Research and Scholarly Development Grant Program Awardees

The Research and Scholarly Development Grant (RSDG) Program has been created to provide tenure and non-tenure track faculty with funding of up to $25,000 to help build their research and scholarly careers. RSDG grants are intended to stimulate interactions across disciplines, departments, colleges, and programs. The funding is designed to facilitate preliminary data collection or planning efforts to assist in the development of competitive proposals that will attract external funding.  Each RSDG proposal is required to demonstrate how funding for the project will lead directly to external funding requests. This USA internally-funded competition is sponsored by the Office of Research and Economic Development. Proposals are reviewed by faculty from Schools and Colleges across campus in three-member review panels. Review assignments are made to minimize conflict of interest and equalize the distribution of applications from each School/College.

2020 Awardees

Dr. Melike Dizbay-Onat

Dr. Melike Dizbay-Onat
Assistant Professor, Department of Mechanical Engineering
College of Engineering

"A Novel Method for Preparation of Activated Recycled Carbon Fiber Mats for Carbon Dioxide (CO2) Filtration"

Abstract: In this study, recycled carbon fibers (RCFs) represent a “green”, and efficient alternative precursor to prepare Activated Carbon Fiber (ACF) mats. While demand is increasing to carbon fiber composite applications (automotive, airplanes), disposing of these materials become a huge problem when they reach the end of their lifecycles. RCFs that are produced from these scrap materials would reduce landfilling. The proposed project has two environmental friendly benefits: utilization of RCFs and using a new alternative to prepare ACFs. Carbon dioxide (CO2) is a key pollutant that causes outdoor air pollution and it has been also recognized as a workplace hazard at high concentrations. The research focuses on CO2 adsorption properties of ACF samples and two product applications – (a) filters for the industrial emissions, (b) lighter and efficient respiratory filtering masks for use at workplaces. The broad impact of the research is a pollution- free workspace and improving the quality of people's lives. Moreover, this project will provide learning opportunities such as developing a new course on Activated Carbon Adsorption Principles for both undergraduate and graduate students. The proposed research project is an interdisciplinary study between the units of USA Mechanical Engineering, Chemical and Biomolecular Engineering, and Oak Ridge National Laboratory (ORNL).

Dr. Edward Duranty

Dr. Edward Duranty
Assistant Professor, Department of Chemistry
College of Arts and Sciences

"CaLevIR: A Calorimetric Method Combining Acoustic Levitation and Infrared Thermography"

Abstract: Small volume chemistry has become of interest recently since the first reports of increased reaction rates within small volume containers - including microfluidic systems, thin films on surfaces, and in droplets were published. There have been many recent examples in the literature of this phenomenon in aqueous droplets and micro-droplets involving bimolecular acid-catalyzed reactions, various syntheses, and even in more complex processes such as protein unfolding. These studies attribute the increase in rates of reaction to two key parameters inherent to small containers: increased surface area to volume ratio and rapid mixing times within the small volume. We propose to leverage these important characteristics to study thermochemical mechanisms within acoustically levitated droplets in order to develop a new calorimetric method suitable for in situ measurement of reaction progress and thermodynamics. While acoustically levitated droplets on the microscale, nanoliters in volume, have been studied using Raman/FTIR spectroscopy and in mass spectrometry, this work will be first to study the thermochemistry of macroscale droplets in situ, on the order of microliters, a size more appropriate for industrial application. This project aims to develop a new calorimetric technique combining the free-floating, container-less nature of levitated samples with the in situ measurement ability of infrared thermography. This will be done using an acoustic levitation device cited in the literature named "TinyLev" and a high-speed FLIR infrared camera capable of monitoring the temperature conditions of a levitating droplet >200 times per second. This technique would most likely be of interest to industries monitoring reactions taking place in aerosols or other small volumes and will offer industrial partners who focus on reactions taking place in the aerosol phase a method for instantaneous in situ monitoring of reaction progress and thermodynamics. Our area offers a plethora of tech-based companies that include Airbus, BASF, Arkema, and Austal Industries which have created a high demand for individuals with high-quality STEM educations and the research experiences and new technologies that will emerge from this project will have an important role to play in sustaining that forward momentum.

Dr. K-T Hsiao

Dr. K-T Hsiao
Professor, Department of Mechanical Engineering
College of Engineering

"Robotic Additive Manufacturing Method for Carbon Fiber Composites"

Abstract: Currently commercially available Additive Manufacturing (AM) technologies are incapable of producing aerospace qualified Continuous Carbon Fiber Reinforced Polymer (C-CFRP) composite parts. This is due to the lack of effective means to apply compaction pressure during 3D printing of C-CFRP. This RSDG project will investigate the relationship between the processing parameters (such as the compaction magnitude and duration) and the quality of C-CFRP produced by a patent-pending method (US20190275737A1) that applies compaction force using magnetic attraction during additive manufacturing, i.e., Magnetic Compaction Force Assisted Additive Manufacturing (MCFA-AM). The electro-magnetic devices and the means to control the compaction pressure distribution during the 3D printing of C-CFRP composites will be developed. The electro-magnetic MCFA-AM printing head will be mounted on an industrial robot arm (already located in the PI’s lab) to precisely drive the printing head at a specified speed along a complex path based on the Computer-Aided Design (CAD) digital file of a C-CFRP part. The C-CFRP composite samples will be tested for their void content and mechanical properties such as the interlaminar shear strength. These novel data will indicate how the manufacturing parameters can influence the void content and mechanical properties towards aerospace qualified C-CFRP parts. Upon completion of this project, the team expect to achieve the following goals: (1) to build a robot-based electromagnetic MCFA-AM 3D printer for C-CFRP comparable to C-CFRP products currently used in the aerospace industry, (2) to understand the relationship between the processing parameters and the C-CFRP parts’ performance, (3) to use the data and the ability from this project to obtain external funding for supporting this new research direction and Industry 4.0.

Dr. Phillip Smith

Dr. Phillip Smith
Associate Professor, Department of Psychology
College of Arts and Sciences

"Development and Pilot Testing of a Training and Assessment System for Behavioral Health Trainees’ Practice of Suicide Risk Assessment and Management"

Abstract: The training and evaluation of behavioral health care providers’ clinical practice (e.g., psychotherapy, counseling) has historically relied on unproven methods (e.g., knowledge-based written exams). There is an emerging emphasis on ensuring that behavioral healthcare providers demonstrate competence prior to obtaining licensure. However, there remains little research examining how such competence should be evaluated. Further, there are no empirically supported standards for training and evaluating the clinical practice of suicide risk assessment and management (SRAM); arguably one of the most important skills for behavioral health providers. Indeed, although there has been a substantial increase in the availability of evidence-based practices specific to SRAM in the last 20 years, suicide rates have continued to rise over 33% since 1999. Informed by implementation science, the tragic increase in suicide rates is, at least in part, owed to our failure to effectively train and evaluate providers’ competency in SRAM. Though virtually unheard of in behavioral healthcare training, medical and health professions utilize performance-based evaluations to determine competence in applied skills, most notably Objective Structured Clinical Examinations (OSCEs).

Specific Aims: We will develop and assess the reliability and validity of a performance-based SRAM-OSCE. This evaluation system will serve as the basis for a new collaboration between an expert in the understanding and prevention of suicide with the USA Simulation Program and expert in the training and evaluation of healthcare professionals.

Dr. Xiangli Wang

Dr. Xiangli Wang
Assistant Professor, Department of Marine Sciences
College of Arts and Sciences

"A Multi-Proxy Approach to Track the Sources and Constrain Fluxes of Metals into Mobile Bay"

Abstract: Heavy metals can have long-lasting deleterious environmental effects because they can bioaccumulate as they enter and migrate upward along the food chain, threatening fisheries and other important ecosystem services that benefit the public. Metals can be introduced into coastal seawater by rivers and submarine groundwater discharge (SGD), with the latter being poorly studied. Mobile Bay is the fourth largest estuary system in the U.S., with its freshwater budget dominated by surface water discharge from the Alabama-Mobile River system. Although submarine groundwater discharge (SGD) contributes less than 10% of freshwater into the bay compared to river water discharge, it carries a disproportionately large fraction of nutrients to the coastal water. Therefore, SGD is considered a significant source of pollutants to Mobile Bay. Compared to nitrogen and phosphate loading from SGD, toxic heavy metal  loading (e.g. arsenic, mercury, chromium, lead etc.) via SGD into Mobile Bay and other coastal estuaries has received very little attention. Knowing the relative importance of surface vs. groundwater discharge of metals into the bay, and whether these metals are anthropogenic or naturally derived from regional bedrocks, will provide key guidance for adjusting regulations on industrial and municipal wastewater treatment practices. Here we propose a novel multi-proxy approach combining metal isotope and concentration measurements to constrain seasonal heavy metal fluxes from SGD and rivers to Mobile Bay. This study will provide the first SGD metal data for Mobile Bay, and will provide key pilot data for future studies on broader spatial scales, which will not only place constraints on the importance of SGD in metal fluxes to coastal seawater, but also move forward our understanding of the oceanic budget of many biogeochemically important trace metals.

▼   2019 Awardees
Dr. Brian Dzwonkowski

Dr. Brian Dzwonkowski
Assistant Professor, Department of Marine Sciences
College of Arts and Sciences

"Development of an innovative turbulence mooring to advance coupled physical-
biogeochemical processes"

Abstract: Seasonally stratified shelf seas, like that of coastal Alabama, are critical ecosystems that provide an enormous level of biological productivity relative to their geographic size. In stratified conditions, the layering of coastal water can have significant impacts on ecosystem function (e.g., contribute to hypoxia formation). Consequently, understanding turbulence in the water column and how it effects stratification is of fundamental importance to a broad range of physical and biogeochemical processes. For example, the ability to ventilate bottom water and replenish dissolved oxygen levels is directly related to water column turbulence. A potentially important mechanism for generating turbulence in the water column on seasonally stratified shelves is near-inertial motion. These clockwise rotating ocean currents are hypothesized to be a critical mixing mechanism that generate strong vertical fluxes of dissolved oxygen and nutrients by increasing water column turbulence. However, the relative importance of this process on mixing has not been extensively studied due to the difficulty in making turbulence and mixing measurements in the field.

The proposed work will focus on developing a new instrument capacity at the University of South Alabama that will allow measurement of turbulence in the water column from a moving platform (i.e., turbulence mooring), which will allow us to better study the impacts of near-inertial oscillations (as well as other turbulence generating mechanisms and biogeochemical fluxes). An innovative advancement of this mooring design is the coupling of an acoustic Doppler velocimeter (ADV) with an inertial motion unit which allows for any movement of the mooring to be removed from the current velocity measurements obtained from the ADV. This turbulence mooring will be deployed at a site in the coastal ocean for ~ 2 weeks as a demonstration of our new capacity for determining turbulence properties in the pycnocline, a fundamental issue in coastal and oceanic research.

Dr. Sharon Fruh

Dr. Sharon Fruh
College of Nursing

"Healthy Student, Happy Nurse: A Longitudinal Investigation of Nursing Students' Health-Related Behaviors to Promote Professional Well-being"

Abstract: Emerging research suggests practicing nurses frequently experience mental and physical health problems that seriously impact patient care; nurses with sub-optimal physical and mental health are 26% to 71% more likely to make medical errors. As both a university and healthcare system, the University of South Alabama (USA) aims to produce healthcare professionals that deliver superior care to their patients. Our team, consisting of USA faculty from Nursing, Counseling, Kinesiology, and Health Informatics, can promote USA’s mission by illuminating mechanisms contributing to nursing students’ poor health and facilitating development of positive health-related behaviors among current nursing students to improve the health of USA students and promote future quality care for patients. Developing healthy habits before graduation may be the key to both healthier, happier nurses and superior patient care in the future.

Despite the detrimental effects of nurses’ health problems, researchers have not examined nursing students’ health longitudinally, revealing a dearth of information about the causes and long-term impact of nursing students’ health problems. Longitudinal investigations are needed to inform the development of interventions promoting improved nursing students’ health. We propose to assess nursing students’ health over a period of nine-months with the ultimate goal of developing a user-centered mobile health (mHealth) application (app) using established theories of health-behavior change. Currently, there are NO theory-driven mHealth apps designed to improve the health of nursing students.

Dr. Ryon McDermott

Dr. Ryon McDermott
Assistant Professor, Department of Counseling and Instructional Sciences
College of Education and Professional Studies

"College Student Success and Persistence: An Interdisciplinary Longitudinal Study of Risk and Protective Factors"

Abstract: Approximately 50% of college students drop out, making the study of student success and persistence a critical area of inquiry. Non-academic risk factors for student attrition include (a) mental health (e.g., anxiety, depression, history of adverse events and trauma), (b) physical health (e.g., poor diet, exercise, and lack of sleep), (c) aversion to seeking personal or academic help, and (d) certain socio-cultural factors evident through racial and gender disparities in retention. Emergent research also suggests protective factors, such as positive psychological characteristics, may mitigate these risks and can be harnessed through intervention. However, investigators have not examined the combined contributions of these risk and protective factors as predictors of student success and persistence over time.

Examining the prospective associations between mental/physical health, help seeking, socio-cultural factors, and positive psychology allows researchers to determine how these variables influence student success and persistence longitudinally. Specifically, by obtaining data across three different time points over nine months, the study team will identify how risk and protective factors interact and work together to predict college student success and persistence, thus revealing variables that can be targeted in future interventions. To date, no such data set exists, and the present project would give the authors a competitive edge for external funding.

After IRB approval, a random sample of 1000 first and second-year USA students will complete validated measures of mental/physical health problems, help seeking, socio-cultural factors, positive psychology, and student success/persistence every three months for nine months. Men and racial minorities will be oversampled to ensure adequate participation of these groups. Upon completion, selected survey respondents will participate in individual interviews to gather in-depth qualitative data. Interview information will contextualize quantitative findings and identify themes related to the
lived experiences of college students.

Dr. Krista Mehari

Dr. Krista Mehari
Assistant Professor, Department of Psychology
College of Arts and Sciences

"Development and Evaluation of a Universal Violence Prevention Curriculum for Ninth Grade Students"

Abstract: Youth violence is a health disparity that disproportionately affects African American youth. In addition to risk for physical injury and death, there are significant
psychological sequelae to violence exposure, including traumatic stress symptoms, increased internalizing and externalizing problems, and decreased academic achievement. Despite the fact that about 84% of high schools require the implementation of violence prevention programs, there is limited research supporting the effectiveness of such programs. This research-practice discrepancy may be due to researchers’ failure to integrate end-user consideration when developing programming.

The aims of this study are to (1) develop a ninth grade violence prevention curriculum in collaboration with end-users based on Facing Forward, an eighth grade violence prevention program adapted by the investigators; (2) pilot and adapt the curriculum using a rapid-cycle research design; and (3) obtain preliminary data about the effectiveness of the program on targeted outcomes (e.g., aggression) and hypothesized mechanisms of change.

Following curriculum development, the program will be implemented in a public high school by police officers in Fall 2019 and in a second school in Spring 2020. Using rapid-
cycling evaluation, researchers will adapt the program based on feedback from student and officers during implementation. The effects of the intervention will be evaluated using a
matched-control design. Outcomes will be assessed by collecting survey data from a sample of 200 students and their teachers at pretest and posttest as well as through qualitative interviews and focus groups.

Dr. Larry Yet

Dr. Larry Yet
Associate Professor, Department of Chemistry
College of Arts and Sciences

"Synthesis of Diarylquinoline Analogs as Viable Inhibitors of HIV-1 Integrase (IN) Enzyme"

Abstract: There are now more than 34 million people living with human immunodeficiency
virus (HIV), which once was a lethal disease is now treated as a chronic infection with the
treatment of AIDS patients with Highly Active Anti-Retroviral Therapy (HAART). HAART employs cocktails of different drug classes to target the various steps in the HIV replication
cycle: entry, fusion, reverse transcription, integration, and protein maturation. However,
HAART is not often well-tolerated by patients because of the harsh side effects. Our hypothesis is that HIV-1 integrase (IN) oligomerization is a novel target for antiviral drug development. The Scripps Research Molecular Screening Center screened a 375,000 small-molecule library to detect compounds that inhibit the allosteric catalytic activity of HIV-1 IN in an ultra-high-throughput screening (uHTS)-campaign and about three dozen active hits were obtained from this screen. The antiviral activity of this system will be investigated by the chemical probes produced from these efforts, which will be greatly aided by the elucidation of the biological and the antiviral roles played by HIV-1 IN. The interdisciplinary team of organic chemists and biochemists are assembled to prepare, test, and tune our 4-arylquinoline “hit” from the screen with both the expertise and experience having worked together on IN inhibitors. Funds are requested to synthesize multiply-substituted diarylquinoline inhibitors to gather further preliminary data to increase our competitiveness for submission to external research support from the NIH funding agencies.

▼   2018 Awardees
Dr. Kyre Lahtinen

Dr. Kyre Lahtinen
Assistant Professor, Department of Economics and Finance
Mitchell College of Business

"An Examination of the Effect of High-Frequency Trading on Financial Markets Utilizing Data Mining and Adaptive Cluster Distributed Machine Learning"

Abstract: Advancements in technology have greatly expanded the availability of data. Along with the ability to collect vast quantities of data comes the need to be able to analyze the data to find useful meaning. Data mining is the term used to describe the examination of large data sets to find new and meaningful information. Financial markets provide huge databases when collecting data on equity transactions across wide markets. The ability to sift through these large databases of high-frequency data and make meaningful interpretations of the underlying information can provide insight into the markets that most investors are not able to find.

Many in the media have accused high-frequency trading of giving certain corporate securities traders an unfair advantage. Regulatory bodies are contemplating new rules for high-frequency trading. This proposal seeks to fund the creation of a dataset to conduct research on high-frequency financial markets data with hopes to shed light on this trading activity. The proposed data system is expected to include high volumes of data, approaching 64 terabytes. The ability to perform the data mining of such a large data set will be one of the applications in support of NSF Grant "MRI: Acquisition of Adaptive Cluster for Performance and Forensics Analysis of Distributed Machine Learning," award #1726069, funded October 1, 2017.

Specifically, we will examine relevant questions related to stock return volatility, realized volatility and implied volatility, and short-term cross-correlation in securities returns. Each of these research lines is supported by and will augment well-established literature in finance. The research lines in question will be both extensions and new areas of scholarly work for the investigators.

Our goals are to produce insightful research related to the areas previously mentioned, to support the above funded NSF grant, to establish a database providing tools and computational heft for future research, and to create a financial analysis center as many top business school have. Accomplishing these goals will allow for the application of data-driven research in the classroom. It will support the development of Business Analytics courses which are strongly recommended by external accreditation, AACSB.

Dr. Georgios Lazarou

Dr. Georgios Lazarou
Assistant Professor, Department of Electrical and Computer Engineering
College of Engineering

"Network Protocol Architecture for 5G/LTE to 4G/LTE Seamless Handover"

Abstract: A ubiquitous Internet, connectivity for all anytime and anywhere, requires the convergence of the existing Internet with the mobile-based access networks. A pervasive Internet is envisioned to be ‘One Network for All.’ The existing 4G/LTE mobile systems have reached their limit and can no longer be extended or incrementally improved to meet the growing demand of high bandwidth-consumptive mobile services. It is now recognized that in order to meet the ever-increasing bandwidth demand of mobile applications, future 5G/LTE mobile devices must be able to operate at the abundant and unused millimeter wave (mmWave) bands, 10-300GHz. Recent experimental studies have demonstrated the feasibility of utilizing mmWave bands in densely populated urban areas. However, these 5G/LTE mobile devices need to be able to operate in multiple mmWave bands as well as in sub-3 GHz bands (4G/LTE, outside of urban areas where small mmWave-based cells are not economically feasible). The emergence of mmWave communications has created the need for new antennas, signal processing and communication technologies. Transition between dense urban heterogeneous mmWave cells to traditional 4G/LTE cells will be required in the near future, so that forthcoming 5G/LTE mobile devices, or so-called New Radios (NR), will be able to operate in multiple mmWave bands and in 4G/LTE bands. The Principal Investigators have been developing a single antenna system that covers all necessary 4G and 5G LTE frequency bands. A critical component of our proposed antenna system is the seamless handover between 5G/LTE and 4G/LTE user wireless connectivity. In this project, we propose to design the network protocol architecture that will make mobile wireless devices capable for operating in 5G and 4G LTE cellular networks. The aim of this one-year long project is to generate the necessary preliminary results needed to obtain federal funding for a three-year research project.

Dr. John Lehrter

Dr. John Lehrter
Associate Professor, Department of Marine Science
College of Arts and Sciences

"Predicting Intermediate Trophic Level Abundance and Behavior in Relation to Ocean Eddies, Fronts, and Primary Production"

Abstract: The goal of this work is to understand and predict the abundance and distribution of the intermediate trophic level (ITL) community (primarily zooplankton, jellyfish, and small fish) in relation to ocean eddies, fronts, and patchy primary production, which are ubiquitous features in the ocean. Specifically, the aims are twofold: to observe ITL responses and feedbacks to varying ocean acoustical, optical, and hydrographical properties; and to predict ITL responses and feedbacks to ocean biophysical properties using numerical models. In an observational component, we will conduct a novel pilot study to characterize ITL abundance, diversity, and behavior in a dynamic ocean region, the Middle Atlantic Bight, where frequent eddies and fronts and variable phytoplankton primary production occur. In an ecosystem modeling component, the ITL community will be represented within a numerical model to test hypotheses of dominant mechanisms controlling ITL dynamics and to assess how the activities of ITL communities, in turn, may affect ocean biophysics.

The ocean’s ITL constitutes a significant biomass and exerts control on important ocean biophysical properties. To date, observational studies and numerical models describing the role of the ITL have primarily focused on their function in the food web as predators of lower trophic levels, prey for higher trophic levels, and important mediators of the ocean’s biological carbon pump. Yet, the ITL also significantly influences biophysical properties such as acoustics, optics, and mixing at both local and global scales. And these processes, in contrast to food web processes, are generally not well understood nor represented in numerical ocean ecosystem models that are used for both short-term operational forecasts and long-term environmental change analysis. Thus, gaining understanding of mechanisms regulating ITL abundance and feedbacks between the ITL and ocean biophysical properties will advance and augment our ability to robustly predict ocean ecosystem states. Moreover, the grant will foster inter-disciplinary collaboration between USA and Naval Research Lab scientists leading to scientific outcomes that include manuscripts and proposals, and will afford one graduate student at USA the opportunity to gain inter-disciplinary observation and modeling experience.

Dr. Stephanie Smallegan

Dr. Stephanie Smallegan
Assistant Professor, Department of Civil, Coastal, and Environmental Engineering
College of Engineering

"Post-2017 Hurricane Season Assessment of Critical Beach Access Infrastructure Vulnerabilities"

Abstract: The focus of this proposal is to describe the effects of beach access points on community vulnerability through a coupling of collected data and numerical modeling techniques. The 2017 hurricane season caused severe destruction in the U.S., hundreds of fatalities, and billions of dollars in economic losses. For the first time in over 150 years, two major hurricanes (category 3 or greater on the Saffir-Simpson scale) made landfall in the continental U.S. in the same year. Within one month’s time, Hurricanes Harvey and Irma devastated coastal communities in Texas and Florida, respectively. In early October, Dauphin Island, Alabama was impacted by Hurricane Nate, which caused severe erosion on the barrier island’s narrower western end, requiring several months of sand removal from the primary access road. In response to Hurricanes Harvey, Irma and Nate, interdisciplinary multi-institutional teams of researchers who were funded by National Science Foundation’s Geotechnical Extreme Event Reconnaissance program rapidly deployed to Texas, Florida, and Alabama to collect extremely perishable geotechnical data. Based on observations, geotechnical damage such as erosion was greater near beach access points that transected dune fields. Despite these observations, vulnerability assessments often neglect the influence of beach access points because it is assumed they do not have a significant impact on vulnerability. Data collected at Dauphin Island will be used to conduct a complete site characterization, including beach and dune geometry, vegetation density and coverage, and number and locations of beach access points. The erosion near beach access points will be compared to “control” locations where access points do not exist. A numerical model will be used to simulate erosion caused by Hurricane Nate for both the existing conditions with beach access points and synthetic conditions where beach access points have been removed. The observed and simulated damage will be correlated to beach access point locations to determine the degree to which these points increase vulnerability. The outcomes of this study will be leveraged in external funding proposals, which will focus on cross-comparison of study sites, storm characteristics and early recovery of locations in Texas, Florida and Alabama.

Dr. Dhananjay Tambe

Dr. Dhananjay Tambe
Assistant Professor, Department of Mechanical Engineering
College of Engineering

"Discovering the mechanical principles that emerge from endothelial heterogeneity"

Abstract: The inner surface of blood vessels has a layer of endothelial cells. These cells are subjected to mechanical stimuli such as pressure and shear stress from the blood. Also, each endothelial cell can exert forces on its neighbor. We hypothesize that in each endothelial cell, these stimuli induce a unique mechanical signal which triggers both transient and long-lasting changes in cellular structure and molecular composition.

We propose to test this hypothesis and use it as a framework to examine the fundamental role of dissimilarities between the cells. Endothelial Cells from pulmonary Artery (ECA) have distinct molecular and functional properties compared to those from Microvessels (ECM). These heterogeneities are persistent, and they originate from distinct mechanical stimuli in those vascular segments. Even within say pulmonary artery, one can argue that no two cells are exactly same. However, these heterogeneities keep evolving, and they potentially originate from the cell being an active matter which continuously interacts with its neighbors.

Through the invention of the technique – Monolayer Stress Microscopy (MSM) – that enabled tracking of local mechanical stresses in a cell layer, we are uniquely capable of conducting the proposed study (Tambe et al. US Patent 9,714,932, 2017). By combining the expertise in advanced molecular probes (Rich lab), endothelial heterogeneity (Stevens lab) and MSM (Tambe lab), we will focus on the context of pulmonary hypertension induced leakiness and hyperproliferation in the region of lung vasculature where ECA and ECM are thought to co-exist. The proposed study will address following Specific Aims:

Aim 1. In a co-cultured ECA-ECM, quantify mechanical signals, layer integrity, and cell proliferation.

Aim 2. Test the hypothesis by identifying the relationship between mechanical signals and endothelial integrity.

Preliminary data indicate an opportunity to discover novel mechanical principles that emerge from endothelial heterogeneity. The proposed research will be a crucial component of several proposals including an NSF-CAREER in June 2018, an R01 to NHLBI in 2019, and an interdisciplinary Program Project Grant (PPG) to NHLBI in 2020.

▼   2017 Awardees
Dr. Ylenia Chiari on the beach

Dr. Ylenia Chiari
Assistant Professor, Department of Biology
College of Arts and Sciences

"Are looks really everything? Investigating body color pattern as a measure of individual success in animals."

Abstract: Individual fitness is a key concept in biology. Individuals that can survive better and reproduce more (individual fitness) will ensure their success and consequently the continuation of the species. In this context, the capacity of an organism to recognize and escape predators and recognize suitable mates (same species, males versus females) is essential for achieving high individual fitness. Individual recognition – the capacity of an organism to discriminate between individuals of the same species from those of a different species and among individuals of different sex – is therefore critical to ensure survival and success in animals and has been identified as a key step in the maintenance and formation of new species. Despite the significance of individual recognition, data indicating which animals are capable of distinguishing among individuals of the same versus different species or sex, how the recognition is achieved (visual, scent, acoustic), and the relationship between recognition and increased survival or reproduction, are still limited to a few representative species. In the proposed project, we will study the key components of how individual recognition through visual cues is achieved in a group of reptiles. First, we will test the ability of the animal to visually distinguish individual of the same or different species and same or different sex. Then we will analyze which visual clues (alone and in combination) - body color, color pattern, body size, and movements of the animal – are essential for the individual recognition. We will use a multidisciplinary approach (morphological and behavioral data and mathematical models) and live animals as well as video-manipulation and video-animation. We will interpret the results obtained in the context of cognitive abilities of the studies species and individual success. Our results will provide preliminary data to apply for funding to study: 1) how species are generated and maintained (NSF, HFSP funding), 2) how color and color pattern is obtained in vertebrates and the relationship between dysfunction in melanin based coloration and cancer (NSF, NIH), 3) the relationship between brain characteristics and individual recognition capacities (NSF, HFSP, NIH).

Dr. Phil Menard

Dr. Phil Menard
Assistant Professor, Department of Information Systems and Technology
School of Computing

"Improving Smart Home Security Through Targeted Training on Internet of Things (IoT)"

Abstract: The emergence of the Internet of Things (IoT) has marked an importance change in computing by utilizing modern telecommunications, thus making normal devices that were not previously networked “smart.” The market for smart home appliances alone is projected to reach $26 billion by 2019. Many IoT developers are rushing devices to production to capitalize on the growing market, with device security lacking as a result. IoT security weaknesses are the byproduct of allowing remote management and communication between devices. The number of potential vulnerabilities of Internet-enabled devices will grow exponentially as unsecure IoT device continue to be adopted by consumers, resulting in consumers likely being targeted more often by hackers. Vulnerability detection and user education together are paramount in mitigating this growing problem. I am proposing the development of a network analysis tool that scans the network, identifies devices, and provides specific security recommendations. My proposed tool will automate various penetration testing techniques and report the severity of each device’s vulnerabilities. I also propose the development of a scoring algorithm that quantifies the strength of a network’s security (scored from 0 to 100), based on the number of devices on the network and the severity of their vulnerabilities. Targeted recommendations and training modules are provided to the user for strengthening the network. This proposal will significantly contribute to security research by developing a tool that targets a growing threat vector. By mitigating the ability to compromise networks and propagate malware in the short term, my proposed tool ultimately contributes to the long-term security goal of realizing safer computing environment for everyone. If funded, I will use the award to build and test a prototype network analysis and training tool, along with a small test lab of IoT devices and mobile devices (both iOS and Android based). The results of the research will contribute to a submission to the NSF Secure and Trustworthy Cyberspace (SaTC) RFP. The IoT lab will also be beneficial to students currently enrolled in USA’s School of Computing.

Dr. Carlos Montalvo

Dr. Carlos Montalvo
Assistant Professor, Department of Mechanical Engineering
College of Engineering

"Investigating Sea Breeze Structure and Convective Initiation Using Unmanned Aerial Systems (UASs)"

Abstract: The recent reduced cost and technological advances in Unmanned Aerial Vehicles (UAVs) has brought about an explosion of applications in atmospheric observations. Compact, lightweight atmospheric sensors have been developed for UAVs. Many questions remain regarding this new technology including 1) optimal sensor placement on the UAV; 2) sensor data validation; and 3) development of sensors to measure wind speed and direction from vertical take off and landing aircraft. These 3 questions will be addressed in this collaborative RSDG project with the goal to gather preliminary data that will be used to write two competitive proposals to the National Science Foundation (NSF). One will be submitted to the Physical and Dynamic Meteorology program of the NSF Division of Atmospheric and Geospace Sciences to study thunderstorm formation in Mobile area sea breezes using UAV observations. Two previous submissions have been declined for funding. Based on reviewer comments, preliminary data will be helpful in drafting a more competitive proposal. Another proposal will be submitted to the National Robotics Initiative which seeks to accelerate the development and use of robots in the US and will study optical sensor placement, wind sensor development and integration of UAVs into standard weather modeling. The proposed RSDG project is a collaboration between 3 departments: Earth Sciences (ES), Mathematics and Statistics (MS), and Mechanical Engineering (ME). Dr. Kimball (ES) has expertise in atmospheric sensors and data analysis, Dr. Carlos Montalvo (ME) is an expert in UAV technology, and Dr. Madhuri Mulekar (MS) will perform statistical analysis. At least 2 UAVs will be flown on a weekly basis in different weather conditions to gather data to address the above research questions. The UAVs will carry several atmospheric sensors each. Dr. Montalvo will analyze data obtained to determine optimal sensor placement and feasibility of measuring wind speed. UAVs will be flown alongside a 10 m tower with research-grade atmospheric sensors. Data from UAV-based sensors will be compared to tower measurements. Preliminary vertical soundings up to 112 m in altitude in mature sea breezes will be undertaken. Undergraduate and graduate students will assist with all parts of this research project.

Dr. Matthew Reichert

Dr. Matthew Reichert
Associate Professor, Chemistry Department
College of Arts and Sciences

"Novel 3D Printing Technology Utilizing Ionic Liquids"

Abstract: Additive manufacturing, more commonly known as 3-D printing, is an emerging field with many research opportunities. Currently additive manufacturing techniques use petroleum-based polymers. In an effort to reduce our dependence on petroleum products and maintain our demand for polymer based products, new renewable and sustainable polymers are needed. One of the main prospects for replacement of petroleum based polymers are biopolymers, such as cellulose. One area that has been neglected is the 3-D printing of biopolymers. This neglect is mainly due to the difficultly in producing consistent printable medium using these unique polymers. Ionic liquids have the potential to remove this hurdle and impact various areas of research in the 3-D printing field. One of those areas is the ability to 3-D print biopolymers such as cellulose and chitin. Ionic liquids can dissolve various biopolymers, including cellulose and chitin. This ability can allow for the replacement of petroleum-based polymers in 3-D printing with biorenewable, biocompatible, and recyclable polymers. A neglected area of 3-D printing technology is the incorporation of additives such as plasticizers into the printed objects. Current polymer additives are volatile and leech out of the polymer leading to “new car" smell. Ionic liquids usually do not evaporate and therefore remain in the plastics giving the plastic better durability and flexibility. The incorporation of ionic liquids as additives to current stereolithography (SLA) and digital light processing (DLP) printing methods could have a large impact on 3-D printing technology. As additives to the resin bath, ionic liquids can also have an impact on SLA and DLP 3-D printing. Ionic liquids have the advantage of being able to carry various functionalities, such as flame resistance, within their structure. By incorporating functionalized ionic liquids into the resin bath, the final 3-D printed object will have these ionic liquids embedded in their structure. The final product will not only be a high-detailed object, but it will also possess the chemical functionality of the embedded ionic liquid. The incorporation of ionic liquids into current additive manufacturing technologies can have a considerable environmental benefit as well as an increase in consumer safety and product lifetimes.

Dr. Wito Richter

Dr. Wito Richter
Assistant Professor, Department of Biochemistry and Molecular Biology
College of Medicine

"cAMP-Phosphodiesterase PDE 4D as a Target for Colon Cancer Therapy"

Abstract: Type 4 cyclic nucleotide phosphodiesterases (PDE4s) comprise a family of isoenzymes that hydrolyze and inactivate the second messenger cAMP. Recent studies have shown that treatment with non-selective PDE4 inhibitors impairs cancer cell proliferation and migration, tumor growth and angiogenesis in various types of cancers; suggesting that PDE4s represent a potential target for the development of novel cancer therapeutics. However, non-selective PDE4 inhibitors induce a number of side effects, including nausea, emesis and diarrhea that limit their clinical utility. The PDE4 family comprises four subtypes/genes, PDE4A to D. As each plays unique and non-overlapping physiological and pathophysiological roles in the body, targeting individual PDE4 subtypes can serve to separate the therapeutic benefits from the side effects of non-selective PDE4 inhibitors. To this end, we explored the role of PDE4s in five human colon cancer cell lines. Treatment with non-selective PDE4 inhibitors ablated the chief portion of total cAMP hydrolytic activity in extracts prepared from all five cell lines, suggesting that PDE4s are the main cAMP-PDE expressed in colon cancer cells. Treatment with non-selective PDE4 inhibitors reduced the viability and motility of colon cancer cells in culture, confirming the potential of PDE4 as a therapeutic target. Western blotting and immunoprecipitation with subtype-selective antibodies revealed that PDE4 activity and protein in colon cancer cells is largely due to PDE4D, with none of the other PDE4 subtypes (PDE4A-C) being expressed in four of the five cell lines. As these cells exclusively express PDE4D, then the effect of non-selective PDE4 inhibitors on cell viability/motility must necessarily have been mediated via inhibition of PDE4D. We thus propose PDE4D as the most promising target for development of a therapeutic and will test this hypothesis by: 1. assessing the efficacy of 698C4, a novel PDE4D-selective inhibitor identified by high-throughput screening, on cancer cell viability and invasion, 2. identifying the downstream targets of PDE4D, and 3. assessing the anti-tumor activity of PDE4 inhibition in a mouse graft model. Ultimately, we hope to show that selective inhibition of PDE4D retains the cancer therapeutic benefits, but exhibits an improved safety profile, compared to the non-selective PDE4 inhibitors available to date.

▼   2016 Awardees
Dr. John McCreadie

Dr. John McCreadie
Professor, Department of Biology
College of Arts and Sciences

"Measuring Real-Time Changes in Aquatic Ecosystems Using Environmental and Biologically Collected DNA"

Dr. Alison Robertson

Dr. Alison Robertson, Co-PI
Research Assistant Professor, Department of Marine Sciences
College of Arts and Sciences

"High Throughput Next Generation CometChip Platform for Assessment of Fish and Human Genome Damage Following Exposure to Harmful Algal Toxins"

Dr. Robert Sobol

Dr. Robert Sobol, Co-PI
Professor, Oncologic Sciences
Mitchell Cancer Institute

"High Throughput Next Generation CometChip Platform for Assessment of Fish and Human Genome Damage Following Exposure to Harmful Algal Toxins"

Dr. David Weber

Dr. David Weber
Associate Professor, Department of Physiology and Cell Biology
College of Medicine

"Endothelial Calcium Dynamics in Low-Flow Mediated Vascular Remodeling"

Dr. Christy West

Dr. Christy West
Assistant Professor, Department of Chemical and Biomolecular Engineering
College of Engineering

"Solar Water Splitting using Metal-Decorated Titania"

▼   2015 Awardees
Dr. Natalie Bauer

Dr. Natalie Bauer
Assistant Professor, Pharmacology
College of Medicine

"Biologically Targeted Drug Delivery to the Pulmonary Airways and Pulmonary Circulation"

Dr. Alex Beebe

Dr. Alex Beebe
Assistant Professor, Department of Earth Sciences
College of Arts and Sciences

"Characterization of Submarine Groundwater Discharge to Mobile Bay"

Dr. Joe Currier

Dr. Joseph Currier
Assistant Professor, Psychology Department
College of Arts and Sciences

"From Boots to Books: A Longitudinal Study of Returning Veterans' Success in Transitioning to College and Willingness to Seek Help"

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Dr. Padmamalini Thulasiraman
Assistant Professor, Biomedical Sciences
College of Allied Health

"Curcumin: A Therapeutic Initiative for Retinoic Acid-Resistant Triple Negative Breast Cancer"

Dr. Saami Yazdani

Dr. Saami Yazdani
Assistant Professor, Mechanical Engineering
College of Engineering

"A Novel Drug Coated Balloon to Treat Peripheral Disease"

▼   2014 Awardees
Dr. Robert Barrington

Dr. Robert Barrington
Department of Microbiology and Immunology
College of Medicine

"Tracking influenza virus-mediated immune responses in the lung"

Dr. Grant Glover

Dr. Grant Glover
Department of Chemical and Biomolecular Engineering
College of Engineering

"Modification of Fibers Using Reactive Dye Chemistry"

Dr. Lawrence Leclaire

Dr. Lawrence LeClaire
Department of Biochemistry
College of Medicine

"Invasive Aspergillosis and the Actin Cytoskeleton: Pathways for Targeting the 'Achilles' Heel of Fungal Growth'"

Dr. Ryan Littlefield

Dr. Ryan Littlefield 
Assistant Professor, Department of Biology
College of Arts and Sciences

"Investigating the role of myosin on actin filament length regulation in C. elegans"