USA Department of Pathology Faculty

Academic Faculty

▼   Guillermo A. Herrera, M.D.

Guillermo A. Herrera, M.D.Guillermo A. Herrera, M.D.

Locke Eminent Scholar
Professor & Chair, Department of Pathology
Professor, Department of Physiology and Cell Biology

gherrera@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Cytopathology

Education

M.D.: University of Puerto Rico
Anatomic and Clinical Pathology Residency: Brooke Army Medical Center, Ft. Sam Houston, Texas
Internship (Categorical Pathology): Brooke Army Medical Center

Selected Publications

Book Chapters
  • Herrera GA, Lott RL: Colloidal gold labeling for diagnostic pathology. In Colloidal Gold: Principles, Methods, and Applications (M.A. Hayat, Ed.) Vol. 3. Academic Press, San Diego and London, 1990, Chapter 16, pp. 321‑345.
  • Herrera GA, Turbat‑Herrera EA, Bradley D: Current practices in the immunomorphologic evaluation of tumors in surgical pathology. A comprehensive approach with emphasis on immunolabeling at the light and ultrastructural level. In Electron Microscopic Cytochemistry and Immunocytochemistry in Biomedicine. (T. Barka and K. Ogawa, Eds.). CRC Press Inc., Boca Raton, Florida, 1993, Chapter 19, pp. 739‑780.
  • Turbat‑Herrera EA, Harkins L, Herrera GA: Immunoelectron microscopy in diagnostic pathology. In Immunohistochemistry and Immunopathology. Section H, Chapter 50. Manual of Clinical Laboratory Immunology. 5th Ed. (CR Taylor, Ed.) American Society of Microbiology Press, Washington, D.C., 1997, pp. 431‑443.
  • Herrera GA, Turbat‑Herrera EA: The state of the art in the diagnosis of mesothelioma. In Sourcebook on Asbestos Diseases, Volume 18. Chapter 10. (G.A. Peters & B. J. Peters, Eds.). Lexis Law Publishing/Reed Elsevier Inc., Charlottesville, VA, 1998, pp. 219‑267.
  • Solomon A, Weiss DT, Herrera GA: Light chain deposition disease: clinicopathologic and biologic features. In Myeloma (J. Mehta and S. Singhal, Eds.) Chapter 29. Martin Dunitz Ltd. Pub, Oxford, England, 2002, pp. 507‑518.
  • Solomon A, Weiss, DT, Herrera GA: Renal diseases associated with multiple myeloma and related plasma cell dyscrasias. In Biology and Management of Multiple Myeloma (J. Berenson, Ed.) Chapter 14, Humana Press, Totowa, NJ, 2004, pp. 281‑302.
  • Herrera GA, Picken MM: Renal diseases associated with plasma cell dyscrasias, amyloidoses, Waldenström macroglobulinemia and cryoglobulinemic nephropathies. In Heptinstall’s Pathology of the Kidney. 7th Ed. Chapter 22 (JC Jennette, JL Olson, FG Silva, and VD D’Agati, Eds). Wolters Kluwer, Philadelphia, Baltimore, New York, London, Hong Kong, Sydney, Tokyo, 2014, pp. 951-1014.
  • Iskandar SS, Herrera GA: Organized deposits. In Heptinstall’s Pathology of the Kidney. 7th Ed. Chapter 23 (JC Jennette, JL Olson, FG Silva, and VD D’Agati, Eds.) Wolters Kluwer, Philadelphia, Baltimore, New York, London, Hong Kong, Sydney, Tokyo, 2014, pp. 1015-1037.
  • Aufman J, Herrera GA: Renal structural changes in Type 1 and 2 diabetes mellitus: Pathology, pathogenesis, and clinical correlations. In Diabetes and kidney disease (EV Lerma and V Batuman, Eds.), 2014; pp. 39-61.
  • Herrera GA, Turbat-Herrera EA: Light / heavy chain deposition disease as a systemic disorder. In Amyloid and related disorders: Surgical Pathology and Clinical Correlations. (MM Picken, A Dogan, GA Herrera, Eds). Current Clinical Pathology series. Humana Press, Springer, New York, NY, 2015, pp. 153-166.
  • Herrera GA, Turbat-Herrera EA: Differential diagnosis of amyloid in surgical pathology: Organized deposits and other materials in the differential diagnosis of amyloidosis. In Amyloid and related disorders: Surgical Pathology and Clinical Correlations. (MM Picken, A Dogan, GA Herrera, Eds). Current Clinical Pathology series. Humana Press, Springer, New York, NY, 2015, pp. 135-152.
  • Picken MM, Herrera GA: Thioflavin T stain: An easier and more sensitive method for amyloid detection. In Amyloid and related disorders: Surgical Pathology and Clinical Correlations. (MM Picken, A Dogan, GA Herrera, Eds). Current Clinical Pathology series. Humana Press, Springer, New York, NY, 2015, pp. 225-227.
  • Herrera GA: Renal diseases associated with hematopoietic disorders or organized deposits. In: Silva’s Diagnostic Renal Pathology (XJ Zhou, Z Laszik, T Nadasdy, VD D’Agati, F Silva Eds.) Cambridge University Press, New York, NY, 2016, pp.385-448.
  • Herrera GA: Fibronectin Glomerulopathy. In: Trachtman H., Hogan J., Herlitz L., Lerma E. (eds) Glomerulonephritis. Springer, Cham, 2018. https://doi.org/10.1007/978-3-31927334-1_51-1
  • Herrera GA: Collagenofibrotic Glomerulopathy. In: Trachtman H., Hogan J., Herlitz L., Lerma E. (eds) Glomerulonephritis. Springer, Cham, 2018. https://doi.org/10.1007/978-3-319-27334-1_52-1
Publications

The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group.

  1. The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH. Nat Rev Nephrol. 2019 Jan;15(1):45-59. doi: 10.1038/s41581-018-0077-4. Review. PMID: 30510265
  2. Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage. Herrera GA, Teng J, Zeng C, Xu H, Liang M, Alexander JS, Liu B, Boyer C, Turbat-Herrera EA. Ultrastruct Pathol. 2018 May-Jun;42(3):262-288. doi: 10.1080/01913123.2018.1449772. Epub 2018 Apr 18. PMID: 29668344
  3. Animal models of monoclonal immunoglobulin-related renal diseases. Sirac C, Herrera GA, Sanders PW, Batuman V, Bender S, Ayala MV, Javaugue V, Teng J, Turbat-Herrera EA, Cogné M, Touchard G, Leung N, Bridoux F. Nat Rev Nephrol. 2018 Apr;14(4):246-264. doi: 10.1038/nrneph.2018.8. Epub 2018 Feb 19. Review. PMID: 29456245
  4. Contribution of human smooth muscle cells to amyloid angiopathy in AL (light-chain) amyloidosis. Vora M, Kevil CG, Herrera GA. Ultrastruct Pathol. 2017 Sep-Oct;41(5):358-368. doi: 10.1080/01913123.2017.1349852. Epub 2017 Aug 10. PMID: 28796568
  5. Dendritic cells in renal biopsies of patients with acute tubulointerstitial nephritis. Cheng M, Gu X, Herrera GA. Hum Pathol. 2016 Aug;54:113-20. doi: 10.1016/j.humpath.2016.03.020. Epub 2016 Apr 13. PMID: 27085555
  6. Healing the damaged mesangium in nodular glomerulosclerosis using mesenchymal stem cells (MSCs): Expectations and challenges. Herrera GA, Zeng C, Turbat-Herrera EA, Teng J. Ultrastruct Pathol. 2016;40(2):61-70. doi: 10.3109/01913123.2016.1145776. Review. PMID: 27031175
  7. Animal Models of Light Chain Deposition Disease Provide a Better Understanding of Nodular Glomerulosclerosis. Herrera GA, Turbat-Herrera EA, Teng J. Nephron. 2016;132(2):119-36. doi: 10.1159/000443282. Epub 2016 Jan 22. PMID: 26794829
  8. Circulating monoclonal light chains and acute kidney injury: the role of the renal biopsy with emphasis on ultrastructural evaluation in assessing and understanding renal injury. Aufman J, Herrera GA. Ultrastruct Pathol. 2015 May;39(3):159-68. doi: 10.3109/01913123.2015.1013653. Epub 2015 Apr 9. Review. PMID: 25856088
  9. Diagnosis of monoclonal gammopathy of renal significance. Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group. Kidney Int. 2015 Apr;87(4):698-711. doi: 10.1038/ki.2014.408. Epub 2015 Jan 21. Review. PMID: 25607108
  10. Proximal tubulopathies associated with monoclonal light chains: the spectrum of clinicopathologic manifestations and molecular pathogenesis. Herrera GA. Arch Pathol Lab Med. 2014 Oct;138(10):1365-80. doi: 10.5858/arpa.2013-0493-OA. PMID: 25268200
  11. The many faces of cryoglobulinemic nephropathy: a clinico-pathologic study of 47 cases with emphasis on the value of electron microscopy. Ojemakinde K, Turbat-Herrera EA, Zeng X, Gu X, Herrera GA. Ultrastruct Pathol. 2014 Dec;38(6):367-76. doi: 10.3109/01913123.2014.952803. Epub 2014 Sep 5. PMID: 25191813
  12. An animal model of glomerular light-chain-associated amyloidogenesis depicts the crucial role of lysosomes. Teng J, Turbat-Herrera EA, Herrera GA. Kidney Int. 2014 Oct;86(4):738-46. doi: 10.1038/ki.2014.122. Epub 2014 Apr 30. PMID: 24786709
  13. Extrusion of amyloid fibrils to the extracellular space in experimental mesangial AL-amyloidosis: transmission and scanning electron microscopy studies and correlation with renal biopsy observations. Teng J, Turbat-Herrera EA, Herrera GA. Ultrastruct Pathol. 2014 Apr;38(2):104-15. doi: 10.3109/01913123.2013.861568. Epub 2014 Jan 24. PMID: 24460740
  14. Cheng M, Gu X, Turbat-Herrera EA, Herrera GA: Tubular injury and dendritic cell activation are integral components of light chain-associated acute tubulointerstitial nephritis. Arch Pathol Lab Med, 143:1212-1224, 2019.
  15. Lecoq L, Wiegand T, Rodriguez-Alvarez F, Cadalbert R, Herrera GA, del Pozo-Yauner L, Meier BH, Böckmann A: A substantial structural rearrangement leads to in-register parallel amyloid fibril formation in light chain amyloidosis. (In press, Chem Bio Chem, 2019).
  16. Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D’Agati V, Dispenzieri A, Fervenza F, Fernand J-P, Gibbs S, D. Gillmore J, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle R, Lachman H, Larsen C, Nasr N: The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol, 15(1):45-59, 2019.
  17. Ruiz Zamora I R. A, Simon , G, Al-Hilaly Y, Al-Garawi Z, Rodriguez Alvarez FJ, Zavala-Padilla G, Perez-Carreon, JI, Rodriguez-Ambriz SL, Herrera GA, Becerril-Lujan B, Ochoa Leyva A, Melendez-Zajgla J, Serpell L, Del Pozo-Yauner L: The CDR1 and other regions of immunoglobulin light chains are hot spots for amyloid aggregation. Scientific Rep, 9(1):3123-, 2019.
  18. Gopinath A, Baskovich B, Alkhasawneh A, Mubeen A, Masood S, Ginn A, Shukri A, Herrera GA: ultrastructural characteristics of gallbladder epithelial inclusions mimicking Cystoisospora. (In press, Am J Clin Pathol, 2019).
▼   Gary Carnahan, M.D., Ph.D.

Gary Carnahan, M.D., Ph.D.Gary Carnahan, M.D., Ph.D.

Assistant Professor
Blood Bank and Transfusion Medical Director
Clinical Chemistry Laboratories Director

(251)415-1612
gcarnaha@health.southalabama.edu

Board Certification

Clinical Pathology
Blood Bank and Transfusion Medicine 

Education

M.D.: Vanderbilt University
Ph.D. in Biochemistry: Vanderbilt University
Anatomic Pathology Residency: University of Kentucky
Clinical Pathology Residency: Washington University
Thrombosis and Hemostasis Fellowship: Vanderbilt University 

Publications

▼   J. Elliot Carter, M.D.

J. Elliot Carter, M.D.J. Elliot Carter, M.D.

Professor
Pathology Residency Program Director
Clinical Pathology Director
Clinical Laboratories Director

Clinical Microbiology Director

(251) 471-7790
ecarter@health.southalabama.edu

Board Certification

Anatomic and Clinical Pathology

Education

M.D.: University of Mississippi School of Medicine
Anatomic and Clinical Pathology Residency: University of South Alabama

Select Publications

  1. Rolig AS, Shanks J, Carter JE, Ottemann KM.  Helicobacter pylori requires TlpD-driven chemotaxis to proliferate in the antrum. Infect Immun 2012 Oct;80(10):3713-20.

  2. Rolig AS, Cech C, Ahler E, Carter JE, and Ottemann KM. The degree of Helicobacter pylori inflammation is manipulated by the pre-infection host microbiota. Infect Immun. 2013 May;81(5):1382-9.

  3. Tyagi N, Bhardwaj A, Singh AP, McLellan S, Carter JE, and Singh S. P-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of  NF-κB pathway. Oncotarget. August 27, 2014

  4. Arora S, Tyagi N, Bhardwaj A, Rusu L, Palanki R, Vig K, Singh SR, Singh AP, Palanki S, Miller ME, Carter JE, Singh S. Silver nanoparticles protect human keratinocytes against UVB-induced DNA damage and apoptosis: potential for prevention of skin carcinogenesis. Nanomedicine. 11(5):1265-75. 2015

  5. Bhardwaj A., Srivastava SK., Singh S., Arora S., Tyagi N., Andrews J., McClellan S., Carter JE., and Singh AP. CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4- dependent activation of LIM domain kinase 1. Oncotarget 30;5(22):11490-500, 2014

  6. Deshmukh SK., Srivastava SK, Bhardwaj S, Singh AP, Tyagi N, Marimuthus S, Dyess DL, Zotto VD, Carter JE, and Singh S. Resistin and interleukin-6 exhibit racially disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation. Oncotarget 6(13):11231-41, 2015

  7. Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh AP, Carter JE, Scammell JG, Fodstad Ø, and Singh S. Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis. Brit. J. Cancer 112(11):1772-81. 2015

  8. Khan M.A., Srivastava S.K., Bhardwaj A., Singh S., Arora S., Zubair H., Carter J.E., and Singh A.P. Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications. Oncotarget 6(36):39140-50. 2015.

  9. Tyagi N., Bhardwaj A., Srivastava S.K., Arora S., Marimuthu S., Deshmukh S.K., Singh A.P., Carter J.E., and Singh S. Development and characterization of a novel in vitro progression model for UVB-induced skin carcinogenesis. Sci Rep. 2015 Sep 9;5:13894. doi: 10.1038/srep13894.

  10. Palanki R., Arora S., Tyagi N., Rusu L., Singh A.P., Palanki S., Carter J.E., and Singh S. Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes. BMC Cancer. 2015 Sep 15;15:636. doi: 10.1186/s12885-015-1644-8.

  11. Srivastava S, Bhardwaj A, Arora S, Singh S, Azim S, Tyagi N, Carter, JE, Wang B, and Singh AP. MYB is a novel regulator of pancreatic tumor growth and metastasis. Brit J Cancer. 2015 Dec 22;113(12):1694-703.

  12. Tyagi N, Marimuthu S, Bhardwaj A, Deshmukh SK, Srivastava S, Singh AP, McClellan S, Carter J.E, and Singh S. p21-activated kinase 4 maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. Cancer Lett. 2016 Jan 28;370(2):260-7.

  13. Bhardwaj A, Srivastava SK, Singh S, Tyagi N, Arora S, Carter JE, Khushman M, Singh AP. MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin. J Biol Chem. 2016 Jul 29;291(31):16263-70. doi: 10.1074/jbc.M116.732651. Epub 2016 May 31.

  14. Averett C, Bhardwaj A, Arora S, Srivastava SK, Khan MA, Ahmad A, Singh S, Carter JE, Khushman M, Singh AP. Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk. Carcinogenesis. 2016 Sep 8.

  15. Tyagi N, Srivastava SK, Arora S, Omar Y, Ijaz ZM, Al-Ghadhban A, Deshmukh SK, Carter JE, Singh AP, Singh S. Comparative analysis of the relative potential of silver, Zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis. Cancer Lett. 2016 Dec 1;383(1):53-61. doi: 10.1016/j.canlet.2016.09.026. Epub 2016 Sep 28.

  16. Zubair H, Azim S, Srivastava SK, Ahmad A, Bhardwaj A, Khan MA, Patel GK, Arora S, Carter JE, Singh S, Singh AP. Glucose Metabolism Reprogrammed by Overexpression of IKKε Promotes Pancreatic Tumor Growth. Cancer Res. 2016 Dec 15;76(24):7254-7264. Epub 2016 Oct 20.

  17. Bhardwaj A, Srivastava SK, Khan MA, Prajapati VK, Singh S, Carter JE, Singh AP. Racial disparities in prostate cancer: a molecular perspective. Front Biosci (Landmark Ed). 2017 Jan 1;22:772-782.

  18. Ahmad A, Azim S, Zubair H, Khan MA, Singh S, Carter JE, Rocconi RP, Singh AP. Epigenetic Basis of Cancer Health Disparities: Looking Beyond Genetic Differences. Biochim Biophys Acta. 2017 Jan 17;1868(1):16-28.

  19. Deshmukh SK, Srivastava SK, Zubair H, Bhardwaj A, Tyagi N, Al-Ghadhban A, Singh AP, Dyess DL, Carter JE, Singh S. Resistin potentiates chemoresistance and stemness of breast cancer cells: implications for racially disparate therapeutic outcomes. Cancer Lett. 2017 Jun 28;396:21-29. doi: 10.1016/j.canlet.2017.03.010. Epub 2017 Mar 14.

  20. Deshmukh SK, Srivastava SK, Tyagi N, Ahmad A, Singh AP, Ghadhban AA, Dyess DL, Carter JE, Dugger K, Singh S. Emerging evidence for the role of differential tumor microenvironment in breast cancer racial disparity: a closer look at the surroundings. Carcinogenesis. 2017 Aug 1;38(8):757-765.

  21. Tyagi N, Deshmukh SK, Srivastava SK, Azim S, Ahmad A, Al-Ghadhban A, Singh AP, Carter JE, Wang B, Singh S. ETV4 promotes growth of pancreatic cancer cells by facilitating cell cycle progression through direct transcriptional upregulation of Cyclin D1. Mol Cancer Res. 2018 Feb;16(2):187-196. doi: 10.1158/1541-7786.MCR-17-0219. Epub 2017 Nov 8.

  22. Deshmukh SK, Tyagi N, Khan M, Srivastava SK, Al-Ghadhban A, Dugger K, Carter JE, Singh S. Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages. Sci Rep. 2018 Aug 10;8(1):12000. doi: 10.1038/s41598-018-30437-2.

  23. Haque M, Hameed N, Perry CT, Carter JE, Mneimneh WS. Malignant peritoneal mesothelioma in the setting of a ventriculoperitoneal shunt: A novel clinical presentation. Clin Med Insights Oncol. 2018 Jun 5;12:1179554918779583.

  24. Khan MA, Patel GK, Srivastava SK, Carter JE, Pierce JY, Rocconi RP, Singh S, Singh AP. Looking at cancer health disparities without the colored lenses. (In press).

Select Scientific Presentations

  1. Bowman BE, Ravula S, Carter JE. Brevundimonas (Pseudomonas) vesicularis in a Two-Month-Old Infant with a One-Day History of Abdominal Distention and Discomfort: A Case Report and Review of the Literature. College of American Pathologists Meeting, Chicago, Illinois, September 26-29, 2010.

  2. Wang Y, Carter JE. Two Sibs with Trisomy 2q 34-qter. American Society of Human Genetics Meeting. San Francisco, CA. November 6-10, 2012.

  3. Wang Y, Martinez J, Zhou Y, Shrestha D, Carter E. Microcephaly associated with duplication of chromosome 15q24. American Society of Human Genetics Meeting, Boston, Massachusetts, October 22-26, 2013.

  4. Johnson KS, Yang C, Carter JE, Ottemann K. Uncovering how the Helicobacter pylori chemoreceptor TlpA modulates host inflammation. ASM Microbe, American Society for Clinical Microbiology Conference, San Francisco, California, June 20-24, 2019.

  5. Mujahed T, Tazelaar H, Glass C,  Pavlisko E, Roggli V, Haque M, Mneimneh W, Carter E, Galateau-Salle F, Glidden D, Garcia-Kennedy R, Larsen B. Malignant Mesothelioma Associated with Long-Standing Indwelling Intrathoracic and Intraabdominal Shunt Catheters. College of American Pathologists, Orlando, Florida, September 21-25, 2019.

▼   Debanjan Chakroborty, Ph.D.

Debanjan Chakroborty, Ph.D.Debanjan Chakroborty, Ph.D.

Assistant Professor
Member, Cancer Biology Program, Mitchell Cancer Institute

(507) 271-2880
dchakroborty@southalabama.edu

Education

Post-doctoral Research Fellow: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN
Ph.D., Cancer Biology: Chittaranjan National Cancer Institute (Jadavpur University), India
M.S., Zoology: Visva Bharati University, India 

Select Publications

  1. Chakroborty D, Goswami S, Basu S, Sarkar C. Catecholamines in the regulation of angiogenesis in cutaneous wound healing. FASEB J. 2020 Nov;34(11):14093-14102. doi: 10.1096/fj.202001701R. Epub 2020 Sep 19. PMID: 32949437.
  2. Sarkar C, Goswami S, Basu S, Chakroborty D. Angiogenesis Inhibition in Prostate Cancer: An Update. Cancers (Basel). 2020 Aug 23;12(9):2382. doi: 10.3390/cancers12092382. PMID: 32842503; PMCID: PMC7564110.
  3. Sarkar C, Ganju RK, Pompili VJ, Chakroborty D. Enhanced peripheral dopamine impairs postischemic healing by suppressing angiotensin receptor type 1 expression in endothelial cells and inhibiting angiogenesis. Angiogenesis. 2017;20(1):97-107. doi: 10.1007/s10456-016-9531-8.
  4. Chakroborty D, Sarkar C, Lu K, Bhat M, Dasgupta PS, Basu S. Activation of Dopamine D1 receptors in dermal fibroblasts restores vascular endothelial growth factor-A production by these cells and subsequent angiogenesis in diabetic cutaneous wound tissues. Am J Pathol. 2016; 186(9):2262-70. doi: 10.1016/j.ajpath.2016.05.008.
  5. Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine is a safe anti-angiogenic drug which can also prevent 5-fluorouracil induced neutropenia. Int J Cancer. 2015;137:744-9. doi: 10.1002/ijc.
  6. Joseph M, Das M, Kanji S, Lu J, Aggarwal R, Chakroborty D, Sarkar C, Yu H, Mao H-Q, Basu S, Pompili VJ, Das H. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials. 2014; 35(30):8566-75. doi: 10.1016/j.biomaterials.2014.06.037
  7. Lu K, Chakroborty D, Sarkar C, Lu T, Xie Z, Liu Z, Basu S. Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis. PLoS One. 2012;7(8):e43934. PMID: 22937129.
  8. Sarkar C, Chakroborty D, Basu S. Neurotransmitters as regulators of tumor angiogenesis and immunity: The role of catecholamines. J Neuroimmune Pharmacol. 2013;8(1):7-14. PMID: 22886869
  9. Chakroborty D, Sarkar C , Yu H, Wang J, Liu Z, Dasgupta PS, Basu S. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U.S.A. 2011;108(51):20730- 20735. PMID: 22143796.
  10. Shome S, Rana T, Ganguly S, Basu B, Chaki Choudhury S, Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine regulates angiogenesis in normal dermal wound tissues. PLoS One. 2011;6(9):e25215. PMID: 21949884.
  11. Sarkar C, Basu B, Chakroborty D, Dasgupta PS, Basu S. The immunoregulatory role of
    dopamine: An update. Brain Behav Immun. 2010 May;24(4):525-528. PMID: 19896530.
  12. Basu B, Sarkar C, Chakroborty D, Ganguly S, Shome S, Dasgupta PS, Basu S. D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in jurkat T leukemic cells. J Biol Chem. 2010;285(35):27026-27032. PMID: 20592018.
  13. Chakroborty D, Sarkar C, Basu B, Dasgupta PS, Basu S. Catecholamines regulate tumor
    angiogenesis. Cancer Res. 2009 May;69(9):3727-3730. Review. PMID: 19383906
  14. Sarkar C, Chakroborty D, Chowdhury UR, Dasgupta PS, Basu S. Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models. Clin Cancer Res.2008;14(8):2502-2510. PMID: 18413843
  15. Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS, Basu S. Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. J Clin Invest. 2008;118(4):1380-1389. PMID: 18340382
  16. Sarkar C, Das S, Chakroborty D, Chowdhury UR, Basu B, Dasgupta PS, Basu S. Cutting edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation. J Immunol. 2006;177(11):7525-7529. PMID: 17114421. [Cutting Edge]
  17. Sarkar C, Chakroborty D, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells. Am J Physiol Heart Circ Physiol. 2004 Oct;287:H15554-1560. PMID: 15371263.
  18. Basu S, Sarkar C, Chakroborty D, Nagy J, Mitra RB, Dasgupta PS, Mukhopadhyay D. Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis. Cancer Res. 2004;64(16):5551-5555. PMID: 15313889 [Advances in Brief].
  19. Chakroborty D, Sarkar C, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Depleted dopamine in gastric cancer tissues: Dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clin Cancer Res. 2004 Jul;10:4349-4356. PMID: 15240521[Featured Article].
▼   Santanu Dasgupta, Ph.D.

Santanu Dasgupta, Ph.D.Santanu Dasgupta, Ph.D.

Assistant Professor
Head, Mitochondria Research Laboratory
Member, Cancer Biology Program, Mitchell Cancer Institute

(251) 445-9805
dasgupta@southalabama.edu 

Education

Postdoctoral Fellow: Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins School of Medicine
Ph.D., Cancer Biology: Chittaranjan National Cancer Institute, West Bengal, India
M.S.: University of Calcutta, West Bengal, India

Selected Publications

  1. Cancer Testis Antigen Promotes Triple Negative Breast Cancer Metastasis and is Traceable in the Circulating Extracellular Vesicles. Kannan A, Philley JV, Hertweck KL, Ndetan H, Singh KP, Sivakumar S, Wells RB, Vadlamudi RK, Dasgupta S. Sci Rep 2019;9:11632.
  2. Philley JV, Kannan A, Olusola P, McGaha P, Singh KP, Samten B, Griffith DE, Dasgupta S. Microbiome Diversity in Sputum of Nontuberculous Mycobacteria Infected Women with a History of Breast Cancer. Cell Physiol Biochem 2019;52:263-279.
  3. Cervical Cancer Prevention in Racially Disparate Rural Populations. Olusola P, Ousley K, Ndetan H, Singh KP, Banerjee HN, Dasgupta S. Medicines (Basel). 2019:6(3). pii: E93.
  4. Human Papilloma Virus-Associated Cervical Cancer and Health Disparities. Olusola P, Banerjee HN, Philley JV, Dasgupta S. Cells. 2019;8(6). pii: E622.
  5. Mitochondrion: I am more than a fuel server. Dasgupta S. Ann Transl Med 2019;7(20):594.
  6. Philley JV, Hertweck KL, Kannan A, Brown-Elliott BA, Wallace Jr. RJ, Kurdowska A, Ndetan H, Singh KP, Miller EJ, Griffith DE, Dasgupta S. Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease. Sci Rep. 2018;8:11336.
  7. Philley JV, Kannan A, Griffith DE, Devine MS, Benwill JL, Wallace RJ Jr, Brown-Elliott BA, Thakkar F, Taskar V, Fox JG, Alqaid A, Bains H, Gupta S, Dasgupta S. Exosome secretome and mediated signaling in breast cancer patients with nontuberculous mycobacterial disease. Oncotarget 2017;8:18070-18081.
  8. Kannan A, Hertweck KL, Philley JV, Wells RB, Dasgupta S. Genetic Mutation and Exosome Signature of Human Papilloma Virus Associated Oropharyngeal Cancer. Sci Rep 2017;7:46102.
  9. Hertweck KL, Dasgupta S. The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities. Front Oncol 2017 2;7:262.
  10. Kannan A, Wells RB, Shivkumar S, Komatsu S, Singh KP, Samten B, Philley JV, Sauter ER, Ikebe M, Idell S, Gupta S, Dasgupta S. Mitochondrial Reprogramming Regulates Breast Cancer Progression. Clin Can Res 2016;22:3348-60. (Featured article) http://clincancerres.aacrjournals.org/content/22/13/3119.
  11. Philley JV, Kannan A, Qin W, Sauter ER, Ikebe M, Hertweck KL, Troyer DA, Semmes OJ, Dasgupta S. Complex-I alteration and enhanced mitochondrial fusion are associated with prostate cancer progression. J Cell Physiol 2016;231:1364-74.
  12. Duberow DP, Brait M, Hoque MO, Theodorescu D, Sidransky D, Dasgupta S*, Mathies RA. High-performance detection of somatic D-loop mutation in urothelial cell carcinoma patients by polymorphism ratio sequencing. J Mol Med(Berl). 2016;94:1015-24. (*Co- corresponding author).
  13. Qin W, Tsukasaki Y, Dasgupta S, Mukhopadhyay N, Ikebe M, Sauter ER. Exosomes in Human Breast Milk Promote EMT. Clin Cancer Res 2016;22:4517-24.
  14. Oyesanya RA, Bhatia S, Menezes ME, Dumur CI, Singh KP, Bae S, Troyer DA, Wells RB, Sauter ER, Sidransky D, Fisher PB, Semmes OJ, Dasgupta S. MDA-9/Syntenin regulates differentiation and angiogenesis programs in Head and Neck Squamous Cell Carcinoma. Oncoscience 2014;1:725-37.
  15. Dasgupta S*,Menezes ME, Das SK, Emdad L, Janijic A, Bhatia S, Mukhopadhyay ND, Shao C, Sarkar D, Fisher PB*. Novel Role of MDA-9/Syntenin in Regulating Urothelial Cell Proliferation by Modulating EGFR Signaling. Clin Can Res 2013 19:4621-33.(*Co- corresponding author, Featured article). https://clincancerres.aacrjournals.org/content/19/17.cover-expansion
  16. Dasgupta S*, Shao C, Keane TE, Duberow DP, Mathies RA, Fisher PB, Kiemeney LA, Sidransky D*. Detection of Mitochondrial DNA Alterations in Urine from Urothelial Cell Carcinoma Patients. (*Co-corresponding author). Int J Cancer 2012;131:158-64
  17. Dasgupta S*, Soudry E, Mukhopadhyay N, Shao C, Yee J, Lam S, Lam W, Zhang W, Gazdar AF, Fisher PB, Sidransky D*. Mitochondrial DNA Mutations in Respiratory Complex-I in Never-Smoker Lung Cancer Patients Contribute to Lung Cancer Progression and associated with EGFR gene mutation. (*Co-corresponding author). J Cell Physiol 2012;227:2451-60.
  18. Dasgupta S*, Pal P, Shao C, Mukhopadhyay ND, Fu Y, Ratovitski EA, Moon C, Hoque MO, Fisher PB, Trink B*. A Single Nucleotide Polymorphism in human PIGK gene associates with low PIGK expression in colorectal cancer patients. (*Co-corresponding author). Int J Oncology 2012;41:1405-10.
  19. Begum S, Brait M, Dasgupta S, Ostrow K, Zahurak M, Carvalho AL, Califano JA, Goodman SN, Westra WH, Hoque MO, Sidransky D. An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Can Res 2011 17:4494-4503.
  20. Keidar M, Walk R, Shashurin A, Srinivasan P, Sandler A, Dasgupta S, Ravi R Guerrero- Preston R, Trink B. Cold Plasma Selectivity and the Possibility of a Paradigm Shift in Cancer Therapy. Br J Cancer 2011; 105:1295-301.
  21. Chatterjee A*, Dasgupta S*, Sidransky D. Mitochondrial subversion in cancer. Can Prev Res 2011 4:638-654. (*Co-first author) (impact factor 4.5).
  22. Begum S, Brait M, Dasgupta S, Ostrow K, Zahurak M, Carvalho AL, Califano JA, Goodman SN, Westra WH, Hoque MO, Sidransky D. An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin Can Res 2011 17:4494-4503.
  23. Hoque MO, Brait M, Rosenbaum E, Poeta ML, Pal P, Begum S, Dasgupta S, Carvalho AL, Ahrendt SA, Westra WH, Sidransky D. Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. J of Thorac Oncol 2010; 5:1887-93.
  24. Dasgupta S, Koch R, Westra WH, Califano JA, Ha PK, Sidransky D, Koch WM. Mitochondrial DNA mutation in margins and tumors of recurrent HNSCC patients. Can Prev Res 2010; 3:1205-11.
  25. Dasgupta S, Hoque MO, Upadhyay S, Sidransky D. Forced Cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. Int J Cancer 2009 125:2829-35.
  26. Dasgupta S, Yung RC, Westra WH, Rini DA, Brandes J, Sidransky D. Following mitochondrial footprints through a long mucosal path to lung cancer. PLoS One 2009; 4:e6533.
  27. Dasgupta S, Hoque MO, Upadhyay S, Sidransky D. Mitochondrial Cytochrome B Gene Mutation Promotes Tumor Growth in Bladder Cancer. Cancer Research68:700-706, 2008.
  28. Nagpal JK*, Dasgupta S*, Jadallah S, Chae YK, Ratovitski RA, Toubaji A, Netto JG, Nissan A, Sidransky D, Trink B. Profiling the expression pattern of GPI transamidase complex subunits in human cancer. (*Co-first author). Modern Pathology 2008 21:979-991.
  29. Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW Jr. Chatterjee SK. Vaccination with recombinant vaccinia virus expressing IL-2 invokes anti-tumor cellular immunity in an orthotopic murine model of head and neck squamous cell carcinoma. Molecular Therapy 2006 13:183-93.
  30. Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW Jr. Chatterjee SK. Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-Beta 1 secreted by the tumor cells. J Cell Biochem 2006 97:1036-1051.
  31. Dasgupta S, Tripathi P, Qin H, Bhattacharya-Chatterjee M, Valentino J, Chatterjee SK. Identification of Molecular Targets for Immunotherapy of Patients with Head and Neck Squamous cell carcinoma. Oral Oncology 2006 42:306-16.
  32. Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW Jr. Chatterjee SK. Inhibition of NK Cell Activity through TGF-1 by Down Regulation of NKG2D in a Murine Model of Head and Neck Cancer. Journal of Immunology 2005 175: 5541-5550.
  33. Dasgupta S, Tripathi PK, Bhattacharya-Chatterjee M, O'Malley BW Jr. Chatterjee SK. Recombinant vaccinia virus expressing IL-2 generates effective anti-tumor responses in an orthotopic murine model of head and neck carcinoma. Molecular Therapy 2003 8:238- 248.
  34. Dasgupta S, Chakraborty SB, Roy A, Roychowdhury S, Panda CK. Differential deletions in chromosome 3p are associated with the development of uterine cervical carcinoma in Indian patients. Molecular Pathology 2003 56: 263-269.
  35. Dasgupta S, Mukherjee N, Roy S, Roy A, Sengupta A, Roychowdhury S et al. Mapping of the candidate tumor suppressor genes' loci on human chromosome 3 in head and neck squamous cell carcinoma of an Indian patient population. Oral Oncology 2002 38:6-15.
▼   Luis del Pozo-Yauner, M.D., Ph.D.

Luis del Pozo-Yauner, M.D., Ph.D.Luis del Pozo-Yauner, M.D., Ph.D.

Assistant Professor
Director Clinical Chemistry

(251) 470-5863
ldelpozoyauner@health.southalabama.edu 

Education

M. D.: University of Medical Sciences, Cienfuegos, Cuba.
Clinical Biochemistry Residency: Superior Institute of Medical Science, Villa Clara, Cuba.
Ph.D. Biochemistry: Institute of Biotechnology National Autonomous University of Mexico (UNAM), México.

Publications (2014-2019)

  1. Robin A. Ruiz Zamora, Simon Guillaumé, Youssra Al-Hilaly, Zahraa Al-Garawi, Francisco Javier Rodríguez Alvarez, Guadalupe Zavala-Padilla, Julio I. Pérez Carreón, Sandra L. Rodríguez-Ambriz, Guillermo A. Herrera, Baltazar Becerril-Luján, Adrián Ochoa Leyva, Jorge Melendez-Zajgla, Louise Serpell, Luis del Pozo-Yauner. The CDR1 And Other Regions Of Immunoglobulin Light Chains Are Hot Spots For Amyloid Aggregation. Accepted for publication in Scientific Reports 2019.
  2. Lauriane Lecoq, Thomas Wiegand, Francisco J. Rodriguez-Alvarez, Riccardo Cadalbert, Guillermo A. Herrera,  Luis del Pozo-Yauner, Beat H. Meier, and Anja Böckmann. A Substantial Structural Conversion of the Native Monomer Leads to In-Register Parallel Amyloid Fibril Formation in Light Chain Amyloidosis. ChemBioChem. 2018 Dec 18. doi: 10.1002/cbic.201800732.
  3. Torres-Mena JE, Salazar-Villegas KN, Sánchez-Rodríguez R, López-Gabiño B, Del Pozo-Yauner L, Arellanes-Robledo J, Villa-Treviño S, Gutiérrez-Nava MA, Pérez-Carreón JI. Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC. Dig Dis Sci. 2018 Apr;63(4):934-944. doi: 10.1007/s10620-018-4943-5. Epub 2018 Jan 30.
  4. Fernanda Cornejo-Granados, Zyanya L. Zatarain-Barrón, Vito A. Cantu-Robles, Alfredo Mendoza-Vargas, Camilo Molina-Romero, Filiberto Sánchez, Luis Del Pozo-Yauner, Rogelio Hernández-Pando, Adrián Ochoa-Leyva. Secretome Prediction of Two M. tuberculosis Clinical Isolates Reveals Their High Antigenic Density and Potential Drug Targets. Front. Microbiol. 2017; 8:128. doi: 10.3389/fmicb.2017.00128
  5. Sánchez SA, Rodríguez Álvarez FJ, Zavala-Padilla G, Mejia-Cristobal LM, Cruz Rangel A, Costas M, Fernández Velasco DA, Melendez-Zajgla J, del Pozo-Yauner L. Stability and aggregation propensity do not fully account for the association of various germline variable domain gene segments with light chain amyloidosis. Biol Chem. 2016 Nov 17. doi: 10.1515/hsz-2016-0178.
  6. Sánchez-Rodríguez R, Torres-Mena JE, Quintanar-Jurado V, Chagoya-Hazas V, Rojas Del Castillo E, Del Pozo Yauner L, Villa-Treviño S, Pérez-Carreón JI. Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress. Free Radic Biol Med. 2017 Jan;102:87-99. doi: 10.1016/j.freeradbiomed.2016.11.027.
  7. Shirley Bikel, Alejandra Valdez-Lara, Fernanda Cornejo-Granados, Karina Rico, Samuel Canizales-Quinteros, Xavier Soberón, Luis Del Pozo-Yauner, Adrián Ochoa-Leyva. Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome. Comput Struct Biotechnol J. 2015, 13:390–401
  8. Sandra Gómez, Laura Adalid-Peralta, Hector Palafox-Fonseca, Vito Adrian Cantu-Robles, Xavier Soberón, Edda Sciutto, Gladis Fragoso, Raúl J. Bobes, Juan P. Laclette, Luis del Pozo Yauner, Adrián Ochoa-Leyva. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR). Scientific Reports 2015, Mayo 5:9683. DOI: 10.1038/srep09683.
  9. González-Andrade M, Rodríguez-Sotres R, Madariaga-Mazón A, Rivera-Chávez J, Mata R, Sosa-Peinado A, Del Pozo-Yauner L, Arias-Olguín II. Insights into molecular interactions between CaM and its inhibitors from molecular dynamics simulations and experimental data. J Biomol Struct Dyn. 2015 Feb 23:1-39.
  10. Olga Mata Ruiz, Yolanda Medina Flores, Miying Dessire Gómez Cervantes, Diana Reynada Castillo1, Robin Axel Ruiz Zamora, Francisco Javier Rodríguez Álvarez, Karen Cortes Sarabia, Luis del Pozo Yauner. Generation And Preliminary Characterization of Murine IgM Monoclonal Antibodies against the N-terminal β-strand Of A Fibrillogenic Light Chain Variable Domain. JCBPS; Special Issue, Section C; 30 Nov . 2014 Vol. 4, No. 5, 60-69.
  11. High-Quality Draft Genomes of Two Vibrio Parahaemolyticus Strains Aid in Understanding Acute Hepatopancreatic Necrosis Disease of Cultured Shrimps in Mexico. Silvia Gomez-Jimenez, Lorena Noriega-Orozco, Rogerio R. Sotelo-Mundo, Vito A. Cantu-Robles, Ana G. Cobian-Guemes, Rosario G. Cota-Verdugo, Luis A. Gamez-Alejo, Luis del Pozo-Yauner, Eduardo Guevara-Hernandez, Karina D. Garcia-Orozco, Alonso A. Lopez-Zavala, Adrián Ochoa-Leyva. Genome Announc. 2014 Aug 14;2(4). pii: e00800-14. doi: 10.1128/genomeA.00800-14. .
  12. García-Magallanes N, Luque-Ortega F, Aguilar-Medina EM, Ramos-Payán R, Galaviz-Hernández C, Romero-Quintana JG, del Pozo-Yauner L, Rangel-Villalobos H, Arámbula-Meraz E. Glucose-6-phosphate dehydrogenase deficiency in northern Mexico and description of a novel mutation. Journal of Genetics, 2014 August 93(2)325-330.
  13. Sánchez-Rodríguez R, Torres-Mena JE, De-la-Luz-Cruz M, Bernal-Ramos GA, Villa-Treviño S, Chagoya-Hazas V, Landero-López L, García-Román R, Rouimi P, Del Pozo-Yauner L, Meléndez-Zajgla J, Pérez-Carreón JI. Increased expression of prostaglandin reductase 1 in hepatocellular carcinomas from clinical cases and experimental tumors in rats. Int J Biochem Cell Biol. 2014 May 20;53C:186-194. doi: 10.1016/j.biocel.2014.05.017.
  14. del Pozo-Yauner L, Wall JS, González Andrade M, Sánchez-López R, Rodríguez-Ambriz SL, Pérez Carreón JI, Ochoa-Leyva A, Fernández-Velasco DA. The N-terminal strand modulates immunoglobulin light chain fibrillogenesis. Biochem Biophys Res Commun. 2014 Jan 10;443(2):495-9. doi: 10.1016/j.bbrc.2013.11.123.
  15. Torres Mena JE, Sánchez Rodríguez R, Quintanar Jurado V, Mojica Espinosa R, Del Pozo Yauner L, Meléndez Zajgla J, Villa Treviño S, Pérez Carreón JI. Laser capture microdissection after γ-glutamyl transferase histochemistry: an optimization for gene expression analysis. Anal Biochem. 2014 Feb 15;447:126-32. doi: 10.1016/j.ab.2013.11.015.
▼   Osama R. Elkadi, M.D.

Osama R. Elkadi, M.D.Osama R. Elkadi, M.D.

Assistant Professor
Director, Neuropathology
Associate Director, Residency Program
Director, Autopsy Services

(251) 471-7790
oelkadi@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Neuropathology
Cytopathology

Education

M.D. Cairo University, Kasr Alainy Faculty of Medicine, Cairo, Egypt 1999-2006
Anatomic and Clinical Pathology Residency, Albany Medical Center, Albany, NY 2010-2014
Neuropathology Fellowship, Oregon Health & Science University (OHSU), Portland, OR 2014-2016
Cytopathology Fellowship, Drexel University, Philadelphia, PA 2017-2018

Publications

  • J S Ross, K Wang, Elkadi O, A Tarasen, L Foulke, C E Sheehan, G A Otto, G Palmer, R Yelensky, D Lipson, J Chmielecki, S M Ali, J Elvin, D Morosini, V A Miller, P J Stephens. Next-generation sequencing reveals frequent consistent genomic alterations in small cell undifferentiated lung cancer. Journal of Clinical Pathology  06/2014; 67(9).
  • Mneimneh WS, Ashraf MA, Li L, Elkadi O, Qian J, Nazeer T, Hayner-Buchan A. Primary Dural Lymphoma: a Novel Concept of Heterogenous Disease. Pathol Int. 2013 Jan;63(1):68-72.
  • Mneimneh WS, Ashraf MA, Elkadi O, Li L, Nazeer T, Homan S. Enteropathy-associated anaplastic large T cell lymphoma ALK-positive (EA-ALCL-ALK+): variant of T cell lymphoma with possible two-hit pathogenesis, J  Hematopathol., 2013 May.
  • Igor Sorokin · R C Welliver, Elkadi O, Tipu Nazeer, Ronald P Kaufman. Tumor Seeding of Percutaneous Nephrostomy Tract from Urothelial Carcinoma of the Kidney. Hindawi Publishing Corporation Case Reports in Urology Volume 2013, Article ID 819470
▼   Carlos A. Galliani, M.D.

Carlos A. Galliani, M.D.Carlos A. Galliani, M.D.

Professor
Pediatric Pathology Director

(251) 415-1614
cgalliani@health.southalabama.edu

Board Certification

Anatomic and Pediatric Pathology

Education

M.D.: National University of Buenos Aires, Buenos Aires, Argentina
Anatomical Pathology Residency: United Hospitals of St. Paul, St. Paul, MN
Research Associate in Cardiovascular Pathology: United Hospitals of St. Paul, St. Paul, MN
Surgical Pathology Fellowship: University of Minnesota, Minneapolis, MN
Pediatric Pathology Fellowship: Children's Hospital of Los Angeles, Los Angeles, CA

Clinical Expertise

Congenital and Acquired Pediatric Heart Disease, Pediatric Tumors and Cancer Predisposition Syndromes

▼   Eugene Hart, M.D.

Eugene Hart, M.D.Eugene Hart, M.D.

Adjunct Assistant Professor

(251) 471-7026
eugene.hart@adfs.alabama.gov 

Board Certification

Anatomic and Clinical Pathology
Forensic Pathology

Education

M.D.: University of Miami School of Medicine
Anatomic and Clinical Pathology Residency: University of South Alabama
Forensic Pathology Fellowship: Harris County Medical Examiner's Office

▼   Kurt J. Knowles, M.D.

Kurt J. Knowles, M.D.Kurt J. Knowles, M.D.

Assistant Professor
Interim Director of Anatomic Pathology
Interim Director of Surgical Pathology

(251) 471-7790
kknowles@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Cytopathology

Education

M.D.: Louisiana State University Health Science Center, Shreveport, LA
United States Naval Aviator, Helicopter Aircraft Commander, Helicopter Combat Support
Flexible Internship: LSU Health Science Center, Shreveport, LA
Pathology Residency: LSU Health Science Center, Shreveport, LA
Cytopathology Fellowship: LSU Health Science Center, Shreveport, LA

Publications

  • Knowles KJ, Berkovic J, Gungor A, Al Shaarani M, Lockhart V, Al-Delphi F, Turbat- Herrera EA. Oral foregut duplication cysts: A rare and fascinating congenital lesion. Case report and review of the literature. Am J Otolaryngol. 2017 Nov - Dec; 38 (6):724-725. doi: 10.1016/j.amjoto.2016.11.008. Epub 2016 Nov 23. Review.
  • Knowles KJ, Chen S, Herrera GA. Metastatic Colonic Adenocarcinoma to the Extrahepatic Common Bile Duct: The Critical Role of the Pathologist and Immunohistochemistry in Guiding Patient Care Decisions.  Am J Case Rep. 2017 Mar 14; 18:263-7.
  • Knowles KJ, Alattia L, Cheng M, Chu Q, Turbat-Herrera EA, Herrera GA. Synchronous Primary Tumors of the Liver and Gallbladder: Case Report and Review of the Literature. Ann Clin Case Rep. 2017; 2: 1407.
  • Shi M, Al-Delfi F, Al Shaarani M, Knowles K, Cotelingam J. Ovarian Adenomatoid Tumor Coexisting with Mature Cystic Teratoma: A Rare Case Report. Case Rep Obstet Gynecol. 2017;2017:3702682. doi: 10.1155/2017/3702682. Epub 2017 Sep 11
  • Knowles KJ, Wei EX, Seth A, Bienvenu J, Morris J, Manas K, Jordan P, Boktor M. Synthetic Cannabinoid Abuse and a Rare Alpha-1-Antitrypsin Mutant Causing Acute Fulminant Hepatitis: A Case Report and Review of the Literature. Case Reports Hepatol. 2017;2017:9627452. doi: 10.1155/2017/9627452. Epub 2017 Dec 3
  • Knowles KJ, Al-Delfi F, Abdulsattar J, Lacour R, Black D, Chaudhery S, Turbat-Herrera EA. Malignant granular cell tumors: the role of electron microscopy in the definitive diagnosis of an extremely aggressive soft tissue neoplasm. Ultrastruct Pathol. 2018 May-Jun;42(3):304-311. doi: 10.1080/01913123.2018.1465501. Epub 2018 May 8.
  • Kurt J. Knowles, Shoujun Chen, Kathryn Rhymes, Kevin Boykin and Ailing Li. Emperipolesis In A Juvenile Xanthogranuloma: Sentinel Case Report and Review of the Literature
  • Knowles KJ, Xu H, Hamiter MJ, Lian TJ, Nathan CO, Li A. Biphenotypic Sinonasal Sarcoma successfully treated with complete excision of the tumor and facial reconstruction with flap: Case report and review of the literature.
  • Knowles KJ, Patel KS, Haque M, Alzubaid Y, Li A, Mneimneh WS, Turbat-Herrera EA. Rare and Unusual Tumors of the Head and Neck: Case Reports and Review of the Literature. Am J Otolaryngol Head Neck Surg. 2019; 2(8): 1066.
▼   John J. Lazarchick, M.D.

John J. Lazarchick, M.D.John J. Lazarchick, M.D.

Adjunct Assistant Professor

(251) 471-7790 

Board Certification

Anatomic and Clinical Pathology
Dermatopathology 

Education

M.D.: University of South Carolina
Anatomic and Clinical Pathology Residency: Emory University
Dermatopathology Fellowship: University of Oklahoma

▼   Carlina Madelaire, M.D.

Carlina Madelaire, M.D.Carlina Madelaire, M.D.

Assistant Professor

(251) 471-7799
cmadelaire@health.southalabama.edu 

Board Certification

Anatomic Pathology
Cytopathology

Education

Renal and Genitourinary Pathology Fellowship: Louisiana State University Health Science Center, Shreveport, LA
Cytopathology Fellowship: LSU Health Science Center, Shreveport, LA
Surgical Pathology Fellowship: University of Alabama at Birmingham, Birmingham, AL
Anatomic and Clinical Pathology Residency: MetroHealth Medical Center at Case Western Reserve University, Cleveland OH
General Surgery Residency: Santatorio Nosiglia, Argentina
Degree of Physician and Surgeon, National University of the Northeast (UNNE), Corrientes, Argentina

Publications

  • LIUY, C Cleveland, Madelaire C. Discordant Immunophenotype of Chronic B Cell Lymphoproliferative Disorder in Simultaneous Specimens from Bone Marrow and Peripheral Sites: A Possible Reflection of Disease Progression and Transformation. Arch Pathol Lab Med 1995; 119:53-58.
  • Rhodes RH, Madelaire CN, Petrelli M, Karaman BA. Primary Angiitiss and Angiopathy of the Central Nervous System and Their Relationship to Systemic Giant Cell Arteritis. Arch Pathol Lab Med 1995; 119:334-349.

Poster Presentation

  • Discordant Immunophenotype of Chronic B Cell Lymphoproliferative Disorder in Simultaneous Specimens from Bone Marrow and Peripheral Sites: A Possible Reflection of Disease Progression and Transformation. ASCP Meeting, Orlado, FL, 1994
▼   Elizabeth Ann Manci, M.D.

Elizabeth Manci, M.D.Elizabeth Ann Manci, M.D.

Professor
Director of Pediatric Pathology
Director of Centralized Pathology Unit for Sickle Cell Disease
Director of Alabama Placenta Registry

(251) 415-1612
emanci@health.southalabama.edu

Board Certification

Diplomate of American Board of Pathology (Anatomical Pathology, Clinical Pathology and Pediatric Pathology)

Education

M.D.: University of Alabama College of Medicine
Anatomic and Clinical Pathology Residency: University of Alabama
Anatomic and Clinical Pathology Residency: University of South Alabama

Publications

  • Shet AS, Hoffmann TJ, Jirouskova M, Janczak CA, Stevens JR, Adamson A, Mohandas N, Manci EA, Cynober T, Coller BS. Morphological and functional platelet abnormalities in Berkeley sickle cell mice. Blood Cells Mol Dis. 2008 Jul-Aug;41(1):109-18.
  • Hsu LL, Champion HC, Campbell-Lee SA, Bivalacqua TJ, Manci EA, Diwan BA, Schimel DM, Cochard AE, Wang X, Schechter AN, Noguchi CT, Gladwin MT. Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood. 2007 Apr 1;109(7):3088-98.
  • Manci EA, Hillery CA, Bodian CA, Zhang ZG, Lutty GA, Coller BS. Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. Blood. 2006 Feb 15;107(4):1651-8.
  • Manci EA, Martinez JE, Horenstein MG, Gardner TM, Ahmed A, Mancao MC, Gremse DA, Gardner DM, Nimityongskul P, Maertens P, Riddick L, Kavamura MI. Cardiofaciocutaneous syndrome (CFC) with congenital peripheral neuropathy and nonorganic malnutrition: an autopsy study. Am J Med Genet A. 2005 Aug 15;137(1):1-8.
  • Horenstein MG, Manci EA, Walker AB, Dehner LP. Lumbosacral ectopic nephrogenic rest unassociated with spinal dysraphism. Am J Surg Pathol. 2004 Oct;28(10):1389-92.
  • Manci EA, Culberson DE, Gardner JM, Brogdon BG, Shah AK, Holladay JE, Powell RW, Mankad VN. Perivascular fibrosis in the bone marrow in sickle cell disease. Arch Pathol Lab Med. 2004 Jun;128(6):634-9.
  • Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003 Dec 15;102(13):4582-93.
  • Manci EA, Culberson DE, Yang YM, Gardner TM, Powell R, Haynes J Jr, Shah AK, Mankad VN; Investigators of the Cooperative Study of Sickle Cell Disease. Causes of death in sickle cell disease: an autopsy study. Br J Haematol. 2003 Oct;123(2):359-65.
  • Mancao MY, Figarola MS, Wilson FM, Manci EA. Detection by CT scan of Penicillium sp. lesions in a patient with B-precursor acute lymphoblastic leukemia. Pediatr Radiol. 2003 Jan;33(1):66-8. Epub 2002 Mar 23.
  • Culberson DE, Manci EA, Shah AK, Haynes J, Ballas SK, Pegelow C, Vichinsky E. Nesidioblastosis in sickle cell disease. Pediatr Pathol Mol Med. 2001 Mar-Apr;20(2):155-65.
  • Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, Orringer E, McKie V, Bellevue R, Daeschner C, Manci EA. Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. N Engl J Med. 2000 Jun 22;342(25):1855-65.
  • Mvumbi L, Manci EA, Ulmer RD, Shah AK. Decreased placental and umbilical cord glycogen levels associated with meconium-stained amniotic fluid. Placenta. 1998 May;19(4):295-9.
  • Tuohy AM, McKie V, Manci EA, Adams RJ. Internal carotid artery occlusion in a child with sickle cell disease: case report and immunohistochemical study. J Pediatr Hematol Oncol. 1997 Sep-Oct;19(5):455-8.
  • Mvumbi L, Manci EA, Ulmer D, Shah AK. Glycogen levels in human term placental disks, umbilical cords, and membranes. Pediatr Pathol Lab Med. 1996 Jul-Aug;16(4):597-605.
  • Powell RW, Weber ED, Manci EA. Intradural extension of a sacrococcygeal teratoma. J Pediatr Surg. 1993 Jun;28(6):770-2.
  • Gremse DA, Boudreaux CW, Manci EA. Collagenous colitis in children. Gastroenterology. 1993 Mar;104(3):906-9
  • Manci EA, Culberson DE, Chen GJ, Mankad V, Joshi VV, Fujimura FK. Polymerase chain reaction facilitates archival autopsy studies of sickle cell disease. Pediatr Pathol. 1993 Jan-Feb;13(1):75-81.
  • Saenger JS, Mayer DC, D'Angelo LJ, Manci EA. Ductus-dependent fetal cardiac defects contraindicate indomethacin tocolysis. J Perinatol. 1992 Mar;12(1):41-7.
  • Pitt RM, McKelvey TG, Saenger JS, Shah AK, Jones HP, Manci EA, Powell RW. A tungsten-supplemented diet delivered by transplacental and breast-feeding routes lowers intestinal xanthine oxidase activity and affords cytoprotection in ischemia-reperfusion injury to the small intestine. J Pediatr Surg. 1991 Aug;26(8):930-5.
  • Manci EA, Coffin CM, Smith SM, Ganong CA. Placental vanadium in gestational diabetes mellitus. Placenta. 1989 Jul-Aug;10(4):417-25.
  • Manci EA. Excretion of lead by chronic blood loss. Med Hypotheses. 1988 Jun;26(2):97-8.
  • Kvietys PR, Smith SM, Grisham MB, Manci EA. 5-Aminosalicylic acid protects against ischemia/reperfusion-induced gastric bleeding in the rat. Gastroenterology. 1988 Mar;94(3):733-8.
  • Manci EA, Maisel DA, Conrad ME. Systemic necrotizing vasculitis in sickle cell disease. Am J Hematol. 1987 Sep;26(1):93-6.
  • Manci EA, Blackburn WR. Regional variations in the levels of zinc, iron, copper, and calcium in the term human placenta. Placenta. 1987 Sep-Oct;8(5):497-502.
  • Smith SM, Grisham MB, Manci EA, Granger DN, Kvietys PR. Gastric mucosal injury in the rat. Role of iron and xanthine oxidase. Gastroenterology. 1987 Apr;92(4):950-6.
  • Manci EA, Gardner WA Jr. Bruch's De Morbis Glandulae Prostatae: an early account of prostatic diseases (1835). Prostate. 1986;8(2):103-21.
  • Manci EA, Gardner LL, Pollock WJ, Dowling EA. Osteoclastic giant cell tumor of the pancreas. Aspiration cytology, light microscopy, and ultrastructure with review of the literature. Diagn Cytopathol. 1985 Apr-Jun;1(2):105-10.
  • Manci EA, Heath LS, Leinbach SS, Coggin JH Jr. Lymphoma-associated ulcerative bowel disease in the hamster (Mesocricetus auratus) induced by an unusual agent. Am J Pathol. 1984 Jul;116(1):1-8.
  • Manci EA, Balch CM, Murad TM, Soong SJ. Polypoid melanoma, a virulent variant of the nodular growth pattern. Am J Clin Pathol. 1981 Jun;75(6):810-5.
▼   Pamela Moore Campbell

Pamela V. MoorePamela Moore Campbell

Instructor, Pathologists Assistant

(251) 471-7790
pvmoore@health.southalabama.edu 

▼   Jacek M. Polski, M.D.

Jacek M. Polski, M.D.Jacek M. Polski, M.D.

Associate Professor
Hematopathology Laboratories Medical Director

(251) 471-7790
jpolski@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Hematopathology

Education

M.D.: Medical Academy of Lublin, Poland
Anatomic and Clinical Pathology Residency: St. Louis University, St. Louis, Missouri
Hematopathology Fellowship: St. Louis University, St. Louis, Missouri 

Publications

▼   Thuy L. Phung, M.D., Ph.D.

Thuy L. Phung, M.D., Ph.D.Thuy L. Phung, M.D., Ph.D.

Associate Professor
Director, Molecular Genetic Pathology and Dermatopathology

(251) 471-7790
tphung@health.southalabama.edu

Board Certification

Anatomic Pathology
Dermatopathology
Molecular Genetic Pathology

Education

M.D.: University of Rochester School of Medicine and Dentistry, Rochester, NY
Ph.D.: University of Rochester School of Medicine and Dentistry, Rochester, NY.
Anatomic Pathology Internship: Brigham and Women’s Hospital, Boston, MA
Anatomic Pathology Residency: Barnes-Jewish Hospital, Washington University, St. Louis, MO
Dermatopathology Clinical Fellowship: Harvard Medical School, Boston, MA
Vascular Biology Postdoctoral Research Fellowship: Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
Molecular Genetic Pathology Clinical Fellowship: Houston Methodist Hospital, Houston, TX

Publications

  1. Phung TL, Roncone A, Jensen KL, Sparks CE, Sparks JD. Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum. J Biol Chem 1997;272:30693-702.
  2. Phung TL, Hochman M, Mihm MC. Current knowledge of the pathogenesis of infantile hemangiomas. Arch Facial Plast Surg 2005;7:319-21.
  3. Sun JF, Phung T, Shiojima I, Felske T, Upalakalin JN, Feng D, Kornaga T, Dor T, Dvorak AM, Walsh K, Benjamin LE. Microvascular patterning is controlled by fine-tuning the Akt signal. Proc Natl Acad Sci U S A 2005;102:128-33.
  4. Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, Sessa WC, Dvorak HF, Benjamin LE. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell 2006;10:159-70.
  5. Phung TL, Eyiah-Mensah G, O'Donnell RK, Bieniek R, Shechter S, Walsh K, Kuperwasser C, Benjamin LE. Endothelial Akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res 2007;67:5070-5.
  6. Phung TL, Oble DA, Jia W, Benjamin LE, Mihm MC, Jr., Nelson JS. Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks. Lasers Surg Med 2008;40:1-5.
  7. Xue Q, Nagy JA, Manseau EJ, Phung TL, Dvorak HF, Benjamin LE. Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase. Arterioscler Thromb Vasc Biol 2009;29:1172-8.
  8. Kazerounian S, Gerald D, Huang M, Chin YR, Udayakumar D, Zheng N, O'Donnell RK, Perruzzi C, Mangiante L, Pourat J, Phung TL, Bravo-Nuevo A, Shechter S, McNamara S, Duhadaway JB, Kocher ON, Brown LF, Toker A, Prendergast GC, Benjamin LE. RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res 2012;73:50-61.
  9. Phung TL, Hochman M. Pathogenesis of infantile hemangioma. Facial Plast Surg 2012;28:554-62.
  10. Du W, Gerald D, Perruzzi CA, Rodriguez-Waitkus P, Enayati L, Krishnan B, Edmonds J, Hochman ML, Lev DC, Phung TL. Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin. Lab Invest 2013;93:1115-27.
  11. Phung TL. Molecular signaling pathways in infantile hemangioma. J SciMed Central Cell 2013;1:1004.
  12. Thuy L. Phung, Wa Du, Qi Xue, Sriram Ayyaswamy, Damien Gerald, Zeus Antonello, Sokha Nhek, Carole A. Perruzzi, Isabel Acevedo, Rajesh Ramanna-Valmiki, Paul Rodriguez-Waitkus, Ladan Enayati, Marcelo L. Hochman, Dina Lev, Sandaruwan Geeganage and Laura E. Benjamin. Akt1 and Akt3 exert opposing roles in the regulation of vascular tumor growth.  Cancer Research, Cancer Res; 75(1) January 1, 2015
  13. Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH.  Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming.  Nature. 2017 Apr 13;544(7649):250-254
  14. Thuy L Phung.  Mouse Skin Graft Model of Vascular Tumor.  Bio-Protocol, 2017, Vol 7, Iss 13
  15. Meghan Riddell, Akiko Nakayama, Takao Hikita, Fatemeh Mirzapourshafiyi, Takuji Kawamura, Ayesha Pasha, Mengnan Li, Mikio Masuzawa, Mario Looso, Tim Steinbacher, Klaus Ebnet5, Michael Potente, Tomonori Hirose, Shigeo Ohno, Ingrid Fleming, Stefan Gattenlöhner, Phyu P. Aung, Thuy Phung, Osamu Yamasaki, Teruki Yanagi, Hiroshi Umemura and Masanori Nakayama, “aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA binding ability” (Nature Communications, 2018 Dec 17;9(1):5357)
  16. Phung TL, Pipkin CA, Tahan SR, Chiu DS. Beta-lactam antibiotic-induced pseudoporphyria. J Am Acad Dermatol 2004;51:S80-2.
  17. Hu S, Kim CC, Jessup C, Phung TL, Curiel-Lewandrowski C. Primary cutaneous melanomas seen as inflamed pigmented lesions in patients undergoing adjuvant interferon treatment: a possible diagnostic clue for physicians. Arch Dermatol 2009;145:565-8.
  18. Metry DW, Garzon MC, Drolet BA, Frommelt P, Haggstrom A, Hall J, Hess CP, Heyer GL, Siegel D, Baselga E, Katowitz W, Levy ML, Mancini A, Maronn ML, Phung T, Pope E, Sun G, Frieden IJ. PHACE syndrome: current knowledge, future directions. Pediatr Dermatol 2009;26:381-98.
  19. Lahat G, Dhuka AR, Hallevi H, Xiao L, Zou C, Smith KD, Phung TL, Pollock RE, Benjamin R, Hunt KK, Lazar AJ, Lev D. Angiosarcoma: clinical and molecular insights. Ann Surg 2010;251:1098-106.
  20. Haws AL, Rojano R, Tahan SR, Phung TL. Accuracy of biopsy sampling for subtyping basal cell carcinoma. J Am Acad Dermatol 2012;66:106-11.
  21. Minh Van Hoang, Phuoc Van Dang, Duc Van Bui, Haider Mejbel, Divya Thomas-Mani, Bruce Smoller and Thuy Phung. “Acquired cutis laxa associated with cutaneous mastocytosis."  Dermatology Online Journal 2015; 21(7):4-7
  22. Mahmoud Bokhary and Thuy L. Phung.  Molecular Pathogenesis of Leprosy.  Current Tropical Medicine Reports, 2016. doi:10.1007/s40475-016-0094-y
  23. Hoang Van Minh, Bui Van Duc and Thuy L. Phung.  Clinical Characteristics and Treatment of Leprosy.  Current Tropical Medicine Reports, 2016. doi:10.1007/s40475-016-0095 
  24. Victoria Mitre, Danielle Brown, Thuy Phung and Raegan D. Hunt.  Classic Pseudoxanthoma Elasticum in a Girl with Sickle Cell Disease.  Pediatric Dermatology, 2018,1-2
  25. Ionela Iacobas, Thuy Phung, Denise M. Adams, Cameron C. Trenor III, Francine Blei, Douglas S. Fishman, Adrienne Hammill, Prakash M. Masand, and Steven J. Fishman.  “Guidance Document for Hepatic Hemangioma (Infantile and Congenital) Evaluation and Monitoring," J Pediatr 2018;203:294-300
  26. Iacobas Ionela, Adams Denise M, Pimpalwar Sheena, Phung Thuy, Blei Francine, Burrows Patricia, Lopez-Gutierrez Juan Carlos, Levine Michael A, Trenor Cameron IIIrd.  “Multidisciplinary Guidelines for Initial Evaluation of Complicated Lymphatic Anomalies – Expert Opinion Consensus”, Pediatr Blood Cancer. 2020 Jan;67(1):e28036. doi: 10.1002/pbc.28036. Epub 2019 Oct 16.
  27. Huang JT, Coughlin CC, Hawryluk EB, Hook K, Humphrey SR, Kruse L, Lawley L, Al-Sayegh H, London WB, Marghoob A, Phung TL, Pope E, Gerami P, Schmidt B, Robinson S, Bartenstein D, Bahrani E, Brahmbhatt M, Chen L, Haddock E, Mansour D, Nguyen J, Raisanen T, Tran G, Travis K, Wolner Z, Eichenfield LF. "Risk Factors and Outcomes of Nonmelanoma Skin Cancer in Children and Young Adults", J Pediatr. 2019 Aug;211:152-158. doi: 10.1016/j.jpeds.2019.04.017. Epub 2019 May 15
  28. Sudhen B. Desai, MD, Raphael C. Sun, MD, Brittany L. Johnson, MD, Kristy L. Rialon, MD , Ionela Iacobas, MD, Kamlesh U. Kukreja, MD, Deborah A. Schady, MD, Thuy Phung, MD, PhD, Sridhar Sanvitha, Bindi J. Naik-Mathuria, MD, MPH, "Renal Lymphangiectasia in a Pediatric Patient", Lymphatic Research and Biology (in press)
  29. A. Surinach, T. Phung, O. Abdul-Rahim, M. Khushman.  "Prolonged (51 weeks) response to liposomal irinotecan in a patient with stage IV pancreatic/bile duct cancer previously treated with FOLFIRINOX and gemcitabine plus nab-paclitaxel", Current Oncology (in press)
  30. Smith RJ, Metry D, Deardorff MA, Heller E1, Grand KL, Iacobas I, Rubin AI, Phung TL, Lopez-Terrada D, Steicher J, Cahill AM, Low D, Treat JR. "Segmental congenital hemangiomas: Three cases of a rare entity," Pediatr Dermatol. 2020 Apr 7. doi: 10.1111/pde.14143

Book Chapter

  1. Chad J. Jessup, Megan K. Dishop, Denise W. Metry, Linda Rozell-Shannon, Thuy L. Phung, and Martin C. Mihm Jr., Pathology of Congenital Vascular Lesions. In: Vascular Lesions of the Head and Neck: Diagnosis and Management (Editors: Persky, Waner, Blei and Berenstein) Thiema Medical Publishers, 2015.

Medical Textbook

  1. Thuy L. Phung, Teresa S. Wright, Crystal Y. Pourciau and Bruce R. Smoller. “Pediatric Dermatopathology”, Spinger-Verlag, 2017, ISBN 978-3-319-44822-0. This is the only comprehensive textbook in pediatric skin pathology currently available. http://www.springer.com/la/book/9783319448220#aboutBook (rated among the top 25% most downloaded eBooks in Springer’s respective eBook Collection in 2018)
▼   Chandrani Sarkar, Ph.D.

Chandrani Sarkar, Ph.D.Chandrani Sarkar, Ph.D.

Assistant Professor
Member, Cancer Biology Program, Mitchell Cancer Institute

(251) 445-9871
csarkar@southalabama.edu 

Education

Post-doctoral Research Fellow: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN
Ph.D., Cancer Biology: Chittaranjan National Cancer Institute (Jadavpur University), India
M.S., Applied Clinical and Preclinical Research (MACPR): The Ohio State University, Columbus, OH
M.S., Zoology: Visva Bharati University, India 

Selected Publications

  1. Chakroborty D, Goswami S, Basu S, Sarkar C. Catecholamines in the regulation of angiogenesis in cutaneous wound healing. FASEB J. 2020 Nov;34(11):14093-14102. doi: 10.1096/fj.202001701R. Epub 2020 Sep 19. PMID: 32949437.
  2. Sarkar C, Goswami S, Basu S, Chakroborty D. Angiogenesis Inhibition in Prostate Cancer: An Update. Cancers (Basel). 2020 Aug 23;12(9):2382. doi: 10.3390/cancers12092382. PMID: 32842503; PMCID: PMC7564110.
  3. Sarkar C, Ganju RK, Pompili VJ, Chakroborty D. Enhanced peripheral dopamine impairs postischemic healing by suppressing angiotensin receptor type 1 expression in endothelial cells and inhibiting angiogenesis. Angiogenesis. 2017;20(1):97-107. doi: 10.1007/s10456-016-9531-8.
  4. Chakroborty D, Sarkar C, Lu K, Bhat M, Dasgupta PS, Basu S. Activation of Dopamine D1 receptors in dermal fibroblasts restores vascular endothelial growth factor-A production by these cells and subsequent angiogenesis in diabetic cutaneous wound tissues. Am J Pathol. 2016; 186(9):2262-70. doi: 10.1016/j.ajpath.2016.05.008.
  5. Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine is a safe anti-angiogenic drug which can also prevent 5-fluorouracil induced neutropenia. Int J Cancer. 2015;137:744-9. doi: 10.1002/ijc.
  6. Joseph M, Das M, Kanji S, Lu J, Aggarwal R, Chakroborty D, Sarkar C, Yu H, Mao H-Q, Basu S, Pompili VJ, Das H. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials. 2014; 35(30):8566-75. doi: 10.1016/j.biomaterials.2014.06.037
  7. Lu K, Chakroborty D, Sarkar C, Lu T, Xie Z, Liu Z, Basu S. Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis. PLoS One. 2012;7(8):e43934. PMID: 22937129.
  8. Sarkar C, Chakroborty D, Basu S. Neurotransmitters as regulators of tumor angiogenesis and
    immunity: The role of catecholamines. J Neuroimmune Pharmacol. 2013;8(1):7-14. PMID:
    22886869
  9. Chakroborty D, Sarkar C , Yu H, Wang J, Liu Z, Dasgupta PS, Basu S. Dopamine stabilizes tumor blood vessels by up-regulating angiopoietin 1 expression in pericytes and Kruppel-like factor-2 expression in tumor endothelial cells. Proc Natl Acad Sci U.S.A. 2011;108(51):20730- 20735. PMID: 22143796.
  10. Shome S, Rana T, Ganguly S, Basu B, Chaki Choudhury S, Sarkar C, Chakroborty D, Dasgupta PS, Basu S. Dopamine regulates angiogenesis in normal dermal wound tissues. PLoS One. 2011;6(9):e25215. PMID: 21949884.
  11. Sarkar C, Basu B, Chakroborty D, Dasgupta PS, Basu S. The immunoregulatory role of
    dopamine: An update. Brain Behav Immun. 2010 May;24(4):525-528. PMID: 19896530.
  12. Basu B, Sarkar C, Chakroborty D, Ganguly S, Shome S, Dasgupta PS, Basu S. D1 and D2 dopamine receptor-mediated inhibition of activated normal T cell proliferation is lost in jurkat T leukemic cells. J Biol Chem. 2010;285(35):27026-27032. PMID: 20592018.
  13. Chakroborty D, Sarkar C, Basu B, Dasgupta PS, Basu S. Catecholamines regulate tumor
    angiogenesis. Cancer Res. 2009 May;69(9):3727-3730. Review. PMID: 19383906
  14. Sarkar C, Chakroborty D, Chowdhury UR, Dasgupta PS, Basu S. Dopamine increases the efficacy of anticancer drugs in breast and colon cancer preclinical models. Clin Cancer Res.2008;14(8):2502-2510. PMID: 18413843
  15. Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS, Basu S. Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. J Clin Invest. 2008;118(4):1380-1389. PMID: 18340382
  16. Sarkar C, Das S, Chakroborty D, Chowdhury UR, Basu B, Dasgupta PS, Basu S. Cutting edge: Stimulation of dopamine D4 receptors induce T cell quiescence by up-regulating Kruppel-like factor-2 expression through inhibition of ERK1/ERK2 phosphorylation. J Immunol. 2006;177(11):7525-7529. PMID: 17114421. [Cutting Edge]
  17. Sarkar C, Chakroborty D, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Dopamine in vivo inhibits VEGF-induced phosphorylation of VEGFR-2, MAPK, and focal adhesion kinase in endothelial cells. Am J Physiol Heart Circ Physiol. 2004 Oct;287:H15554-1560. PMID: 15371263.
  18. Basu S, Sarkar C, Chakroborty D, Nagy J, Mitra RB, Dasgupta PS, Mukhopadhyay D. Ablation of peripheral dopaminergic nerves stimulates malignant tumor growth by inducing vascular permeability factor/vascular endothelial growth factor-mediated angiogenesis. Cancer Res. 2004;64(16):5551-5555. PMID: 15313889 [Advances in Brief].
  19. Chakroborty D, Sarkar C, Mitra RB, Banerjee S, Dasgupta PS, Basu S. Depleted dopamine in gastric cancer tissues: Dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clin Cancer Res. 2004 Jul;10:4349-4356. PMID: 15240521 [Featured Article].
▼   Mingxia Shi, M.D.

Mingxia Shi, M.D.Mingxia Shi, M.D.

Assistant Professor

(251) 471-7790
mshi@health.southalabama.edu 

Board Certification

Anatomic and Clinical Pathology
Cytopathology

Education

Cytopathology Fellowship: Louisiana State University Health Science Center, Shreveport, LA
Anatomic and Clinical Pathology Residency, LSU Health Science Center, Shreveport, LA
M.S. Molecular Biology: University of Louisiana, Lafayette, LA
M.Med. Pathology: Shanghai Medical College, Fundan University, Shanghai, China
MD: Huazong University of Science and Technology, Tongji Medical College, Wuhan, China

Publications

  1. Xu, H., Feng, X., Lockhart, V., Cotelingam, J., Veillon, D., Shi, M. Angiomyomatous hamartoma in the inguinal lymph node: A case report and literature review. Human Pathology: Case Reports. 19 (2020) 200351
  2. Mirza, R., Shi, M. Large Pleomorphic Carcinoma of the Lung: A Case Report.  Human Pathology: Case Reports.  Volume 16, June 2019, 200309.
  3. Guidry, J., Myers, J., Bienkowska-Haba M., Songock, W., Ma, X., Shi, M., Nathan, C., Sapp, M., Scott, R. Inhibition of Epstein-Barr Virus Replication in Human Papillomavirus-Immortalized Keratinocytes. J Virol. 2019 Jan 4; 93(2).  doi: 10.1128/JVI.01216-18. Print 2019 Jan 15.
  4. Mirza, R., Ellsworth, S.K., King, J.A., Shi, M. Cutaneous Metastasis of Renal Cell Carcinoma: Fine Needle Aspiration Provides Rapid Diagnosis. Clin Case Rep. 2018 Dec 14; 7(1):218-221.
  5. Shi, M., Xu, H., Sangster, G. & Gu, X. Pulmonary Metastases from an Undifferentiated Embryonal Sarcoma of the Liver: A Case Report and Review. Case Rep Oncol Med. 2018 Sep 4; 2018:7840865. doi: 10.1155/2018/7840865.
  6. Shi, M., Xu, H., DiPoto Brahmbhatt, A., Gonzalez-Toledo, E. & Georgescu, M. Hemorrhagic Brain Metastases in a Patient with ALK-Rearranged Invasive Mucinous Adenocarcinoma of the Lung.  Am J Case Rep. 2018 Jan 26; 19:99-104
  7. Shi, M., Al-Delfi, F., Al Shaarani, M., Knowles, K. & Cotelingam, J.D. Ovarian Adenomatoid Tumor Co-Existing with Mature Cystic Teratoma: A Rare Case Report. Case Rep Obstet Gynecol. 2017; 2017:3702682. doi: 10.1155/2017/3702682.
  8. Jiang, R., Ekshyyan, O., Moore-Medlin, T., Rong, X., Gu, X., Abreo, F., Shi, M., Guidry, J., Scott, R., Hutt-Fletcher, L., Nathan, C. Association between HPV/EBV co-infection and oral carcinogenesis. J Oral Pathol Med. 2015 Jan; 44(1): 28–36.
  9. Shi, M., Gan, Y., Davis, T.O. and Scott, R.S.  Downregulation of the Polyamine Regulator Spermidine/Spermine N1-Acetyltransferase by Epstein- Barr Virus in a Burkitt’s Lymphoma Cell Line.  Virus Research.  October 177(1):11-21 (2013)
  10. Queen,K.J., Shi, M., Zhang, F., Gvek, U. and Scott, R.S.  Epstein-Barr Virus Induced Epigenetic Alterations Following Transient Infection.  International Journal of Cancer.  May 1; 132(9):2076-86 (2013)
  11. Repic, A.M., Shi, M., Scott, R.S. & Sixbey, J.W.  Augmented LMP1 Expression from Epstein-Barr Virus (EBV) Episomes with Minimal Terminal Repeats.  Journal of Virology.  84(5):236-44 (2010)
  12. Zhu, L., Lavoir, M-C., Albanese, J., Shi, M., Etches, R. J. Production of Human Monoclonal Antibody in Eggs of Chimeric Chickens.  Nature Biotechnology.  23 (9):1159-1169 (2005)
  13. Zhou, J., Shi, M., Mitchell, T.D., Smagin, G.N., Thomas, S.R., Ryan, D.H. & Harris, R.B.  Changes in Rat Adipocyte and Liver Glucose Metabolism Following Repeated Restraint Stress. Experimental Biology and Medicine (Maywood).  226(4), 312-9 (2001)
  14. Harris, R.B., Zhou, J., Shi, M., Redmann, S., Mynatt, R.L. & Ryan, D.H.  Overexpression of Agouti Protein and Stress Responsiveness in Mice.   Physiology & Behavior.  73(4), 599-608 (2001)
  15. Shi,M., Yan, D., Ryan, H. & Harris, R.B.  Identification of Urocortin mRNA Antisense Transcripts in Rat Tissue.  Brain Research Bulletin.  53 (3), 317-24 (2000).
  16. Ennis, D.G., Woodgate, R., Shi, M.  Selective Inhibition of RecA Functions by the Hc1 Nucleoid Condensation Protein from Chlamydia Trachomatis.  FEMS Microbiology Letters.  182 (2), 279-83 (2000)
  17. Shi, M. & Zhu, S. Relationship Between Hepatocellular Carcinoma and Hepatitis C Virus infection. Foreign Medical Sciences in Tumor.  19 (1), 5 -10 (1992).
  18. Shi, M. & Zhu, S. Expression of Hepatitis C Virus Antigens on Hepatocytes in Human Hepatic Diseases.  Acta Academiae Medicinae Shanghai   19 (2), 94 - 99 (1992).
  19. Shi, M.  Association Between Hepatitis C Virus Infection and Hepatocellular Carcinoma.  Research Advances in Viral Liver Diseases.  Chinese Science and Technology Press, Beijing,  pp 204-215 (1992).
  20. Shi, M. Detection of Hepatic Amyloidosis Using a Novel Method.  Acta Academiae Medicinae Yunyang  2 (1), 5-6 (1987)

Presentations / Abstracts / Posters

  1. Shi, M., Yang, S., Shi, R., Lopez Matias, L., Yu, X. Expression of FOXA1 and EZH2 in Breast Cancer and Association with Clinicopathological Features and TP53/RB1 Alterations. Abstract/Poster.  Accepted for USCAP 2020 Annual Meeting (109th), Los Angeles, California, February 29-March 5, 2020.
  2. Shi, M., Yang, S., Khalil, I., Chen, F., Yu, X. The Expression of EZH2 and Polycomb Genes in Neuroendocrine Prostate Cancer. Abstract/Poster.  USCAP 2019 Annual Meeting (108th), National Harbor, Maryland, March 16-21, 2019.
  3. Kurian, S., Shi, M., Mirfakhraee, M., Nathan, C. O.  Intratracheal Ectopic Parathyroid: An Unexpected Diagnosis. Selected for poster presentation at the Triological Society 2019 Combined Sections Meeting; January 24-26, 2019, Coronado, California.
  4. Nowack, B., Shi, M., Chadha, M., Virk, C., Aziz, M., Yang, Z. Indium-111 WBC and Gallium-67 SPECT/CT Evaluation of Infection: A Head-to-Toe Case-Based Review. Educational exhibit at the 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America; Nov. 25-30, 2018; Chicago, IL.
  5. Shi, M., Connelly, Z., Yang, S., Zhang, X., Morrissey, C., Corey, E., Shi, R., Yu, X.  FOXA2 Protein Expression Is Associated with Neuroendocrine Phenotype and Androgen Receptor Status in the Metastatic Castration-Resistant Prostate Cancer. Abstract/Poster.  USCAP 2018 Annual Meeting (107th), Vancouver, BC, Canada, March 2018.
  6. Alzubaidi, Y., Abdulsattar, J., Shi, M. Juvenile Xanthogranuloma: An Infrequent Lesion in an Uncommon Location. Abstract/Poster.  College of American Pathologists (CAP) The Pathologists Meeting 2017, National harbor, MD, October 2017.
  7. Alattia, L., Knowles , K., Shi, M., Georgescu, M. Neuroendocrine carcinoma of the breast: An underdiagnosed neoplasm with enhanced metastatic potential. Abstract/Poster. American Society for Clinical Pathology (ASCP) 2017 Annual Meeting.  Chicago, IL.  September 2017.
  8. Shi, M., Guidry, J., Scott, R.S.  HPV-Induced Changes to the EBV Life Cycle in an EBV/HPV Co-Infection Model Utilizing Organotypic Raft Culture.  Abstract/Poster.  USCAP 2017 Annual Meeting (106th), San Antonio, TX, March 2017.
  9. Shi, M., Birdwell, C., Prouty, L. and Scott, R.S. EBV Infection of Oral Keratinocytes leads to a Cellular Epigenetic  Alteration  that is Retained After Loss of the Virus.  Abstract/Poster.  USCAP 2015 Annual Meeting (104th), Boston, MA, March 2015.
  10. Shi, M., Jiang, R., Ekshyyan, O., Nathan, C.O., Hutt-Fletcher. L. and Scott, R.S. Enhancement of Cellular Tumorigenic Potential by Human Papilloma Virus and Epstein-Barr Virus Co-infection.  Abstract/Poster.  USCAP 2013 Annual Meeting (102th), Baltimore, MD. March 2013.
  11. Queen, K.J., Shi, M. and Scott, R.S. Epigenetic Alterations as a Mark for Past Epstein-Barr Virus Infection.  Abstract/Talk.  South Central Branch of the American Society for Microbiology Annual Meeting. Monroe, LA. December 2011.
  12. Queen, K.J., Shi, M. and Scott, R.S. Hit-and-Run Carcinogenesis via Epstein-Barr Virus-Induced Epigenetic Imprinting.  Abstract/Poster P6-10 presentation by RSS. Department of Defense Breast Cancer Research Program Era of Hope 2011 Conference. Orlando, FL. August 2011.
  13. Queen, K.J., Shi, M. and Scott, R.S.  Epigenetic Alterations as a Mark for Past Epstein-Barr Virus Infection. Poster. 9th Annual Meeting, Louisiana Biomedical Research Network. Shreveport, LA. January 2011.
  14. Queen, K.J., Shi, M. and Scott, R.S. Epigenetic Alterations as a Mark for Past Epstein-Barr Virus Infection.  Abstract/Poster.  Biennial Meeting of the International Association for EBV Research. Birmingham, United Kingdom. September 2010.
  15. Zhang, F., Shi, M. & Scott, R.S. Persistence of a P3HR-1-Dereved Heterogeneous EBV DNA in the Absence of Parental Virus in Epithelial Cells. Presented at 35th International Herpesvirus Workshop. Salt Lake City, Utah, July 2010.
▼   Ajay Singh, Ph.D.

Ajay Singh, Ph.D.Ajay Singh, Ph.D.

Professor
Director of Research
Program Leader, Cancer Biology, Mitchell Cancer Institute
Professor, Oncologic Sciences, Mitchell Cancer Institute
Adjunct Professor, Dept. of Biochemistry and Molecular Biology
Head, Tumor Microenvironment Laboratory

Office: (251) 445-9843
Lab: (251) 445-9874
asingh@health.southalabama.edu 
asingh@southalabama.edu

Education

Ph.D.: Devi Ahilya University, Indore, Madhya Pradesh, India
M.S.: Aligarh Muslim University, Aligarh, Uttar Pradesh, India

Selected Publications

  1. Saranyutanon S, Deshmukh SK, Dasgupta S, Pai S, Singh S, Singh AP. (2020) Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research. Cancers. 12(9):E2651. doi: 10.3390/cancers12092651.
  2. Kanchanapally R, Khan MA, Deshmukh SK, Srivastava SK, Khushman M, Singh S, and Singh AP (2020). Exosomal formulation escalates cellular uptake of honokiol leading to enhancement of its anti-tumor efficacy. ACS Omega. 5(36):23299-23307. doi: 10.1021/acsomega.0c03136.
  3. Anand S, Khan MA, Khushman, M, Dasgupta S, Singh S, Singh AP (2020). Comprehensive analysis of expression, clinicopathological association, and prognostic significance of RABs in pancreatic cancer. Int J Mol Sci., 21(15):5580. doi: 10.3390/ijms21155580
  4. Zubair H, Khan MA, Anand S, Srivastava SK, Singh S, Singh AP (2020). Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy. Semin Cancer Biol. S1044-579X(20)30105-X. doi: 10.1016/j.semcancer.2020.05.009. Online ahead of Print
  5. Khan MA, Srivastava SK, Zubair H, Patel GK, Arora S, Khushman M, Carter JE, Gorman GS, Singh S, Singh AP (2020). Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer. J Biol Chem. 295(25):8413-8424. doi: 10.1074/jbc.RA119.011748.
  6. Zubair H, Patel GK, Khan MA, Azim S, Zubair A, Singh S, Srivastava SK and Singh AP (2020). Proteomic analysis of MYB-regulated secretome identifies functional pathways and Biomarkers: Potential pathobiological and clinical implications. J. Proteome Res. 19 (2): 794-804
  7. Khan MA, Zubai H, Anand S, Srivastava SK, Singh and Singh AP (2020) Dysregulation of metabolic enzymes in tumor and stromal cells: role in oncogenesis and therapeutic opportunities. Cancer Lett. 473: 176-185
  8. Saranyutanon S, Srivastava SK, Pai S, Singh S and Singh AP (2020) Therapies targeted to androgen receptor signaling axis in prostate cancer: Progress, challenges and hope. Cancers (Basel) 12 (1): 51 https://doi.org/10.3390/cancers12010051
  9. Patton MC, Zubair H, Khan MA, Singh S, Singh AP. (2020) Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival. J Cell Biochem. 121(1):828-839 doi: 10.1002/jcb.29328 (featured on the Journal Cover Page)
  10. Patel GK, Khan MA, Zubair H, Srivastava SK, Khushman M, Singh S, Singh AP (2019) Comparative analysis of exosome isolation methods for optimum yield, purity and downstream applications. Scientific Reports 29;9(1):5335. doi: 10.1038/s41598-019-41800-2
  11. Deshmukh SK, Tyagi N, Khan MA, Srivastava SK, Al-Ghadhban A, Dugger K, Carter JE, Singh S, Singh AP. (2018) Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages. Sci Rep. 8(1):12000. doi: 10.1038/s41598-018-30437-2.
  12. Srivastava S, Ahmad A, Miri O, Patel GK, Singh S, Rocconi R, Singh AP (2017) Racial health disparities in ovarian cancer: not just black and white. J. Ovarian Res. 10(1):58. doi: 10.1186/s13048-017-0355-y
  13. Zubair H, Bhardwaj A, Ahmad A, Srivastava SK, Khan MA, Patel GK, Singh S, Singh AP (2017) Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells. Nutr. Cancer. 18:1-11. doi: 10.1080/01635581.2017.1339818.
  14. Srivastava SK, Ahmad A, Zubair H, Miree O, Singh S, Rocconi RP, Scalici J, Singh AP (2017). MicroRNAs in gynecological cancers: Small molecules with big implications. Cancer Lett. pii: S0304-3835(17)30333-6. doi: 10.1016/j.canlet.2017.05.011.
  15. Khan MA, Azim S, Zubair H, Bhardwaj A, Patel GK, Khushman M, Singh S, Singh AP. (2017). Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward. Int J Mol Sci., 18(4). pii: E779. doi: 10.3390/ijms18040779.
  16. Ross J, Braswell KV, da Silva LM, Mujica F, Stutsman S, Finan MA, Nicolson W, Harmon MD, Missanelli M, Cohen A, Singh AP, Scalici JM, Rocconi RP (2017). Unraveling the etiology of ovarian cancer racial disparity in the deep south: Is it nature or nurture? Gynecol Oncol. pii: S0090-8258(17)30146-4. doi: 10.1016/j.ygyno.2017.02.025.
  17. Ahmad A., Azim S., Zubair H., Khan M.A., Singh S., Carter J.E., Rocconi R., Singh A.P. (2017). Epigenetic basis of cancer health disparities: looking beyond genetic differences. BBA Rev. in Cancer 1868(1):16-28. doi: 10.1016/j.bbcan.2017.01.001.
  18. Patel G., Khan M.A., Bhardwaj A., Srivastava S.K., Zubair H., Patton M., Singh S., Khushman M., and Singh A.P. (2017) Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS-detoxification and miR-155-mediated suppression of key gemcitabine-metabolizing enzyme, DCK. Brit. J. Cancer. 116(5):609-619. doi: 10.1038/bjc.2017.18.
  19. Zubair H., Azim S., Srivastava S.K., Ahmad A., Bhardwaj A., Khan M.A., Patel G., Arora S., Carter J.E., Singh S., and Singh A.P. (2016). Glucose metabolism reprogrammed by overexpression of IKK-epsilon promotes pancreatic tumor growth. Cancer Res. 76(24); 7254–64.
  20. Averett C., Bhardwaj A., Arora S., Srivastava S.K., Khan M.A., Ahmad A., Singh S., Carter J.E., Khushman M., Singh A.P. (2016) Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk. Carcinogenesis. 37(11):1052-1061. doi: 10.1093/carcin/bgw096.
  21. Azim S., Zubair H., Srivastava S.K., Bhardwaj A., Zubair A., Ahmad A., Singh S., Khushman M., and Singh A.P. (2016) Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer. Sci. Rep. 6:28446
  22. Bhardwaj A, Srivastava SK, Singh S, Tyagi N, Arora S, Carter JE, Khushman M, Singh AP. (2016) MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin. J. Biol Chem. 291(31):16263-70
  23. Srivastava S., Bhardwaj A. Arora S., Singh S., Azim, S., Tyagi N., Carter, J.E., Wang B., and Singh A.P. (2015). MYB is a novel regulator of pancreatic tumor growth and metastasis. Brit. J. Cancer 113(12):1694-703
  24. Srivastava S., Arora S., Bhardwaj A. Tyagi N., Singh S., Andrews J., McClellan S., and Singh A.P. (2015). MicroRNA-345 confers apoptosis-resistance to pancreatic cancer cells via caspase-dependent and independent pathways. Brit. J. Cancer 113(4):660-8.
  25. Khan M.A., Srivastava S.K., Bhardwaj A., Singh S., Arora S., Zubair H., Carter J.E., Singh A.P. (2015) Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: therapeutic implications. Oncotarget 6(36):39140-50.
  26. Bhardwaj A., Srivastava S.K., Singh S., Arora S., Andrews J., McClellan S., Singh A.P. (2014) CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4- dependent activation of LIM domain kinase 1. Oncotarget 5(22):11490-500
  27. Arora S., Swaminathan S.K., Kirtane A., Srivastava S.K., Bhardwaj A., Singh S., Panyam J., and Singh A.P. (2014) Synthesis, characterization and evaluation of poly (D, L-lactide-co-glycolide)-based nanoformulation of miR-150: potential implications for pancreatic cancer therapy. Int. J. Nanomed. 18(9):2933-42
  28. Bhardwaj A., Singh S., Srivastava S.K., Arora S., Hyde S., Andrews J., Grizzle W.E. and Singh A.P. (2014) Restoration of PPP2CA reverses epithelial to mesenchymal transition and suppresses prostate tumor growth and metastasis in orthotopic mouse model. Br. J. Cancer.110(8): 2000-10
  29. Srivastava S.K., Arora S., Singh S., Bhardwaj A., Averett C. and Singh A.P. (2014) MicroRNAs in pancreatic malignancy: progress and promises. Cancer Lett. 347(2): 167-74
  30. Arora,S., Bhardwaj, A., Singh, S., Srivastava, S.K., McClellan, S., Nirodi, C.S., Piazza G., Grizzle W.E., Owen, L,B., and Singh, A.P. (2013). An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell aggressiveness through ROS-dependent, NF-κB- and HIF-1α-mediated upregulation of CXCR4. J. Biol. Chem. 288(29):21197-207
  31. Singh, A.P., Arora,S., Bhardwaj, A., Srivastava, S.K., Kadakia, M.P., Wang, B., Grizzle W.E., Owen, L,B., and Singh, S (2012). CXCL12/CXCR4 signaling axis induces SHH expression in pancreatic cancer cells via ERK- and Akt- mediated activation of NF-κB: implications for bidirectional tumor-stromal interactions. J. Biol. Chem. 287(46): 39115-24
  32. Srivastava S.K., Bhardwaj A., Singh S. Arora S., McClellan S., Grizzle W.E., Reed E. and Singh A.P. (2012) Myb overexpression overrides androgen depletion- induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration-resistance. Carcinogenesis 33(6):1149-57
  33. Srivastava S.K., Bhardwaj A., Singh S., Arora S., Wang B., Grizzle W.E., and Singh A.P. (2011) MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis 32(12): 1832-9
  34. Bhardwaj A., Singh S., Srivastava S.K., Honkanen R.E., Reed E., and Singh A.P. (2011) Modulation of protein phosphatase 2A (PP2A) activity alters androgen-independent growth of prostate cancer cells: therapeutic implications. Mol Cancer Ther. 10(5): 720-731 (featured in “highlights of the issue”, p709)
  35. Singh S., Srivastava S.K., Bhardwaj A., Owen L.B., and Singh A.P. (2010) CXCL12-CXCR4 signaling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy. Brit. J. Cancer 103(11): 1671-1679.
▼   Seema Singh, Ph.D.

Seema Singh, Ph.D. Seema Singh, Ph.D.

Professor
Head, Inflammation and Immunobiology Laboratory
Professor, Oncologic Sciences, Mitchell Cancer Institute
Senior Member, Cancer Biology Program, Mitchell Cancer Institute
Adjunct Associate Professor, Dept. of Biochemistry and Molecular Biology

Office: (251) 445-9844
Lab: (251) 445-9872
seemasingh@health.southalabama.edu
seemasingh@southalabama.edu

Education

Ph.D.: Aligarh M University, Aligarh, Uttar Pradesh, India
M.S.: Aligarh M University, Aligarh, Uttar Pradesh, India

Selected Publications

  1. Sudan SK, Deshmukh SK, Poosarla T, Holliday NP, Dyess DL, Singh AP, Singh S. Resistin: An inflammatory cytokine with multi-faceted roles in cancer. Biochim Biophys Acta Rev Cancer. 2020 Aug 19;1874(2):188419. doi: 10.1016/j.bbcan.2020.188419. [Epub ahead of print] Review. PubMed PMID: 32822824.
  2. Kanchanapally R, Khan MA, Deshmukh SK, Srivastava SK, Khushman M, Singh S, Singh AP. Exosomal Formulation Escalates Cellular Uptake of Honokiol Leading to the Enhancement of Its Antitumor Efficacy. ACS Omega. 2020 Sep 15;5(36):23299-23307. doi: 10.1021/acsomega.0c03136. eCollection 2020 Sep 15. PubMed PMID: 32954181; PubMed Central PMCID: PMC7495913.
  3. Khan MA, Srivastava SK, Zubair H, Patel GK, Arora S, Khushman M, Carter JE, Gorman GS, Singh S, Singh AP. Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer. J Biol Chem. 2020 Jun 19;295(25):8413-8424. doi: 10.1074/jbc.RA119.011748. Epub 2020 May 1. PubMed PMID: 32358063; PubMed Central PMCID: PMC7307206.
  4. Zubair H, Khan MA, Anand S, Srivastava SK, Singh S, Singh AP. Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy. Semin Cancer Biol. 2020 May 26;. doi: 10.1016/j.semcancer.2020.05.009. [Epub ahead of print] Review. PubMed PMID: 32470379.
  5. Khan MA, Zubair H, Anand S, Srivastava SK, Singh S, Singh AP. Dysregulation of metabolic enzymes in tumor and stromal cells: Role in oncogenesis and therapeutic opportunities. Cancer Lett. 2020 Mar 31;473:176-185. doi: 10.1016/j.canlet.2020.01.003. Epub 2020 Jan 7. Review. PubMed PMID: 31923436; PubMed Central PMCID: PMC7067140.
  6. Deshmukh SK, Srivastava SK, Poosarla T, Dyess DL, Holliday NP, Singh AP, Singh S. Inflammation, immunosuppressive microenvironment and breast cancer: opportunities for cancer prevention and therapy. Ann Transl Med. 2019 Oct;7(20):593. doi: 10.21037/atm.2019.09.68. Review. PubMed PMID: 31807574; PubMed Central PMCID: PMC6861749.
  7. Chavva SR, Deshmukh SK, Kanchanapally R, Tyagi N, Coym JW, Singh AP, Singh S. Epigallocatechin Gallate-Gold Nanoparticles Exhibit Superior Antitumor Activity Compared to Conventional Gold Nanoparticles: Potential Synergistic Interactions. Nanomaterials (Basel). 2019 Mar 8;9(3). doi: 10.3390/nano9030396. PubMed PMID: 30857226; PubMed Central PMCID: PMC6474148.
  8. Kanchanapally R, Deshmukh SK, Chavva SR, Tyagi N, Srivastava SK, Patel GK, Singh AP, Singh S. Drug-loaded exosomal preparations from different cell types exhibit distinctive loading capability, yield, and antitumor efficacies: a comparative analysis. Int J Nanomedicine. 2019;14:531-541. doi: 10.2147/IJN.S191313. eCollection 2019. PubMed PMID: 30666112; PubMed Central PMCID: PMC6333392.
  9. Frankel AE, Deshmukh S, Reddy A, Lightcap J, Hayes M, McClellan S, Singh S, Rabideau B, Glover TG, Roberts B, Koh AY. Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419846379. doi: 10.1177/1534735419846379. Review. PubMed PMID: 31014119; PubMed Central PMCID: PMC6482659.
  10. Deshmukh SK, Singh AP, Singh S. ETV4: an emerging target in pancreatic cancer. Oncoscience. 2018 Sep;5(9-10):260-261. doi: 10.18632/oncoscience.471. eCollection 2018 Sep. PubMed PMID: 30460327; PubMed Central PMCID: PMC6231443.
  11. Deshmukh SK, Tyagi N, Khan MA, Srivastava SK, Al-Ghadhban A, Dugger K, Carter JE, Singh S, Singh AP. Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages. Sci Rep. 2018 Aug 10;8(1):12000. doi: 10.1038/s41598-018-30437-2. PubMed PMID: 30097594; PubMed Central PMCID: PMC6086900.
  12. Tyagi N, Deshmukh SK, Srivastava SK, Azim S, Ahmad A, Al-Ghadhban A, Singh AP, Carter JE, Wang B, Singh S. ETV4 Facilitates Cell-Cycle Progression in Pancreatic Cells through Transcriptional Regulation of Cyclin D1. Mol Cancer Res. 2018 Feb;16(2):187-196. doi: 10.1158/1541-7786.MCR-17-0219. Epub 2017 Nov 8. PubMed PMID: 29117940; PubMed Central PMCID: PMC5805611.
  13. Srivastava SK, Ahmad A, Zubair H, Miree O, Singh S, Rocconi RP, Scalici J, Singh AP. MicroRNAs in gynecological cancers: Small molecules with big implications. Cancer Lett. 2017 Oct 28;407:123-138. doi: 10.1016/j.canlet.2017.05.011. Epub 2017 May 24. Review. PubMed PMID: 28549791; PubMed Central PMCID: PMC5601032.
  14. Deshmukh SK, Srivastava SK, Tyagi N, Ahmad A, Singh AP, Ghadhban AAL, Dyess DL, Carter JE, Dugger K, Singh S. Emerging evidence for the role of differential tumor microenvironment in breast cancer racial disparity: a closer look at the surroundings. Carcinogenesis. 2017 Aug 1;38(8):757-765. doi: 10.1093/carcin/bgx037. Review. PubMed PMID: 28430867; PubMed Central PMCID: PMC5862302.
  15. Deshmukh SK, Srivastava SK, Zubair H, Bhardwaj A, Tyagi N, Al-Ghadhban A, Singh AP, Dyess DL, Carter JE, Singh S. Resistin potentiates chemoresistance and stemness of breast cancer cells: Implications for racially disparate therapeutic outcomes. Cancer Lett. 2017 Jun 28;396:21-29. doi: 10.1016/j.canlet.2017.03.010. Epub 2017 Mar 14. PubMed PMID: 28302531; PubMed Central PMCID: PMC5437742.
  16. Sun J, Shi J, Murthy Konda NVSN, Campos D, Liu D, Nemser S, Shamshina J, Dutta T, Berton P, Gurau G, Rogers RD, Simmons BA, Singh S. Efficient dehydration and recovery of ionic liquid after lignocellulosic processing using pervaporation. Biotechnol Biofuels. 2017;10:154. doi: 10.1186/s13068-017-0842-9. eCollection 2017. PubMed PMID: 28638441; PubMed Central PMCID: PMC5472906.
  17. Khan MA, Azim S, Zubair H, Bhardwaj A, Patel GK, Khushman M, Singh S, Singh AP. Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward. Int J Mol Sci. 2017 Apr 6;18(4). doi: 10.3390/ijms18040779. Review. PubMed PMID: 28383487; PubMed Central PMCID: PMC5412363.
  18. Zubair H, Azim S, Ahmad A, Khan MA, Patel GK, Singh S, Singh AP. Cancer Chemoprevention by Phytochemicals: Nature's Healing Touch. Molecules. 2017 Mar 3;22(3). doi: 10.3390/molecules22030395. Review. PubMed PMID: 28273819; PubMed Central PMCID: PMC6155418.
  19. Patel GK, Khan MA, Bhardwaj A, Srivastava SK, Zubair H, Patton MC, Singh S, Khushman M, Singh AP. Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK. Br J Cancer. 2017 Feb 28;116(5):609-619. doi: 10.1038/bjc.2017.18. Epub 2017 Feb 2. PubMed PMID: 28152544; PubMed Central PMCID: PMC5344296.
  20. Bhardwaj A, Srivastava SK, Khan MA, Prajapati VK, Singh S, Carter JE, Singh AP. Racial disparities in prostate cancer: a molecular perspective. Front Biosci (Landmark Ed). 2017 Jan 1;22:772-782. doi: 10.2741/4515. Review. PubMed PMID: 27814645; PubMed Central PMCID: PMC5242333.
  21. Deshmukh SK, Azim S, Ahmad A, Zubair H, Tyagi N, Srivastava SK, Bhardwaj A, Singh S, Rocconi RP, Singh AP. Biological basis of cancer health disparities: resources and challenges for research. Am J Cancer Res. 2017;7(1):1-12. eCollection 2017. Review. PubMed PMID: 28123843; PubMed Central PMCID: PMC5250676.
  22. Zubair H, Azim S, Srivastava SK, Ahmad A, Bhardwaj A, Khan MA, Patel GK, Arora S, Carter JE, Singh S, Singh AP. Glucose Metabolism Reprogrammed by Overexpression of IKKε Promotes Pancreatic Tumor Growth. Cancer Res. 2016 Dec 15;76(24):7254-7264. doi: 10.1158/0008-5472.CAN-16-1666. Epub 2016 Oct 20. PubMed PMID: 27923829; PubMed Central PMCID: PMC5161695.
  23. Tyagi N, Srivastava SK, Arora S, Omar Y, Ijaz ZM, Al-Ghadhban A, Deshmukh SK, Carter JE, Singh AP, Singh S. Comparative analysis of the relative potential of silver, Zinc-oxide and titanium-dioxide nanoparticles against UVB-induced DNA damage for the prevention of skin carcinogenesis. Cancer Lett. 2016 Dec 1;383(1):53-61. doi: 10.1016/j.canlet.2016.09.026. Epub 2016 Sep 28. PubMed PMID: 27693632; PubMed Central PMCID: PMC5086276.
  24. Averett C, Bhardwaj A, Arora S, Srivastava SK, Khan MA, Ahmad A, Singh S, Carter JE, Khushman M, Singh AP. Honokiol suppresses pancreatic tumor growth, metastasis and desmoplasia by interfering with tumor-stromal cross-talk. Carcinogenesis. 2016 Nov 1;37(11):1052-1061. doi: 10.1093/carcin/bgw096. PubMed PMID: 27609457; PubMed Central PMCID: PMC5091041.
  25. Bhardwaj A, Srivastava SK, Singh S, Tyagi N, Arora S, Carter JE, Khushman M, Singh AP. MYB Promotes Desmoplasia in Pancreatic Cancer through Direct Transcriptional Up-regulation and Cooperative Action of Sonic Hedgehog and Adrenomedullin. J Biol Chem. 2016 Jul 29;291(31):16263-70. doi: 10.1074/jbc.M116.732651. Epub 2016 May 31. PubMed PMID: 27246849; PubMed Central PMCID: PMC4965574.
  26. Azim S, Zubair H, Srivastava SK, Bhardwaj A, Zubair A, Ahmad A, Singh S, Khushman M, Singh AP. Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer. Sci Rep. 2016 Jun 29;6:28446. doi: 10.1038/srep28446. PubMed PMID: 27354262; PubMed Central PMCID: PMC4926062.
  27. Tyagi N, Marimuthu S, Bhardwaj A, Deshmukh SK, Srivastava SK, Singh AP, McClellan S, Carter JE, Singh S. p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. Cancer Lett. 2016 Jan 28;370(2):260-7. doi: 10.1016/j.canlet.2015.10.028. Epub 2015 Nov 3. PubMed PMID: 26546043; PubMed Central PMCID: PMC4684758.
  28. Srivastava SK, Bhardwaj A, Arora S, Singh S, Azim S, Tyagi N, Carter JE, Wang B, Singh AP. MYB is a novel regulator of pancreatic tumour growth and metastasis. Br J Cancer. 2015 Dec 22;113(12):1694-703. doi: 10.1038/bjc.2015.400. Epub 2015 Dec 10. PubMed PMID: 26657649; PubMed Central PMCID: PMC4701995.
  29. Palanki R, Arora S, Tyagi N, Rusu L, Singh AP, Palanki S, Carter JE, Singh S. Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes. BMC Cancer. 2015 Sep 15;15:636. doi: 10.1186/s12885-015-1644-8. PubMed PMID: 26373391; PubMed Central PMCID: PMC4571131.
  30. Tyagi N, Bhardwaj A, Srivastava SK, Arora S, Marimuthu S, Deshmukh SK, Singh AP, Carter JE, Singh S. Development and Characterization of a Novel in vitro Progression Model for UVB-Induced Skin Carcinogenesis. Sci Rep. 2015 Sep 9;5:13894. doi: 10.1038/srep13894. PubMed PMID: 26349906; PubMed Central PMCID: PMC4563561.
  31. Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh S, Andrews J, McClellan S, Wang B, Singh AP. MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. Br J Cancer. 2015 Aug 11;113(4):660-8. doi: 10.1038/bjc.2015.252. Epub 2015 Aug 6. PubMed PMID: 26247574; PubMed Central PMCID: PMC4647684.
  32. Arora S, Tyagi N, Bhardwaj A, Rusu L, Palanki R, Vig K, Singh SR, Singh AP, Palanki S, Miller ME, Carter JE, Singh S. Silver nanoparticles protect human keratinocytes against UVB radiation-induced DNA damage and apoptosis: potential for prevention of skin carcinogenesis. Nanomedicine. 2015 Jul;11(5):1265-75. doi: 10.1016/j.nano.2015.02.024. Epub 2015 Mar 21. PubMed PMID: 25804413; PubMed Central PMCID: PMC4476928.
  33. Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh AP, Carter JE, Scammell JG, Fodstad Ø, Singh S. Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis. Br J Cancer. 2015 May 26;112(11):1772-81. doi: 10.1038/bjc.2015.154. Epub 2015 May 5. PubMed PMID: 25942396; PubMed Central PMCID: PMC4647250.
  34. Deshmukh SK, Srivastava SK, Bhardwaj A, Singh AP, Tyagi N, Marimuthu S, Dyess DL, Dal Zotto V, Carter JE, Singh S. Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation. Oncotarget. 2015 May 10;6(13):11231-41. doi: 10.18632/oncotarget.3591. PubMed PMID: 25868978; PubMed Central PMCID: PMC4484452.
  35. Tyagi N, Bhardwaj A, Srivastava S, Arora S, Marimuthu S, Deshmukh S, Singh A, Carter J, Singh S. Development and characterization of a novel in vitro cell line model of UVB-induced skin carcinogenesis. Sci Rep. 2015; Sep 9;5:13894. doi: 10.1038/srep13894. PubMed PMID: 26349906; PubMed Central PMCID: PMC4563561.
▼   Jiamin Teng M.D., Ph.D.

Jiamin Teng M.D., Ph.D.Jiamin Teng M.D., Ph.D.

Associate Professor of Clinical Research

Office: (251) 460-7608
Lab: (251) 460-7609
jteng@health.southalabama.edu 

Education

M.D.: Changzhi Medical College, Changzhi, China
Master of Medical Science: Tongji Medical University, Wuhan, China
Ph.D.: Nihon University School of Medicine, Tokyo, Japan
Post-Doctoral Fellowship: Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA

Book Chapters / Meeting Proceedings

  1. Herrera, GA, Turbat-Herrera,  EA, Teng. J: Mesangial homeostasis  and pathobiology: Their role in health and disease. In Experimental models for renal diseases: impact on understanding pathogenesis and improving diagnosis. (GA Herrera, Ed). Contributions  to Nephrology series. S. Karger A.G., Basel, Switzerland. pp 6-22. 2011
  2. Herrera, GA, Turbat-Herrera, EA, Teng. J: Renal amyloidosis: Current views on pathogenesis and impact on diagnosis. In Experimental models for renal diseases: impact on understanding pathogenesis and improving diagnosis. (GA Herrera, Ed) Contributions  to Nephrology series. S. Karger A.G., Basel, Switzerland   Pp 232-246. 2011
  3. Herrera, GA, Turbat-Herrera, EA,  Teng. J: Glomerular  repair: Current status and future expectations. In Experimental models for renal diseases: impact on understanding pathogenesis and improving diagnosis. (GA Herrera, Ed). Contributions  to Nephrology series. S. Karger A.G., Basel, Switzerland. pp 351-362.2011
  4. Teng J. Herrera GA: Mesangial amyloid formation in an isolated rat kidney perfusion model: A new model to study renal amyloidogenesis.  In Xlth International Symposium on Amyloidosis (M. Skinner, JL Berk, LH Connors, DC Seldin, Eds). CRC Press, Taylor and Francis Group,  Boca Raton, London, New York, pp. 307-309. 2008
  5. Herrera GA, Keeling J,  Teng J: Pathogenesis of renal AL-amyloidogenesis (AL-Am): An in-vitro approach to understanding mechanisms involved.   In Amyloid and Amyloidosis. (G Grateau, RA Kyle, M Skinner, Eds.) CRC Press, Boca Raton, London, New York, Washington DC, pp. 139-141.  2005
  6. Hayagawa, S. Karasaki, B. Teng. J. Basic for the molecular biological experiment.  In: Research Compass for Obstetrics and Gynecologist,  K. Satoh (Eds.) Tokyo: Medical View Press, pp. 283-292. 1998.

Journal Publications, Including Manuscripts And Editorials

  1. Herrera GA, Jiamin Teng, Chun Zeng, Hongzhi Xu, Man Liang and Elba A. Turbat-Herrera, Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin  light chain associated mesangial damage. Nephron. Submitted.
  2. Herrera GA, Zeng C, Turbat-Herrera EA, Teng J: Healing the damaged mesangium  in nodular glomerulosclerosis using mesenchymal stem cells (MSCs): Expectations and challenges. Ultrastructure Pathology. 2016 40(2), 61-70,
  3. Herrera GA, Turbat-Herrera EA, Teng J: Animal models of light  chain deposition disease provide  a better  understanding of nodular glomerulosclerosis. Nephron  132(2):119-136, 2016
  4. Herrera GA, Turbat-Herrera EA, Teng J: Understanding mesangial damage and repair: Insights  from an experimental model of immunoglobulin light chain-associated mesangiopathy Journal of Cell Biology and Cell Metabolism 2014 1(1): 002-011
  5. Teng J, Herrera  GA, Liu X, Zhang  Y, Turbat-Herrera EA: Mesenchymal stem cells  in mesangial repair in a model of light chain-mediated mesangial injury. J Stem Cell Res Ther  4:215-227, 2014. doi:10.4172/2157-7633.1000215.
  6. Teng. J. Herrera, E. Herrera,  GA. An animal model of glomerular light­ chain-associated amyloidogenesis depicts  the crucial role of lysosomes Kidney Int. 86(4):738-46. doi: 10.1038/ki. 2014.122. Oct. 2014
  7. Teng. J. Herrera, E. Herrera,  GA. Extrusion of amyloid  fibrils  to the extracellular space in experimental mesangial AL-amyloidosis: Transmission and scanning electron  microscopy studies  and correlation with renal biopsy  observations. Ultr£1$lrvcLE&hoL; 38(2):104-15. Apr. 2014
  8. G. A. Herrera, E. A. Turbat-Herrera, &  Teng. J. Mesangial homeostasis and pathobiology: their role in health and disease. Contrib  Nephrol 2011 20;169:6-22. Epub  Jan 20. 2011
  9. G. A. Herrera, Teng. J. , & E. A. Turbat-Herrera. Renal amyloidosis: current views  on pathogenesis and impact  on diagnosis. Contrib  Nephrol 2011 20;169:232-46. Epub Jan 20.2011
  10. G. A. Herrera, E. A. Turbat-Herrera, &  Teng. J. Glomerular repair: present status and future expectations. Contrib  Nephrol2011 20;169:351-62. Epub   Jan 20. 2011
  11. G. A. Herrera, E. A. Turbat-Herrera, &  Teng. J. Animal model  of renal AL­amyloidogenesis recapitulates in vitro findings.  Amyloid. 18 Suppl1:34-7. 2011
  12. Teng. J., Herrera, GA, Mesangial amyloid  formation in an isolated rat kidney  perfusion model: A new model to study renal amyloidogenesis. Xlth international symposium on amyloidosis. Martha  Skinner,  John L. Berk, Lawreen H. Connors, David C. Seldin (Eds) CRC Press,  pp.307-309, 2007
  13. Teng. J. Herrera, E. Herrera, GA. The role of translational research advancing the understanding of the pathogenesis of light chain mediated glomerulopathies. Pathology International 57: 398-412. 2007
  14. Herrera, GA, Keeling,  J, Teng. J., Pathogenesis of renal al-amyloidosis: an in vitro approach to understanding mechanisms involved. Amyloid and Amyloidosis. Gilles Grateau,  Robert A. Kyle, Martha  Skinner (Eds) CRC Press, pp.139-141, 2004
  15. Zhang,  PL.,   Lun, M., Teng, J., Huang, J., Blasick, TM., Yin, L., Herrera, GA. and Cheung, JY., Preinduced Molecular Chaperones in the Endoplasmic Reticulum Protect Cardiomyocytes from Lethal Injury. Annals of Clinical & Laboratory Science  34:449-457. 2004
  16. Keeling, J, Teng, J. Herrera,  GA, AL-amyloidosis and light-chain deposition disease  light chains induce  divergent phenotypic transformations of human mesangial cells. Laboratory Investigation 84:1322-1338.2004
  17. Teng. J, Russell, WJ.,Gu, X., Cardelli, C., Jones,  ML.,  and Herrera, GA., Different types of glomerulopathic light chains  interact  with mesangial cells using a common receptor  but exhibit different  intracellular trafficking patterns. Laboratory Investigation 84: 440-451. 2004
  18. Teng. J, Zhang,  PL, Russell,  WJ., Zheng, LP., Herrera,  GA., Insights into mechanisms responsible for mesangial alterations associated with fibrogenic glomerulopathic light chains.  Nephron physiology, 94: 28-38, 2003
  19. Hayagawa. S. Karasaki, B.  Teng. J. Basic for the molecular  biological experiment. In: Research Compass for Obstetrics and Gynecologist, K. Satoh (Eds.) Tokyo: Medical View Press. pp. 283-292. 1998.
  20. Teng. J, Tochigi. M. and Satoh, K. Reverse effects of PGE2on ovulation inhibited by Indomethacin  or/and Nordihydro-guaiaretic acid in mice. Nihon Univ. J. Med. 39(4): 187-202, 1997.
  21. Satoh, K., Tochigi. M. and Teng. J. Endometriosis and Pain: the role of prostaglandins. In: Endometriosis Today-Advances in research and practice, The Proceedings  of the 5" World Congress on Endometriosis,  Yokohama. Japan. October, 1996. Published in the International Congress. Symposium and Seminar Series (I.C.S.S) 13: 75-79, 1997.
  22. Tochigi, M. Hayagawa. S. Teng. J. and Satoh, K. Recurring spontaneous pneumothorax accompanied  with menstruation due to endometriosis  of the diaphragma. J. Endometriosis  Research. 17: 120-123. 1996.
  23. Teng J., Tochigi, M. and Satoh. K. Role of eicosanoids in ovulation. Nihon Univ. J. Med. 37(5): 249-262, 1995.
  24. Xiong C. Teng J. Effect of Succinate dehydrogenase on sperm livability. Chinese Journal of Andrology  8 (03):  138-42, 1994
  25. Teng J. Xia, W. and Wu, X. Synergistic effects of injectio leonuri with 15-methyi­ PGF2tc methyl ester and sulprostone on rabbits' myometrium. Acta University Medicinae Tongji, 21(2): 103-5, 1992.
▼   Elba A. Turbat-Herrera, M.D., Ph.D.

Elba A. Turbat-Herrera, M.D., Ph.D.Elba A. Turbat-Herrera, M.D., Ph.D.

Professor, MCI Interdisciplinary Clinical Oncology
Director, MCI Pathological Services
Director, USA Health Biobank

(251) 471-7790
etherrera@health.southalabama.edu 

Board Certifications

American Board of Pathology in Anatomic and Clinical Pathology
American Board of Pathology Special Certification in Cytopathology

Education

M.D.: University of Alabama, Birmingham   
University of Alabama, Birmingham: Pathology Residency (1985-1988)
Mount Sinai Medical Center, Miami Beach, Florida: Pathology Residency (1988-1989)
University of Mississippi Medical Center: Fellowship, Cytopathology
University of Alabama, Birmingham: Fellowship, Molecular Biology of HPV

Selected Publications

  1. Wellikoff AS, Holladay RC, Downie GH, Chaudoir CS, Brandi L, Turbat-Herrera EA. Comparison of in vivo probe-based confocal laser endomicroscopy with histopathology in lung cancer: A move toward optical biopsy. Respirology. 2015 Aug;20(6):967-74.
  2. Herrera GA, Turbat-Herrera EA, Teng J: Animal models of light chain deposition disease provide a better understanding of nodular glomerulosclerosis. Nephron 132:119-136, 2016.
  3. Herrera GA, Zeng C, Turbat-Herrera EA, Teng J: Healing the damaged mesangium in nodular glomerulosclerosis using mesenchymal stem cells (MSCs): Expectations and challenges. Ultrastruct. Pathol 40:61-70, 2016.
  4. Vora M, Lacour RA, Black DR, Turbat-Herrera EA ,Gu X: Neuroendocrine  tumors in the ovary: histogenesis, pathologic differentiation, and clinical presentation. See comment in PubMed Commons belowArch Gynecol Obstet. Mar;293(3):659-65 ,2016.
  5. Knowles KJ, Berkovic J, Gungor A, Al Shaarani M, Lockhart V, Al-Delphi F, Turbat-Herrera EA.: Oral foregut duplication cysts: A rare and fascinating congenital lesion. Case report and review of the literature Am J Otolaryngol. 2016 Nov 23.  [Epub ahead of print].
  6. Herrera GA, Teng J, Zeng C, Turbat-Herrera EA1: Plasticity of mesenchymal stem cells (MSCs) in mesangial repair: The crucial role of electron microscopy (EM) monitoring and understanding the process. Ultrastruct Pathol. 2017 Jan-Feb;41(1):97.
  7. Flowers A, Turbat-Herrera EA. EM proves invaluable in the confirmation of chordoma in the sacral mass of a middle aged man Ultrastruct  Pathol 41, p258-263, 2017.
  8. Herrera GA, Turbat-Herrera EA, Teng J, Liu B, Rodriguez-Alvarez F, Pozo-Yauner L: Understanding lambda 6 light chain fibrillogenesis/translational application to renal biopsy. Lab Invest 97A:407A, 2017; Mod Pathol 30:407A, 2017.
  9. Herrera GA, Teng J, Turbat-Herrera EA: Receptor on mesangial cells for glomerulopathic light chains: the search continues.  Mod Pathol 2018 March; 31(S2):613.
  10. Sirac C, Herrera GA, Sanders P, Batuman V, Bender S, Ayala M, Javavue V, Teng J, Turbat-Herrera EA, Cogne M, Touchard G, Leung N, Bridoux F: Animal models of monoclonal immunoglobulin –related renal diseases. Nat Rev Nephrol, 14(4):246-264, 2018.
  11. Al Shaarani M, Abdulsatter J, Cotelingam J, Coppola D, Turbat-Herrera EA, Shackelford RE. Nicotinamide Phosphoribosyl Transferase Immunohistochemistry Differentiates thyroid follicular carcinomas from follicular adenomas, Herrera GA, Teng J, Zeng C, Xu H, Liang M, Turbat-Herrera EA:  Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage.  Ultrastruct Pathol 42:3:246-254, 2018.
  12. Herrera GA, Teng J, Zeng C, Xu H, Liang M, Turbat-Herrera EA: Phenotypic plasticity of mesenchymal stem cells is crucial for mesangial repair in a model of immunoglobulin light chain-associated mesangial damage. Ultrastruct Pathol 42(3):246-254, 2018.
  13. Wei E, Chen S, Turbat-Herrera EA, Herrera GA, Chadha M, Shackelford R: Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study. Ultrastruct Pathol 42(4):369-375, 2018.
  14. Cheng M, Gu X, Turbat-Herrera EA, Herrera GA: Tubular injury and dendritic cell activation are integral components of light chain-associated acute tubulointerstitial nephritis. (In press, Arch Pathol Lab Med, 2019).
▼   Eric X. Wei, M.D, Ph.D.

Eric X. Wei, M.D, Ph.D.Eric X. Wei, M.D, Ph.D.

Associate Professor
Director, Cytogenetics

(251) 471-7790
ewei@health.southalabama.edu 

Board Certifications

Anatomic and Clinical Pathology
Hematopathology

Education

M.D.: Shanghai Medical College Fudan University, Shanghai, China
M.S.: Ohio State University, Columbus, OH
Ph.D.: Johns Hopkins University School of Medicine, Baltimore, MD
Computer Science: Palomar College and California State University San Marcos
Anatomic and Clinical Pathology Residency: LSU Health Sciences Center, Shreveport, LA 
Hematopathology Fellowship: MD Anderson Cancer Center, Houston, TX

Selected Publications

  1. Aksionau A, Wei EX.  Accuracy of the Criteria for Hemophagocytic Lymphohistiocytosis.  Int J Clin Exp Pathol. 2020 Dec 1;13(12):3139-3148. eCollection 2020.
  2. Dabrowski D, Ozluk E, Barbieto S, Wei EX.  Focal Segmental Glomerulosclerosis Preceding Papillary Renal Cell Carcinoma Type 2.  Case Rep Pathol. 2020 Oct 15;2020:8811905. doi: 10.1155/2020/8811905. eCollection 2020.
  3. Dabrowski D, Silva RF, Constantinescu M, Shackelford RF, Dela Cruz N, Wei EX.  Synchronous Occurrence of Splenic Pleomorphic Mantle cell Lymphoma and esophageal adenocarcinoma with overexpression of BCL1 Protein.  Case Rep Oncol Med. 2020 Dec 21;2020:8888829. doi: 10.1155/2020/8888829. eCollection 2020.
  4. Al Shaarani M, Shackelford RE, Master SR, Mills GM, AlZubaidi Y, Mamilly A, Wei EX. Plasmablastic Lymphoma, a Rare Entity in Bone Marrow with Unusual Immunophenotype and Challenging Differential Diagnosis.  Case Rep Hematol Volume 2019, Article ID 1586328.  https://doi.org/10.1155/2019/1586328
  5. Mirza R, Wei EX.  A giant parathyroid tumor during pregnancy: adenoma versus carcinoma.  Case Rep Pathol Jun 13;2019:4383698. doi: 10.1155/2019/4383698. eCollection 2019.
  6. Kim D, Chen J, Meram A, Patel S, Wei E, Ansaric J, Ghalia G, Kevil C, Shackelford RE.  Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Cavity Mucoepidermoid Carcinoma.  Case Rep Oncol. 2018;11:682–687.   doi: 10.1159/000493008
  7. Jiang AS, Wu Z, Wei EX, Ni H, You B, Yang T, Jiang JG.  Plasma cell myeloma with dual expression of kappa and lambda light chains.  Int J Clin Exp Pathol 2018;11(9): 4718-4723
  8. Dongsoo K, Chen J, Wei E, Ansari J, Meram A, Patel S, Ghali G, Kevil C, Shackelford RE.  Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma.  Case Rep Oncol. 2018 Aug 27;11(2):585-590. doi: 10.1159/000492464. eCollection 2018 May-Aug.
  9. Egge S, Wei E, Clements E, Chandranesan ASJ.  Post-traumatic fatal disseminated Apophysomyces elegans infection. Med Mycol Case Rep. 2018 Sep 6;22:45-47. doi: 10.1016/j.mmcr.2018.08.002. eCollection 2018 Dec.
  10. Chen S, Turbat-Herrera EA, Herrera GA, Chadha M, Shackelford RE, Wei EX.  Metastatic TFE3-overexpressing renal clear cell carcinoma with dense granules: a histological, immunohistochemical, and ultrastructural study.  Ultrastruct Pathol. 2018 Jul-Aug;42(4):369-375. doi: 10.1080/01913123.2018.1499686. Epub 2018 Jul 24.
  11. Meram AT, Chen J, Patel S, Kim DD, Shirley B, Covello P, Coppola D, Wei EX, Ghali G, Kevil CG, Shackelford RE. Hydrogen Sulfide Is Increased in Oral Squamous Cell Carcinoma Compared to Adjacent Benign Oral Mucosae. Anticancer Res. 2018 Jul;38(7):3843-3852. doi: 10.21873/anticanres.12668.
  12. Jiang JG, Xu Y, Wu Z, Ni H, Wei EX.  Acute myeloid leukemia developed in Ph- cells with MLL gene amplification in a patient with chronic myelogenous leukemia.  Leuk Lymphoma. 2018 Feb 23:1-3. doi: 10.1080/10428194.2018.1436174.
  13. Wei EX, Silva R, Cotelingam JD, Shackelford RE.   Pediatric Pulmonary Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature.  Case Rep Pathol.  2017;2017:8946807. doi: 10.1155/2017/8946807. Epub 2017 Oct 8.
  14. Wei EX, Leventaki V, Choi JK, Raimondi SC, Azzato E, Shurtleff SA, Ong M, Veillon DM, Cotelingam JD, Shackelford RE.  γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies.  Case Rep Hematol.  Volume 2017 (2017), Article ID 5873015, 7 pages.  https://doi.org/10.1155/2017/5873015.
  15. Shackelford RE, Ansari JM, Wei EX, Alexander JS, Cotelingam J.  Anaplastic lymphoma kinase rearrangements in non-small-cell lung cancer: novel applications in diagnostics and treatment.  Pharmacogenomics. 2017 Aug;18(12):1179-1192. doi: 10.2217/pgs-2017-0098. Epub 2017 Jul 26.
  16. Shackelford RE, Abdulsattar J, Wei EX, Cotelingam J, Coppola D, Herrera GA.  Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-β-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma.  Anticancer Res. 2017 Jul;37(7):3423-3427.
  17. Shackelford RE, Al Shaarani M, Ansari J, Wei E, Cotelingam J.  A Twenty-Four-Year-Old Woman with Left Flank Lipoma-Like Hibernoma.  Case Rep Oncol. 2017 May 9;10(2):438-441. doi: 10.1159/000475708. eCollection 2017 May-Aug.
  18. Knowles KJ, Wei EX, Seth A, Bienvenu J, Morris J, Jordan P, and Boktor M.  Synthetic cannabinoid abuse and a rare alpha-1-antitrypsin mutant causing acute fulminant hepatitis. Case report and review of the literature.  Case Reports Hepatol. 2017 ; 2017:9627452. doi: 10.1155/2017/9627452. Epub 2017 Dec 3.
  19. Barakat FH, Medeiros LJ, Wei EX, Konoplev S, Lin P, Jorgensen JL.  Residual Monotypic Plasma Cells in Patients with Waldenstrom Macroglobulinemia after Therapy. Am J Clin Pathol 2011 Mar; 35(3):365-73.
  20. Muzzafar T, Wei EX, Lin P, Medeiros LJ, Jorgensen JL.  Flow cytometry immunophenotyping of anaplastic large cell lymphoma.  Arch Pathol Lab Med 2009 Jan;133(1):49-56.
  21. Wei EX, Anga AA, Martin SS, Jackson JG, Nordberg ML, Herrera GA, Turbat-Herrera EA.  EGFR expression as an ancillary tool for diagnosing lung cancer in cytology specimens.  Mod Pathol 2007 Sept; 20(9):905-13. Epub 2007 Jul 20
  22. Wei XE, Bao F, Veillon DM, Heldmann M, Cotelingam JD. Pathology case of the month.  A Mediastinal mass.  Castleman’s disease, hyaline-vascular type.  J La State Med Soc.  2006 Sept-Oct; 158(5):222-4, 226
  23. Wei EX, Dancer YJ, Veillon DM, Linscott AJ, Dowden K, Fowler M, Cotelingam JD. Pathology case of the month.  Fever, Chills, and Weakness in a 61-Year-Old Man.  Mixed fungal infection: Blastomycosis (Blastomyces dermatitidis) and zygomycosis.  J La State Med Soc. 2005 Sept-Oct; 157(5):245-50.
  24. Wei EX, Albores-Savvedra J, Fowler MR.  Plexiform neurofibroma of the uterine cervix.  Arch Pathol Lab Med.  2005 Jun;129(6):783-6.
  25. Wei EX, Flamholz RB, Nordberg ML, Veillon DM, Behm W, Heldmann M, Cotelingam JD.  Pathology case of the month.  A mediastinal mass.  Malignant lymphoma, composite (nodular sclerosis Hodgkin lymphoma and diffuse large B-cell lymphoma).  J La State Med Soc. 2004 Nov-Dec; 156(6):294-7.
  26. Wei XE, Veillon DM, Flamholz RB, Heldmann M, Grafton WD, Fowler MR, Cotelingam JD. Pathology case of the month. Tumor of the pineal region. Pineoblastoma, recurrent. J La State Med Soc. 2004 May-Jun;156(3):125-7, 129
  27. Wei X, Sasaki M, Huang H, Dawson VL, Dawson TM. Steroidogenic factor 1 (SF-1), regulates neuronal nitric oxide synthase gene expression in pituitary gonadotropes. Mol Endocrinol 2002 Dec;16(12):2828-39
  28. Jiang C, Wei X.  Current Status in Epilepsy Surgery Therapy.  Shanghai Medicine 1993 May;16(5): 299-304 
  29. Jiang C, Wei X.  Recent Progress in Epilepsy Neurosurgery.  Chinese Journal of Stereotactic and Functional Neurosurgery 1993;6(1): 46-50

Selected Scientific Presentations

  1. Ozluk E, Friday ER, Wei EX.  Advanced melanoma associates with high frequency TERT mutations. College of American Pathologists, Las Vegas, NV, 2020
  2. Li Y, Friday ER, Wei EX.  The Molecular Genomic Profiling of Primary Lung Adenocarcinoma in Local Population.  College of American Pathologists, Las Vegas, NV, 2020
  3. Xu H, Wei EX.  Frequent Mutations in p53, CDKN2A, PTEN Genes in Lung Squamous Cell Carcinoma: A Next Generation Sequencing Study.  American Society for Clinical Pathology, Austin, TX, 2020
  4. Patil A, Tirupathi R, Dabrowski D, Ganti N, Vanga P, Otohinoyi D, Gundale A, Ghildyal A, Cotelingam J, Veillon D, Ong M, Dela Cruz N, Wei EX.  Establishing adrenocortical carcinoma specific prognostic genes signature.  American Society for Clinical Pathology, Austin, TX, 2020
  5. Patil A, Tirupathi R, Dabrowski D, Ganti N, Vanga P, Otohinoyi D, Gundale A, Ghildyal A, Cotelingam J, Veillon D, Ong M, Dela Cruz N, Wei EX.  Genomic analysis identifies rare ALK positive cases in the TCGA database.  American Society for Clinical Pathology, Austin, TX, 2020
  6. Mirza R, Aksionau A, Wei EX.  Next generation sequencing assay demonstrated frequent mutation in PI3K3CA, PI3R1 and p53 gene in clinically aggressive head neck squamous cell carcinoma.  USCAP, Los Angeles, CA 2020.  Modern Pathology 2020 March; 33(3 supplement 2):1214