Welcome to the Borchert Lab

Research in the Borchert laboratory explores the regulation of gene expression by small RNAs. Our main focus is on microRNAs (miRNAs), which are ~20 nucleotide RNAs that repress gene expression by base-pairing to messenger RNAs transcribed from specific protein-coding genes. Recent work indicates that more than half of human protein-coding genes are regulatory targets of miRNAs. My lab will examine the roles that miRNAs play during growth and development, how miRNAs contribute to speciation, and how miRNA misregulation can lead to oncogenesis.