. Klewer, Norwell MA 1993 19. Cardiovascular Research Journal focused issue: "Spotlight on the cardioprotective properties of adenosine" J.M. Downey and M. B. Forman, eds, Vol 27 (1), 1993 20. Downey, J.M. and D.M. Yellon: Do free radicals contribute to myocardial cell death during ischemia-reperfusion? in: Myocardial Protection; the Pathophysiology of Reperfusion and Reperfusion Injury. D.M. Yellon and R.B.Jennings eds, pp 35-59 Raven, New York, 1992 21. Downey, J.M., K. Ytrehus, Y. Liu Adenosine and the ant-infarct effects of preconditioning. in ischemic preconditioning: the concept of endogenous cardioprotection. K. Przyklenk, R.A. Kloner and D.M. Yellon ed. pp 137-152. Klewer, Boston 1994 22. Downey, J.M., M.V. Cohen, K. Ytrehus, Y. Liu: Cellular Mechanisms of ischemic preconditioning: the role of adenosine and protein kinase C. in: Cellular, Biochemical and Molecular Aspects of Reperfusion Injury. D.K. Das ed. pp 82-98, New York Academy of Sciences, New York, 1994 Times Cited: 94 23. Downey, J.M. Extravascular coronary resistance. In: Physiology and Pathophysiology of the Heart, 3rd edition. Nicholas Sperlakis, ed., pp 1109-1124, Kluwer Academic Publishers, Norwell, MA, 1995. 24. Downey, J.M. M.V. Cohen, K. Ytrehus, Y. Liu. Cellular mechanisms of ischemic preconditioning: the role of protein kinase C. in Cellular, biochemical and molecular aspects of reperfusion injury D. Das ed. Ann New York Acad Science 723:82-99, 1994 25. Downey, J.M., T. Miura. The role of adenosine in ischemic preconditioning. in: Cardiac Adaptation and Failure. M Hori, Y. Maruyama, R.S. Reneman, eds. Springer-Verlag, NewYork. pp 147-166, 1994 26. Downey, J.M., Liu, G.S., and Cohen, M.V.: Do Adenosine A3 Receptors Cause Preconditioning? In Purines and Myocardial Protection. Eds. Abd-Elfattah, A.-S. A., and Wechsler, A.S. Kluwer Academic Publishers, Boston, 1996, pp. 447-458. 27. Downey, J.M., and Cohen, M.V.: Mechanisms of Preconditioning: Correlates and Epiphenomena. In Ischaemia: Preconditioning and Adaptation. Eds Marber, M.S., and Yellon, D.M. Bios Scientific Publishers, Oxford, 1996, pp. 21-34. 28. Cohen, M.V., Liu, Y., and Downey, J.M.: Activation of Protein Kinase C is Critical to the Protection of Preconditioning. In Myocardial Preconditioning. Eds. Parratt, J.R., and Wainwright, C.L. R.G. Landes Co., Austin, TX, 1996, pp. 185-206. 29. Goto, M., Cohen, M.V., and Downey, J.M.: The Role of Protein Kinase C in Ischemic Preconditioning. In Myocardial Preservation, Preconditioning, and Adaptation: Annals of the New York Academy of Sciences, Vol. 793. Ed. Das, D.K. The New York Academy of Sciences, New York, 1996, pp. 177-190. 30. Liu, G.-S., Downey, J.M., and Cohen, M.V.: Adenosine, Ischemia and Preconditioning. InPurinergic Approaches in Experimental Therapeutics. Eds. Jacobson, K.A., and Jarvis, M.F. Wiley-Liss, Inc., New York, 1997, pp. 153-173. 31. Downey, J.M., and Cohen, M.V.: Signal Transduction in Ischemic Preconditioning. In Alfred Benzon Symposium 41. Munksgaard, Copenhagen, 1997, pp. 339-355. 32. Downey, J.M., and Cohen, M.V.: Signal Transduction in Ischemic Preconditioning. InAnalytical and Quantitative Cardiology: From Genetics to Function. Vol 430. Eds. Sideman, S., and Beyar, R.Plenum Press, New York. 1997, pp 39-56. 33. Downey, J.M. Six chapters in Essential Medical Physiology, Second Edition. Ed. Leonard R. Johnson, Lippencott-Raven, Philadelphia, 1997, pp 149-199 and 825-834. 34. Downey, J.M., and Cohen, M.V.: Preconditioning: Markers vs. epiphenomena. In: New Paradigms of Coronary Artery Disease. Eds. Heusch, G., and Schulz, R., Darmstadt: Steinkopff: Springer, New York, 1996, pp 153-155. 35 Weinbrenner, C. and Downey, J.M.,: Protein kinase C- the key enzyme in ischemic preconditioning? In Adenosine Cardioprotection and its Clinical Applicaton. Ed. R.M Mentzer, M. Kitakaze, J.M. Downey and M. Hori. Klewer, Norwell Mass, 1997pp73-92. 36 Downey, J.M. and Cohen, M.V.: Preconditioning: Markers vs epiphenomenon. In New Paradigms of Coronary Artery Disease. Ed. G Heusch and R. Schultz. Darmstadt: SteinKopff; New York, 1996 pp 153-155. 37.Goto M, Cohen MV, Downey JM.: The role of protein kinase C in ischemic preconditioning. Ann N Y Acad Sci 1996 Sep 30;793:177-90 38. Downey, J.M. and Cohen, M.V.: The biology of preconditioning. In: Stunning, Hibernation and Preconditioning. Ed. G.R. Heyndrickx, S.F. Vatner and W. Winjs. Lippincott-Raven, Philadelphia 1997. pp 105-120. 39. Myocardial ischemia and reperfusion. Ed. Cohen, M.V., Downey, J.M., Gelpi, R.J. and Slezak, J. Klewer Academic Publishers, Boston 1998 40. Downey, J.M. and Cohen, M.V. Preconditioning (Ch 4) in: Myocardial Viability: A Clinical and Scientific Treatise. Dilsizian V., Ed, Futura Armonk, NY 2000, pp55-75. 41. Downey, J.M. and G Heusch. Pumping and electrical activity of the heart. in: Heart Physiology and Pathophysiology N. Sperelakis, Y. Kurachi, A. Terzic, and M.V. Cohen, eds. Academic Press, New York. 2001, pp3-18 42. Downey, J.M. and G Heusch: Control of Cardiac output and its alterations during exercise and in heart failure. in: Heart Physiology and Pathophysiology N. Sperelakis, Y. Kurachi, A. Terzic, and M.V. Cohen, eds. Academic Press, New York. 2001, pp 61-69. 43. M. V. Cohen and J.M. Downey: Ischemic preconditioning: description, mechanism and significance. in: Heart Physiology and Pathophysiology N. Sperelakis, Y. Kurachi, A. Terzic, and M.V. Cohen, eds. Academic Press, New York. 2001, pp 867-886. 44. M. Krenz, M.V. Cohen and J.M. Downey: The protective and anti protective effects of ethanol in a myocardial infarct model. in Alcohol and Wine in Health and Disease. D.K. Das and F. Ursini, eds. New York Academy of Science, NY 2002, pp103-114. 45. J.M. Downey and M.V. Cohen: Ischemic preconditioning. In Myocardial Ischemia: From Mechanisms to Therapeutic Potentials. D.V. Cokkinos, C. Pantos, G. Heusch, and H. Tagtmeyer eds. Springer Science, New York 2006, pp 99-112. ABSTRACTS 1. Downey, J.M., H.F. Downey, and E.S. Kirk. Effect of myocardial strains on distribution of coronary blood flow in systole. The Physiologist 13:183, 1970. 2. Demibitsky, W.P., J.M. Downey, E.S. Kirk, and Edmund H. Sonnenblick. Inhibition of right coronary blood flow by high right ventricular pressure. Circulation 44:II-158, 1971. 3. Cohn, P.F., E.S. Kirk, J.M. Downey, Edmund H.Sonnenblick, and Richard Gorlin. Autoradiographic evaluation of myocardial collateral circulation. Circulation 44:II-158, 1971. 4. Forman, R., E.S. Kirk, J.M. Downey, and E.H. Sonnenblick. Reduced subendocardial blood flow and ventricular contractile force caused by nitroglycerine. Am. J. Cardiol. 29:262, 1972. 5. Downey, J.M., B.N. Singh, D.F. Cowan, C.W. Urschel, and E.S. Kirk. Adequacy of coronary perfusion during hemorrhagic hypotension. Fed. Proc. 31:329, 1972. 6. Snyder, R., J.M. Downey, and E.S. Kirk. The contribution of active muscle contraction to the extravascular component of coronary resistance. Presented at the American Congress of Engineering in Medicine and Biology, Bal Harbor, Florida, 1972. 7. Downey, J.M., and E.S. Kirk. Inhibition of coronary blood flow by a sluice mechanism and an estimate of the intramyocardial pressure. Physiologist 16:299, 1973. 8. Downey, J.M. Intramyocardial compression in the fibrillating heart. Physiologist 18:196, 1975. 9. Parker, P.E., H.F. Downey, J.M. Downey, and F.A. Bashour. Myocardial contractility during coronary reperfusion. Fed. Proc. 35:345, 1976. 10. Russell, R.E. and J.M. Downey. Inhibitory effect of cardiac contraction on collateral blood flow. Clin. Res. 25:7A, 1977. 11. Downey, J.M. An evaluation of the coronary constriction following propranolol. The Physiologist 20:22, 1977. 12. Downey, J., V. Hemphill, and R. Chagrasulis. Compression of the coronary arteries by the fibrillating heart. Fed. Proc. 37:418, 1978. 13. Downey, J.M., L.J. Eddy, M. Goodlett, and K. Dowling. Failure of isoproterenol to alter metabolic turnover in ischemic myocardium. Fed. Proc.38:905, 1979. 14. Munch, D.F. and J.M. Downey. A critical test of DPTI as an index of subendocardial flow. Fed. Proc. 38:1305, 1979. 15. Eddy, L.J., M.D. Goodlett, and J.M. Downey. Effect of propranolol on high energy phosphate turnover in ischemic myocardium. The Physiologist 22:33,1979. 16. Downey, J.M., R.D. Wilkerson, and D.F. Munch. An autoradiographic method for prediction of infarct size in dogs. Circulation 60:II-05, 1979. 17. Munch, D.F., H.T. Comer, and J.M. Downey. Graded barium contracture: A model of systole. Fed. Proc. 39:1170, 1979. 18. Downey, J.M., R.D. Wilkerson, and D.F. Munch. Inability of isoproterenol and propranolol to alter lateral infarct size in dogs. The Physiologist 23:163, 1980. 19. Lee, J., J.M. Downey, and D.E. Chambers. Coronary artery capacitance. The Physiologist 24:26, 1981. 20. Downey, J.M., J. Lee, and D.E. Chambers. Coronary critical closing pressure corrected for coronary capacitance effects. The Physiologist 24:26, 1981. 21. Chambers, D.E., J. Lee, and J.M. Downey. Absence of overlapping circulations between adjacent coronary arteries. The Physiologist 24:27, 1981. 22. Eddy, L.J., J.M. Downey, and D.E. Chambers. Lack of a direct metabolic effect of Fructose-1,6-Diphosphate in canine myocardium. Fed. Proc. 40:730, 1981. 23. Downey, J.M. D. Wyatt, and J. Lee. A load line analysis of the coronary collateral flow. Fed. Proc. 40:546, 1981. 24. Holloway, H., P. Kvietys, J. Downey, J.C. Parker, and A.E. Taylor. Estimation of pulmonary capillary pressure in intact dog. Fed.Proc. 40:404, 1981. 25. Chambers, D.E., D.M. Yellon, D.J. Hearse, and J.M. Downey. Flurbiprofen may limit infarct size 6 hours but not 24 hours following coronary occlusion in the dog. Fed. Proc. 41:7372, 1982. 26. Downey, J.M., J. Lee, and D. Chambers. Capacitive time constant of the coronary artery. Circulation 66:II-42, 1982. 27. Downey, J.M., D.J. Hearse, and D.M. Yellon. The application of risk zone analysis to the study of infarct size limitation in the closed-chest dog with coronary artery embolization. Journal of Physiology 339:7, 1983. 28. Chambers, D.E., D.A. Parks, G. Patterson, S. Yoshida, K. Burton, L.F.Parmley, J.M. McCord, and J.M. Downey. Role of oxygen derived radicals in myocardial ischemia. Fed. Proc. 42:4696, 1983. 29. Yellon, D.M., D.J. Hearse, M. Maxwell, D.E. Chambers, and J.M. Downey. Verapamil limits infarct size 24 hours following coronary embolization in the dog. Fed. Proc. 42:6163, 1983. 30. Yoshida, S., D.E. Chambers, G. Patterson, D.M. Yellon, D.J. Hearse, and J.M. Downey. Limitation of myocardial infarct size in coronary embolized dogs. Fed. Proc. :6165, 1983. 31. Downey, J.M., D.J. Hearse, S. Yoshida, M.P. Maxwell, and D.M. Yellon. Verapamil and nifedipine limits infarct size in the dog. J. Mol. and Cell. Cardiol.15(1):105, 1983. 32. Yellon, D.M., M.P. Maxwell, D.J. Hearse, S. Yoshida, L. Eddy, and J.M.Downey. Flurbiprofen causes an apparent but not real limitation of infarct size in the dog. J. Mol. and Cell. Cardiol. 15(a):395, 1983. 33. Yellon, D.M., J.M. Downey, D.J. Hearse, M.P. Maxwell, and S. Yoshida. Calcium antagonists limit infarct size. Circulation 68(Supp. III):186, 1983. 34. Bulkley, G.B., W.A. Womack, J.M. Downey, P.R. Kvietys, and D.N. Granger. Quantitative Characterization of segmental collateral blood flow in the canine small intestine. Fed. Proc. 43:323, 1984. 35. Roy, R., D.E. Chambers, J. McCord, and J.M. Downey. Myocardial ischemia causes xanthine dehydrogenase to be convected to xanthine oxidase. Fed. Proc. 43:323, 1984. 36. Akizuki S., S. Yoshida, D.E. Chambers, L. Eddy, L. Parmley, D. Yellon,and J.M. Downey. Blockage of the O2 radical producing enzyme, xanthine oxidase reduces infarct size in the dog. Fed. Proc. 43:540, 1984. 37. Yoshida, S., S. Akizuki, D. Gowski, and J.M. Downey. Discrepancy between collateral blood flow measured by microspheres and by diffusible indicators in canine hears. Fed. Proc. 43:1004, 1984. 38. Downey, J.M., D. Chambers, S. Yoshida, M. Harpin, and S. Akizuki. Functional and anatomical measurement of overlapping circulations between adjacent coronary arteries. Fed. Proc. 43:1004, 1984. 39. Downey, J.M., S. Yoshida, S. Akizuki, D. Gowski. Microspheres fail to measure all of the coronary collateral flow in the dog. Circulation 70:II14, 1984. 40. Downey, J., S. Akizuki, Y. Kudoh, L. Eddy, M. Maxwell, D. Hearse and D. Yellon. Two Beta blockers: Metoprolol and Cetamolol fail to limit infarct size in the dog. Circulation 70: II 179, 1984. 41. Yellon, D.M., V. Richard, D. J. Hearse, J. Deleiris, M. Maxwell, P. Kithas, S. Frank, M. Artman, and J.M. Downey, The effect of allopurinol on myocardial infarct size in rat vs. rabbit. Fed. Proc. 44: 1480, 1985. 42. Miura, T. S. Yoshida, O. Iimura, D. Yellon and J. Downey. Diltiazem reduced infarct size but not ventricular arrhythmias in coronary embolized greyhounds. Fed. Proc. 44: 1478, 1985. 43. Downey, J.M. and D.N. Granger. Source of free radicals in the ischemic myocyte. Int. Union Physiol. Sciences, in press, 1986. 44. Downey, J.M., D.E. Chambers, T. Miura, D. Yellon, and D. Jones. Xanthine oxidase inhibition fails to limit infarct size in the rabbit. The Physiologist 29:133, 1986. 45. Eddy, L., J. Stewart, H. Jones, D. Yellon, J. McCord, and J. Downey. Xanthine oxidase is detected in ischemic rat heart but not human hearts. The Physiologist 29:166, 1986. 46. Downey, J., D. Chambers, T. Miura, D. Yellon, and D. Jones. Allopurinol fails to reduce infarct size in a xanthine oxidase deficient species. Circulation 74:372, 1986. 47. Molina, P. and J. Downey. Oxyradical-mediated injury occurs on reperfusion of ischemic rabbit heart. Fed. Proc. 46:831, 1987. 48. Shirato, C., T. Matsuki, and J. Downey. Neutrophil depletion does not affect coronary collateral flow. Fed. Proc. 46:831, 1987. 49. Downey, J.M. The source of injurious oxygen derived free radical in the ischemic heart differs between species. Proc. Canadian Fed. Biol. Soc. 1987,p. 72. 50. Matsuki, T., C. Shirato, M.V. Cohen, and J.M. Downey. Oxypurinol and allopurinol reduce infarct size in reperfused dog heart without pretreatment. The Physiologist 30:187, 1987. 51. Cohen, M.V. and J.M. Downey. Coronary venous flow during angioplasty is not equivalent to collateral flow. Circulation 76:IV-184, 1987. 52. Shirato, C., T. Matsuki, B. Twohig, and J.M. Downey. Neutrophil depletion does not augment coronary collateral flow. Circulation 76:IV-51, 1987. 53. Shirato, C., T. Miura, and J.M. Downey. Superoxide dismutase (single dose) delays rather than prevents necrosis in reperfused rabbit heart. FASEB Journal 2:A918, 1988. 54. Matsuki, T., M.V. Cohen, G. Holt, D.J. Hearse, and J.M. Downey. Chronic sympathectomy fails to augment coronary collateral flow or limit infarct size in rabbit. FASEB Journal 2:A946, 1988. 55. Downey, J.M. Species specificity of free radical source and the pharmacological consequences. FASEB Journal 2:A1477, 1988. 56. Downey, J.M., C. Shirato, T. Miura, and T. Toyofuku. Tetrazolium is unreliable as an index of drug induced salvage. J. Mol. Cell. Cardiol. 20 (suppl V):s.70, 1988 56. Van Winkle, D.M., T. Matsuki, N. Gad, M.C. Jordan, and J.M. Downey. Unloading the ventricle during reperfusion fails to limit infarct size. FASEB Journal 3:A2688 1989 57. Jordan, M., B.E. Headlund and J.M. Downey. Hydroxyethyl starch-deferoxamine conjugate does not alter infarct size in rabbit heart. FASEB Journal 3:A2689, 1989 58. Downey,J.M., M. Jordan. Preconditioning limits infarct size in rabbits. Circulation 80:II-949, 1989 59. Downey, J.M, N.M. Gad, W.S. Chitwood, D.M. Van Winkle, A.W.H. Stanley. Hyperkalemic reperfusion restores function during reperfusion after short term ischemia. Circulation 80:II-950, 1989 60. Ooiwa, H, M. Jordan, A. Bylund-Felaneous, J.M. Downey. Polyethylene glycol-superoxide dismutase fails to limit infarct size in reperfused rabbit hearts. Circulation 80:II-1173, 1989 61. Omar, B., M. Jordan, J.M. Downey, J.M. McCord. Protection afforded by superoxide dismutase is dose-dependent in the in situ reperfused rabbit heart. Circulation 80:II-1174, 1989 62. Van Winkle, D.M., W.S. Chitwood, J.M. Downey. Transmural blood flow in rabbits is unaffected by low loading conditions but altered by cardiac arrest. Circulation 80:II-2187, 1989 63. Downey, J.M., D.M. Van Winkle, and J.D. Pollard. Preconditioning in rabbit hearts: Effect of varying number and duration of transient ischemic events. FASEB J.4:A852 1990 64. Van Winkle, D.M., A.N. Swafford and J.M. Downey. The subendocardial extravascular resistance in dogs is independent of ventricular lumenal pressure. FASEB J. 4:A946, 1990 65. Swafford, A.N., S.P. Striplin, J. Thornton, D.M. Van Winkle and J.M. Downey. Inhibition of protein synthesis does not block myocardial protection afforded by preconditioning. FASEB J. 4:A496, 1990 66. Downey, J.M., J.D. Thornton, G.S. Liu, and A.W.H. Stanley. Preconditioning does not involve synthesis of a protective protein. Circulation 82:III-271, 1990 67. Thornton, J.D., D.M. Van Winkle, and J.M. Downey. Preconditioning is mediated through adenosine receptors. Circulation 82:III-464, 1990 68. Yellon, D.M., E. Pasini, R. Ferrari, J.M. Downey, and D.S. Latchman. Whole body heat stress protects the isolated perfused rabbit heart. Circulation 82: III-463, 1990 69. Cohen, M.V., G.S. Liu, J.M. Downey. Preconditioning by a brief coronary occlusion preserves wall motion in ischemia/reperfusion. Circulation 82: III-271, 1990 70. Yellon, D.M., E. Iliodromitis, D.S. Latchman, D.M. Van Winkle, J.M. Downey, F.M. Williams, T.F. Williams. Failure of whole body heat shock to limit infarct size in reperfused rabbit heart. FASEB J. 5:3945, 1991 71. Liu, G.S., J. Thornton, D.M. Van Winkle, A.W.H. Stanley, R.A. Olsson, J.M. Downey. Preconditioning's protection is mediated by A1 adenosine receptors in the rabbit heart. FASEB J. 4:3948, 1991 72. Thornton, J., G.S. Liu, R.A. Olsson, J.M. Downey. Intravenous A1 selective adenosine agonists limit infarct size in the rabbit heart. FASEB J. 4:4256, 1991 73. Thornton, J., J.M. Downey. Gi Proteins are involved in preconditioning's protective effect. Circulation 84 (supp II): II-192, 1991 74. Turrens, J. F., J. Thornton, G.S. Liu, M.Barnard, S. Snyder, J.M. Downey. Preconditioning does not alter the heart's antioxidant defenses. Circulation 84 (supp II): II-193, 1991 75. Liu, G.S., W.Wilborn, A.W.H. Stanley, J.M. Downey. Neutrophil free reperfusion does not alter infarct size. Circulation 84 (supp II): II-281, 1991 76. Bunch, F.T., J. Thornton, J.M. Downey. Adenosine, an endogenous protectant against staccato ischemia. Circulation 84 (supp II): II-306, 1991 77. Van Winkle, D.M., J.D. Thornton, J.M. Downey. Cardioprotection from preconditioning is lost following prolonged reperfusion in rabbits. Circulation 84 (supp II):II-432, 1991 78. Thornton, J.D., J.M. Downey. Blockade of ATP-sensitive potassium channels does not block preconditioning in the rabbit heart. Circulation 84 (supp II): II-432, 1991 79. Kucukoglu, S., E. Illiodromitis, D. VanWinkle, J.M. Downey, M.S. Marber, R.J. Heads, D.M. Yellon. Preconditioning appears to be independent of stress protein synthesis. J. Mol. Cell. Cardiol. 23 (supp V): S-73, 1991 80. Thornton, J.D., G.S. Liu, J.M. Downey. Adenosine mediates preconditioning. J. Mol. Cell. Cardiol. 23 (supp V): S-34, 1991 81. Liu, G.S., J.M. Downey. Preconditioning protects against myocardial damage equally well with pyruvate or glucose containing substrate. J. Mol. Cell Cardiol. 24(Sup I):S93, 1992 82. Downey, J.M. Cardioprotective role of A1 receptor ligands. J. Mol. Cell Cardiol. 24(Sup I):S32, 1992 83. Walsh, R.S., Richards, S.C., Liu, G.S., Cohen, M.V., Downey, J.M. Role of adenosine receptor subtypes in preconditioning. JACC 21:116A, 1993 84. Tsuchida, A., Liu, G., Downey, J.M. Pretreatment with adenosine A1 selective agonist CCPA limits infarct size in a chronic rabbit model. Circulation (Suppl.) 86(4):I-23, 1992 85. Tsuchida, A., Liu, G., Mullane, K., Downey, J. Acadesine (AICAR) lowers the threshold for ischemic preconditioning in rabbits. Circulation (Suppl.) 86(4):I-25, 1992 86. Liu, G., Downey, J.M. Acetylcholine preconditions rabbit heart: further evidence for Gi protein coupling in preconditioning. Circulation (Suppl.) 86(4):I-174, 1992 87. Liu, Y., Downey, J.M. Blocking adenosine receptors of ATP sensitive K+ channels does not prevent preconditioning in rat heart. Circulation (Suppl.) 86(4):I-341, 1992 88. Thornton, J., Downey, J.M. Blocking adenosine receptors between preconditioning and prolonged ischemic prevents protection. Circulation (Suppl.) 86(4):I-343, 1992 89. Sterling, D., Thornton, J., Swafford, A., Stanley, A., Gottlieb, S., and Downey, J. Hyperbaric oxygen protects the reperfused heart. Circulation (Suppl.) 86(4):I-688, 1992 90. Thornton, J., Liu, Y., Cohen, M.V., Downey, J., Schaffer, S.W. Metabolic effects of diabetes mellitus protect ischemic myocardium from infarction. Circulation (Suppl.) 86(4):I-828, 1992 91. Liu, G.S., X. Yang, A. Tsuchida, S. Arnault, J. Thornton, D. Cope, M.V. Cohen and J.M. Downey Ischemic preconditioning can be reinstated in rabbit hearts. FASEB J, 7:A119, 1993 92. Tsuchida, A., R.A. Olsson and J.M. Downey. Cardioprotective effect of CCPA is lost after 72 hour infusion along with the ability to precondition. FASEB J, 7:A119, 1993 93. Yang, X., K. Snell, J.M. Downey and M.V. Cohen. Brief repetitive ischemia does not stimulate collateral growth in rabbits. FASEB J, 7:A320, 1993 94. Ytrehus, K., Y. Liu, J.M. Downey. Preconditioning protects the ischemic rabbit heart by protein kinase C activation. FASEB J, 7:A418, 1993 95. Thornton, J.D., J.F. Daly, M.V. Cohen and J.M. Downey. Catecholamines can protect ischemic myocardium but are not involved in ischemic preconditioning. FASEB J, 7:A418, 1993 96. Liu, Y., J.M. Downey. Pretreatment with pertussis toxin does not prevent preconditioning in rat heart. FASEB J, 7:A818, 1993 97. Brooks, G, R. Walsh, and J. Downey. Phosphorylation of 80k/MARCKS, a Specific Substrate of Protein Kinase C, Occurs After 5' Ischemia but Only in Preconditioned Hearts. Circulation 88:I-101, 1993 98. Cohen, M.V., X-M Yang, and J. Downey. Multiple Brief Episodes of Myocardial Ischemia Abolish Protection of Ischemic Preconditioning Seen After 1 Episode of Brief Ischemia. Circulation 88:I-138, 1993 99. Ytrehus, K., M.V. Cohen, J. Downey. Volume of Risk Zone Influences Infarct Size in Rabbits and May Account for Unexplained Variability in Infarction Studies Circulation 88:I-137, 1993 100. Tsuchida, A., R.S. Walsh, and J. Downey. Protection by ATP-Sensitive K+ Channel Opener Pinacidil Can Be Blocked With an Adenosine Receptor Antagonist. Circulation 88:I-632, 1993 101. Tsuchida, A., X-M Yang, K. Mullane, J. Downey. Acadesine Slows the Natural Decay of Preconditioning in Rabbits Circulation 88:I-633, 1993 102. Tsuchida, A., J. Ardell, M.V. Cohen, J. Downey, A. Heymann, B.A. Barron, M. Hamrick, C. Jones. Elimination of Myocardial Catecholamines With Ventricular Sympathectomy Fails to Limit Infarct Size in Canine Heart. Circulation 88:I-42, 1993 103. Walsh, R.S., Abd-Elfatah, A.S., Daly, J.J.F., Weschler, A.S.,Downey, J.M. Nucleoside transport inhibition prevents ischemic preconditioning. Circulation 88:I-432, 1993 104. Walsh, R.S., Abd-Elfatah, A.S., Daly, J.J.F., Weschler, A.S.,Downey, J.M. Selective blockade of nucleoside transport channels prevents preconditioning in rabbit myocardium. Surgical Forum 44: 234-236, 1993 105. Snell, K.S., A. Tsuchida, D.G.L. Van Wylen, J.M. Downey, M.V. Cohen. ATP-sensitive potassium channels fail to regulate cardiac interstitial fluid adenosine levels. FASEB J, 8:A560, 1994 106. Shen, Y-T, J.T. Fallon, J.M. Downey, S.F. Vatner. Superoxide dismutase fails to protect ischemic myocardium in conscious pigs. FASEB J, 8:A831, 1994 107. Yang, X.-M., M.V. Cohen, B. Burckhartt, A. Tsuchida, K. Mullane, J.M. Downey. Acadesine Extends Window of Protection for Preconditioning. J Mol Cell Cardiol.. 26:CL, 1994. 108. Hashimi, W., J.M. Downey, M.V. Cohen. Loss of Preconditioning's Protection After Chronic Adenosine Exposure Is Not Related to PKC Downregulation. J Mol Cell Cardiol. 26:CLII, 1994. 109. Liu, Y., A. Tsuchida, M.V. Cohen, J.M. Downey. Pretreatment with Angiotensin II Limits Infarction in Rabbit Hearts. J Mol Cell Cardiol. 26:CLV, 1994. Times Cited: 113 110. Hashimi, W., J. Thornton, J.M. Downey, M.V. Cohen. Chronic adenosine A1-agonist exposure results in adenosine receptor rather than G protein downregulaton. Circulation 90:I-107, 1994 111. Ardell, J.L., X-M Yang, J.D. Thornton, A. Swafford, M.V. Cohen, J.M. Downey. Depletion of norepinephrine by chronic surgical sympathectomy does not block protection from ischemic preconditioning. Circulation 90:I-108, 1994 112. Liu, Y., M.V. Cohen, J.M. Downey. Chelerythrine, a highly specific protein kinase C inhibitor blocks the anti-infarct effect of preconditioning in rabbit hearts. Circulation 90:I-207, 1994 113. Goto, M., Y. Liu, J.L. Ardell, M.V. Cohen, J.M. Downey. Bradykinin limits myocardial infarct size by protein kinase C activation and not by nitric oxide synthesis. Circulation 90:I-208, 1994 114. Liu, G-S, C.E. Ganote, J.M. Downey. Activation of adenosine receptors is required for protection from a direct opener of the KATP channel. Circulation 90:I-478, 1994 115. Ardell, J.L., X.-M. Yang, M.V. Cohen, J.M. Downey. Depletion of norepinephrine by reserpine increases the threshold for protection by ischemic preconditioning. FASEB Journal 9:A000, 1995 116. Liu, G.S., M.V. Cohen, J.M. Downey. Preconditioning of rabbit myocytes depends on activation of phospholipase D. Circulation 92:I-135, 1995 117. Shattock, M.J., C.S. Lawson, D.J. Hearse, J.M. Downey. Monophasic action potential and ST segment changes are indicative of preconditioning only during early ischemia in the pig heart. Circulation 92:I-390, 1995 118. W. Hashimi, X.-M. Yang, C. Lambert, J.M. Downey, M.V. Cohen. Bradykinin may be the drug of choice for preconditioning the heart in the clinical setting. Circulation 92:I-456, 1995 119. Ytrehus, K., R.S. Walsh, S.C. Richards, J.M. Downey. Hydrogen peroxide as a protective agent during reperfusion of the isolated perfused rabbit heart. J Mol Cell Cardiol., 27:A-22, 1995 120. Armstrong, S.C., G. Liu, J. Downey, C. Ganote. K+ATP channels and preconditioning of rabbit cardiomyocytes. J Mol Cell Cardiol. 27:A-23, 1995 121. Yang, X.-M., G.F. Baxter, D.M. Yellon, J.R. Fletcher, J.M. Downey, M.V. Cohen. Second window of protection in conscious rabbits. J Mol Cell Cardiol. 27:A-27, 1995 122. Goto, M., A. Tsuchida, Y. Liu, M.V. Cohen, J.M. Downey. Transient inhibition of glucose uptake can protect rabbit heart. J Mol Cell Cardiol. 27:A-27, 1995 123. Liu, Y., G.A. Cordis, D.K. Das, J.M. Downey, M.V. Cohen. Protein kinase C may be activated by phospholipase D rather than C in ischemic preconditioning. J Mol Cell Cardiol. 27:A-41, 1995 124. Bruton, J., M. Goto, J.M. Downey. Endogenous angiotensin II contributes to ischemic preconditioning. J Mol Cell Cardiol. 27:A-43, 1995 125. Wang, P., K. Gallagher, J.M. Downey, M.V. Cohen. Endothelin-1 limits myocardial infarction through PKC activation. J Mol Cell Cardiol. 27:A-44, 1995 126. Liu, G.S., M.V. Cohen, J.M. Downey. Phospholipase D is involved in preconditioning of rabbit myocytes. J Mol Cell Cardiol. 27:A-44, 1995 127. Ardell, J.L., Y. Liu, X.-M. Yang, M.V. Cohen, J.M. Downey. Triggering of ischemic preconditioning involves bradykinin in in situ not in vitro rabbit hearts. J Mol Cell Cardiol. 27:A-44, 1995 128. Cope, D.K., K. Impastato, M.V. Cohen, J.M. Downey. Adenosine receptors are necessary for protection of ischemic rabbit myocardium by halothane. J Mol Cell Cardiol. 27:A-46, 1995 129. Shattock, M.J., C.S. Lawson, D.J. Hearse, J.M. Downey. Do temporal electrophysiological and collateral flow changes mirrow preconditioning-induced infarct size limitation in the pig? J Mol Cell Cardiol. 27:A-143, 1995 130. Cohen, M.V., X.-M. Yang, J.R. Fletcher, J.M. Downey. Less ST segment elevation during subsequent coronary occlusions indicates preconditioning in rabbit. J Mol Cell Cardiol. 27:A-144, 1995 131. Yang, X.-M., J.R. Fletcher, J.M. Downey, M.V. Cohen. The long ischemia is the critical time for kinase activity during ischemic preconditioning. J Mol Cell Cardiol. 27:A-156, 1995 132. Liu, G.S., M.V. Cohen, J.M. Downey. Rabbit ventricular myocytes can be preconditioned by activation of protein kinase C-coupled receptors. Journal of the American College of Cardiology (suppl.) 27:33A, 1996 133. Goto, M., M.V. Cohen, J.M. Downey. Attenuated purine release from preconditioned rabbit myocardium is unrelated to protection. Journal of the American College of Cardiology (suppl.) 27:194A, 1996 134. Liu, G.S., M.V. Cohen, J.M. Downey. Preconditioning of rabbit myocytes depends on activation of phospholipase D. Circulation (suppl.) 92:I-135, 1995 135. Shattock, M.J., C.S. Lawson, D.J. Hearse, J.M. Downey. Monphasic action potential and ST segment changes are indicative of preconditioning only during early ischemia in the pig heart. Circulation (suppl.) 92:I-390, 1995 136. Hashimi, W., X.-M. Yang, C. Lambert, J.M. Downey. Bradykinin may be the drug of choice for preconditioning the heart in the clinical setting. Circulation (suppl.) 92:I-456, 1995 137. Miki, T., H. Sato, M.V. Cohen, J.M. Downey. Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits. Circulation (suppl.) 94:I-392, 1996 138. Baines, C., M. Goto, J.M. Downey. Oxygen radical release during ischemic preconditioning triggers protection in rabbit myocardium via activation of protein kinase C. Circulation (suppl.) 94:I-424, 1996 139. Weinbrenner, C., P. Wang, M.V. Cohen, J.M. Downey. Glycogen loss during preconditioning does not correlate with protection. Circulation (suppl.) 94:I-424, 1996 140. Baines, C., M.V. Cohen, J.M. Downey. Protein tyrosine kinase inhibitor, genistein, blocks preconditioning in isolated rabbit hearts. Circulation (suppl.) 94:I-661, 1996 141. Liu,G.S., M.V. Cohen, J.M. Downey. Rabbit ventricular myocytes can be preconditioned by activation of protein kinase C-coupled receptors. Journal of the American College of Cardiology (suppl.) 27:33A, 1996 142. Goto, M., M.V. Cohen, J.M. Downey. Attenuated purine release from preconditioned rabbit myocardium is unrelated to protection. Journal of the American College of Cardiology (suppl.) 27:194A, 1996 143. Goto, M., C.P. Baines, J.M. Downey. Oxygen radical scavenger blocks protection by single but not repeated episodes of preconditioning. J Mol Cell Cardiol.(suppl.) 28:A158, 1996 144. Baines, C.P., M. Goto, J.M. Downey. Oxygen radicals precondition rabbit heart via activation of protein kinase C. J Mol Cell Cardiol.(suppl.) 28:A158, 1996 145. Liu, G., S. Critz, M. Chujo, M.V. Cohen, J.M. Downey. Pinacidil but not nicorandil opens KATP channels in rabbit myocytes and mimics ischemic preconditioning. J Mol Cell Cardiol. (suppl.) 28:A164, 1996 146. Prasad, R.V., P. Wang, M.V. Cohen, J.M. Downey. Inhibition of Na+-H+ exchange late in ischemia reduces infarct size. J Mol Cell Cardiol. (suppl.) 28:A167, 1996 147. Yang, X.-M., M.V. Cohen, J.M. Downey. The sustained ischemia is the critical time for kinase activity during ischemic preconditioning. J Mol Cell Cardiol. (suppl.) 28:A186, 1996 148. Cope, D.K., W.K. Impastato, M.V. Cohen, J.M. Downey. Protection from volatile anesthesics is adenosine receptor-dependent in isolated ischemic rabbit heart. J Mol Cell Cardiol. (suppl.) 28:A186, 1996 149. Miki, T., J.M. Downey. Opioid receptors participate in ischemic preconditioning in rabbits. J Mol Cell Cardiol. (suppl.) 28:A187, 1996 150. Weinbrenner, C., P. Wang, J.M. Downey. Glycogen loss during preconditioning does not correlate with protection. J Mol Cell Cardiol.(suppl.) 28:A188, 1996 151. Yang, X.-M., J.M. Downey, M.V. Cohen. Diminution of ST segment deviation in sequential coronary occlusions is a true indicator of preconditioning. J Mol Cell Cardiol. (suppl.) 28:A188, 1996 152. Liu, G.S., C.P. Baines, M.V. Cohen, and J.M. Downey. Activation of p38 mitogen-activated protein kinase is involved in ischemic preconditioning in rabbit heart. Circulation (suppl.) 96(8):I-71, 1997 153. Weinbrenner, C., J.M. Downey, and M.V. Cohen. Cyclosporine a preconditions rabbit heart when administered before as well as after onset of ischemia. Circulation (suppl.) 96(8):I-252, 1997 154. Baines, C.P., L. Wang, J.M. Downey, and M.V. Cohen. Cardioprotection by insulin is dependent on phosphatidylinositol 3-kinase but not protein kinase C. Circulation (suppl.) 96(8):I-573, 1997 155. Weinbrenner, C., C.P. Baines, R.E. Honkanen, M.V. Cohen, and J.M. Downey. Ischemic preconditioning in the rabbit heart does not protect by inhibiting protein phosphatase 1 or 2A. Circulation (suppl.) 96(8):I-574, 1997 156. Miki, T., M.V. Cohen, and J.M. Downey. Hypothermia's cardioprotective effect is additive to that of ischemic preconditioning. Circulation (suppl.) 96(8): I-687, 1997 157. Cope, D.K., W.K. Impastato, M.V. Cohen, and J.M. Downey. Halothane administered before or during ischemia reduces infarction. J Mole & Cell Cardiol. 29(6):A-170, 1997 158. Liu, G.S., R. Honkanen, M.V. Cohen, and J.M. Downey. Inhibition of protein phosphatase 2A protects rabbit cardiomyocytes. J Mole & Cell Cardiol. 29(6):A-198, 1997 159. Liu, G.S., M.V. Cohen, and J.M. Downey. Protection of cardiomyocytes by mild cooling plus preconditioning is additive. J Mole & Cell Cardiol. 29(6):A-198, 1997 160. Weinbrenner, C., M.V. Cohen, and J.M. Downey. Phosphorylation of p38 MAP kinase correlates with the protection of ischemic preconditioning. J Mole & Cell Cardiol. 29(6):A-203, 1997 161. Baines, C.P., R.E. Honkanen, M.V. Cohen, and J.M. Downey. Fostriecin limits infarction even when infused after the onset of ishemia. J Mole & Cell Cardiol 29(6):A-204, 1997 162. Miki, T., M.V. Cohen, and J.M. Downey. Mild hypothermia reduces infarct size in the beating rabbit heart. J Mole & Cell Cardiol. 29(6):A-210, 1997 163. Armstrong, S., L.C. Shivell, R. Kao, J. Downey and C. Ganote. Pig cardiomyocytes precondition in vitro: role for KATPchannels and metabolic rate. J Mole & Cell Cardiol. 29(6):A-227, 1997 164. Liu, G.S., D. Mochly-Rosen, M.V. Cohen, and J.M. Downey. Protein kinase C-, not, is responsible for the protection of preconditioning in rabbit cardiomyocytes. Circulation 98(17):I-71, 1998 165. Fan, T.-H.M., J. Xu, C.P. Baines, and J.M. Downey. Suppression of apoptosis by ischemic preconditioning in the rabbit myocardium. Circulation 98(17):I-261, 1998 166. Baines, C.P., G.S. Liu, M. Birincioglu, M.V. Cohen, and J.M. Downey. Diazoxide, a mitochondrial KATP-channel opener, is cardioprotective in ischemic rabbit myocardium. Circulation 98(17):I-343, 1998 167. Cohen, M.V., X.-M. Yang, and J.M. Downey. Ischemic preconditioning improves post-ischemic myocardial function in conscious rabbits. Circulation 98(17):I-485, 1998 168. Liu, G.S., M.V. Cohen, and J.M. Downey. Hypo-osmotic stress protects rabbit cardiomyocytes. Circulation 98(17):I-585, 1998 169. Liu, G.S., C. Baines, M. Birincioglu, M.V. Cohen, and J.M. Downey. KATP channel is involved in the protection from an activator of p38 MAP kinase in rabbit hearts. Circulation 98(17):I-585, 1998 170. Kim, S.O., T.S. Pain, S.L. Pelech, M.V. Cohen, S. Katz, and J.M. Downey. Activation of MAPKAP kinase 2 during ischemia in preconditioned rabbit heart. Circulation 98(17):I-585, 1998 171.Krenz, M., C.P. Baines, X.M.Yang, M.V.Cohen and J.M.Downey. Acute ethanol exposure does not limit infarct size in in situ rabbit hearts. J Mol Cell Cardiol. 31:A10, 1999. 172. Baines, C.P., M.V. Cohen and J.M. Downey. Acute ethanol exposure limits infarct size in isolated rabbit hearts by a preconditioning-like mechanism. J Mol Cell Cardiol. 31:A16 1999. 173. Pain, T., M.V. Cohen, and J.M. Downey. Mitochondrial KATP channels may play a role in preconditioning's memory. J Mol Cell Cardiol. 31:A33, 1999. 174. Fan, T.M. J.Xu, T. Pain, M.V. Cohen, J.M. Downey. Ischemic preconditioning inhibits mitochondrial cytochrome C release in ischemic rabbit myocardium. J Mol Cell Cardiol. 31:A33, 1999. 175. Nakano, A., S.O. Kim, S.L. Pelech, J.M. Downey, M.V. Cohen, S. D. Critz. Activation of MAPKAPK2 is involved in preconditioned rabbit heart. J Mol Cell Cardiol. 31:A43, 1999. 176. Liu, G.S., Cohen, M.V., Mochly-Rosen, D., and Downey, J.M.: Protection from Non-Selective PKC Activation Can Be Aborted by Blockade of Only PKC-e. J Mol Cell Cardiol. 31: A17, 1999. 177. Liu, G.S., Cohen, M.V., and Downey, J.M.: Inhibition of Nitric Oxide Synthesis Does Not Affect Ischemic Preconditioning in Isolated, Perfused Rabbit Hearts. Circulation 100: I-243, 1999. 178. Nakano, A., Baines, C.P., Kim, S.O., Pelech, S.L., Pain, T.S., Downey, J.M., Cohen, M.V., and Critz, S.D.: MAPKAPK2, but Not JNK, Is Activated During Ischemia in Preconditioned Hearts. Circulation 100: I-325, 1999. 179. Pain, T.S., Cohen, M.V., and Downey, J.M.: The Mitochondrial KATP Channel May Be a Trigger Rather Than the End-effector of Preconditioning's Anti-infarct Effect. Circulation 100: I-342, 1999. 180. Yang, X.-M., Downey, J.M., and Cohen, M.V.: HMR 1883, a Surface KATP Channel Antagonist, Blocks Protection From Diazoxide: Diazoxide's Specificity for Mitochondrial KATP Is Questionable. Circulation 100: I-342, 1999. 181. Fan, T.-H.M., Xu, J., Pain, T.S., Krenz, M., Cohen, M.V., and Downey, J.M.: Diazoxide Inhibits Mitochondrial Cytochrome C Release in Ischemic Rabbit Myocardium. Circulation 100: I-630, 1999. 182. Krenz, M., Heusch, G., Cohen, M.V., and Downey, J.M.: Inhibition of JAK-2 Does Not Block Ischemic Preconditioning in Rats. J Mol Cell Cardiol. 32: A19, 2000. 183. Nakano, A., Liu, G.S., Heusch, G., Downey, J.M., and Cohen, M.V.: Exogenous, But Not Endogenous, Nitric Oxide Triggers Preconditioning of the Isolated Rabbit Heart by Formation of Free Radicals. J Mol Cell Cardiol. 32: A24, 2000. 184. Krenz, M., Xu, Z., Baines, C.P., Heusch, G., Cohen, M.V. and Downey, J.M.: Acute Ethanol Exposure Is Protective Both In Vitro and In Situ, But Only if Washed Out Before Ischemia. J Mol Cell Cardiol. 32: A45, 2000. 185. Yang, X.-M., Pain, T., Heusch, G., Cohen, M.V., and Downey, J.M.: Diazoxide Protects the Heart by Release of Free Radicals. J Mol Cell Cardiol. 32: A49, 2000. 186. Xu, Z., Cohen, M.V., Heusch, G., and Downey, J.M.: AMP 579 Started During Ischemia Limits Infarct Size in Rabbit Hearts. J Mol Cell Cardiol. 32: A55, 2000. 187. Krenz, M., Wimpee, H., Cohen, M.V., Downey, J.M., and Benoit, J.N.: Opening of Mitochondrial ATP-Sensitive Potassium Channels Generates Reactive Oxygen Species in Vascular Smooth Muscle Cells. FASEB J 15: A488, 2001. 188. Oldenburg, O., Krenz, M., Cohen, M.V., Downey, J.M., and Benoit, J.N.: Mitochondrial K+ Influx Per Se Causes Generation of Reactive Oxygen Species in Vascular Smooth Muscle Cells. J Mol Cell Cardiol. 33: A87, 2001. 189. Xu, Z., Cohen, M.V., and Downey, J.M.: Protective Effect of AMP 579 Depends on Drug's Timing of Administration and Can Be Added to That of Ischemic Preconditioning. J Mol Cell Cardiol. 33: A132, 2001. 190. Yang, X.-M., Krenz, M., Downey, J.M., and Cohen, M.V.: Protective and Anti-Protective Effects of Acute Ethanol Exposure Have Similar Thresholds in Isolated Rabbit Hearts. J Mol Cell Cardiol. 33: A133, 2001. 191. Critz, S.D., Yue, Y., Cohen, M.V., and Downey, J.M.: Menadione Preconditions Rat Heart by Stimulating Production of Cardiac Mitochondrial Free Radicals Which Activate PKC and P38 MAPK. Circulation 104: II-101, 2001. 192. Xu, Z., Downey, J.M., and Cohen, M.V.: Adenosine Does Not Duplicate the Anti-Infarct Effect of AMP 579 at Reperfusion Although the Two Agents Have the Same Receptors. Circulation 104: II-149, 2001. 193. Xu, Z., Cohen, M.V., Downey, J.M., Vanden Hoek, T.L., and Yao, Z.: Differential Effects of AMP 579 and Adenosine on Free Radical Burst at Reoxygenation in Isolated Chick Cardiomyocytes Subjected to Simulated Ischemia. Circulation 104: II-149, 2001. 194. Oldenburg, O., Cohen, M.V., Downey, J. M., and Benoit, J.N.: Acetylcholine Leads to Free Radical Production Dependent on KATP Channels, Gi Proteins, Phosphatidylinositol 3-, and Tyrosine Kinases. FASEB Journal 16: A452, 2002. 195. Qin, Q., Cohen, M.V., and Downey, J.M.: Acetylcholine But Not Adenosine Triggers Preconditioning Through PI3-Kinase and a Tyrosine Kinase. FASEB Journal 16: A855, 2002. 196. Krieg, T., Qin, Q., Critz, S.D., Cohen, M.V., and Downey, J.M.: Acetylcholine Activates Akt in Myocardium Confirming a Role for Phosphatidylinositol 3-Kinase in Acetylcholine's Cardioprotection. FASEB Journal 16: A856, 2002. 197. Oldenburg, O., Mochly-Rosen, D., Cohen, M.V., and Downey, J.M.: Acetylcholine-Induced Production of Reactive Oxygen Species in A7r5 Cells is Dependent on Protein Kinase C. J Mol Cell Cardiol. 34: A30, 2002. 198. Qin, Q., Oldenburg, O., Cohen, M.V., and Downey J.M.: The Potassium Ionophore Valinomycin Mimics Preconditioning and Generates Reactive Oxygen Species. Presented International Society for Heart Research, July, 2002. J Mol Cell Cardiol. 34: A33, 2002. 199. Krieg, T., Qin, Q., Cohen, M.V., and Downey, J.M.: Acetylcholine Activates Phosphatidylinositol 3-Kinase via Transactivation of the EGF Receptor. J Mol Cell Cardiol. 34: A36, 2002. 200. Yang, X.-M., Krieg, T., Downey, J.M., and Cohen, M.V.: NECA Limits Infarction in Rabbit Heart by Activating Adenosine A2 Receptor and PI3-Kinase. J Mol Cell Cardiol. 34: A36, 2002. 201. Krieg, T., Qin, Q., Cohen, M.V., and Downey, J.M.: Acetylcholine and Adenosine Activate Phosphatidylinositol 3-Kinase Through Transactivation of Receptor Tyrosine Kinases in a Src-Dependent Manner. Circulation 106: II-7, 2002. 202. Oldenburg, O., Cohen, M.V., Downey, J.M.: Acetylcholine-induced Production of Reactive Oxygen Species in Adult Rabbit Myocytes Is Dependent on Phosphatidylinositol 3-Kinase Activation and Mitochondrial KATP Channel Opening. Circulation 106: II-230, 2002. 203. Qin, Q., Cohen, M.V., and Downey, J.M.: Acetylcholine But Not Adenosine Triggers Preconditioning by a Pathway Involving Src and PI3 Kinases. Circulation 106: II-314, 2002. 204. Oldenburg, O., Cohen M. V., Downey J. M. Acetylcholine-induced production of reactive oxygen species in ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation, and mitochondrial KATP channel opening. Z Kardiol 92 (Suppl. I): 132, 2003 205. Oldenburg, O., Cohen, M.V., and Downey, J.M.: Acetylcholine-Induced Production of Reactive Oxygen Species in Ventricular Myocytes Is Dependent on Phosphatidylinositol 3- and Src-Kinase Activation, and Mitochondrial KATP Channel Opening. Zeitshrift für Kardiologie 92 (Suppl I): 132, 2003. 206. Oldenburg, O., Cohen, M.V., and Downey, J.M.: Bradykinin Leads to Generation of Reactive Oxygen Species in Cardiomyocytes by Activation of B2-Receptor and Opening of Mitochondrial KATP Channels via PKG. European Journal of Heart Failure Supplements 2: 44, 2003. 207. Krieg, T., Yang, X.-M., Downey, J., and Cohen, M.V.: Bradykinin and NECA But Not Acetylcholine at Reperfusion Limit Infarction in Rabbit Heart Through Activation of PI3-kinase. European Journal of Heart Failure Supplements 2: 46, 2003. 208. Cohen, M.V.: Protecting the Ischemic Heart at Reperfusion. J Mol Cell Cardiol. 35: A-19, 2003. 209. Pemberton, K., Zhang, S.-J., Cohen, M.V., and Downey, J.M.: The Conopeptide CGX-1051 Administered at Reperfusion Limits Infarct Size with No Hemodyanmic Effects. J Mol Cell Cardiol. 35: A-28, 2003. 210. Qin, Q., Yang, X.-M., Cohen, M.V., Critz, S.D., and Downey, J.M.: Bradykinin Protects Rabbit Hearts by a NO- and CGMP-Dependent Pathway. J Mol Cell Cardiol. 35: A-29, 2003. 211. Krieg, T., Cohen, M.V., and Downey, J.M.: Mitochondrial ROS Generation Following Acetylcholine in Cardiomyocytes Invovles EGF Receptor Transactivation and Metalloproteinase Cleavage of proHB-EGF. J Mol Cell Cardiol. 35: A-46, 2003. 212. Qian, X., Cohen, M.V., Downey, J.M., and Critz, S.D.: Cyclic GMP Triggers p38 MAPK Activation in H9c2 Cells and Rabbit Cardiomyocytes. J Mol Cell Cardiol.35: A-49, 2003. 213. Yang, X.-M., Oldenburg, O., Downey, J.M., and Cohen, M.V.: Ischemic Preconditioning, But Not AT1 Blockade, Attenuates Collagen Deposition and Improves Regional Myocardial Function Following Ischemia in Rabbit Hearts. J Mol Cell Cardiol. 35: A-49, 2003. 214. Yang, X.M., Downey J.M., Cohen M.V., Multiple brief coronary occlusions during reperfusion protect rabbit hearts by activation of ERK and production of nitric oxide. Circulation 108:IV-158, 2003 215. Krieg, T., Cui, L., Cohen, M.V., and Downey, J.M.: Acetylcholine-induced EGF Receptor Transactivation Requires Metalloproteinase Cleavage of pro-HB-EGF to Generate Mitochondrial ROS. Presented American Heart Association, November 2003. Circulation 108: IV-93, 2003. 216. Krieg, T., Qin, Q., Alexeyev, M.F., Cohen, M.V., and Downey, J.M. Acetylcholine preconditions by activating Akt and NOS to generate ROS.J Mol Cell Cardiol 36:741, 2004 217. Yang, X.-M., Cui, L., Krieg, T., Downey, J.M., and Cohen, M.V.: Postconditioning Protects Isolated Hearts Through PI3K Signaling. Presented International Society for Heart Research, May, 2004. J Mol and Cell Cardiol 36: 613, 2004. 218. Garlid, K.D., Costa, A.D., Cohen, M.V., Downey, J.M., and Critz, S.D.: Cyclic GMP and PKG Activate mito KATP Channels in Isolated Mitochondria. Cardiovascular Journal of South Africa 15 (Suppl 1): S5, 2004. 219. Downey, J.M. The cellular mechanisms of ischeamic
and pharmacological preconditioning. 220. Yang, X.-M., Downey, J.M., and Cohen, M.V.: Postconditioning’s Protection Is Not Dependent on Circulating Blood Factors or Cells but Requires PI3-kinase and Guanylyl Cyclase Activation. Circulation 110: III-168, 2004. 221. Philipp, S., Downey, J.M., and Cohen, M.V.: Postconditioning Must Be Initiated in Less Than 1 Minute Following Reperfusion and Is Dependent on Adenosine Receptors and PI3-Kinase. Circulation 110: III-168, 2004 222. Philipp, S., Yang, X.-M., Willenbrock, R., Downey, J.M., and Cohen, M.V.: Postconditioning Must Be Initiated in Less Than 1 Minute Following Reperfusion and Is Dependent on Adenosine 2b Receptors and PI3-kinase. Zeitshrift für Kardiologie 94 (Suppl 1):V803, 2005. 223. Solenkova, N., Cohen, M.V., and Downey, J.M.: PI3 Kinase Supports the Preconditioned Heart Through a Critical Convalescent Period. Journal of Molecular and Cellular Cardiology 38: 848, 2005. 224. Solenkova, N., Cohen, M.V., and Downey, J.M.: Ischemic Preconditioning Protects the Heart Through Adenosine Receptor Activation During Reperfusion. Journal of Molecular and Cellular Cardiology 38: 848, 2005. 225. Philipp, S., Cui, L., Cohen, M.V., and Downey, J.M.: Prolyl Hydroxylase Inhibitors Protect the Heart by Inducing Mitochondrial ROS Generation via NO, cGMP, PKG, and mitoKATP. Journal of Molecular and Cellular Cardiology 38: 857, 2005. 226. Krahn, T., Albrecht, B., Rosentreter, U., Cohen, M.V., Cui, L., and Downey, J.M.: Adenosine A2b Receptor Agonist Mimics Preconditioning: Characterization of a Selective Adenosine A2b Receptor Agonist in a Rabbit Infarct Model. 2006 Ferrarra Adenosine Symposium.
227. Yang, X.-M., Philipp, S., Davis, A., Downey, J.M., and Cohen, M.V.: PMA Administered Just Before Reperfusion Salvages Ischemic Myocardium by an Adenosine A2b-Dependent Mechanism.Journal of Molecular and Cellular Cardiology 40: 869, 2006.
228. Kuno, A., Critz, S.D., Cohen, M.V., and Downey, J.M.: Nicorandil Opens Mitochondrial KATP Channels Both Directly and Through a NO-PKG-Dependent Pathway. Journal of Molecular and Cellular Cardiology 40: 882, 2006.
229. Philipp, S., Krieg, T., Cui, L., Critz, S.D., Cohen, M.V., and Downey, J.M.: DADLE But Not Bradykinin Activates Src and PI3-Kinase Through the EGF Receptor. Journal of Molecular and Cellular Cardiology 40: 892-893, 2006.
230. Tissier, R., Parker, J.C., Hamanaka, K., Cohen, M.V., and Downey, J.M.: Total Liquid Ventilation Rapidly Cools the Heart to Protect It from Infarction. Journal of Molecular and Cellular Cardiology 40: 906, 2006.
231. Philipp, S., Krieg, T., Cui, L., Critz, S.D., Cohen, M.V., and Downey, J.M.: DADLE But Not Bradykinin Activates Src and PI3-Kinase Through the EGF Receptor. European Heart Journal 27 (Suppl 1):000, 2006. 232. Albrecht B, Krahn T, Philipp S, Rosentreter U, Cohen M, and Downey J. Selective A2b receptor activation mimics postconditioning in a rabbit infarct model. Circulation 114 (Suppl II), II-14-II-15. 2006. 233. Couvreur, N., Ghaleh, B., Bruneval, P., Dubois-Randé, J.-L., Parker, J.C., Cohen, M.V., Downey, J.M., Berdeaux, A., and Tissier, R.: Ultrafast cooling initiated by a short and safe temperature-controlled liquid ventilation abolishes post-ischemic myocardial infarction and contractile dysfunction in chronically instrumented rabbits. Circulation 116 (Suppl II): II-66-II-67, 2007. 234. Krieg, T., Richter, H., Kuno, A., Förster, K., Cohen, M.V., Downey, J.M., and Felix, S.B.: Cardioprotection from GSK-3β inhibition requires activation of PI-3 kinase and Src but not Akt, PKC, or ERK. Circulation 116 (Suppl II): II-164, 2007. 235. Davis, A., Cohen, M.V., and Downey, J.M.: Brief Exposure to Intracoronary Bradykinin at Reperfusion Limits Infarct Size in Isolated Rabbit Hearts by a Mechanism that Involves Both Free Radical Production and PKC. FASEB Journal 22: 000, 2008. 236. Dost, T., Cohen, M.V., and Downey, J.M.: Redox Signaling Triggers Protection During the Reperfusion Rather Than the Ischemic Phase of Preconditioning. Journal of Molecular and Cellular Cardiology 44: 000, 2008. 237. Yang, X.-M., Liu, Y., Liu, Y., Tandon, N., Kambayashi, J., Downey, J.M., and Cohen, M.V.: Preconditioning in cynomolgus monkey heart protects against both ischemic and reperfusion injury. Circulation 118 (Suppl 2): S401, 2008. 238. Xin, W., Liu, Y., Cohen, M.V., Downey, J.M., and Rich, T.C.: Regulation of basal cAMP levels in rabbit cardiomyocytes. FASEB Journal 23: 582.2, 2009. 239. Liu, Y., Yang, X.-M., Walker, S., Yang, X., Cohen, M.V., and Downey, J.M.: AMP579 binds to adenosine A2b receptors thus resolving longstanding mystery of its cardioprotective signaling. FASEB Journal 23: 793.24, 2009. 240. Xin, W., Cohen, M.V., Rich, T.C., and Downey, J.M.: Which preconditioning-associated G protein-coupled receptors are expressed on the sarcolemma? FASEB Journal 23: 793.25, 2009. 241. Kuno, A., Walker, S., Dost, T., Cohen, M.V., and Downey, J.M.: Adenosine A2b receptors unexpectedly activate cardioprotective kinases through Gi rather than Gs. FASEB Journal 23: 1026.4, 2009. 242. Krieg T, Liu
Y, Rütz T,Methner C, Yang X-M, Felix SB, and Downey JM. BAY 58-2667,
NO-independent guanylyl cyclase activator, pharmacologically post-conditions
rabbit and rat hearts. BMC Pharmacology, 9(Suppl 1):42,
2009 243. Downey JM, Liu Y, and Xin W.
The role of cGMP and PKG in cardioprotection. BMC Pharmacology, 9
(Suppl 1):4, 2009 244. Yang, X., Xin, W., Cohen, M.V., Rich, T., and Downey, J.M.: Suppressed Radical Production by Intracellular A2b Adenosine Receptors in Rabbit Cardiomyocytes. Journal of Molecular and Cellular Cardiology 48 (Suppl): S34, 2010. 245. Krieg, T., Förster, K., Xu,
Z., Rüdebusch, J., Cuello, F., Cohen, M.V., and Downey, J.M.:
Cardioprotective A2b Adenosine Receptors Are Localized to
Mitochondria Rather Than the Sarcolemma.
Journal of Molecular and Cellular Cardiology 48 (Suppl): S118, 2010. 246. Methner, C., Cohen, M.V., Downey, J.M., and Krieg, T.: Bother A2a and A2b Adenosine Receptors Are Necessary to Reduce Infarct Size at Reperfusion in Mouse Hearts. Journal of Molecular and Cellular Cardiology 48 (Suppl): S159-S160, 2010. 247. Cui L., Yang X.-M., Yang X., Cohen M.V., Downey J.M. Phosphotase
inhibitor, cantharidin, protects the ischemic heart during the index ischemia
through a phospho-ERK1/2-dependent mechanism. J Mol Cell Cardiol 51: S8, 2011 251. Michael V Cohen, Xi-Ming Yang, Lin Cui, Glenn L
Wilson, Mikhail Alexeyev, Mark N Gillespie, and James M Downey. Is
Mitochondrial DNA Fragmentation a Major Contributor to Necrosis in Myocardial
Infarction?
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